CD210 (IL-10R) Antibody, anti-human, PE, REAfinity™ | Miltenyi Biotec 130-101-488 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD210 (IL-10R) Antibody, anti-human, PE, REAfinity™

catalog :

130-101-488

quantity :

100 tests in 1 mL

price :

278,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA239

reactivity :

human

application :

flow cytometry

citations: 3

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 3c	Fuchs S, Kaiser Labusch P, Bank J, Ammann S, Kolb Kokocinski A, Edelbusch C, et al. Tyrosine kinase 2 is not limiting human antiviral type III interferon responses. Eur J Immunol. 2016;46:2639-2649 pubmed publisher
	Siegmund D, Kums J, Ehrenschwender M, Wajant H. Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis. Cell Death Dis. 2016;7:e2375 pubmed publisher
	Donnelly R, Dickensheets H, Finbloom D. The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. J Interferon Cytokine Res. 1999;19:563-73 pubmed

product information

Catalog Number :

130-101-488

Product Name :

CD210 (IL-10R) Antibody, anti-human, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

CD210 (IL-10R)

Clone Name :

REA239

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

278,00 USD

Product Description :

Clone REA239 recognizes the human CD210 antigen, a 90–110 kDa protein, which is also known as IL-10 receptor (IL-10R) alpha subunit. CD210 is expressed on various cell types like monocytes, B cells, large granular lymphocytes, and T cells. The IL-10R protein is structurally related to interferon receptors. Functional IL-10R complexes are tetramers consisting of two IL-10Rα polypeptide chains and two IL-10Rβ chains. Binding of IL-10 to the extracellular domain of IL-10Rα activates the IL-10 signal transduction pathway by inducing phosphorylation of STAT1a and STAT3 and by inducing activation of Jak1 and Tyk. IL-10R has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. Additional information: Clone REA239 displays negligible binding to Fc receptors.

ALTnames :

IL10RA, CD210a, CDW210A, HIL-10R, IL-10R1, IL10R, IL-10R1, IL-10Rα

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.