CD64 (FcγRI) antibodies | Miltenyi Biotec 130-103-808 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD64 (FcγRI) antibodies

catalog :

130-103-808

quantity :

30 µg in 1 mL

clonality :

recombinant

host :

human

conjugate :

clone name :

REA286

reactivity :

mouse

application :

flow cytometry

product information

Item Name :

CD64 (FcγRI) antibodies

Catalog Number :

130-103-808

Quantity :

30 µg in 1 mL

Target :

CD64 (FcγRI)

Reactivity :

mouse

Applications :

Flow Cytometry

Primary / Secondary :

Primary

Host :

human

Conjugate/Tag/Label :

Format :

Antibodies are supplied in buffer containing stabilizer and 0.05% sodium azide.

Isotype :

recombinant human IgG1

Clone :

REA286

Clonality :

recombinant

Long text :

Clone REA286 recognizes the CD64 antigen, a 72 kDa integral membrane glycoprotein also known as high affinity immunoglobulin gamma Fc receptor I (FcγRI). Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively expressed on macrophages, monocytes, dendritic cells and mast cells. Treatment with cytokines like IFNγ and G-CSF induces CD64 upregulation. CD64 binds monomeric IgG-type antibodies with high affinity and mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine release and superoxide generation. Additional information: Clone REA286 displays negligible binding to Fc receptors.