Histone H3 pS28 Antibody, anti-human/mouse, APC, REAfinity™ | Miltenyi Biotec 130-105-654 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

Histone H3 pS28 Antibody, anti-human/mouse, APC, REAfinity™

catalog :

130-105-654

quantity :

100 tests in 1 mL

price :

294,00 USD

clonality :

monoclonal

host :

human

conjugate :

APC

clone name :

REA379

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Dong Z, Bode A. The role of histone H3 phosphorylation (Ser10 and Ser28) in cell growth and cell transformation. Mol Carcinog. 2006;45:416-21 pubmed
Choi H, Choi B, Cho Y, Zhu F, Bode A, Dong Z. Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. J Biol Chem. 2005;280:13545-53 pubmed

product information

Catalog Number :

130-105-654

Product Name :

Histone H3 pS28 Antibody, anti-human/mouse, APC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

APC

Antigen Modification :

Histone H3 pS28

Clone Name :

REA379

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

294,00 USD

Product Description :

Clone REA379 recognizes the human and mouse histone H3 antigen phosphorylated at serine 28 (pS28). Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Phosphorylation of histone H3 at pS10 and pS28 is very important for chromosome condensation and segregation during mitosis. The phosphorylation of histone H3 at pS10 appears to be involved in the initiation of chromosome condensation but not the maintenance of it. Although phosphorylation of histone H3 at pS10 is related to chromosome assembly, congregation at the metaphase plate, and segregation, phosphorylation of histone H3 at pS28 occurs in chromosomes predominantly during early mitosis and coincides with the initiation of mitotic chromosome condensation in various mammalian cell lines. Additional information: Clone REA379 displays negligible binding to Fc receptors.

CrossReactivity :

Drosophila, rat, cow

ALTnames :

H3F3B, H3.3B, H3.3A, H3F3, H3F3A, H3 (pS28), H3.1, H3.2, H3.3

Specificity :

human, mouse, rat, other

Concentration :

1:11

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.