Oct3/4 Isoform A Antibody, anti-human/mouse, PE, REAfinity™ | Miltenyi Biotec 130-105-554 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

Oct3/4 Isoform A Antibody, anti-human/mouse, PE, REAfinity™

catalog :

130-105-554

quantity :

100 tests in 1 mL

price :

278,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA338

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Nakagawa E, Zhang L, Kim E, Shin J, Cho S, Ohshima H, et al. The novel function of Oct3/4 in mouse tooth development. Histochem Cell Biol. 2012;137:367-76 pubmed publisher
Niwa H, Miyazaki J, Smith A. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet. 2000;24:372-6 pubmed

product information

Catalog Number :

130-105-554

Product Name :

Oct3/4 Isoform A Antibody, anti-human/mouse, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

Oct3/4 Isoform A

Clone Name :

REA338

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

278,00 USD

Product Description :

Clone REA338 recognizes the human octamer-binding transcription factor 3/4 isoform A (Oct3/4A) and the mouse Oct3/4. Oct3/4 is a homeodomain transcription factor belonging to the POU transcription factor family and is also known as POU domain class 5 transcription factor 1 (POU5F1). Oct3/4 is critical for the maintenance of totipotency in primate blastomeres and for pluripotency of the inner cell mass of developing mammalian embryos. This critical role of Oct3/4 is maintained in embryonic stem cells, the developing germline, and germline tumors, such as seminomas and embryonic teratocarcinomas. When inducing pluripotency in differentiated cells, Oct3/4 appears to be an essential, but not the only required transcription factor. Oct3/4 acts as a transcriptional activator of genes involved in maintenance of undifferentiated state and as a repressor of differentiation-specific genes.In human it encodes two chief isoforms that are generated by alternative splicing – Oct3/4A and Oct3/4b. Only the Oct3/4A protein consequently contains the unique N-terminal transactivation domain that regulates DNA binding of Oct3/4A to target promoters. It is only this full length Oct3/4A protein – that localizes to the nucleus, binds to Oct3/4-regulated promoters, and contributes to the maintenance of pluripotency and self-renewal. Additional information: Clone REA338 displays negligible binding to Fc receptors.

ALTnames :

POU5F1, OTF-3, OTF-4, Oct-3, Oct-4, Oct3/4A, Oct-3A, NF-A3

Specificity :

human, mouse

Concentration :

1:11

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.