CD158e1/e2 Antibody, anti-human, PerCP-Vio® 700, REAfinity™ | Miltenyi Biotec 130-104-837 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD158e1/e2 Antibody, anti-human, PerCP-Vio® 700, REAfinity™

catalog :

130-104-837

quantity :

100 tests in 1 mL

price :

325,00 USD

clonality :

monoclonal

host :

human

conjugate :

PerCP

clone name :

REA168

reactivity :

human

application :

flow cytometry

citations: 4

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 6d	Dulberger C, McMurtrey C, Hölzemer A, Neu K, Liu V, Steinbach A, et al. Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors. Immunity. 2017;46:1018-1029.e7 pubmed publisher
	Korner C, Altfeld M. Role of KIR3DS1 in human diseases. Front Immunol. 2012;3:326 pubmed publisher
	Carr W, Pando M, Parham P. KIR3DL1 polymorphisms that affect NK cell inhibition by HLA-Bw4 ligand. J Immunol. 2005;175:5222-9 pubmed
	Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Mingari M, et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol. 2001;19:197-223 pubmed

product information

Catalog Number :

130-104-837

Product Name :

CD158e1/e2 Antibody, anti-human, PerCP-Vio® 700, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

PerCP-Vio 700

Antigen Modification :

CD158e1/e2

Clone Name :

REA168

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

325,00 USD

Product Description :

Clone REA168 recognizes the CD158e1/e2 antigens, which are single-pass type I membrane proteins. CD158e is expressed on CD56dimCD16+ natural killer (NK) cells and CD8+ T cells. Killer cell immunoglobulin-like receptors (KIRs) contribute to the regulation of NK cell–mediated cytotoxicity. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long or short cytoplasmic domain. According to the length of their cytoplasmic tail, KIRs can be further subdivided into inhibitory KIRs and activating KIRs. The CD158e1 antigen is also known as KIR3DL1 (KIR, three Ig like domain extracellular domains, long cytoplasmic tail, 1) and the CD158e2 antigen as KIR3DS1 (KIR, three extracellular Ig like domains, short cytoplasmic tail, 1). Within the KIR3DL1/S1 gene locus, CD158e2 represents a conserved allelic variant and displays unique features in comparison to the highly polymorphic CD158e1 allele. CD158e1 provides an inhibitory signal of NK cell lytic activity upon interaction with its specific ligand, HLA-Bw4. Despite the lack of formal evidence for an interaction of CD158e2 with HLA-Bw4 or any other HLA class I subtype, a growing number of associations between the presence of CD158e2 and the outcome of viral infections have been described. Especially, the potential protective role of CD158e2 in combination with HLA-Bw4-I80 in the context of HIV-1 infection has been studied intensively. Additional information: Clone REA168 displays negligible binding to Fc receptors.

ALTnames :

KIR3DL1, KIR3DS1, HLA-BW4-specific inhibitory NK cell receptor, MHC class I NK cell receptor, Natural killer-associated transcript 3 (NKAT-3, NKAT3), p70 natural killer cell receptor clones CL-2/CL-11 (p70 NK receptor CL-2/CL-11), KIRp70/NKB1

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.