Slug Antibody, anti-human, PE, REAfinity™ | Miltenyi Biotec 130-106-135 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

Slug Antibody, anti-human, PE, REAfinity™

catalog :

130-106-135

quantity :

100 tests in 1 mL

price :

278,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA404

reactivity :

human

application :

flow cytometry

citations: 3

Reference
Guo W, Keckesova Z, Donaher J, Shibue T, Tischler V, Reinhardt F, et al. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell. 2012;148:1015-28 pubmed publisher
Sanchez Martin M, Rodríguez García A, Perez Losada J, Sagrera A, Read A, Sanchez Garcia I. SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum Mol Genet. 2002;11:3231-6 pubmed
Hemavathy K, Guru S, Harris J, Chen J, Ip Y. Human Slug is a repressor that localizes to sites of active transcription. Mol Cell Biol. 2000;20:5087-95 pubmed

product information

Catalog Number :

130-106-135

Product Name :

Slug Antibody, anti-human, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

Slug

Clone Name :

REA404

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

278,00 USD

Product Description :

Clone REA404 recognizes the human slug antigen, a zinc finger transcriptional repressor also known as SNAI2. Slug is an inducer of the epithelial to mesenchymal transition (EMT) which is a highly conserved developmental program activated during mesoderm formation and neural crest development. This program also promotes dissemination of single malignant cells from primary epithelial tumors. During EMT, cells discard their epithelial characteristics, including cell adhesion and polarity, reorganize their cytoskeleton and acquire a mesenchymal morphology and the ability to migrate. One of the hallmarks of EMT is the functional loss of the cell-cell junction protein E-cadherin. Several transcription factors including slug have been identified to repress E-cadherin expression, which plays important roles in cell adhesion and in the maintenance of tissue structure. These EMT transcription factors bind to E-box elements in the promoter region of E-cadherin leading to transcriptional repression of junctional complexes and induction of the mesenchymal phenotype. Additional information: Clone REA404 displays negligible binding to Fc receptors.

ALTnames :

SNAI2, SLUGH1, SNAIL2, WS2D, SLUG, SLUGH

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.