Azebi S, Batsche E, Michel F, Kornobis E, Muchardt C. Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells. EMBO J. 2019;38: pubmed publisher

Brennan F, Jogia T, Gillespie E, Blomster L, Li X, Nowlan B, et al. Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight. 2019;4: pubmed publisher

Thangaraj A, Periyasamy P, Guo M, Chivero E, Callen S, Buch S. Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics. Autophagy. 2019;:1-24 pubmed publisher

Tang S, Tabet F, Cochran B, Cuesta Torres L, Wu B, Barter P, et al. Apolipoprotein A-I enhances insulin-dependent and insulin-independent glucose uptake by skeletal muscle. Sci Rep. 2019;9:1350 pubmed publisher

Sil S, Niu F, Tom E, Liao K, Periyasamy P, Buch S. Cocaine Mediated Neuroinflammation: Role of Dysregulated Autophagy in Pericytes. Mol Neurobiol. 2019;56:3576-3590 pubmed publisher

Southard S, Kotipatruni R, Rust W. Generation and selection of pluripotent stem cells for robust differentiation to insulin-secreting cells capable of reversing diabetes in rodents. PLoS ONE. 2018;13:e0203126 pubmed publisher

Brillada C, Zheng J, Krüger F, Rovira Diaz E, Askani J, Schumacher K, et al. Phosphoinositides control the localization of HOPS subunit VPS41, which together with VPS33 mediates vacuole fusion in plants. Proc Natl Acad Sci U S A. 2018;115:E8305-E8314 pubmed publisher

Thangaraj A, Periyasamy P, Liao K, Bendi V, Callen S, Pendyala G, et al. HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy. Autophagy. 2018;14:1596-1619 pubmed publisher

Tang D, Zhao D, Wu Y, Yao R, Zhou L, Lu L, et al. The miR-3127-5p/p-STAT3 axis up-regulates PD-L1 inducing chemoresistance in non-small-cell lung cancer. J Cell Mol Med. 2018;: pubmed publisher

Sil S, Periyasamy P, Guo M, Callen S, Buch S. Morphine-Mediated Brain Region-Specific Astrocytosis Involves the ER Stress-Autophagy Axis. Mol Neurobiol. 2018;55:6713-6733 pubmed publisher

Zhou X, Luo Y, Zhu Y, Liu Z, Kent T, Rong J, et al. Inhibition of autophagy blocks cathepsins-tBid-mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes. Cell Death Dis. 2017;8:e2618 pubmed publisher

Cai Y, Yang L, Hu G, Chen X, Niu F, Yuan L, et al. Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy. J Cell Biol. 2016;215:245-258 pubmed

Sahu S, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, et al. JNK-dependent gene regulatory circuitry governs mesenchymal fate. EMBO J. 2015;34:2162-81 pubmed publisher

Guo M, Liao K, Periyasamy P, Yang L, Cai Y, Callen S, et al. Cocaine-mediated microglial activation involves the ER stress-autophagy axis. Autophagy. 2015;11:995-1009 pubmed publisher

Ghorbani A, Jeddi Tehrani M, Saidpour A, Safa M, Bayat A, Zand H. PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in human pre-B NALM-6 cells. Arch Biochem Biophys. 2015;566:58-66 pubmed publisher

Bernard M, Dieudé M, Yang B, Hamelin K, Underwood K, Hébert M. Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF. Autophagy. 2014;10:2193-207 pubmed publisher

Huang J, Fujimoto M, Fujiwara M, Fukao Y, Arimura S, Tsutsumi N. Arabidopsis dynamin-related proteins, DRP2A and DRP2B, function coordinately in post-Golgi trafficking. Biochem Biophys Res Commun. 2015;456:238-44 pubmed publisher

Li S, Zhou X, Dang Y, Kwan Y, Chan S, Leung G, et al. Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis. Biochim Biophys Acta. 2015;1850:373-84 pubmed publisher

Li Y, Wei Z, Mao H, Gao M, Liu Y, Ma Y, et al. Pretreatment with wortmannin alleviates lipopolysaccharide/d-galactosamine-induced acute liver injury. Biochem Biophys Res Commun. 2014;455:234-40 pubmed publisher

Matsumoto Y, Ishii M, Ishii K, Miyaguchi W, Horie R, Inagaki Y, et al. Transgenic silkworms expressing human insulin receptors for evaluation of therapeutically active insulin receptor agonists. Biochem Biophys Res Commun. 2014;455:159-64 pubmed publisher

Capurro V, Gianotti A, Caci E, Ravazzolo R, Galietta L, Zegarra Moran O. Functional analysis of acid-activated Cl⁻ channels: properties and mechanisms of regulation. Biochim Biophys Acta. 2015;1848:105-14 pubmed

Kitahara A, Takahashi K, Moriya R, Onuma H, Handa K, Sumitani Y, et al. Ghrelin augments the expressions and secretions of proinflammatory adipokines, VEGF120 and MCP-1, in differentiated 3T3-L1 adipocytes. J Cell Physiol. 2015;230:199-209 pubmed publisher

