Granzyme A Antibody, anti-human, APC, REAfinity™ | Miltenyi Biotec 130-099-780 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

Granzyme A Antibody, anti-human, APC, REAfinity™

catalog :

130-099-780

quantity :

100 tests in 1 mL

price :

294,00 USD

clonality :

monoclonal

host :

human

conjugate :

APC

clone name :

REA162

reactivity :

human

application :

flow cytometry

citations: 3

Reference
Grossman W, Verbsky J, Tollefsen B, Kemper C, Atkinson J, Ley T. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood. 2004;104:2840-8 pubmed
Trapani J. Granzymes: a family of lymphocyte granule serine proteases. Genome Biol. 2001;2:REVIEWS3014 pubmed
Mullbacher A, Waring P, Tha Hla R, Tran T, Chin S, Stehle T, et al. Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc Natl Acad Sci U S A. 1999;96:13950-5 pubmed

product information

Catalog Number :

130-099-780

Product Name :

Granzyme A Antibody, anti-human, APC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

APC

Antigen Modification :

Granzyme A

Clone Name :

REA162

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

294,00 USD

Product Description :

Clone REA162 recognizes granzyme A, a member of serine protease family expressed exclusively by cytotoxic T lymphocytes and natural killer (NK) cells. Granzyme A is a homodimeric protease and is one of the five granzymes expressed by humans. Also known as granule enzymes, granzymes comprise majority of the mass of cytolytic granules in cytotoxic T lymphocytes (CTLs) and NK cells. NK cells and γδ T cells express granzymes constitutively, whereas expression in T lymphocytes is stimulation dependent. Main function attributed to granzymes is to indue apoptotic death of infected and transformed cells. Granzymes other than granzyme B, exert relatively weaker apoptotic activity. Additional reported functions of granzyme A include, to facilitate the migration of T and NK cells and induction of cytokine secretion. Additional information: Clone REA162 displays negligible binding to Fc receptors.

ALTnames :

GZMA, CTLA-3, HFSP, Granzyme 1

Specificity :

human

Concentration :

1:10

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.