CD177 Antibody, anti-human, FITC, REAfinity™ | Miltenyi Biotec 130-101-521 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD177 Antibody, anti-human, FITC, REAfinity™

catalog :

130-101-521

quantity :

30 tests in 300 µL

price :

84,00 USD

clonality :

monoclonal

host :

human

conjugate :

FITC

clone name :

REA258

reactivity :

human

application :

flow cytometry

citations: 5

Reference
Monti M, Iommelli F, De Rosa V, Carriero M, Miceli R, Camerlingo R, et al. Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells. PLoS ONE. 2017;12:e0171362 pubmed publisher
Thackeray J, Bankstahl J, Wang Y, Wollert K, Bengel F. Targeting Amino Acid Metabolism for Molecular Imaging of Inflammation Early After Myocardial Infarction. Theranostics. 2016;6:1768-79 pubmed publisher
Wu Z, Liang R, Ohnesorg T, Cho V, Lam W, Abhayaratna W, et al. Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion. PLoS Genet. 2016;12:e1006067 pubmed publisher
Beyrau M, Bodkin J, Nourshargh S. Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity. Open Biol. 2012;2:120134 pubmed publisher
Sachs U, Andrei Selmer C, Maniar A, Weiss T, Paddock C, Orlova V, et al. The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). J Biol Chem. 2007;282:23603-12 pubmed

product information

Catalog Number :

130-101-521

Product Name :

CD177 Antibody, anti-human, FITC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

FITC

Antigen Modification :

CD177

Clone Name :

REA258

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

84,00 USD

Product Description :

Clone REA258 recognizes CD177, which is also known as neutrophil specific antigen 1. CD177, a member of the µPAR family, is a 58–64 kDa glycosylphosphatidylinositol-anchored glycoprotein expressed exclusively by subset of neutrophils, neutrophilic metamyelocytes, and myelocytes and is suggested to play a role in neutrophil mediated immune reponse as evident by its up-regulation on neutrophils in a number of inflammatory settings such as bacterial infection. Furthermore, CD177 can directly bind to PECAM-1 allowing neutrophil-endothelial cell interactions and thus contributing to neutrophil transmigration. Overexpression of CD177 is also seen in patients with polycythemia vera, making it a useful diagnostic marker. Additional information: Clone REA258 displays negligible binding to Fc receptors.

CrossReactivity :

rhesus monkey (Macaca mulatta)

ALTnames :

HNA-2a, NB1, NB1 GP, PRV-1, PRV1

Specificity :

human, non-human primate

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.