Li B, Qiu T, Zhang P, Wang X, Yin Y, Li S. IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation. Cell Prolif. 2014;47:133-45 pubmed publisher

Xie N, Zhong L, Liu L, Fang Y, Qi X, Cao J, et al. Autophagy contributes to dasatinib-induced myeloid differentiation of human acute myeloid leukemia cells. Biochem Pharmacol. 2014;89:74-85 pubmed publisher

Xu B, Guan X, Yu J, Lv J, Zhang H, Fu Q, et al. Activation of spinal phosphatidylinositol 3-kinase/protein kinase B mediates pain behavior induced by plantar incision in mice. Exp Neurol. 2014;255:71-82 pubmed publisher

Hashimoto D, Bläuer M, Hirota M, Ikonen N, Sand J, Laukkarinen J. Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs. Eur J Cancer. 2014;50:1382-90 pubmed publisher

Jiang Y, Zsombok A. Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1. Front Neurosci. 2014;7:270 pubmed publisher

Schaper K, Kietzmann M, Baumer W. Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells. Mol Immunol. 2014;59:10-8 pubmed publisher

Mimura K, Shiraishi K, Mueller A, Izawa S, Kua L, So J, et al. The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer. J Immunol. 2013;191:6261-72 pubmed publisher

Tsuchiya A, Kanno T, Nishizaki T. PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway. J Endocrinol. 2014;220:49-59 pubmed publisher

Shugg R, Thomson A, Tanabe N, Kashishian A, Steiner B, Puri K, et al. Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption. J Biol Chem. 2013;288:35346-57 pubmed publisher

Roviezzo F, De Angelis A, De Gruttola L, Bertolino A, Sullo N, Brancaleone V, et al. Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate. Clin Sci (Lond). 2014;126:545-56 pubmed publisher

Clark S, Rainville J, Zhao X, Katzenellenbogen B, Pfaff D, Vasudevan N. Estrogen receptor-mediated transcription involves the activation of multiple kinase pathways in neuroblastoma cells. J Steroid Biochem Mol Biol. 2014;139:45-53 pubmed publisher

Quast S, Berger A, Eberle J. ROS-dependent phosphorylation of Bax by wortmannin sensitizes melanoma cells for TRAIL-induced apoptosis. Cell Death Dis. 2013;4:e839 pubmed publisher

Sung C, Im H, Park N, Kwon Y, Shin S, Ye D, et al. Induction of steroid sulfatase expression in PC-3 human prostate cancer cells by insulin-like growth factor II. Toxicol Lett. 2013;223:109-15 pubmed publisher

Su N, Peng T, Tsai P, Huang C. Phosphoinositide 3-kinase/Akt pathway is involved in mediating the anti-inflammation effects of magnesium sulfate. J Surg Res. 2013;185:726-32 pubmed publisher

Akiyama M, Ozaki K, Kawano T, Yamada O, Kawauchi K, Ida H, et al. Telomerase activation as a repair response to radiation-induced DNA damage in Y79 retinoblastoma cells. Cancer Lett. 2013;340:82-7 pubmed publisher

Münzer P, Tolios A, Pelzl L, Schmid E, Schmidt E, Walker B, et al. Thrombin-sensitive expression of the store operated Ca(2+) channel Orai1 in platelets. Biochem Biophys Res Commun. 2013;436:25-30 pubmed publisher

Zou Y, Zhong W. A likely role for a novel PH-domain containing protein, PEPP2, in connecting membrane and cytoskeleton. Biocell. 2012;36:127-32 pubmed

Caldas L, Seabra S, Attias M, de Souza W. The effect of kinase, actin, myosin and dynamin inhibitors on host cell egress by Toxoplasma gondii. Parasitol Int. 2013;62:475-82 pubmed publisher

Krafft P, Caner B, Klebe D, Rolland W, Tang J, Zhang J. PHA-543613 preserves blood-brain barrier integrity after intracerebral hemorrhage in mice. Stroke. 2013;44:1743-7 pubmed publisher

Meng Y, Yong Y, Yang G, Ding H, Fan Z, Tang Y, et al. Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism. J Neurochem. 2013;126:805-18 pubmed publisher

Liu J, Liao Y, Ma K, Wang Y, Zhang G, Yang R, et al. PI3K is required for the physical interaction and functional inhibition of NF-?B by ?-catenin in colorectal cancer cells. Biochem Biophys Res Commun. 2013;434:760-6 pubmed publisher

Brennan Minnella A, Shen Y, el Benna J, Swanson R. Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death. Cell Death Dis. 2013;4:e580 pubmed publisher

Hong D, Choi I, Son Y, Kim D, Na S, Jung W, et al. The effect of PI3 kinase inhibitor LY294002 on voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells. Life Sci. 2013;92:916-22 pubmed publisher

Song J, Chen Q, Xing D. Enhanced apoptotic effects by downregulating Mcl-1: evidence for the improvement of photodynamic therapy with Celecoxib. Exp Cell Res. 2013;319:1491-504 pubmed publisher

