Wetzel L, Blanchard S, Rama S, Beier V, Kaufmann A, Wollert T. TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes. Nat Commun. 2020;11:2993 pubmed publisher

Yun C, Roh E, Kim S, Han J, Lee J, Jung D, et al. Stem Cell Factor-Inducible MITF-M Expression in Therapeutics for Acquired Skin Hyperpigmentation. Theranostics. 2020;10:340-352 pubmed publisher

Aguilar C, Cruz A, Rodrigues Lopes I, Maudet C, Sunkavalli U, Silva R, et al. Functional screenings reveal different requirements for host microRNAs in Salmonella and Shigella infection. Nat Microbiol. 2020;5:192-205 pubmed publisher

Chen W, Wang Q, Xu X, Saxton B, Tessema M, Leng S, et al. Vasorin/ATIA Promotes Cigarette Smoke-Induced Transformation of Human Bronchial Epithelial Cells by Suppressing Autophagy-Mediated Apoptosis. Transl Oncol. 2020;13:32-41 pubmed publisher

Cao P, Kim S, Xing A, Schenck C, Liu L, Jiang N, et al. Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis. elife. 2019;8: pubmed publisher

Wang S, Crisman L, Miller J, Datta I, Gulbranson D, Tian Y, et al. Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis. J Biol Chem. 2019;294:19988-19996 pubmed publisher

Wu L, Ahmadvand D, Su J, Hall A, Tan X, Farhangrazi Z, et al. Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide. Nat Commun. 2019;10:4635 pubmed publisher

Yang Y, Wang B, Li B. Structural Requirement of Casein Peptides for Transcytosis through the Caco-2 Cell Monolayer: Hydrophobicity and Charge Property Affect the Transport Pathway and Efficiency. J Agric Food Chem. 2019;67:11778-11787 pubmed publisher

Castrejón Jiménez N, Leyva Paredes K, Baltierra Uribe S, Castillo Cruz J, Campillo Navarro M, Hernández Pérez A, et al. Ursolic and Oleanolic Acids Induce Mitophagy in A549 Human Lung Cancer Cells. Molecules. 2019;24: pubmed publisher

Rai U, Kosuru R, Prakash S, Singh S, Birla H, Tiwari V, et al. Tetramethylpyrazine prevents diabetes by activating PI3K/Akt/GLUT-4 signalling in animal model of type-2 diabetes. Life Sci. 2019;236:116836 pubmed publisher

Bravo San Pedro J, Sica V, Martins I, Pol J, Loos F, Maiuri M, et al. Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity. Cell Metab. 2019;30:754-767.e9 pubmed publisher

Salloum G, Jakubik C, Erami Z, Heitz S, Bresnick A, Backer J. PI3Kβ is selectively required for growth factor-stimulated macropinocytosis. J Cell Sci. 2019;132: pubmed publisher

Walia V, Cuenca A, Vetter M, Insinna C, Perera S, Lu Q, et al. Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis. Dev Cell. 2019;: pubmed publisher

Janssens G, Lin X, Millán Ariño L, Kavšek A, Sen I, Seinstra R, et al. Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell Rep. 2019;27:467-480.e6 pubmed publisher

Barkai O, Puig S, Lev S, Title B, Katz B, Eli Berchoer L, et al. Platelet-derived growth factor activates nociceptive neurons by inhibiting M-current and contributes to inflammatory pain. Pain. 2019;160:1281-1296 pubmed publisher

Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer K, Cedillo L, et al. Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension. Cell. 2019;177:299-314.e16 pubmed publisher

Turco E, Witt M, Abert C, Bock Bierbaum T, Su M, Trapannone R, et al. FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Mol Cell. 2019;74:330-346.e11 pubmed publisher

Hsieh C, Yang W. Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy. Nat Commun. 2019;10:969 pubmed publisher

Poluzzi C, Nastase M, Zeng Brouwers J, Roedig H, Hsieh L, Michaelis J, et al. Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury. Kidney Int. 2019;95:540-562 pubmed publisher

Edwards T, Bloom D. Lund Human Mesencephalic (LUHMES) Neuronal Cell Line Supports Herpes Simplex Virus 1 Latency In Vitro. J Virol. 2019;93: pubmed publisher

Ge D, Gao J, Han L, Li Y, Liu H, Yang W, et al. Novel effects of sphingosylphosphorylcholine on the apoptosis of breast cancer via autophagy/AKT/p38 and JNK signaling. J Cell Physiol. 2019;234:11451-11462 pubmed publisher

Chatterjee B, Ghosh K, Suresh L, Kanade S. Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells. Mol Cell Biochem. 2019;455:73-90 pubmed publisher

Arbogast F, Arnold J, Hammann P, Kuhn L, Chicher J, Murera D, et al. ATG5 is required for B cell polarization and presentation of particulate antigens. Autophagy. 2019;15:280-294 pubmed publisher

Gupta P, Singh P, Pandey H, Seth P, Mukhopadhyay C. Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation. Biochim Biophys Acta Gen Subj. 2018;1863:547-564 pubmed publisher

Lee J, Nam H, Kim L, Jeon Y, Min H, Ha S, et al. TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia. Autophagy. 2018;: pubmed publisher

Plesch E, Chen C, Butz E, Scotto Rosato A, Krogsaeter E, Yinan H, et al. Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells. elife. 2018;7: pubmed publisher

Lee H, Jung Y, Oh J, Choi G, Chae C, Kim J, et al. BICD1 mediates HIF1α nuclear translocation in mesenchymal stem cells during hypoxia adaptation. Cell Death Differ. 2018;: pubmed publisher

García Gil A, Galán Enríquez C, Perez Lopez A, Nava P, Alpuche Aranda C, Ortiz Navarrete V. SopB activates the Akt-YAP pathway to promote Salmonella survival within B cells. Virulence. 2018;9:1390-1402 pubmed publisher

Meyer N, Zielke S, Michaelis J, Linder B, Warnsmann V, Rakel S, et al. AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy. 2018;14:1693-1709 pubmed publisher

Barbero Camps E, Roca Agujetas V, Bartolessis I, de Dios C, Fernandez Checa J, Mari M, et al. Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion. Autophagy. 2018;14:1129-1154 pubmed publisher

Zhang Y, Zimmer M, Guardia T, Callahan S, Mondal C, Di Martino J, et al. Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. Dev Cell. 2018;45:580-594.e7 pubmed publisher

Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N. Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. J Cell Biol. 2018;217:2633-2645 pubmed publisher

Dedoni S, CAMPBELL L, Harvey B, Avdoshina V, Mocchetti I. The orphan G-protein-coupled receptor 75 signaling is activated by the chemokine CCL5. J Neurochem. 2018;146:526-539 pubmed publisher

Jati S, Kundu S, Chakraborty A, Mahata S, Nizet V, Sen M. Wnt5A Signaling Promotes Defense Against Bacterial Pathogens by Activating a Host Autophagy Circuit. Front Immunol. 2018;9:679 pubmed publisher

