STAT3 pS727 Antibody, anti-human, APC, REAfinity™ | Miltenyi Biotec 130-104-948 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

STAT3 pS727 Antibody, anti-human, APC, REAfinity™

catalog :

130-104-948

quantity :

100 tests in 1 mL

price :

294,00 USD

clonality :

monoclonal

host :

human

conjugate :

APC

clone name :

REA324

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Sakaguchi M, Oka M, Iwasaki T, Fukami Y, Nishigori C. Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells. J Invest Dermatol. 2012;132:1877-85 pubmed publisher
Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009;9:798-809 pubmed publisher

product information

Catalog Number :

130-104-948

Product Name :

STAT3 pS727 Antibody, anti-human, APC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

APC

Antigen Modification :

STAT3 pS727

Clone Name :

REA324

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

294,00 USD

Product Description :

Clone REA324 recognizes the signal transducer and activator of transcription 3 (STAT3) antigen phosphorylated at serine 727 (pS727). STAT3 expression is found ubiquitously. It is activated in response to various growth factors, hormones, and cytokines, and has an important role in their signaling. When these ligands bind to the specific transmembrane STAT3 receptor, STAT3 becomes activated by tyrosine phosphorylation of two important phosphorylation sites, pY705 and pS727. The dimeric STAT3 translocates to the nucleus, where it binds to consensus STAT3 binding sequences within the promoter region of target genes and thereby activates their transcription. The persistent activation of STAT3 also mediates tumor-promoting inflammation. STAT3 promotes pro-oncogenic inflammatory pathways in tumor inflammation and immunity, including nuclear factor-κB and interleukin-6-GP130-Janus kinase pathways, and by opposing STAT1- and NF-κB-mediated T helper 1 anti-tumor immune responses. Additional information: Clone REA324 displays negligible binding to Fc receptors.

ALTnames :

ADMIO, APRF, HIES

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.