CD98 Antibody, anti-human, APC, REAfinity™ | Miltenyi Biotec 130-105-709 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD98 Antibody, anti-human, APC, REAfinity™

catalog :

130-105-709

quantity :

30 tests in 300 µL

price :

128,00 USD

clonality :

monoclonal

host :

human

conjugate :

APC

clone name :

REA387

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Cantor J, Ginsberg M. CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci. 2012;125:1373-82 pubmed publisher

product information

Catalog Number :

130-105-709

Product Name :

CD98 Antibody, anti-human, APC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

APC

Antigen Modification :

CD98

Clone Name :

REA387

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

128,00 USD

Product Description :

Clone REA387 recognizes the human CD98 antigen, a single-pass type II membrane glycoprotein. CD98 is broadly expressed on non-hematopoietic cells and also on peripheral blood lymphocytes, monocytes, and granulocytes. The CD98 heterodimer consists of a 80–85 kDa heavy chain (CD98hc, also known as 4F2 antigen heavy chain or FRP-1) that is disulfide-linked with a multi-pass light chain of 40 kDa. The heavy chain binds to the cytoplasmic tails of integrin-β chains and mediates adhesive signals that control cell spreading, survival, and growth. The light chain functions in amino acid transport. Some of the light chains have broad specificity, but the large neutral amino acid transporters LAT-1 and LAT-2 have preference for importing certain essential amino acids, particularly leucine, isoleucine, and arginine (LAT-1), in exchange for glutamine. Through its nutrient function, CD98 can contribute to the survival and growth of many cell types. CD98hc functions in amplifying integrin signaling and in the transport of amino acids. Both of these functions can contribute to cell survival and proliferation. Additional information: Clone REA387 displays negligible binding to Fc receptors.

CrossReactivity :

olive baboon (Papio anubis), chimpanzee (Pan troglodytes)

ALTnames :

SLC3A2, SLC7A5, 4F2hc

Specificity :

human, non-human primate

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.