CD52 Antibody, anti-human, PE, REAfinity™ | Miltenyi Biotec 130-099-634 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD52 Antibody, anti-human, PE, REAfinity™

catalog :

130-099-634

quantity :

30 tests in 300 µL

price :

99,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA164

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Ambrose L, Morel A, Warrens A. Neutrophils express CD52 and exhibit complement-mediated lysis in the presence of alemtuzumab. Blood. 2009;114:3052-5 pubmed publisher
Rawstron A, Laycock Brown G, Hale G, Davies F, Morgan G, Child J, et al. CD52 expression patterns in myeloma and the applicability of alemtuzumab therapy. Haematologica. 2006;91:1577-8 pubmed

product information

Catalog Number :

130-099-634

Product Name :

CD52 Antibody, anti-human, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

CD52

Clone Name :

REA164

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

99,00 USD

Product Description :

Clone REA164 recognizes CD52, a glycosylphosphatidylinositol (GPI)-anchored, 25–29 kDa heavily glycosylated antigen. The CD52 core peptide is only 12 amino acids long and is linked to the surface via C-terminal GPI anchor. Expression of CD52 is found on lymphocytes, monocytes, macrophages, eosinophils, and in the male reproductive tract on the epithelial cells of the epididymis and seminal vesicle. CD52 is absent in immature spermatozoa in the efferent ducts but is acquired by the sperm membrane, progressively, as they pass through the epididymis proper, where CD52 is shed into the seminal plasma by the epididymis. Though the exact role of CD52 is unclear, antibodies against CD52 elicit antibody dependent cellular and complement mediated cytolysis of the CD52 expressing lymphocytes. Owing to this, such antibodies are often used to target malignant cells. CD52 expressed on sperms and on lymphocytes are basically different glycoforms of the same core peptide. Additional information: Clone REA164 displays negligible binding to Fc receptors.

ALTnames :

CDW52, CAMPATH-1

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.