Skowyra M, Schlesinger P, Naismith T, Hanson P. Triggered recruitment of ESCRT machinery promotes endolysosomal repair. Science. 2018;360: pubmed publisher

Sun Y, Huang Y, Huang F, Mei W, Liu Q, Wang C, et al. 3'-epi-12β-hydroxyfroside, a new cardenolide, induces cytoprotective autophagy via blocking the Hsp90/Akt/mTOR axis in lung cancer cells. Theranostics. 2018;8:2044-2060 pubmed publisher

Freudenblum J, Iglesias J, Hermann M, Walsen T, Wilfinger A, Meyer D, et al. In vivo imaging of emerging endocrine cells reveals a requirement for PI3K-regulated motility in pancreatic islet morphogenesis. Development. 2018;145: pubmed publisher

Fletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh J, et al. The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. EMBO J. 2018;37: pubmed publisher

Kondratskyi A, Kondratska K, Vanden Abeele F, Gordienko D, Dubois C, Toillon R, et al. Ferroquine, the next generation antimalarial drug, has antitumor activity. Sci Rep. 2017;7:15896 pubmed publisher

Gulbranson D, Davis E, Demmitt B, Ouyang Y, Ye Y, Yu H, et al. RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. Proc Natl Acad Sci U S A. 2017;114:E8224-E8233 pubmed publisher

He R, Peng J, Yuan P, Yang J, Wu X, Wang Y, et al. Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest. Sci Rep. 2017;7:10532 pubmed publisher

Wood M, Ishiyama N, Singaram I, Chung C, Flozak A, Yemelyanov A, et al. α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion. J Cell Biol. 2017;216:3767-3783 pubmed publisher

Chen C, Butz E, Chao Y, Grishchuk Y, Becker L, Heller S, et al. Small Molecules for Early Endosome-Specific Patch Clamping. Cell Chem Biol. 2017;24:907-916.e4 pubmed publisher

Bakula D, Müller A, Zuleger T, Takacs Z, Franz Wachtel M, Thost A, et al. WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. Nat Commun. 2017;8:15637 pubmed publisher

Monel B, Compton A, Bruel T, Amraoui S, Burlaud Gaillard J, Roy N, et al. Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells. EMBO J. 2017;36:1653-1668 pubmed publisher

Vashi N, Andrabi S, Ghanwat S, Suar M, Kumar D. Ca2+-dependent Focal Exocytosis of Golgi-derived Vesicles Helps Phagocytic Uptake in Macrophages. J Biol Chem. 2017;292:5144-5165 pubmed publisher

Keir L, Firth R, Aponik L, Feitelberg D, Sakimoto S, Aguilar E, et al. VEGF regulates local inhibitory complement proteins in the eye and kidney. J Clin Invest. 2017;127:199-214 pubmed publisher

Pan H, Zhong X, Lee S. Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. BMC Biochem. 2016;17:14 pubmed publisher

Zappia C, Granja Galeano G, Fernández N, Shayo C, Davio C, Fitzsimons C, et al. Effects of histamine H1 receptor signaling on glucocorticoid receptor activity. Role of canonical and non-canonical pathways. Sci Rep. 2015;5:17476 pubmed publisher

Luo X, Xu B, Zhou M, Bao Y, Zhou S, Fan J, et al. Co-Inhibition of GLUT-1 Expression and the PI3K/Akt Signaling Pathway to Enhance the Radiosensitivity of Laryngeal Carcinoma Xenografts In Vivo. PLoS ONE. 2015;10:e0143306 pubmed publisher

Pratsinis H, Kletsas D. Organotypic Cultures of Intervertebral Disc Cells: Responses to Growth Factors and Signaling Pathways Involved. Biomed Res Int. 2015;2015:427138 pubmed publisher

Liu H, Meng Q, Huang C, Wang J, Liu X. Nephroprotective Effects of Polydatin against Ischemia/Reperfusion Injury: A Role for the PI3K/Akt Signal Pathway. Oxid Med Cell Longev. 2015;2015:362158 pubmed publisher

Liao F, Zheng Y, Cai J, Fan J, Wang J, Yang J, et al. Catestatin attenuates endoplasmic reticulum induced cell apoptosis by activation type 2 muscarinic acetylcholine receptor in cardiac ischemia/reperfusion. Sci Rep. 2015;5:16590 pubmed publisher

Quintero Barceinas R, García Regalado A, Aréchaga Ocampo E, Villegas Sepúlveda N, González De la Rosa C. All-Trans Retinoic Acid Induces Proliferation, Survival, and Migration in A549 Lung Cancer Cells by Activating the ERK Signaling Pathway through a Transcription-Independent Mechanism. Biomed Res Int. 2015;2015:404368 pubmed publisher

Hutchinson T, Patel J. Peptide-stimulated angiogenesis: Role of lung endothelial caveolar signaling and nitric oxide. Nitric Oxide. 2015;51:43-51 pubmed publisher

Felemban S, Garner A, Smida F, Boocock D, Hargreaves A, Dickenson J. Phenyl Saligenin Phosphate Induced Caspase-3 and c-Jun N-Terminal Kinase Activation in Cardiomyocyte-Like Cells. Chem Res Toxicol. 2015;28:2179-91 pubmed publisher

Xu Y, Morse L, da Silva R, Wang D, Battaglino R. A short report: PAMM, a novel antioxidant protein, induced by oxidative stress. Redox Biol. 2015;6:446-453 pubmed publisher

Yamaguchi M, Murata T. Exogenous regucalcin suppresses the proliferation of human breast cancer MDA-MB-231 bone metastatic cells in vitro. Mol Med Rep. 2015;12:7801-5 pubmed publisher

Yamaguchi M, Murata T, El Rayes B, Shoji M. The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine. Oncol Rep. 2015;34:3304-10 pubmed publisher

Chen Z, Qiu S, Lu X. The expression and clinical significance of HDGF in osteosarcoma. Onco Targets Ther. 2015;8:2509-17 pubmed publisher

Ryu J, Lee S, Seong J, Han H. Glutamine contributes to maintenance of mouse embryonic stem cell self-renewal through PKC-dependent downregulation of HDAC1 and DNMT1/3a. Cell Cycle. 2015;14:3292-305 pubmed publisher

Araldi D, Ferrari L, Levine J. Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain. J Neurosci. 2015;35:12502-17 pubmed publisher

Gao C, Cai Y, Zhang X, Huang H, Wang J, Wang Y, et al. Ischemic Preconditioning Mediates Neuroprotection against Ischemia in Mouse Hippocampal CA1 Neurons by Inducing Autophagy. PLoS ONE. 2015;10:e0137146 pubmed publisher

Habash T, Saleh A, Roy Chowdhury S, Smith D, Fernyhough P. The proinflammatory cytokine, interleukin-17A, augments mitochondrial function and neurite outgrowth of cultured adult sensory neurons derived from normal and diabetic rats. Exp Neurol. 2015;273:177-89 pubmed publisher

