CD319 (CRACC) Antibody, anti-human, APC, REAfinity™ | Miltenyi Biotec 130-099-569 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD319 (CRACC) Antibody, anti-human, APC, REAfinity™

catalog :

130-099-569

quantity :

30 tests in 300 µL

price :

128,00 USD

clonality :

monoclonal

host :

human

conjugate :

APC

clone name :

REA150

reactivity :

human

application :

flow cytometry

citations: 3

Reference
Lee J, Mathew S, Vaidya S, Kumaresan P, Mathew P. CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 2007;179:4672-8 pubmed
Tassi I, Colonna M. The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol. 2005;175:7996-8002 pubmed
Lee J, Boles K, Mathew P. Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur J Immunol. 2004;34:2791-9 pubmed

product information

Catalog Number :

130-099-569

Product Name :

CD319 (CRACC) Antibody, anti-human, APC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

APC

Antigen Modification :

CD319 (CRACC)

Clone Name :

REA150

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

128,00 USD

Product Description :

Clone REA150 recognizes CD319, which is a single-pass type I transmembrane protein. CD319 belongs to the SLAM-related receptors (SRRs) family, a subgroup of the CD2 family of Ig-like receptors. Expression of CD319 is found on activated B lymphocytes, natural killer (NK) cells, CD8+T lymphocytes, and mature dendritic cells. The cytoplasmic domain of CD319 contains immunoreceptor tyrosine-based switch motifs (ITSMs), which provide the docking sites for recruitment of small SH2-containing adapter proteins, such as SH2D1A/SLAM-associated protein (SAP) and EWS activated transcript 2 (EAT-2). CD319 displays homophilic interaction and is involved in mediating NK cell cytotoxicity, in the absence of an inhibitory receptor engagement. Additional information: Clone REA150 displays negligible binding to Fc receptors.

ALTnames :

SLAMF7, 19A, CRACC, CS1

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.