CD100 Antibody, anti-human, FITC, REAfinity™ | Miltenyi Biotec 130-104-672 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD100 Antibody, anti-human, FITC, REAfinity™

catalog :

130-104-672

quantity :

30 tests in 300 µL

price :

79,00 USD

clonality :

monoclonal

host :

human

conjugate :

FITC

clone name :

REA316

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Basile J, Afkhami T, Gutkind J. Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. Mol Cell Biol. 2005;25:6889-98 pubmed

product information

Catalog Number :

130-104-672

Product Name :

CD100 Antibody, anti-human, FITC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

FITC

Antigen Modification :

CD100

Clone Name :

REA316

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

79,00 USD

Product Description :

Clone REA316 recognizes the human CD100 antigen, a single-pass type I membrane protein which is also known as semaphorin-4D (SEMA4D). CD100 is strongly expressed in skeletal muscle, and at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung, and pancreas. In the immune system, it is present on peripheral blood lymphocytes, spleen, and thymus, especially interfollicular T cells and B cells in the germinal centers of secondary lymphoid follicles. CD100 is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein and repels axon growth cones in the central nervous system. In the immune system, CD100 plays a critical role by turning off negative signaling by CD72 and significantly enhancing the effects of CD40 on B cell and dendritic cell responses. During skin damage repairs, SEMA4D interacts with plexin B2 on gamma delta T cells to play a role in the healing process. Additional information: Clone REA316 displays negligible binding to Fc receptors.

CrossReactivity :

rhesus monkey (Macaca mulatta), cynomolgus monkey (Macaca fascicularis)

ALTnames :

SEMA4D, M-sema-G, SEMAJ, coll-4, A8, BB18, GR3

Specificity :

human, non-human primate

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.