This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
XAV939
catalog :
X3004
citations: 207
Reference
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Siraj A, Kumar Parvathareddy S, Pratheeshkumar P, Padmaja Divya S, Ahmed S, Melosantos R, et al. APC truncating mutations in Middle Eastern Population: Tankyrase inhibitor is an effective strategy to sensitize APC mutant CRC To 5-FU chemotherapy. Biomed Pharmacother. 2020;121:109572 pubmed publisher
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Guo J, Chen Z, Jiang H, Yu Z, Peng J, Xie J, et al. The lncRNA DLX6-AS1 promoted cell proliferation, invasion, migration and epithelial-to-mesenchymal transition in bladder cancer via modulating Wnt/β-catenin signaling pathway. Cancer Cell Int. 2019;19:312 pubmed publisher
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Kim S, Han S, Kim Y, Kim H, Gu Y, Kang D, et al. Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation. Nat Commun. 2019;10:4898 pubmed publisher
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Zhou Q, Chen S, Lü M, Luo Y, Wang G, Xiao Y, et al. EFEMP2 suppresses epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human bladder cancer. Int J Biol Sci. 2019;15:2139-2155 pubmed publisher
Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, et al. Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Commun. 2019;520:179-185 pubmed publisher
Li N, Wang Y, Neri S, Zhen Y, Fong L, Qiao Y, et al. Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling. Nat Commun. 2019;10:4363 pubmed publisher
Zhao Y, Rao W, Wan Y, Yang X, Wang G, Deng J, et al. Overexpression of microRNA‑155 alleviates palmitate‑induced vascular endothelial cell injury in human umbilical vein endothelial cells by negatively regulating the Wnt signaling pathway. Mol Med Rep. 2019;20:3527-3534 pubmed publisher
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Li C, Jiao G, Wu W, Wang H, Ren S, Zhang L, et al. Exosomes from Bone Marrow Mesenchymal Stem Cells Inhibit Neuronal Apoptosis and Promote Motor Function Recovery via the Wnt/β-catenin Signaling Pathway. Cell Transplant. 2019;28:1373-1383 pubmed publisher
Cao M, Chan R, Cheng F, Li J, Li T, Pang R, et al. Myometrial Cells Stimulate Self-Renewal of Endometrial Mesenchymal Stem-Like Cells Through WNT5A/β-Catenin Signaling. Stem Cells. 2019;37:1455-1466 pubmed publisher
Uzquiano A, Cifuentes Diaz C, Jabali A, Romero D, Houllier A, Dingli F, et al. Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia. Cell Rep. 2019;28:1596-1611.e10 pubmed publisher
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Silva C, Correia Branco A, Andrade N, Ferreira A, Soares M, Sonveaux P, et al. Selective pro-apoptotic and antimigratory effects of polyphenol complex catechin:lysine 1:2 in breast, pancreatic and colorectal cancer cell lines. Eur J Pharmacol. 2019;859:172533 pubmed publisher
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Bejaoui M, Villareal M, Isoda H. β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid. Aging (Albany NY). 2019;11:4216-4237 pubmed publisher
Huo Y, Chen W, Lee J, Feng G, Newton I. Stress Conditions Induced by Locoregional Therapies Stimulate Enrichment and Proliferation of Liver Cancer Stem Cells. J Vasc Interv Radiol. 2019;: pubmed publisher
Sun X, Huang H, Pan X, Li S, Xie Z, Ma Y, et al. EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. Biochim Biophys Acta Mol Basis Dis. 2019;: pubmed publisher
Yu H, Han Z, Xu Z, An C, Xu L, Xin H. RNA sequencing uncovers the key long non-coding RNAs and potential molecular mechanism contributing to XAV939-mediated inhibition of non-small cell lung cancer. Oncol Lett. 2019;17:4994-5004 pubmed publisher
