Anti-Akt pS473 antibodies | Miltenyi Biotec 130-105-293 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

Anti-Akt pS473 antibodies

catalog :

130-105-293

quantity :

for 30 tests

clonality :

recombinant

host :

human

conjugate :

APC

clone name :

REA359

reactivity :

human, mouse

application :

flow cytometry

product information

Item Name :

Anti-Akt pS473 antibodies

Catalog Number :

130-105-293

Quantity :

for 30 tests

Target :

Akt pS473

Reactivity :

human, mouse

Applications :

Flow Cytometry

Primary / Secondary :

Primary

Host :

human

Conjugate/Tag/Label :

APC

Format :

Antibodies are supplied in buffer containing stabilizer and 0.05% sodium azide.

Isotype :

recombinant human IgG1

Clone :

REA359

Clonality :

recombinant

Long text :

Clone REA359 recognizes the human and mouse Akt antigen phosphorylated at serine 473 (pS473). Akt is a family of serine/threonine kinases which is also known as protein kinase B (PKB) or related to the A and C kinases (RAC-PK). Akt intricately regulates many cellular functions such as cell growth and proliferation, cell survival, apoptosis, energy metabolism, and resistance to anticancer therapeutics. It consists of three isoforms, Akt1, Akt2, and Akt3 (or PKBα, β, and γ). Although these three isoforms are encoded by separate genes, they share a common NH2-terminal pleckstrin homology (PH) domain, a catalytic domain in the middle, and a COOH terminus. The identity of the overall amino acid sequence of the three isoforms is very high (about 80%); however, the COOH terminus and the PH-linker region are more diverse. All three isoforms contain similar phosphorylation/activation sites: threonine 308 (Akt1), 309 (Akt2), and 305 (Akt3) and serine 473 (Akt1), 474 (Akt2), and 472 (Akt3). Phosphorylated or activated Akt regulates many of its cellular functions through the phosphorylation of a series of downstream players. Additional information: Clone REA359 displays negligible binding to Fc receptors.