CD209b (SIGN-R1) Antibody, anti-mouse, APC-Vio® 770, REAfinity™ | Miltenyi Biotec 130-106-333 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD209b (SIGN-R1) Antibody, anti-mouse, APC-Vio® 770, REAfinity™

catalog :

130-106-333

quantity :

30 µg in 1 mL

price :

144,00 USD

clonality :

monoclonal

host :

human

conjugate :

APC

clone name :

REA125

reactivity :

mouse

application :

flow cytometry, immunohistochemistry - frozen section

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; loading ...; fig 5e	Tsai F, Homan P, Agrawal H, Misharin A, Abdala Valencia H, Haines G, et al. Bim suppresses the development of SLE by limiting myeloid inflammatory responses. J Exp Med. 2017;214:3753-3773 pubmed publisher
	Saunders S, Barlow J, Walsh C, Bellsoi A, Smith P, McKenzie A, et al. C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide. J Immunol. 2010;184:2627-37 pubmed publisher
	Geijtenbeek T, Groot P, Nolte M, van Vliet S, Gangaram Panday S, van Duijnhoven G, et al. Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo. Blood. 2002;100:2908-16 pubmed
	Park C, Takahara K, Umemoto E, Yashima Y, Matsubara K, Matsuda Y, et al. Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int Immunol. 2001;13:1283-90 pubmed

product information

Catalog Number :

130-106-333

Product Name :

CD209b (SIGN-R1) Antibody, anti-mouse, APC-Vio® 770, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

APC-Vio 770

Antigen Modification :

CD209b (SIGN-R1)

Clone Name :

REA125

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 µg in 1 mL

US List Price :

144,00 USD

Product Description :

Clone REA125 recognizes the mouse CD209b antigen, a single-pass type II membrane protein also known as DC-SIGN-related protein 1 (SIGN-R1). CD209b was identified by examination of the mouse genome in search of the complete set of proteins related to the human glycan binding receptor CD209 (DC-SIGN). Unlike the human CD209, mouse CD209b is not expressed on dendritic cells (DCs) but is on splenic marginal zone, lymph node, and peritoneal macrophages. Its high affinity for murine ICAM-2, and its localization at sites that are in close contact with blood, suggest a role for CD209b in lymphocyte migration from the blood into tissues. Moreover, marginal zone macrophages in the spleen efficiently capture blood-borne antigens in vivo through CD209b. CD209b has also been shown to interact with the TLR signaling system, with CD209b associating with the TLR4-MD2 complex to enhance signal transduction in response to LPS in Gram-negative bacteria in vitro. Additional information: Clone REA125 displays negligible binding to Fc receptors.

ALTnames :

DC-SIGNR1, OtB7, SIGNR1, mSIGNR1

Specificity :

mouse

Concentration :

1:10

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.