Guan N, Wang R, Guo W, Lai Y, Zhang Y, Cheng Y. Long non-coding RNA H19 regulates the development of gliomas through the Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci. 2019;23:4243-4253 pubmed publisher
Yang S, Gu Y, Wang G, Hu Q, Chen S, Wang Y, et al. HMGA2 regulates acute myeloid leukemia progression and sensitivity to daunorubicin via Wnt/β-catenin signaling. Int J Mol Med. 2019;44:427-436 pubmed publisher
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Sharon N, Vanderhooft J, Straubhaar J, Mueller J, Chawla R, Zhou Q, et al. Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development. Cell Rep. 2019;27:2281-2291.e5 pubmed publisher
Zhan T, Ambrosi G, Wandmacher A, Rauscher B, Betge J, Rindtorff N, et al. MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer. Nat Commun. 2019;10:2197 pubmed publisher
Bocchicchio S, Tesone M, Irusta G. Convergence of Wnt and Notch signaling controls ovarian cancer cell survival. J Cell Physiol. 2019;234:22130-22143 pubmed publisher
Chen Y, Chen Z, Chen L, Zhang J, Fu L, Tao L, et al. Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling. Biochem Pharmacol. 2019;166:33-45 pubmed publisher
Ishiuchi T, Ohishi H, Sato T, Kamimura S, Yorino M, Abe S, et al. Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development. Cell Rep. 2019;27:1742-1754.e6 pubmed publisher
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Cheng J, Yang J, Xue K, Zhao Y, Zhao C, Li S, et al. Desmoglein 3 Silencing Inhibits Inflammation and Goblet Cell Mucin Secretion in a Mouse Model of Chronic Rhinosinusitis via Disruption of the Wnt/β-Catenin Signaling Pathway. Inflammation. 2019;: pubmed publisher
Otomo N, Takeda K, Kawai S, Kou I, Guo L, Osawa M, et al. Bi-allelic loss of function variants of TBX6 causes a spectrum of malformation of spine and rib including congenital scoliosis and spondylocostal dysostosis. J Med Genet. 2019;: pubmed publisher
Huang H, Lin H, Huang M. Lactoferrin promotes hair growth in mice and increases dermal papilla cell proliferation through Erk/Akt and Wnt signaling pathways. Arch Dermatol Res. 2019;311:411-420 pubmed publisher
Mu X, Li H, Zhou L, Xu W. TRIM52 regulates the proliferation and invasiveness of lung cancer cells via the Wnt/β‑catenin pathway. Oncol Rep. 2019;41:3325-3334 pubmed publisher
Farrell A, Alahari S, Ermini L, Tagliaferro A, Litvack M, Post M, et al. Faulty oxygen sensing disrupts angiomotin function in trophoblast cell migration and predisposes to preeclampsia. JCI Insight. 2019;4: pubmed publisher
Gao L, Hu Y, Tian Y, Fan Z, Wang K, Li H, et al. Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun. 2019;10:1665 pubmed publisher
Fukumoto T, Zhu H, Nacarelli T, Karakashev S, Fatkhutdinov N, Wu S, et al. N6-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance. Cancer Res. 2019;79:2812-2820 pubmed publisher
Shen Y, Xu L, Ning Z, Liu L, Lin J, Chen H, et al. ARHGAP4 regulates the cell migration and invasion of pancreatic cancer by the HDAC2/β-catenin signaling pathway. Carcinogenesis. 2019;40:1405-1414 pubmed publisher
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Senouthai S, Wang J, Fu D, You Y. Fractalkine is Involved in Lipopolysaccharide-Induced Podocyte Injury through the Wnt/β-Catenin Pathway in an Acute Kidney Injury Mouse Model. Inflammation. 2019;: pubmed publisher
Seita Y, Tsukiyama T, Azami T, Kobayashi K, Iwatani C, Tsuchiya H, et al. Comprehensive evaluation of ubiquitous promoters suitable for the generation of transgenic cynomolgus monkeys†. Biol Reprod. 2019;100:1440-1452 pubmed publisher
Cohen J, Raviv S, Adir O, Padmanabhan K, Soffer A, Luxenburg C. The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt-Sox9 signaling. J Cell Biol. 2019;218:1390-1406 pubmed publisher
