MEK1 pS298 Antibody, anti-human/mouse, PE, REAfinity™ | Miltenyi Biotec 130-105-604 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

MEK1 pS298 Antibody, anti-human/mouse, PE, REAfinity™

catalog :

130-105-604

quantity :

30 tests in 300 µL

price :

99,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA375

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Coles L, Shaw P. PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway. Oncogene. 2002;21:2236-44 pubmed

product information

Catalog Number :

130-105-604

Product Name :

MEK1 pS298 Antibody, anti-human/mouse, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

MEK1 pS298

Clone Name :

REA375

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

99,00 USD

Product Description :

Clone REA375 recognizes the human and mouse MEK1 antigen phosphorylated at serine 298 (pS298). The dual specificity kinases MEK1 and MEK2 are activated by RAF and mediate phosphorylation of ERK1 and ERK2. MEK1 and MEK2 are very similar but differ structurally in a proline-rich domain in the C-terminal half of the catalytic core. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival, and differentiation, predominantly through the regulation of transcription, metabolism, and cytoskeletal rearrangements. MEK1 is phosphorylated at S298 by PAK. MAPK1/ERK2 phosphorylation of T292 occurs in response to cellular adhesion and leads to inhibition of S298 phosphorylation by PAK. Additional information: Clone REA375 displays negligible binding to Fc receptors.

ALTnames :

MAP2K1, CFC3, MAPKK 1, MKK1, PRKMK1, MEK1

Specificity :

human, mouse

Concentration :

1:11

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.