CD269 (BCMA) Antibody, anti-human, Biotin, REAfinity™ | Miltenyi Biotec 130-104-549 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD269 (BCMA) Antibody, anti-human, Biotin, REAfinity™

catalog :

130-104-549

quantity :

30 tests in 300 µL

price :

89,00 USD

clonality :

monoclonal

host :

human

conjugate :

biotin

clone name :

REA315

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M, et al. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat Immunol. 2000;1:252-6 pubmed
Shu H, Johnson H. B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. Proc Natl Acad Sci U S A. 2000;97:9156-61 pubmed

product information

Catalog Number :

130-104-549

Product Name :

CD269 (BCMA) Antibody, anti-human, Biotin, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Biotin

Antigen Modification :

CD269 (BCMA)

Clone Name :

REA315

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

89,00 USD

Product Description :

Clone REA315 recognizes the human CD269 antigen, a single-pass type III membrane protein which is also known as B cell maturation antigen (BCMA). CD269 is a member of the TNF-receptor superfamily that is preferentially expressed in mature B lymphocytes. It is the receptor for CD256 (TNFSF13, APRIL) and CD257 (TNFSF13B, BLyS, BAFF). CD269 promotes B cell survival and plays a role in the regulation of humoral immunity. Binding of CD269 to CD257 blocks the binding of CD257 to its receptor on the plasma membrane and inhibits CD257-triggered B lymphocyte costimulation. Overexpression of CD269 activates NF-κB and JNK, and this activation is potentiated by CD257. Additional information: Clone REA315 displays negligible binding to Fc receptors.

ALTnames :

TNFRSF17, Bcm, BCMA

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.