Fan Z, Duan J, Wang L, Xiao S, Li L, Yan X, et al. PTK2 promotes cancer stem cell traits in hepatocellular carcinoma by activating Wnt/β-catenin signaling. Cancer Lett. 2019;450:132-143 pubmed publisher
Liu X, Meng J, Zhang X, Liang X, Zhang F, Zhao G, et al. ING5 inhibits lung cancer invasion and epithelial-mesenchymal transition by inhibiting the WNT/β-catenin pathway. Thorac Cancer. 2019;10:848-855 pubmed publisher
Chen D, Lin X, Zhang C, An G, Li Z, Dong B, et al. Activated Wnt signaling promotes growth and progression of AFP-producing gastric cancer in preclinical models. Cancer Manag Res. 2019;11:1349-1362 pubmed publisher
Tchieu J, Calder E, GUTTIKONDA S, Gutzwiller E, Aromolaran K, Steinbeck J, et al. NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells. Nat Biotechnol. 2019;37:267-275 pubmed publisher
Yang J, Zhang X, Chen Z, Shen Y, Wang F, Wang Y, et al. Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer. Cell Death Dis. 2019;10:179 pubmed publisher
Cao Z, Mao X, Luo L. Germline Stem Cells Drive Ovary Regeneration in Zebrafish. Cell Rep. 2019;26:1709-1717.e3 pubmed publisher
Kalita B, Ranjan R, Gupta M. Combination treatment of podophyllotoxin and rutin promotes mouse Lgr5+ ve intestinal stem cells survival against lethal radiation injury through Wnt signaling. Apoptosis. 2019;24:326-340 pubmed publisher
Sellgren C, Gracias J, Watmuff B, Biag J, Thanos J, Whittredge P, et al. Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nat Neurosci. 2019;22:374-385 pubmed publisher
Chen W, Fu W, Su Y, Fang W, Fu A, Ip N. Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect. Sci Rep. 2019;9:1190 pubmed publisher
Castagnoli L, Cancila V, Cordoba Romero S, Faraci S, Talarico G, Belmonte B, et al. WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer. Oncogene. 2019;38:4047-4060 pubmed publisher
Schacke M, Kumar J, Colwell N, Hermanson K, Folle G, Nechaev S, et al. PARP-1/2 Inhibitor Olaparib Prevents or Partially Reverts EMT Induced by TGF-β in NMuMG Cells. Int J Mol Sci. 2019;20: pubmed publisher
Song J, Shu H, Zhang L, Xiong J. Long noncoding RNA GAS5 inhibits angiogenesis and metastasis of colorectal cancer through the Wnt/β-catenin signaling pathway. J Cell Biochem. 2019;: pubmed publisher
Liu D, Li S, Cui Y, Tong H, Li S, Yan Y. Podocan affects C2C12 myogenic differentiation by enhancing Wnt/β-catenin signaling. J Cell Physiol. 2019;234:11130-11139 pubmed publisher
Chen H, Jgamadze D, Lim J, Mensah Brown K, Wolf J, Mills J, et al. Functional cortical axon tracts generated from human stem cell-derived neurons. Tissue Eng Part A. 2019;: pubmed publisher
Ferrari N, Ranftl R, Chicherova I, Slaven N, Moeendarbary E, Farrugia A, et al. Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts. Nat Commun. 2019;10:130 pubmed publisher
Yang F, Fang E, Mei H, Chen Y, Li H, Li D, et al. Cis-Acting circ-CTNNB1 Promotes β-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1. Cancer Res. 2019;79:557-571 pubmed publisher
Zhang L, Cheng F, Wei Y, Zhang L, Guo D, Wang B, et al. Inhibition of TAZ contributes radiation-induced senescence and growth arrest in glioma cells. Oncogene. 2019;38:2788-2799 pubmed publisher
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Nan J, Kim O, Lee M. β-Catenin expression is associated with cell invasiveness in pancreatic cancer. Korean J Intern Med. 2019;34:618-625 pubmed publisher
Lee J, An J, Kang T, De D, Kim K. Discovery of Natural Compounds Promoting Cardiomyocyte Differentiation. Stem Cells Dev. 2019;28:13-27 pubmed publisher
Lim H, Periasamy P, O Neill H. In Vitro Murine Hematopoiesis Supported by Signaling from a Splenic Stromal Cell Line. Stem Cells Int. 2018;2018:9896142 pubmed publisher
Zhang C, Wang T, Wu H, Zhang L, Li K, Wang F, et al. HEF1 regulates differentiation through the Wnt5a/β-catenin signaling pathway in human gastric cancer. Biochem Biophys Res Commun. 2018;: pubmed publisher
