IRF-4 Antibody, anti-human/mouse, PE, REAfinity™ | Miltenyi Biotec 130-100-917 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

IRF-4 Antibody, anti-human/mouse, PE, REAfinity™

catalog :

130-100-917

quantity :

100 tests in 1 mL

price :

278,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA201

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

citations: 3

Reference
Nayar R, Enos M, Prince A, Shin H, Hemmers S, Jiang J, et al. TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. Proc Natl Acad Sci U S A. 2012;109:E2794-802 pubmed publisher
Biswas P, Gupta S, Stirzaker R, Kumar V, Jessberger R, Lu T, et al. Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity. J Exp Med. 2012;209:581-96 pubmed publisher
Klein U, Casola S, Cattoretti G, Shen Q, Lia M, Mo T, et al. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol. 2006;7:773-82 pubmed

product information

Catalog Number :

130-100-917

Product Name :

IRF-4 Antibody, anti-human/mouse, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

IRF-4

Clone Name :

REA201

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

278,00 USD

Product Description :

Clone REA201 recognizes IRF-4, which is a 52 KDa transcription factor and belongs to the family of interferon regulatory transcription factors (IRF).The IRF family consists of nine members in both human and mice and is characterized by a conserved N-terminal DNA-binding domain (DBD) with unique tryptophan pentad repeat and modulates the expression of genes regulated by the presence of interferons and in response to cell activation. Expression of IRF-4 is found in cells of the immune system, including lymphocytes, dendritic cells, and macrophages, where it's multiple functions include regulation of cell proliferation, apoptosis, and differentiation. Transcriptional activity of IRF-4 is further modulated by its interaction with various co-factors including including Pu.1, E47, STAT-6, and IRF-8. Additional information: Clone REA201 displays negligible binding to Fc receptors.

ALTnames :

IRF4, LSIRF, MUM1, NF-EM5, SHEP8, Spip, ICSAT14, LSIRF13

Specificity :

human, mouse

Concentration :

1:11

Uses :

For research use only

Application Summary :

Intracellular flow cytometry, Multiparameter imaging cell screen, Immunofluorescence, Immunohistochemistry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.