CD195 (CCR5) Antibody, anti-human, Biotin, REAfinity™ | Miltenyi Biotec 130-106-260 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD195 (CCR5) Antibody, anti-human, Biotin, REAfinity™

catalog :

130-106-260

quantity :

30 tests in 300 µL

price :

89,00 USD

clonality :

monoclonal

host :

human

conjugate :

biotin

clone name :

REA245

reactivity :

human

application :

flow cytometry

citations: 3

Reference
Li W, Liu L, Gomez A, Zhang J, Ramadan A, Zhang Q, et al. Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease. JCI Insight. 2016;1: pubmed publisher
Shahin K, Sartor M, Hart D, Bradstock K. Alterations in chemokine receptor CCR5 expression on blood dendritic cells correlate with acute graft-versus-host disease. Transplantation. 2013;96:753-62 pubmed publisher
Richardson M, Jadlowsky J, Didigu C, Doms R, Riley J. Kruppel-like factor 2 modulates CCR5 expression and susceptibility to HIV-1 infection. J Immunol. 2012;189:3815-21 pubmed publisher

product information

Catalog Number :

130-106-260

Product Name :

CD195 (CCR5) Antibody, anti-human, Biotin, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Biotin

Antigen Modification :

CD195 (CCR5)

Clone Name :

REA245

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

89,00 USD

Product Description :

Clone REA245 recognizes the human CD195 antigen, a multi-pass membrane protein which is also known as C-C chemokine receptor type 5 (CCR5). CD195 belongs to the G-protein coupled receptor 1 family and is predominantly expressed on T cells, macrophages, and dendritic cells. It is a receptor for a number of inflammatory CC-chemokines including MIP-1-α, MIP-1-β, and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. CD195 is involved in the chemotaxis of leucocytes to inflammation sites and plays an important role in the recruitment of macrophages, T cells, and monocytes in inflammation. Many forms of HIV initially use CD195 to enter and infect host cells. Additionally, CCR5 may have an indirect effect on cancer progression by controlling the antitumor immune response, since it has been demonstrated that its expression could promote tumor growth and contribute to tumor metastasis. Additional information: Clone REA245 displays negligible binding to Fc receptors.

ALTnames :

CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22, CHEMR13

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.