Fan J, An X, Yang Y, Xu H, Fan L, Deng L, et al. MiR-1292 Targets FZD4 to Regulate Senescence and Osteogenic Differentiation of Stem Cells in TE/SJ/Mesenchymal Tissue System via the Wnt/β-catenin Pathway. Aging Dis. 2018;9:1103-1121 pubmed publisher
Mao X, Tong J. ARHGAP30 suppressed lung cancer cell proliferation, migration, and invasion through inhibition of the Wnt/β-catenin signaling pathway. Onco Targets Ther. 2018;11:7447-7457 pubmed publisher
Friedman C, Nguyen Q, Lukowski S, Helfer A, Chiu H, Miklas J, et al. Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation. Cell Stem Cell. 2018;23:586-598.e8 pubmed publisher
Ye P, Chiang Y, Qi Z, Li Y, Wang S, Liu Y, et al. Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death. PLoS Genet. 2018;14:e1007697 pubmed publisher
Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny Geier G, et al. Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018;9:3839 pubmed publisher
Fu K, Nakano H, Morselli M, Chen T, Pappoe H, Nakano A, et al. A temporal transcriptome and methylome in human embryonic stem cell-derived cardiomyocytes identifies novel regulators of early cardiac development. Epigenetics. 2018;13:1013-1026 pubmed publisher
Lee C, Lin J, Hwang W, Kuo Y, Chen H, Tai S, et al. Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization. Nat Commun. 2018;9:3763 pubmed publisher
Kim Y, Jeon H, Kim D, Lee S, Kim K, Hong J, et al. Quantitative Proteomic Analysis of 2D and 3D Cultured Colorectal Cancer Cells: Profiling of Tankyrase Inhibitor XAV939-Induced Proteome. Sci Rep. 2018;8:13255 pubmed publisher
Chee Y, Pahnke J, Bunte R, Adsool V, Madan B, Virshup D. Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche. Dev Cell. 2018;46:681-695.e5 pubmed publisher
Fue M, Miki Y, Takagi K, Hashimoto C, Yaegashi N, Suzuki T, et al. Relaxin 2/RXFP1 Signaling Induces Cell Invasion via the β-Catenin Pathway in Endometrial Cancer. Int J Mol Sci. 2018;19: pubmed publisher
Chen P, Xia C, Mo J, Mei S, Lin X, Fan S. Interpenetrating polymer network scaffold of sodium hyaluronate and sodium alginate combined with berberine for osteochondral defect regeneration. Mater Sci Eng C Mater Biol Appl. 2018;91:190-200 pubmed publisher
Lee J, Choi S, Kim Y, Jun I, Sung J, Lee D, et al. Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells. Invest Ophthalmol Vis Sci. 2018;59:3531-3542 pubmed publisher
Ito Y, Nakamura S, Sugimoto N, Shigemori T, Kato Y, Ohno M, et al. Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production. Cell. 2018;174:636-648.e18 pubmed publisher
Pan F, Shen F, Yang L, Zhang L, Guo W, Tian J. Inhibitory effects of XAV939 on the proliferation of small-cell lung cancer H446 cells and Wnt/β-catenin signaling pathway in vitro. Oncol Lett. 2018;16:1953-1958 pubmed publisher
Cantwell M, Farrar J, Lownik J, Meier J, Hyun M, Raje V, et al. STAT3 suppresses Wnt/β-catenin signaling during the induction phase of primary Myf5+ brown adipogenesis. Cytokine. 2018;111:434-444 pubmed publisher
Armenteros T, Andreu Z, Hortigüela R, Lie D, Mira H. BMP and WNT signalling cooperate through LEF1 in the neuronal specification of adult hippocampal neural stem and progenitor cells. Sci Rep. 2018;8:9241 pubmed publisher
Song Y, Lee S, Jho E. Enhancement of neuronal differentiation by using small molecules modulating Nodal/Smad, Wnt/β-catenin, and FGF signaling. Biochem Biophys Res Commun. 2018;503:352-358 pubmed publisher
Dong P, Xiong Y, Yu J, Chen L, Tao T, Yi S, et al. Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4-miR-18a pathway in cervical cancer. Oncogene. 2018;37:5257-5268 pubmed publisher
