HLA-DM Antibody, anti-human, FITC, REAfinity™ | Miltenyi Biotec 130-106-167 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

HLA-DM Antibody, anti-human, FITC, REAfinity™

catalog :

130-106-167

quantity :

30 tests in 300 µL

price :

84,00 USD

clonality :

monoclonal

host :

human

conjugate :

FITC

clone name :

REA406

reactivity :

human

application :

flow cytometry

citations: 3

Reference
Pos W, Sethi D, Wucherpfennig K. Mechanisms of peptide repertoire selection by HLA-DM. Trends Immunol. 2013;34:495-501 pubmed publisher
van Lith M, McEwen Smith R, Benham A. HLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM. J Biol Chem. 2010;285:40800-8 pubmed publisher
Oldford S, Robb J, Codner D, Gadag V, Watson P, Drover S. Tumor cell expression of HLA-DM associates with a Th1 profile and predicts improved survival in breast carcinoma patients. Int Immunol. 2006;18:1591-602 pubmed

product information

Catalog Number :

130-106-167

Product Name :

HLA-DM Antibody, anti-human, FITC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

FITC

Antigen Modification :

HLA-DM

Clone Name :

REA406

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

84,00 USD

Product Description :

Clone REA406 recognizes the human HLA-DM antigen, a non-classical MHC class II molecule (MHC II) chaperone that works in lysosomes and endosomes. MHC II molecules are transmembrane glycoproteins which function by binding processed antigenic peptides and presenting them to CD4+ T lymphocytes to initiate or maintain a specific immune response. Constitutive MHC II expression is restricted to professional antigen presenting cells including dendritic cells (DCs), B cells, and macrophages and to the epithelial cells of the thymus. Functional class II expression is highly dependent on the expression of two main chaperones, the invariant chain (Ii) and DM. Newly synthesized class II α- and β-chains form a nonameric complex with three Ii molecules in the endoplasmic reticulum where Ii blocks the peptide-binding groove and guides class II dimers to the endocytic pathway where Ii is proteolytically cleaved leaving the CLIP fragment bound to class II. HLA-DM, an endocytic chaperone, protects empty class II dimers until they bind a peptide capable to confer enough stability to the complex. Additional information: Clone REA406 displays negligible binding to Fc receptors.

ALTnames :

HLA-DMA, HLA-DMB, DMA, HLADM, RING6, D6S221E, RING7

Specificity :

human

Concentration :

1:10

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.