Yang J, Bang M, Jang C, Jo G, Jung S, Ki S. Alginate oligosaccharide enhances LDL uptake via regulation of LDLR and PCSK9 expression. J Nutr Biochem. 2015;26:1393-400 pubmed publisher

Blüml S, Sahin E, Saferding V, Goncalves Alves E, Hainzl E, Niederreiter B, et al. Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis. Arthritis Res Ther. 2015;17:230 pubmed publisher

Pan B, Wang Y, Lai M, Mu Y, Huang B. Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways. Sci Rep. 2015;5:13372 pubmed publisher

Liu P, Gan W, Chin Y, Ogura K, Guo J, Zhang J, et al. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer Discov. 2015;5:1194-209 pubmed publisher

Pundir P, MacDonald C, Kulka M. The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production. J Immunol. 2015;195:2774-87 pubmed publisher

Dauletbaev N, Cammisano M, Herscovitch K, Lands L. Stimulation of the RIG-I/MAVS Pathway by Polyinosinic:Polycytidylic Acid Upregulates IFN-β in Airway Epithelial Cells with Minimal Costimulation of IL-8. J Immunol. 2015;195:2829-41 pubmed publisher

Kim N, Gumbiner B. Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway. J Cell Biol. 2015;210:503-15 pubmed publisher

Gabl M, Winther M, Welin A, Karlsson A, Oprea T, Bylund J, et al. P2Y2 receptor signaling in neutrophils is regulated from inside by a novel cytoskeleton-dependent mechanism. Exp Cell Res. 2015;336:242-52 pubmed publisher

Zhang L, Dai F, Sheng P, Chen Z, Xu Q, Guo Y. Resveratrol analogue 3,4,4'-trihydroxy-trans-stilbene induces apoptosis and autophagy in human non-small-cell lung cancer cells in vitro. Acta Pharmacol Sin. 2015;36:1256-65 pubmed publisher

Madera L, Greenshields A, Coombs M, Hoskin D. 4T1 Murine Mammary Carcinoma Cells Enhance Macrophage-Mediated Innate Inflammatory Responses. PLoS ONE. 2015;10:e0133385 pubmed publisher

Pietri J, Pietri E, Potts R, Riehle M, Luckhart S. Plasmodium falciparum suppresses the host immune response by inducing the synthesis of insulin-like peptides (ILPs) in the mosquito Anopheles stephensi. Dev Comp Immunol. 2015;53:134-44 pubmed publisher

Tian Y, Piras B, Kron I, French B, Yang Z. Adenosine 2B Receptor Activation Reduces Myocardial Reperfusion Injury by Promoting Anti-Inflammatory Macrophages Differentiation via PI3K/Akt Pathway. Oxid Med Cell Longev. 2015;2015:585297 pubmed publisher

Seong Y, Sung P, Jang Y, Choi Y, Park B, Park S, et al. Activation of human natural killer cells by the soluble form of cellular prion protein. Biochem Biophys Res Commun. 2015;464:512-8 pubmed publisher

Sahu S, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, et al. JNK-dependent gene regulatory circuitry governs mesenchymal fate. EMBO J. 2015;34:2162-81 pubmed publisher

Agarwal S, Tiwari S, Seth B, Yadav A, Singh A, Mudawal A, et al. Activation of Autophagic Flux against Xenoestrogen Bisphenol-A-induced Hippocampal Neurodegeneration via AMP kinase (AMPK)/Mammalian Target of Rapamycin (mTOR) Pathways. J Biol Chem. 2015;290:21163-84 pubmed publisher

Hrabeta J, Groh T, Khalil M, Poljakova J, Adam V, Kizek R, et al. Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells. Int J Oncol. 2015;47:971-80 pubmed publisher

Tang X, Basavarajappa D, Haeggström J, Wan M. P2X7 Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance. J Immunol. 2015;195:1191-201 pubmed publisher

Lin C, Lin W, Hou W, Hsiao L, Yang C. Endothelin-1 induces VCAM-1 expression-mediated inflammation via receptor tyrosine kinases and Elk/p300 in human tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015;309:L211-25 pubmed publisher

Ruozi G, Bortolotti F, Falcione A, Dal Ferro M, Ukovich L, Macedo A, et al. AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia. Nat Commun. 2015;6:7388 pubmed publisher

Hu J, Cheng T, Zhang L, Sun B, Deng L, Xu H. Anti-tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC-803 proliferation via phospho-extracellular signal-regulated kinase-, Src-, c-Jun N-terminal kinase- and phosphoinositide 3-kinase-associated pathways. Mol Med Rep. 2015;12:4396-4402 pubmed publisher

Sotoodehnejadnematalahi F, Staples K, Chrysanthou E, Pearson H, Ziegler Heitbrock L, Burke B. Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages. PLoS ONE. 2015;10:e0125799 pubmed publisher

Hsu P, Wu C, Shen S, Yang Y. The role of tomatine adjuvant in antigen delivery for cross- presentation. Curr Drug Deliv. 2015;12:342-50 pubmed

Guo M, Liao K, Periyasamy P, Yang L, Cai Y, Callen S, et al. Cocaine-mediated microglial activation involves the ER stress-autophagy axis. Autophagy. 2015;11:995-1009 pubmed publisher

Blair T, Moore S, Hers I. Circulating primers enhance platelet function and induce resistance to antiplatelet therapy. J Thromb Haemost. 2015;13:1479-93 pubmed publisher

Urban B, Collard T, Eagle C, Southern S, Greenhough A, Hamdollah Zadeh M, et al. BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling. Gut. 2016;65:1151-64 pubmed publisher

Vivacqua A, De Marco P, Santolla M, Cirillo F, Pellegrino M, Panno M, et al. Estrogenic gper signaling regulates mir144 expression in cancer cells and cancer-associated fibroblasts (cafs). Oncotarget. 2015;6:16573-87 pubmed

Tang R, Gao L, Kawatani M, Chen J, Cao X, Osada H, et al. Neuritogenic Activity of Tetradecyl 2,3-Dihydroxybenzoate Is Mediated through the Insulin-Like Growth Factor 1 Receptor/Phosphatidylinositol 3 Kinase/Mitogen-Activated Protein Kinase Signaling Pathway. Mol Pharmacol. 2015;88:326-34 pubmed publisher

Stojkov Mimic N, Bjelic M, Radovic S, Mihajlovic A, Sokanovic S, Baburski A, et al. Intratesticular alpha1-adrenergic receptors mediate stress-disturbed transcription of steroidogenic stimulator NUR77 as well as steroidogenic repressors DAX1 and ARR19 in Leydig cells of adult rats. Mol Cell Endocrinol. 2015;412:309-19 pubmed publisher

McCully M, Collins P, Hughes T, Thomas C, Billen J, O Donnell V, et al. Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells. J Immunol. 2015;195:96-104 pubmed publisher

Yu J, Ramasamy T, Murphy N, Holt M, Czapiewski R, Wei S, et al. PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation. Nat Commun. 2015;6:7212 pubmed publisher

