CD159c (NKG2C) antibodies | Miltenyi Biotec 130-103-635 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD159c (NKG2C) antibodies

catalog :

130-103-635

quantity :

for 100 tests

clonality :

recombinant

host :

human

conjugate :

clone name :

REA205

reactivity :

human

application :

flow cytometry

citations: 5

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; 1:11; loading ...; tbl 2	Veluchamy J, Delso Vallejo M, Kok N, Bohme F, Seggewiss Bernhardt R, van der Vliet H, et al. Standardized and flexible eight colour flow cytometry panels harmonized between different laboratories to study human NK cell phenotype and function. Sci Rep. 2017;7:43873 pubmed publisher
	Hu L, Zhao X, Yu X, Lv M, Han T, Han W, et al. Quantity and Quality Reconstitution of NKG2A+ Natural Killer Cells Are Associated with Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2019;25:1-11 pubmed publisher
	Rölle A, Meyer M, Calderazzo S, Jager D, Momburg F. Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells. Cell Rep. 2018;24:1967-1976.e4 pubmed publisher
	LÃ©vy R, Okada S, BÃ©ziat V, Moriya K, Liu C, Chai L, et al. Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency. Proc Natl Acad Sci U S A. 2016;113:E8277-E8285 pubmed publisher
	Granzin M, Soltenborn S, MÃ¼ller S, Kollet J, Berg M, Cerwenka A, et al. Fully automated expansion and activation of clinical-grade natural killer cells for adoptive immunotherapy. Cytotherapy. 2015;17:621-32 pubmed publisher

product information

Item Name :

CD159c (NKG2C) antibodies

Catalog Number :

130-103-635

Quantity :

for 100 tests

Target :

CD159c (NKG2C)

Reactivity :

human

Applications :

Flow Cytometry

Primary / Secondary :

Primary

Host :

human

Conjugate/Tag/Label :

Format :

Antibodies are supplied in buffer containing stabilizer and 0.05% sodium azide.

Isotype :

recombinant human IgG1

Clone :

REA205

Clonality :

recombinant

Long text :

Clone REA205 recognizes the CD159c antigen, a calcium-dependent (C-type) lectin, which is also known as NKG2C type II integral membrane protein or KLRC2. CD159c heterodimerizes with CD94 to form a complex that recognizes HLA-E as ligand. Clone REA205 detects the human CD159c/CD94 heterodimer and does not cross-react with the human CD159a/CD94 heterodimer or with the human CD94 homodimer. CD159c is expressed primarily on natural killer (NK) cells and receptor ligation results in NK cell activation. The proportion of CD3+ T cells expressing the CD159c/CD94 complex is elevated under pathologic conditions, such as human CMV infection, active celiac disease, paroxysmal nocturnal hemoglobinuria, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Moreover, CD159c can mediate the expansion of infiltrating cytotoxic CD8+ T cells in active celiac patients. Additional information: Clone REA205 displays negligible binding to Fc receptors.