Mukaro V, Bylund J, Hodge G, Holmes M, Jersmann H, Reynolds P, et al. Lectins offer new perspectives in the development of macrophage-targeted therapies for COPD/emphysema. PLoS ONE. 2013;8:e56147 pubmed publisher

Li X, Luo R, Jiang R, Meng X, Wu X, Zhang S, et al. The role of the Hsp90/Akt pathway in myocardial calpain-induced caspase-3 activation and apoptosis during sepsis. BMC Cardiovasc Disord. 2013;13:8 pubmed publisher

Wang D, Lu J, Tindall D. Androgens regulate TRAIL-induced cell death in prostate cancer cells via multiple mechanisms. Cancer Lett. 2013;335:136-44 pubmed publisher

Vivas O, Castro H, Arenas I, Elías Viñas D, Garcia D. PIP? hydrolysis is responsible for voltage independent inhibition of CaV2.2 channels in sympathetic neurons. Biochem Biophys Res Commun. 2013;432:275-80 pubmed publisher

Leto D, Uhm M, Williams A, Chen X, Saltiel A. Negative regulation of the RalGAP complex by 14-3-3. J Biol Chem. 2013;288:9272-83 pubmed publisher

Buffen K, Oosting M, Mennens S, Anand P, Plantinga T, Sturm P, et al. Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1? (IL-1?). J Biol Chem. 2013;288:8658-66 pubmed publisher

Yang P, Han Y, Gui L, Sun J, Chen Y, Song R, et al. Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-κB and MAPKs activation via the phosphatidylinositol 3-kinase signaling. Biochem Pharmacol. 2013;85:1124-33 pubmed publisher

Fan R, Kim N, Gumbiner B. Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1. Proc Natl Acad Sci U S A. 2013;110:2569-74 pubmed publisher

Walton J, Bourdolle A, Butler S, Soulie M, Delbianco M, McMahon B, et al. Very bright europium complexes that stain cellular mitochondria. Chem Commun (Camb). 2013;49:1600-2 pubmed publisher

Quan J, Cha G, Zhou W, Chu J, Nishikawa Y, Lee Y. Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis. Exp Parasitol. 2013;133:462-71 pubmed publisher

Strande J, Routhu K, Lecht S, Lazarovici P. Nerve growth factor reduces myocardial ischemia/reperfusion injury in rat hearts. J Basic Clin Physiol Pharmacol. 2013;24:81-4 pubmed publisher

Li Z, Shen J, Wu W, Yu X, Liang J, Qiu G, et al. Leptin induces cyclin D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT, PI3K/Akt and MEK/ERK pathways. PLoS ONE. 2012;7:e53176 pubmed publisher

Chang B, Sang L, Wang Y, Tong J, Wang B. The role of FoxO4 in the relationship between alcohol-induced intestinal barrier dysfunction and liver injury. Int J Mol Med. 2013;31:569-76 pubmed publisher

McAlpine F, Williamson L, Tooze S, Chan E. Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2. Autophagy. 2013;9:361-73 pubmed publisher

Tsai C, Chiang Y, Chen H, Huang P, Hsu H, Tang C. High glucose induces vascular endothelial growth factor production in human synovial fibroblasts through reactive oxygen species generation. Biochim Biophys Acta. 2013;1830:2649-58 pubmed

Dai C, Zheng C, Meng F, Zhou Z, Sang L, Jiang M. VSL#3 probiotics exerts the anti-inflammatory activity via PI3k/Akt and NF-κB pathway in rat model of DSS-induced colitis. Mol Cell Biochem. 2013;374:1-11 pubmed publisher

Shin H, Ryu J, Kim S, Zuo Z, Do S. Caffeine-induced inhibition of the activity of glutamate transporter type 3 expressed in Xenopus oocytes. Toxicol Lett. 2013;217:143-8 pubmed publisher

Alba Betancourt C, Luna Acosta J, Ramírez Martínez C, Avila González D, Granados Ávalos E, Carranza M, et al. Neuro-protective effects of growth hormone (GH) after hypoxia-ischemia injury in embryonic chicken cerebellum. Gen Comp Endocrinol. 2013;183:17-31 pubmed publisher

Engelhardt S, Boevink P, Armstrong M, Ramos M, Hein I, Birch P. Relocalization of late blight resistance protein R3a to endosomal compartments is associated with effector recognition and required for the immune response. Plant Cell. 2012;24:5142-58 pubmed publisher

Binu S, Soumya S, Sudhakaran P. Metabolite control of angiogenesis: angiogenic effect of citrate. J Physiol Biochem. 2013;69:383-95 pubmed publisher

Bosco E, Ni W, Wang L, Guo F, Johnson J, Zheng Y. Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis. Blood. 2010;115:3320-8 pubmed publisher

Liu Y, Jiang N, Wu J, Dai W, Rosenblum J. Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects. J Biol Chem. 2007;282:2505-11 pubmed

Hazeki O, Hazeki K, Katada T, Ui M. Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events. J Lipid Mediat Cell Signal. 1996;14:259-61 pubmed

Hazeki O. [Wortmannin, an inhibitor of phosphatidylinositol 3-kinase]. Seikagaku. 1995;67:33-6 pubmed