CD282 (TLR2) antibodies | Miltenyi Biotec 130-099-020 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD282 (TLR2) antibodies

catalog :

130-099-020

quantity :

for 30 tests

clonality :

recombinant

host :

human

conjugate :

APC

clone name :

REA109

reactivity :

human, mouse

application :

flow cytometry

product information

Item Name :

CD282 (TLR2) antibodies

Catalog Number :

130-099-020

Quantity :

for 30 tests

Target :

CD282 (TLR2)

Reactivity :

mouse, human

Applications :

Flow Cytometry

Primary / Secondary :

Primary

Host :

human

Conjugate/Tag/Label :

APC

Format :

Antibodies are supplied in buffer containing stabilizer and 0.05% sodium azide.

Isotype :

recombinant human IgG1

Clone :

REA109

Clonality :

recombinant

Long text :

Clone REA109 recognises human and mouse CD282, also known as toll like receptor 2 (TLR2). TLRs are the host pattern recognition receptors involved in recognising pathogen associated and certain tissue damage indicating molecules. They are type-1 transmembrane proteins with extracellular leucine-rich repeats and intracellular Toll/IL-1 receptor domains. TLR2 is a plasma membrane associated TLR and recognizes various structurally diverse molecules including, peptidoglycans (PG), lipopeptides and lipoproteins moieties in Gram positive and Gram negative bacteria, lipoteichoic acid (LTA) in Gram positive bacteria, lipoarabinomannan and lipomannan from Mycoplasma and fungal polysaccharides such as zymogen. High-resolution crystal structures suggested that TLR2 by forming heterodimers with TLR6 and TLR1 can distinguish between di-acylated and triacylated lipopeptides. The expression of CD282 (TLR2) is found on monocytes, granulocytes, dendritic, endothelial and epithelial cells. Additional Information: Clone REA109 displays negligible binding to Fc receptors.