Kokona D, Thermos K. Synthetic and endogenous cannabinoids protect retinal neurons from AMPA excitotoxicity in vivo, via activation of CB1 receptors: Involvement of PI3K/Akt and MEK/ERK signaling pathways. Exp Eye Res. 2015;136:45-58 pubmed publisher

Xu L, Auzins A, Sun X, Xu Y, Harnischfeger F, Lu Y, et al. The synaptic recruitment of lipid rafts is dependent on CD19-PI3K module and cytoskeleton remodeling molecules. J Leukoc Biol. 2015;98:223-34 pubmed publisher

Bürki S, Gaschen V, Stoffel M, Stojiljkovic A, Frey J, Kuehni Boghenbor K, et al. Invasion and persistence of Mycoplasma bovis in embryonic calf turbinate cells. Vet Res. 2015;46:53 pubmed publisher

Moscariello M, Wieloch R, Kurosawa A, Li F, Adachi N, Mladenov E, et al. Role for Artemis nuclease in the repair of radiation-induced DNA double strand breaks by alternative end joining. DNA Repair (Amst). 2015;31:29-40 pubmed publisher

Casellas A, Mallol C, Salavert A, Jimenez V, Garcia M, Agudo J, et al. Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage. J Biol Chem. 2015;290:16772-85 pubmed publisher

Kweon S, Song J, Kim H, Kim T, Choi B. Induction of human leukemia cell differentiation via PKC/MAPK pathways by arsantin, a sesquiterpene lactone from Artemisia santolina. Arch Pharm Res. 2015;38:2020-8 pubmed publisher

Bao W, Wang Y, Fu Y, Jia X, Li J, Vangan N, et al. mTORC1 Regulates Flagellin-Induced Inflammatory Response in Macrophages. PLoS ONE. 2015;10:e0125910 pubmed publisher

Lin T, Liu Y, Chan Y, Su C, Lin Y, Hsu S, et al. Ghrelin promotes renal cell carcinoma metastasis via Snail activation and is associated with poor prognosis. J Pathol. 2015;237:50-61 pubmed publisher

Lorenzen J, Schauerte C, Hübner A, Kölling M, Martino F, Scherf K, et al. Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis. Eur Heart J. 2015;36:2184-96 pubmed publisher

Benesch M, Zhao Y, Curtis J, McMullen T, Brindley D. Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate. J Lipid Res. 2015;56:1134-44 pubmed publisher

Olianas M, Dedoni S, Onali P. Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts. Biochem Pharmacol. 2015;95:311-23 pubmed publisher

Gabriel M, Delforge Y, Deward A, Habraken Y, Hennuy B, Piette J, et al. Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis. BMC Cancer. 2015;15:227 pubmed publisher

Park C, Suh Y, Cuervo A. Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage. Nat Commun. 2015;6:6823 pubmed publisher

Wang H, Chang F, Huang T, Kuo C, Tsai Y, Wu C. (-)-Liriopein B Suppresses Breast Cancer Progression via Inhibition of Multiple Kinases. Chem Res Toxicol. 2015;28:897-906 pubmed publisher

Li Q, Wu Y, Fang S, Wang L, Qi H, Zhang Y, et al. BCR/ABL oncogene-induced PI3K signaling pathway leads to chronic myeloid leukemia pathogenesis by impairing immuno-modulatory function of hemangioblasts. Cancer Gene Ther. 2015;22:227-37 pubmed publisher

Doerner J, Wen J, Xia Y, Paz K, Schairer D, Wu L, et al. TWEAK/Fn14 Signaling Involvement in the Pathogenesis of Cutaneous Disease in the MRL/lpr Model of Spontaneous Lupus. J Invest Dermatol. 2015;135:1986-1995 pubmed publisher

Lecat S, Belemnaba L, Galzi J, Bucher B. Neuropeptide Y receptor mediates activation of ERK1/2 via transactivation of the IGF receptor. Cell Signal. 2015;27:1297-304 pubmed publisher

Li P, Shi J, He Q, Hu Q, Wang Y, Zhang L, et al. Streptococcus pneumoniae induces autophagy through the inhibition of the PI3K-I/Akt/mTOR pathway and ROS hypergeneration in A549 cells. PLoS ONE. 2015;10:e0122753 pubmed publisher

Ugajin T, Nishida K, Yamasaki S, Suzuki J, Mita M, Kubo M, et al. Zinc-binding metallothioneins are key modulators of IL-4 production by basophils. Mol Immunol. 2015;66:180-8 pubmed publisher

Niu N, Wang Z, Pan S, Ding H, Au G, He Z, et al. Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling path. Drug Des Devel Ther. 2015;9:1555-84 pubmed publisher

Gentile M, Ciniglia C, Reccia M, Volpicelli F, Gatti M, Thellung S, et al. Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation. PLoS ONE. 2015;10:e0118864 pubmed publisher

Schwalm S, Timcheva T, Filipenko I, Ebadi M, Hofmann L, Zangemeister Wittke U, et al. Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts. Biol Chem. 2015;396:813-25 pubmed publisher

Zub K, Sousa M, Sarno A, Sharma A, Demirovic A, Rao S, et al. Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells. PLoS ONE. 2015;10:e0119857 pubmed publisher

Li J, Yang Y, Liu Q, Zhou Z, Pan S, He Z, et al. The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells. Drug Des Devel Ther. 2015;9:1027-62 pubmed publisher

Wang Y, Yang Y, Zhao R, Pan S, Zhe H, He Z, et al. Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells. Drug Des Devel Ther. 2015;9:993-1026 pubmed publisher

Andreani G, Ouellet M, Menasria R, Gomez A, Barat C, Tremblay M. Leishmania infantum amastigotes trigger a subpopulation of human B cells with an immunoregulatory phenotype. PLoS Negl Trop Dis. 2015;9:e0003543 pubmed publisher

Chen B, Miller A, Rebelatto M, Brewah Y, Rowe D, Clarke L, et al. S100A9 induced inflammatory responses are mediated by distinct damage associated molecular patterns (DAMP) receptors in vitro and in vivo. PLoS ONE. 2015;10:e0115828 pubmed publisher

Song J, Kang S, Lee K, Lee J. The protective effect of melatonin on neural stem cell against LPS-induced inflammation. Biomed Res Int. 2015;2015:854359 pubmed publisher

Blazquez C, Chiarlone A, Bellocchio L, Resel E, Pruunsild P, García Rincón D, et al. The CB? cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway. Cell Death Differ. 2015;22:1618-29 pubmed publisher

Wan J, Che Y, Kang N, Wu W. SOCS3 blocks HIF-1α expression to inhibit proliferation and angiogenesis of human small cell lung cancer by downregulating activation of Akt, but not STAT3. Mol Med Rep. 2015;12:83-92 pubmed publisher

Hung C, Chien C, Chiang W, Lin C, Hour T, Chen H, et al. p22phox confers resistance to cisplatin, by blocking its entry into the nucleus. Oncotarget. 2015;6:4110-25 pubmed

