Hsp70 Antibody, anti-human/mouse, APC, REAfinity™ | Miltenyi Biotec 130-105-550 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

Hsp70 Antibody, anti-human/mouse, APC, REAfinity™

catalog :

130-105-550

quantity :

100 tests in 1 mL

price :

294,00 USD

clonality :

monoclonal

host :

human

conjugate :

APC

clone name :

REA349

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

citations: 2

Reference
Murphy M. The HSP70 family and cancer. Carcinogenesis. 2013;34:1181-8 pubmed publisher
Mayer M, Bukau B. Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci. 2005;62:670-84 pubmed

product information

Catalog Number :

130-105-550

Product Name :

Hsp70 Antibody, anti-human/mouse, APC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

APC

Antigen Modification :

Hsp70

Clone Name :

REA349

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

294,00 USD

Product Description :

Clone REA349 recognizes the human and mouse heat shock 70 kDa protein (Hsp70) antigen, a member of the heat shock protein family that serve critical roles in protein homeostasis. The Hsp70 family is the most conserved in evolution, and all eukaryotes contain multiple members. Their synthesis is increased upon environmental stress. Hsp70 assists a wide range of folding processes, including the folding and assembly of newly synthesized proteins, refolding of misfolded and aggregated proteins, membrane translocation of organellar and secretory proteins, and control of the activity of regulatory proteins. It has thus housekeeping functions in the cell in which it is built-in components of folding and signal transduction pathways, and quality control functions in which it proofreads the structure of proteins and repairs misfolded conformers. All of these activities appear to be based on the property of Hsp70 to interact with hydrophobic peptide segments of proteins in an ATP-controlled fashion. Additional information: Clone REA349 displays negligible binding to Fc receptors.

ALTnames :

HSPA1B, HSPA1A, HSP70-1, HSP70-2, HSP70.1, HSP70.2

Specificity :

human, mouse

Concentration :

1:10

Uses :

For research use only

Application Summary :

Intracellular flow cytometry, Multiparameter imaging cell screen, Immunofluorescence, Immunohistochemistry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.