PKCα Antibody, anti-human, PE, REAfinity™ | Miltenyi Biotec 130-103-623 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

PKCα Antibody, anti-human, PE, REAfinity™

catalog :

130-103-623

quantity :

100 tests in 1 mL

price :

278,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA156

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Xu H, Czerwinski P, Hortmann M, Sohn H, Förstermann U, Li H. Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. Cardiovasc Res. 2008;78:349-55 pubmed
Koivunen J, Aaltonen V, Peltonen J. Protein kinase C (PKC) family in cancer progression. Cancer Lett. 2006;235:1-10 pubmed

product information

Catalog Number :

130-103-623

Product Name :

PKCα Antibody, anti-human, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

PKCα

Clone Name :

REA156

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

278,00 USD

Product Description :

Clone REA156 recognizes the PKCα antigen regardless of its phosphorylation status. It has been reported to cross-react with PKCβ. PKCα is a serine- and threonine-specific protein kinase that can be activated by calcium and the second messenger diacylglycerol. It plays a role in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. PKCα is highly expressed in a number of cancer cells where it can acts as a tumor promoter and it is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca 2)+ handling in myocytes. Additional information: Clone REA156 displays negligible binding to Fc receptors.

CrossReactivity :

mouse, rat, dog, chicken, frog

ALTnames :

PRKCA, AAG6, PKC-alpha, PRKACA, PKC-A

Specificity :

human, mouse, rat, other

Concentration :

1:11

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.