Feng X, Luo J, Liu M, Yan W, Zhou Z, Xia Y, et al. Sirtuin 6 promotes transforming growth factor-β1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence. Cancer Sci. 2015;106:559-66 pubmed publisher

Zhong M, Song W, Xu Y, Ye Y, Feng L. Paeoniflorin ameliorates ischemic neuronal damage in vitro via adenosine A1 receptor-mediated transactivation of epidermal growth factor receptor. Acta Pharmacol Sin. 2015;36:298-310 pubmed publisher

Xu Q, Li X, Lu Y, Shen L, Zhang J, Cao S, et al. Pharmacological modulation of autophagy to protect cardiomyocytes according to the time windows of ischaemia/reperfusion. Br J Pharmacol. 2015;172:3072-85 pubmed publisher

Wang W, Liu S, Li K, Chen Y, Jiang B, Li Y, et al. Leptin: a potential anxiolytic by facilitation of fear extinction. CNS Neurosci Ther. 2015;21:425-34 pubmed publisher

Peres A, Stegen C, Li J, Xu A, Levast B, Surette M, et al. Uncoupling of pro- and anti-inflammatory properties of Staphylococcus aureus. Infect Immun. 2015;83:1587-97 pubmed publisher

Keifer J, Zheng Z. Coincidence detection in a neural correlate of classical conditioning is initiated by bidirectional 3-phosphoinositide-dependent kinase-1 signalling and modulated by adenosine receptors. J Physiol. 2015;593:1581-95 pubmed publisher

Ang Z, Er J, Ding J. The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes. Sci Rep. 2015;5:8134 pubmed publisher

Wang F, Wang Q, Zhou Z, Yu S, Pan S, He Z, et al. Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells. Drug Des Devel Ther. 2015;9:537-60 pubmed publisher

Gessain G, Tsai Y, Travier L, Bonazzi M, Grayo S, Cossart P, et al. PI3-kinase activation is critical for host barrier permissiveness to Listeria monocytogenes. J Exp Med. 2015;212:165-83 pubmed publisher

Joshi A, Orset C, Engelhardt B, Baumgart Vogt E, Gerriets T, Vivien D, et al. Deficiency of Factor VII activating protease alters the outcome of ischemic stroke in mice. Eur J Neurosci. 2015;41:965-75 pubmed publisher

Jin Z, Chung J, Mei W, Strack S, He C, Lau G, et al. Regulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt. Mol Biol Cell. 2015;26:1160-73 pubmed publisher

Chen S, Zhou N, Zhang Z, Li W, Zhu W. Resveratrol induces cell apoptosis in adipocytes via AMPK activation. Biochem Biophys Res Commun. 2015;457:608-13 pubmed publisher

de Oliveira S, Boudinot P, Calado Ã, Mulero V. Duox1-derived H2O2 modulates Cxcl8 expression and neutrophil recruitment via JNK/c-JUN/AP-1 signaling and chromatin modifications. J Immunol. 2015;194:1523-33 pubmed publisher

Singh B, Maharjan S, Park T, Jiang T, Kang S, Choi Y, et al. Tuning the buffering capacity of polyethylenimine with glycerol molecules for efficient gene delivery: staying in or out of the endosomes. Macromol Biosci. 2015;15:622-35 pubmed publisher

Ko C, Chu Y, Narumiya S, Chi J, Furuyashiki T, Aoki T, et al. CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer's disease. Neurobiol Aging. 2015;36:1356-68 pubmed publisher

Li I, Ma K, Weng S, Huang S, Liang C, Huang Y. Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')--induced neurotoxicity in cultured cortical neurons. PLoS ONE. 2014;9:e116565 pubmed publisher

Revalde J, Li Y, Hawkins B, Rosengren R, Paxton J. Heterocyclic cyclohexanone monocarbonyl analogs of curcumin can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance. Biochem Pharmacol. 2015;93:305-17 pubmed publisher

Ben Dov N, Korenstein R. The uptake of HIV Tat peptide proceeds via two pathways which differ from macropinocytosis. Biochim Biophys Acta. 2015;1848:869-77 pubmed publisher

Okada T, Sinha S, Esposito I, Schiavon G, López Lago M, Su W, et al. The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. Nat Cell Biol. 2015;17:81-94 pubmed publisher

Ghorbani A, Jeddi Tehrani M, Saidpour A, Safa M, Bayat A, Zand H. PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in human pre-B NALM-6 cells. Arch Biochem Biophys. 2015;566:58-66 pubmed publisher

Ying H, Kang Y, Zhang H, Zhao D, Xia J, Lu Z, et al. MiR-127 modulates macrophage polarization and promotes lung inflammation and injury by activating the JNK pathway. J Immunol. 2015;194:1239-51 pubmed publisher

Friedrich M, Diegelmann J, Schauber J, Auernhammer C, Brand S. Intestinal neuroendocrine cells and goblet cells are mediators of IL-17A-amplified epithelial IL-17C production in human inflammatory bowel disease. Mucosal Immunol. 2015;8:943-58 pubmed publisher

Ko J, Chiu H, Syu J, Chen C, Jian Y, Huang Y, et al. Down-regulation of MSH2 expression by Hsp90 inhibition enhances cytotoxicity affected by tamoxifen in human lung cancer cells. Biochem Biophys Res Commun. 2015;456:506-12 pubmed publisher

Cho S, Yun S, Jo C, Lee D, Choi K, Song J, et al. SUMO1 promotes Aβ production via the modulation of autophagy. Autophagy. 2015;11:100-12 pubmed publisher

Kreis N, Louwen F, Zimmer B, Yuan J. Loss of p21Cip1/CDKN1A renders cancer cells susceptible to Polo-like kinase 1 inhibition. Oncotarget. 2015;6:6611-26 pubmed

Das S, Ghosh A, Singh S, Saha B, Ganguly A, Das P. Unmethylated CpG motifs in the L. donovani DNA regulate TLR9-dependent delay of programmed cell death in macrophages. J Leukoc Biol. 2015;97:363-78 pubmed publisher

Bacigalupo M, Manzi M, Espelt M, Gentilini L, Compagno D, Laderach D, et al. Galectin-1 triggers epithelial-mesenchymal transition in human hepatocellular carcinoma cells. J Cell Physiol. 2015;230:1298-309 pubmed publisher

Huang J, Fujimoto M, Fujiwara M, Fukao Y, Arimura S, Tsutsumi N. Arabidopsis dynamin-related proteins, DRP2A and DRP2B, function coordinately in post-Golgi trafficking. Biochem Biophys Res Commun. 2015;456:238-44 pubmed publisher

Hatipoglu G, Hock S, Weiss R, Fan Z, Sehm T, Ghoochani A, et al. Sunitinib impedes brain tumor progression and reduces tumor-induced neurodegeneration in the microenvironment. Cancer Sci. 2015;106:160-70 pubmed publisher

Li S, Zhou X, Dang Y, Kwan Y, Chan S, Leung G, et al. Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis. Biochim Biophys Acta. 2015;1850:373-84 pubmed publisher

