CD220 Antibody, anti-human, PE, REAfinity™ | Miltenyi Biotec 130-103-717 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD220 Antibody, anti-human, PE, REAfinity™

catalog :

130-103-717

quantity :

30 tests in 300 µL

price :

99,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA260

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Chiu S, Cline H. Insulin receptor signaling in the development of neuronal structure and function. Neural Dev. 2010;5:7 pubmed publisher
Youngren J. Regulation of insulin receptor function. Cell Mol Life Sci. 2007;64:873-91 pubmed

product information

Catalog Number :

130-103-717

Product Name :

CD220 Antibody, anti-human, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

CD220

Clone Name :

REA260

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

99,00 USD

Product Description :

Clone REA260 recognizes the CD220 antigen, a type I transmembrane receptor tyrosine kinase, which is also known as insulin receptor (IR). CD220 is predominantly expressed in major target tissues of insulin metabolic effects like liver, adipose tissue, and skeletal muscle, but is also expressed in the peripheral nerve, kidney, fibroblasts, monocytes, granulocytes, erythrocytes, and skin. It is composed of two extracellular α-subunits and two transmembrane β-subunits. Upon binding of insulin, CD220 forms a heterotetramer of two units to induce autophosphorylation and activation of the tyrosine kinase activity of the receptor. CD220 plays a key role in the regulation of glucose homeostasis, cell growth, differentiation, and apoptosis- functional processes that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. Additional information: Clone REA260 displays negligible binding to Fc receptors.

ALTnames :

INSR, HHF5

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.