TIM-1 Antibody, anti-human, PE, REAfinity™ | Miltenyi Biotec 130-106-073 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

TIM-1 Antibody, anti-human, PE, REAfinity™

catalog :

130-106-073

quantity :

30 tests in 300 µL

price :

99,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA384

reactivity :

human

application :

flow cytometry

citations: 3

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 5a	Kachko A, Costafreda M, Zubkova I, Jacques J, Takeda K, Wells F, et al. Determinants in the Ig Variable Domain of Human HAVCR1 (TIM-1) Are Required To Enhance Hepatitis C Virus Entry. J Virol. 2018;92: pubmed publisher
	Angiari S, Donnarumma T, Rossi B, Dusi S, Pietronigro E, Zenaro E, et al. TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity. 2014;40:542-53 pubmed publisher
	Moller Tank S, Kondratowicz A, Davey R, Rennert P, Maury W. Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry. J Virol. 2013;87:8327-41 pubmed publisher

product information

Catalog Number :

130-106-073

Product Name :

TIM-1 Antibody, anti-human, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

TIM-1

Clone Name :

REA384

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

99,00 USD

Product Description :

Clone REA384 recognizes the human T cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a single-pass type I membrane protein also known as hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). TIM-1 is widely expressed, with highest levels in kidney and testis. It is also expressed by activated T cells, B cells, natural killer T cells, and dendritic cells. The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity in vivo through responses mediated by Tʜ1, Tʜ2, Tʜ17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. In addition to serving as a receptor for filoviruses, human TIM-1 is reported to serve as a receptor for hepatitis A virus and a variety of flaviviruses, alphaviruses, and arenaviruses. Additional information: Clone REA384 displays negligible binding to Fc receptors.

ALTnames :

CD365, HAVCR, HAVcr-1, KIM-1, TIMD-1, TIM, TIM1

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.