Li Y, Wei Z, Mao H, Gao M, Liu Y, Ma Y, et al. Pretreatment with wortmannin alleviates lipopolysaccharide/d-galactosamine-induced acute liver injury. Biochem Biophys Res Commun. 2014;455:234-40 pubmed publisher

Matsumoto Y, Ishii M, Ishii K, Miyaguchi W, Horie R, Inagaki Y, et al. Transgenic silkworms expressing human insulin receptors for evaluation of therapeutically active insulin receptor agonists. Biochem Biophys Res Commun. 2014;455:159-64 pubmed publisher

Lee J, Patel K, Tae H, Lustig A, Kim J, Mattson M, et al. Ghrelin augments murine T-cell proliferation by activation of the phosphatidylinositol-3-kinase, extracellular signal-regulated kinase and protein kinase C signaling pathways. FEBS Lett. 2014;588:4708-19 pubmed publisher

Zhang Y, Chen Y, Cheng J, Guo Z, Lu Y, Tian B. DPP IV inhibitor suppresses STZ-induced islets injury dependent on activation of the IGFR/Akt/mTOR signaling pathways by GLP-1 in monkeys. Biochem Biophys Res Commun. 2015;456:139-44 pubmed publisher

Aliwaini S, Peres J, Kröger W, Blanckenberg A, de la Mare J, Edkins A, et al. The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells. Cancer Lett. 2015;357:206-18 pubmed publisher

Huang F. Differential regulation of interleukin-8 and human beta-defensin 2 in Pseudomonas aeruginosa-infected intestinal epithelial cells. BMC Microbiol. 2014;14:275 pubmed publisher

Kang Y, Saleem M, Chan K, Yung B, Law H. Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment. PLoS ONE. 2014;9:e113520 pubmed publisher

Yu Y, Yip K, Tam I, Sam S, Ng C, Zhang W, et al. Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation. PLoS ONE. 2014;9:e112989 pubmed publisher

Chan M, Lim G, Skovsø S, Yang Y, Albrecht T, Alejandro E, et al. Effects of insulin on human pancreatic cancer progression modeled in vitro. BMC Cancer. 2014;14:814 pubmed publisher

Mathewson A, Dunn W. A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries. PLoS ONE. 2014;9:e111977 pubmed publisher

Caì Y, Postnikova E, Bernbaum J, Yú S, Mazur S, Deiuliis N, et al. Simian hemorrhagic fever virus cell entry is dependent on CD163 and uses a clathrin-mediated endocytosis-like pathway. J Virol. 2015;89:844-56 pubmed publisher

Ek Ramos M, Avila J, Nelson Dittrich A, Su D, Gray J, Devarenne T. The tomato cell death suppressor Adi3 is restricted to the endosomal system in response to the Pseudomonas syringae effector protein AvrPto. PLoS ONE. 2014;9:e110807 pubmed publisher

Santegoets K, Wenink M, van den Berg W, Radstake T. Fc gamma receptor IIb on GM-CSF macrophages controls immune complex mediated inhibition of inflammatory signals. PLoS ONE. 2014;9:e110966 pubmed publisher

Cunningham M, Javaid A, Waters J, Davidson Wright J, Wong J, Jones M, et al. Development and validation of a "capture-fusion" model to study drug sensitivity of patient-derived hepatitis C. Hepatology. 2015;61:1192-204 pubmed publisher

He Y, Li W, Li Y, Zhang S, Wang Y, Sun C. Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes. PLoS ONE. 2014;9:e110711 pubmed publisher

Rožman S, Yousefi S, Oberson K, Kaufmann T, Benarafa C, Simon H. The generation of neutrophils in the bone marrow is controlled by autophagy. Cell Death Differ. 2015;22:445-56 pubmed publisher

Castro A, Frederico M, Cazarolli L, Mendes C, Bretanha L, Schmidt E, et al. The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance. Biochim Biophys Acta. 2015;1850:51-61 pubmed publisher

Capurro V, Gianotti A, Caci E, Ravazzolo R, Galietta L, Zegarra Moran O. Functional analysis of acid-activated Cl⁻ channels: properties and mechanisms of regulation. Biochim Biophys Acta. 2015;1848:105-14 pubmed

Shebaby W, Mroueh M, Bodman Smith K, Mansour A, Taleb R, Daher C, et al. Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells. BMC Complement Altern Med. 2014;14:387 pubmed publisher

Glassmann A, Winter J, Kraus D, Veit N, Probstmeier R. Pharmacological suppression of the Ras/MAPK pathway in thyroid carcinoma cells can provoke opposite effects on cell migration and proliferation: The appearance of yin-yang effects and the need of combinatorial treatments. Int J Oncol. 2014;45:2587-95 pubmed publisher

Chen J, Zmijewska A, Zhi D, Mannon R. Cyclosporine-mediated allograft fibrosis is associated with micro-RNA-21 through AKT signaling. Transpl Int. 2015;28:232-45 pubmed publisher

Khabele D, Kabir S, Dong Y, Lee E, Rice V, Son D. Preferential effect of akt2-dependent signaling on the cellular viability of ovarian cancer cells in response to EGF. J Cancer. 2014;5:670-8 pubmed publisher

Devadas D, Koithan T, Diestel R, Prank U, Sodeik B, Döhner K. Herpes simplex virus internalization into epithelial cells requires Na+/H+ exchangers and p21-activated kinases but neither clathrin- nor caveolin-mediated endocytosis. J Virol. 2014;88:13378-95 pubmed publisher

Daubney J, Bonner P, Hargreaves A, Dickenson J. Cardioprotective and cardiotoxic effects of quercetin and two of its in vivo metabolites on differentiated h9c2 cardiomyocytes. Basic Clin Pharmacol Toxicol. 2015;116:96-109 pubmed publisher

Harn H, Chuang H, Chang L, Huang A, Hsieh S, Lin S, et al. Taiwanin A targets non-steroidal anti-inflammatory drug-activated gene-1 in human lung carcinoma. Fitoterapia. 2014;99:227-35 pubmed publisher

von Buttlar H, Siegemund S, Büttner M, Alber G. Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells. PLoS ONE. 2014;9:e106188 pubmed publisher

Siman F, Silveira E, Fernandes A, Stefanon I, Vassallo D, Padilha A. Ouabain induces nitric oxide release by a PI3K/Akt-dependent pathway in isolated aortic rings from rats with heart failure. J Cardiovasc Pharmacol. 2015;65:28-38 pubmed publisher

Pawaria S, Ramani K, Maers K, Liu Y, Kane L, Levesque M, et al. Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in lupus. J Immunol. 2014;193:3288-95 pubmed publisher

Kim S, Lee S, Lim S. Formulation and in vitro and in vivo evaluation of a cationic emulsion as a vehicle for improving adenoviral gene transfer. Int J Pharm. 2014;475:49-59 pubmed publisher

Zgheel F, Alhosin M, Rashid S, Burban M, Auger C, Schini Kerth V. Redox-sensitive induction of Src/PI3-kinase/Akt and MAPKs pathways activate eNOS in response to EPA:DHA 6:1. PLoS ONE. 2014;9:e105102 pubmed publisher

