Sox2 Antibody, anti-human/mouse, APC, REAfinity™ | Miltenyi Biotec 130-104-942 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

Sox2 Antibody, anti-human/mouse, APC, REAfinity™

catalog :

130-104-942

quantity :

100 tests in 1 mL

price :

294,00 USD

clonality :

monoclonal

host :

human

conjugate :

APC

clone name :

REA320

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

citations: 3

Reference
Maucksch C, Jones K, Connor B. Concise review: the involvement of SOX2 in direct reprogramming of induced neural stem/precursor cells. Stem Cells Transl Med. 2013;2:579-83 pubmed publisher
Liu K, Lin B, Zhao M, Yang X, Chen M, Gao A, et al. The multiple roles for Sox2 in stem cell maintenance and tumorigenesis. Cell Signal. 2013;25:1264-71 pubmed publisher
Fantes J, Ragge N, Lynch S, McGill N, Collin J, Howard Peebles P, et al. Mutations in SOX2 cause anophthalmia. Nat Genet. 2003;33:461-3 pubmed

product information

Catalog Number :

130-104-942

Product Name :

Sox2 Antibody, anti-human/mouse, APC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

APC

Antigen Modification :

Sox2

Clone Name :

REA320

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

294,00 USD

Product Description :

Clone REA320 recognizes the human and mouse Sox2 antigen, a member of the SRY-related HMG-box family of transcription factors. The SRY-containing protein Sox2 is known to regulate the self-renewal of mouse and human embryonic stem cells. It is also important for the maintenance of stem cells in multiple adult tissues including brain and trachea, and it is one of the key transcription factors for establishing induced pluripotent stem cells. Sox2 forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1, and ZFP206. Overexpression and gene amplification of Sox2 have been associated with the development of squamous cell carcinoma in multiple tissues such as the lung and esophagus. Additional information: Clone REA320 displays negligible binding to Fc receptors.

ALTnames :

ANOP3, MCOPS3, lcc, ysb

Specificity :

human, mouse

Concentration :

1:11

Uses :

For research use only

Application Summary :

Intracellular flow cytometry, Multiparameter imaging cell screen, Immunofluorescence, Immunohistochemistry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.