HLA Class I Bw4 Antibody, anti-human, Biotin, REAfinity™ | Miltenyi Biotec 130-103-849 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

HLA Class I Bw4 Antibody, anti-human, Biotin, REAfinity™

catalog :

130-103-849

quantity :

100 tests in 1 mL

price :

238,00 USD

clonality :

monoclonal

host :

human

conjugate :

biotin

clone name :

REA274

reactivity :

human

application :

flow cytometry

citations: 6

Reference
Garrido C, Spivak A, Soriano Sarabia N, Checkley M, Barker E, Karn J, et al. HIV Latency-Reversing Agents Have Diverse Effects on Natural Killer Cell Function. Front Immunol. 2016;7:356 pubmed
Forlenza C, Boudreau J, Zheng J, Le Luduec J, Chamberlain E, Heller G, et al. KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma. J Clin Oncol. 2016;34:2443-51 pubmed publisher
Boudreau J, Mulrooney T, Le Luduec J, Barker E, Hsu K. KIR3DL1 and HLA-B Density and Binding Calibrate NK Education and Response to HIV. J Immunol. 2016;196:3398-410 pubmed publisher
Martin M, Qi Y, Gao X, Yamada E, Martin J, Pereyra F, et al. Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet. 2007;39:733-40 pubmed
Carr W, Pando M, Parham P. KIR3DL1 polymorphisms that affect NK cell inhibition by HLA-Bw4 ligand. J Immunol. 2005;175:5222-9 pubmed
Hewitt E. The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology. 2003;110:163-9 pubmed

product information

Catalog Number :

130-103-849

Product Name :

HLA Class I Bw4 Antibody, anti-human, Biotin, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Biotin

Antigen Modification :

HLA Class I Bw4

Clone Name :

REA274

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

238,00 USD

Product Description :

Clone REA274 recognizes HLA Bw4, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. Analysis of HIV-infected patients found the combination of the NK cell receptor KIR3DS1/L1 and a presumptive HLA Bw4 ligand to be correlated with slower progression to AIDS. Additional information: Clone REA274 displays negligible binding to Fc receptors.

ALTnames :

HLA-B, AS, SPDA1

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.