Chaudhri R, Hadadi A, Lobachev K, Schwartz Z, Boyan B. Estrogen receptor-alpha 36 mediates the anti-apoptotic effect of estradiol in triple negative breast cancer cells via a membrane-associated mechanism. Biochim Biophys Acta. 2014;1843:2796-806 pubmed publisher

Wang Y, Sato M, Guo Y, Bengtsson T, Nedergaard J. Protein kinase a-mediated cell proliferation in brown preadipocytes is independent of Erk1/2, PI3K and mTOR. Exp Cell Res. 2014;328:143-55 pubmed publisher

Penumarti A, Abdel Rahman A. Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats. J Pharmacol Exp Ther. 2014;351:44-53 pubmed publisher

Bastos T, Barbosa M, da Silva M, da C Júnior J, Meira C, Guimarães E, et al. Nitro/nitrosyl-ruthenium complexes are potent and selective anti-Trypanosoma cruzi agents causing autophagy and necrotic parasite death. Antimicrob Agents Chemother. 2014;58:6044-55 pubmed publisher

Malvezi A, Panis C, da Silva R, de Freitas R, Lovo Martins M, Tatakihara V, et al. Inhibition of cyclooxygenase-1 and cyclooxygenase-2 impairs Trypanosoma cruzi entry into cardiac cells and promotes differential modulation of the inflammatory response. Antimicrob Agents Chemother. 2014;58:6157-64 pubmed publisher

Abu Eid R, Samara R, Ozbun L, Abdalla M, Berzofsky J, Friedman K, et al. Selective inhibition of regulatory T cells by targeting the PI3K-Akt pathway. Cancer Immunol Res. 2014;2:1080-9 pubmed publisher

Vadali S, Post S. Lipid rafts couple class A scavenger receptors to phospholipase A2 activation during macrophage adhesion. J Leukoc Biol. 2014;96:873-81 pubmed publisher

Huang J, Amaral J, Lee J, Rodriguez I. 7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo. PLoS ONE. 2014;9:e100985 pubmed publisher

Wang M, Lu L, Liu Y, Gu G, Tao R. FTY720 attenuates hypoxia-reoxygenation-induced apoptosis in cardiomyocytes. Exp Mol Pathol. 2014;97:218-24 pubmed publisher

Fujita M, Imadome K, Endo S, Shoji Y, Yamada S, Imai T. Nitric oxide increases the invasion of pancreatic cancer cells via activation of the PI3K-AKT and RhoA pathways after carbon ion irradiation. FEBS Lett. 2014;588:3240-50 pubmed publisher

Walther S, Pluteanu F, Renz S, Nikonova Y, Maxwell J, Yang L, et al. Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177. Am J Physiol Heart Circ Physiol. 2014;307:H689-700 pubmed publisher

Ford Siltz L, Viktorova E, Zhang B, Kouiavskaia D, Dragunsky E, Chumakov K, et al. New small-molecule inhibitors effectively blocking picornavirus replication. J Virol. 2014;88:11091-107 pubmed publisher

Ram B, Ramakrishna G. Endoplasmic reticulum vacuolation and unfolded protein response leading to paraptosis like cell death in cyclosporine A treated cancer cervix cells is mediated by cyclophilin B inhibition. Biochim Biophys Acta. 2014;1843:2497-512 pubmed publisher

Ruchaud Sparagano M, Mills R, Scott J, Simpson A. MPLA inhibits release of cytotoxic mediators from human neutrophils while preserving efficient bacterial killing. Immunol Cell Biol. 2014;92:799-809 pubmed publisher

Morgado A, Xavier J, Dionísio P, Ribeiro M, Dias R, Sebastião A, et al. MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins. Mol Neurobiol. 2015;51:1168-83 pubmed publisher

Qiu X, Cheng J, Chang H, Leung P. COX2 and PGE2 mediate EGF-induced E-cadherin-independent human ovarian cancer cell invasion. Endocr Relat Cancer. 2014;21:533-43 pubmed publisher

Makino Okamura C, Niki Y, Takeuchi S, Nishigori C, Declercq L, Yaroch D, et al. Heparin inhibits melanosome uptake and inflammatory response coupled with phagocytosis through blocking PI3k/Akt and MEK/ERK signaling pathways in human epidermal keratinocytes. Pigment Cell Melanoma Res. 2014;27:1063-74 pubmed publisher

Kitahara A, Takahashi K, Moriya R, Onuma H, Handa K, Sumitani Y, et al. Ghrelin augments the expressions and secretions of proinflammatory adipokines, VEGF120 and MCP-1, in differentiated 3T3-L1 adipocytes. J Cell Physiol. 2015;230:199-209 pubmed publisher

Colis L, Peltonen K, Sirajuddin P, Liu H, Sanders S, Ernst G, et al. DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response. Oncotarget. 2014;5:4361-9 pubmed

Hall K, Ward S, Cobine C, Keef K. Spatial organization and coordination of slow waves in the mouse anorectum. J Physiol. 2014;592:3813-29 pubmed publisher

Li Y, Cheng D, Cheng R, Zhu X, Wan T, Liu J, et al. Mechanisms of U87 astrocytoma cell uptake and trafficking of monomeric versus protofibril Alzheimer's disease amyloid-β proteins. PLoS ONE. 2014;9:e99939 pubmed publisher

Hojer C, Frankenberger S, Strobl L, Feicht S, Djermanovic K, Jagdhuber F, et al. B-cell expansion and lymphomagenesis induced by chronic CD40 signaling is strictly dependent on CD19. Cancer Res. 2014;74:4318-28 pubmed publisher

Fukui H, Zhang X, Sun C, Hara K, Kikuchi S, Yamasaki T, et al. IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signaling. Br J Cancer. 2014;111:763-71 pubmed publisher

Chiu S, Chiang E, Tsai S, Wang F, Pai M, Syu J, et al. Eicosapentaenoic acid induces neovasculogenesis in human endothelial progenitor cells by modulating c-kit protein and PI3-K/Akt/eNOS signaling pathways. J Nutr Biochem. 2014;25:934-45 pubmed publisher

Sukhanova K, Thugorka O, Bouryi V, Harhun M, Gordienko D. Mechanisms of the sarcoplasmic reticulum Ca2+ release induced by P2X receptor activation in mesenteric artery myocytes. Pharmacol Rep. 2014;66:363-72 pubmed publisher

Yeh T, Hsu C, Yang S, Hsu M, Liu J. Angelica Sinensis promotes myotube hypertrophy through the PI3K/Akt/mTOR pathway. BMC Complement Altern Med. 2014;14:144 pubmed publisher

Ferreira M, Lima C, Lopes Ferreira M. Anti-inflammatory effect of Natterins, the major toxins from the Thalassophryne nattereri fish venom is dependent on TLR4/MyD88/PI3K signaling pathway. Toxicon. 2014;87:54-67 pubmed publisher

