Anti-Btk antibodies | Miltenyi Biotec 130-105-546 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

Anti-Btk antibodies

catalog :

130-105-546

quantity :

for 100 tests

clonality :

recombinant

host :

human

conjugate :

clone name :

REA367

reactivity :

human

application :

flow cytometry

product information

Item Name :

Anti-Btk antibodies

Catalog Number :

130-105-546

Quantity :

for 100 tests

Target :

Btk

Reactivity :

human

Applications :

Flow Cytometry

Primary / Secondary :

Primary

Host :

human

Conjugate/Tag/Label :

Format :

Antibodies are supplied in buffer containing stabilizer and 0.05% sodium azide.

Isotype :

recombinant human IgG1

Clone :

REA367

Clonality :

recombinant

Long text :

Clone REA367 recognizes the human Btk (bruton tyrosine kinase) antigen, a non-receptor tyrosine kinase belonging to the Tec family of kinases. Btk is critical for B cell–development, –differentiation, and –signaling. Moreover, Btk expression is assumed to be a prerequisite for B cell–proliferation and survival. Consequently, Btk-deficient B lymphocytes fail to reach the mature state and are presumably doomed to premature death. Btk is reported to be associated with human disease. Thus, individuals harboring loss-of-function mutations in the gene encoding Btk virtually lack circulating B lymphocytes, are unable to generate immunoglobulins of all classes, and therefore cannot mount humoral immune responses. This primary immunodeficiency is named X-linked agammaglobulinemia. Additional information: Clone REA367 displays negligible binding to Fc receptors.