Li C, Zheng X, Han Y, Lv Y, Lan F, Zhao J. XAV939 inhibits the proliferation and migration of lung adenocarcinoma A549 cells through the WNT pathway. Oncol Lett. 2018;15:8973-8982 pubmed publisher
Rivron N, Frias Aldeguer J, Vrij E, Boisset J, Korving J, Vivié J, et al. Blastocyst-like structures generated solely from stem cells. Nature. 2018;557:106-111 pubmed publisher
Zheng B, Gao W, Huang X, Lin L, Fang X, Chen Z, et al. HBx promotes the proliferative ability of HL‑7702 cells via the COX‑2/Wnt/β‑catenin pathway. Mol Med Rep. 2018;17:8432-8438 pubmed publisher
Griveau A, Seano G, Shelton S, Kupp R, Jahangiri A, Obernier K, et al. A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment. Cancer Cell. 2018;33:874-889.e7 pubmed publisher
Guo X, Chen Y, Hong T, Chen X, Duan Y, Li C, et al. Induced pluripotent stem cell-derived conditional medium promotes Leydig cell anti-apoptosis and proliferation via autophagy and Wnt/β-catenin pathway. J Cell Mol Med. 2018;22:3614-3626 pubmed publisher
Srikanth P, Lagomarsino V, Muratore C, Ryu S, He A, Taylor W, et al. Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids. Transl Psychiatry. 2018;8:77 pubmed publisher
Kukcinaviciute E, Jonusiene V, Sasnauskiene A, Dabkeviciene D, Eidenaite E, Laurinavicius A. Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells HCT116. J Cell Biochem. 2018;119:5913-5920 pubmed publisher
Tu J, Cao D, Li L, Cheung H, Chan W. MicroRNA profiling during directed differentiation of cortical interneurons from human-induced pluripotent stem cells. FEBS Open Bio. 2018;8:502-512 pubmed publisher
Li X, Wang Z, Chen R, Fu H, Gao C, Yan H, et al. LGR5 and BMI1 Increase Pig Intestinal Epithelial Cell Proliferation by Stimulating WNT/?-Catenin Signaling. Int J Mol Sci. 2018;19: pubmed publisher
Simmons C, Thompson C, Cawthon B, Westlake G, Swoboda K, Kiskinis E, et al. Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood. Neurobiol Dis. 2018;115:29-38 pubmed publisher
Kondrashov A, Duc Hoang M, Smith J, Bhagwan J, Duncan G, Mosqueira D, et al. Simplified Footprint-Free Cas9/CRISPR Editing of Cardiac-Associated Genes in Human Pluripotent Stem Cells. Stem Cells Dev. 2018;27:391-404 pubmed publisher
Li L, Yang D, Cui D, Li Y, Nie Z, Wang J, et al. Quantitative proteomics analysis of the role of tetraspanin-8 in the drug resistance of gastric cancer. Int J Oncol. 2018;52:473-484 pubmed publisher
Yu Y, Wang X, Zhang X, Zhai Y, Lu X, Ma H, et al. ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast. Stem Cell Res Ther. 2018;9:2 pubmed publisher
Li B, Yu F, Wu F, Hui T, A P, Liao X, et al. EZH2 Impairs Human Dental Pulp Cell Mineralization via the Wnt/β-Catenin Pathway. J Dent Res. 2018;97:571-579 pubmed publisher
Cheng Y, Zhu X, Cheng F, Ji L, Zhou Y. Delta-like homolog1/GATA binding protein 2 axis mediates leptin inhibition of PPAR?2 expression in hepatic stellate cells in vitro. Life Sci. 2018;192:183-189 pubmed publisher
Fujita S, Mukai T, Mito T, Kodama S, Nagasu A, Kittaka M, et al. Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis. Bone. 2018;106:156-166 pubmed publisher
Guo W, Shen F, Xiao W, Chen J, Pan F. Wnt inhibitor XAV939 suppresses the viability of small cell lung cancer NCI-H446 cells and induces apoptosis. Oncol Lett. 2017;14:6585-6591 pubmed publisher
Xie D, Zheng G, Xie P, Zhang Q, Lin F, Chang B, et al. Antitumor activity of resveratrol against human osteosarcoma cells: a key role of Cx43 and Wnt/β-catenin signaling pathway. Oncotarget. 2017;8:111419-111432 pubmed publisher
Bhardwaj A, Yang Y, Ueberheide B, Smith S. Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation. Nat Commun. 2017;8:2214 pubmed publisher
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product information
Catalog Number :
X3004
Product Name :
XAV939
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA