STAT1 N-terminus Antibody, anti-human, PE, REAfinity™ | Miltenyi Biotec 130-103-713 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

STAT1 N-terminus Antibody, anti-human, PE, REAfinity™

catalog :

130-103-713

quantity :

30 tests in 300 µL

price :

99,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA272

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Sikorski K, Chmielewski S, Przybyl L, Heemann U, Wesoly J, Baumann M, et al. STAT1-mediated signal integration between IFN? and LPS leads to increased EC and SMC activation and monocyte adhesion. Am J Physiol Cell Physiol. 2011;300:C1337-44 pubmed publisher
ten Hoeve J, de Jesus Ibarra Sanchez M, Fu Y, Zhu W, Tremblay M, David M, et al. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol. 2002;22:5662-8 pubmed

product information

Catalog Number :

130-103-713

Product Name :

STAT1 N-terminus Antibody, anti-human, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

STAT1 N-terminus

Clone Name :

REA272

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

99,00 USD

Product Description :

Clone REA272 recognizes the N-terminus of the signal transducer and activator of transcription 1-α/β (STAT1) antigen, regardless of phosphorylation status. STAT1 is expressed in two alternatively spliced isoforms (91 kDa STAT1α and 84 kDa STAT1β) and clone REA272 recognizes both isoforms. STAT1 expression is found ubiquitously. It is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to interferon γ (IFN-γ) stimulation, the STAT1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus. STAT1 forms homodimers or heterodimers with STAT3 that bind to the IFN-γ activated sequence promoter element. In response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the interferon stimulated response promoter element. In either case, binding of the promoter element leads to an increased expression of interferon stimulated genes. Additional information: Clone REA272 displays negligible binding to Fc receptors.

CrossReactivity :

mouse, rat, dog, chicken, frog

ALTnames :

CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91

Specificity :

human, mouse, rat, other

Concentration :

1:11

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.