CD42b Antibody, anti-human, PE, REAfinity™ | Miltenyi Biotec 130-100-198 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD42b Antibody, anti-human, PE, REAfinity™

catalog :

130-100-198

quantity :

30 tests in 300 µL

price :

99,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA185

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Shrimpton C, Borthakur G, Larrucea S, Cruz M, Dong J, Lopez J. Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation. J Exp Med. 2002;196:1057-66 pubmed

product information

Catalog Number :

130-100-198

Product Name :

CD42b Antibody, anti-human, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

CD42b

Clone Name :

REA185

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

99,00 USD

Product Description :

Clone REA185 recognizes CD42b, a 145 kDa single-pass type I membrane protein. Expression of CD42b is found on platelets and megakaryocytes. CD42b, the α chain, together with the β chain (CD42c), forms the heterodimer, glycoprotein Ib (GP Ib). The GP Ib receptor complex further includes association of the α and β subunits with platelet glycoprotein IX and glycoprotein V and this complex serves as the receptor for von Willebrand factor (VWF). The interaction of the GP Ib-IX-V complex to VWF initiates initial platelet adhesion to vascular subendothelium after vascular injury, platelet activation, thrombosis, and hemostasis. Other known ligands for GPIb–IX–V include α-thrombin, clotting factors XI/XIIa, and high-molecularweight kininogen. Additional information: Clone REA185 displays negligible binding to Fc receptors.

CrossReactivity :

chimpanzee (Pan troglodytes)

ALTnames :

GP1BA, BDPLT1, BDPLT3, BSS, CD42b-alpha, DBPLT3, GP1B, GPIbA, VWDP, gpIbα

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.