CD352 (NTB-A) Antibody, anti-human, FITC, REAfinity™ | Miltenyi Biotec 130-105-541 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD352 (NTB-A) Antibody, anti-human, FITC, REAfinity™

catalog :

130-105-541

quantity :

100 tests in 1 mL

price :

238,00 USD

clonality :

monoclonal

host :

human

conjugate :

FITC

clone name :

REA339

reactivity :

human

application :

flow cytometry

citations: 3

Reference
Katz G, Krummey S, Larsen S, Stinson J, Snow A. SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced cell death. J Immunol. 2014;192:4202-9 pubmed publisher
Valdez P, Wang H, Seshasayee D, van Lookeren Campagne M, Gurney A, Lee W, et al. NTB-A, a new activating receptor in T cells that regulates autoimmune disease. J Biol Chem. 2004;279:18662-9 pubmed
Bottino C, Falco M, Parolini S, Marcenaro E, Augugliaro R, Sivori S, et al. NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease. J Exp Med. 2001;194:235-46 pubmed

product information

Catalog Number :

130-105-541

Product Name :

CD352 (NTB-A) Antibody, anti-human, FITC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

FITC

Antigen Modification :

CD352 (NTB-A)

Clone Name :

REA339

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

238,00 USD

Product Description :

Clone REA339 recognizes the human CD352 antigen, a 60 kDa single-pass type I membrane protein also known as SLAM family member 6 (SLAM6) or natural killer (NK), T, and B cell–antigen (NTB-A). CD352 belongs to the CD2 subfamily of the immunoglobulin superfamily and is expressed on NK, T, and B cells. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases. Monoclonal antibody-mediated cross-linking of CD352 results in the induction of NK-mediated cytotoxicity. CD352 also triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors. This suggests that CD352 may function as a coreceptor in the process of NK cell activation. Importantly, analysis of NK cells derived from patients with X-linked lymphoproliferative disease showed that the lack of SH2D1A protein profoundly affects the function of CD352. Additional information: Clone REA339 displays negligible binding to Fc receptors.

ALTnames :

SLAMF6, KALI, KALIb, LY108, NTB-A, NTBA, SF2000, SLAM6, TCOM

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.