Anti-F4/80 antibodies | Miltenyi Biotec 130-102-988 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

Anti-F4/80 antibodies

catalog :

130-102-988

quantity :

9 µg in 300 µL

clonality :

recombinant

host :

human

conjugate :

FITC

clone name :

REA126

reactivity :

mouse

application :

flow cytometry

product information

Item Name :

Anti-F4/80 antibodies

Catalog Number :

130-102-988

Quantity :

9 µg in 300 µL

Target :

F4/80

Reactivity :

mouse

Applications :

Flow Cytometry

Primary / Secondary :

Primary

Host :

human

Conjugate/Tag/Label :

FITC

Format :

Antibodies are supplied in buffer containing stabilizer and 0.05% sodium azide.

Isotype :

recombinant human IgG1

Clone :

REA126

Clonality :

recombinant

Long text :

Clone REA126 recognizes F4/80, a member of epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 is considered as one of the most specific cell-surface markers for murine macrophages. F4/80 is a seven-span transmembrane molecule with a large extracellular, multiple EGF module containing, domain. Constitutive and high expression of F4/80 is found on most resident tissue macrophages, including the spleen, microglia in the brain, Kupffer's cells in the liver, and Langerhans cells in the skin. In addition, the expression of F4/80 can also be regulated depending on the physiological status of the cell. F4/80 molecule is required for the differentiation of antigen-specific CD8+ Tregs and is involved in inducing peripheral immune tolerance. No specific ligand for F4/80 has been reported so far. Additional Information: Clone REA126 displays negligible binding to Fc receptors.