Cunha D, Gurzov E, Naamane N, Ortis F, Cardozo A, Bugliani M, et al. JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway. Cell Death Differ. 2014;21:1313-24 pubmed publisher

Kim H, Jung B, Jeong J, Chun H, Chung D. Lipoteichoic acid from Lactobacillus plantarum inhibits the expression of platelet-activating factor receptor induced by Staphylococcus aureus lipoteichoic acid or Escherichia coli lipopolysaccharide in human monocyte-like cells. J Microbiol Biotechnol. 2014;24:1051-8 pubmed

Ong C, Shannon N, Ross Innes C, O Donovan M, Rueda O, Hu D, et al. Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy. J Natl Cancer Inst. 2014;106: pubmed publisher

Pfisterer S, Bakula D, Frickey T, Cezanne A, Brigger D, Tschan M, et al. Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells. J Lipid Res. 2014;55:1267-78 pubmed publisher

Kondratskyi A, Yassine M, Slomianny C, Kondratska K, Gordienko D, Dewailly E, et al. Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death. Cell Death Dis. 2014;5:e1193 pubmed publisher

Console Bram L, Brailoiu E, Brailoiu G, Sharir H, Abood M. Activation of GPR18 by cannabinoid compounds: a tale of biased agonism. Br J Pharmacol. 2014;171:3908-17 pubmed publisher

Ma X, Gao Q, Jia Z, Zhang Z. Neuroprotective capabilities of TSA against cerebral ischemia/reperfusion injury via PI3K/Akt signaling pathway in rats. Int J Neurosci. 2015;125:140-6 pubmed publisher

Plantinga T, Heinhuis B, Gerrits D, Netea M, Joosten L, Hermus A, et al. mTOR Inhibition promotes TTF1-dependent redifferentiation and restores iodine uptake in thyroid carcinoma cell lines. J Clin Endocrinol Metab. 2014;99:E1368-75 pubmed publisher

Fan R, Zhong J, Zheng S, Wang Z, Xu Y, Li S, et al. microRNA-218 increase the sensitivity of gastrointestinal stromal tumor to imatinib through PI3K/AKT pathway. Clin Exp Med. 2015;15:137-44 pubmed publisher

Kim W, Zhu Y, Deng Q, Chin C, He C, Grieco A, et al. Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. Stem Cells. 2014;32:1503-14 pubmed publisher

Beristain A, Molyneux S, Joshi P, Pomroy N, Di Grappa M, Chang M, et al. PKA signaling drives mammary tumorigenesis through Src. Oncogene. 2015;34:1160-73 pubmed publisher

Yamamoto R, Hatano N, Sugai T, Kato N. Serotonin induces depolarization in lateral amygdala neurons by activation of TRPC-like current and inhibition of GIRK current depending on 5-HT(2C) receptor. Neuropharmacology. 2014;82:49-58 pubmed publisher

Yau S, Henry B, Russo V, McConell G, Clarke I, Werther G, et al. Leptin enhances insulin sensitivity by direct and sympathetic nervous system regulation of muscle IGFBP-2 expression: evidence from nonrodent models. Endocrinology. 2014;155:2133-43 pubmed publisher

Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller J, et al. PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor. Br J Pharmacol. 2014;171:3328-37 pubmed publisher

Flannagan R, Canton J, Furuya W, Glogauer M, Grinstein S. The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis. Mol Biol Cell. 2014;25:1511-22 pubmed publisher

Li B, Qiu T, Zhang P, Wang X, Yin Y, Li S. IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation. Cell Prolif. 2014;47:133-45 pubmed publisher

Gardner E, Connis N, Poirier J, Cope L, Dobromilskaya I, Gallia G, et al. Rapamycin rescues ABT-737 efficacy in small cell lung cancer. Cancer Res. 2014;74:2846-56 pubmed publisher

Moore S, Hunter R, Hers I. Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets. J Thromb Haemost. 2014;12:748-60 pubmed publisher

Xie N, Zhong L, Liu L, Fang Y, Qi X, Cao J, et al. Autophagy contributes to dasatinib-induced myeloid differentiation of human acute myeloid leukemia cells. Biochem Pharmacol. 2014;89:74-85 pubmed publisher

Ahmed N, Iu J, Brown C, Taylor D, Kandel R. Serum- and growth-factor-free three-dimensional culture system supports cartilage tissue formation by promoting collagen synthesis via Sox9-Col2a1 interaction. Tissue Eng Part A. 2014;20:2224-33 pubmed publisher

Xu B, Guan X, Yu J, Lv J, Zhang H, Fu Q, et al. Activation of spinal phosphatidylinositol 3-kinase/protein kinase B mediates pain behavior induced by plantar incision in mice. Exp Neurol. 2014;255:71-82 pubmed publisher

Yamaki T, Kamiya Y, Ohtake K, Uchida M, Seki T, Ueda H, et al. A mechanism enhancing macromolecule transport through paracellular spaces induced by Poly-L-Arginine: Poly-L-Arginine induces the internalization of tight junction proteins via clathrin-mediated endocytosis. Pharm Res. 2014;31:2287-96 pubmed publisher

Bader A, Brodarac A, Klose K, Bieback K, Choi Y, Kurtz A, et al. Mechanisms of paracrine cardioprotection by cord blood mesenchymal stromal cells. Eur J Cardiothorac Surg. 2014;45:983-92 pubmed publisher

Kwon M, Kim M, Kim S, Park K, Yoo S, Oh I, et al. Erythropoietin exerts cell protective effect by activating PI3K/Akt and MAPK pathways in C6 Cells. Neurol Res. 2014;36:215-23 pubmed publisher

Hashimoto D, Bläuer M, Hirota M, Ikonen N, Sand J, Laukkarinen J. Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs. Eur J Cancer. 2014;50:1382-90 pubmed publisher

Kim H, Jung B, Kim J, Chung D. Differential effects of low and high doses of lipoteichoic acid on lipopolysaccharide-induced interleukin-6 production. Inflamm Res. 2014;63:419-28 pubmed publisher

Kushchayeva Y, Jensen K, Recupero A, Costello J, Patel A, Klubo Gwiezdzinska J, et al. The HIV protease inhibitor nelfinavir down-regulates RET signaling and induces apoptosis in medullary thyroid cancer cells. J Clin Endocrinol Metab. 2014;99:E734-45 pubmed publisher

Poillet L, Pernodet N, Boyer Guittaut M, Adami P, Borg C, Jouvenot M, et al. QSOX1 inhibits autophagic flux in breast cancer cells. PLoS ONE. 2014;9:e86641 pubmed publisher

Zhang W, Han Y, Meng G, Bai W, Xie L, Lu H, et al. Direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion injury by activating nitric oxide synthase signaling in spontaneously hypertensive rats. J Am Heart Assoc. 2014;3:e000606 pubmed publisher

Tripathi V, Kumar R, Dinda A, Kaur J, Luthra K. CXCL12-CXCR7 signaling activates ERK and Akt pathways in human choriocarcinoma cells. Cell Commun Adhes. 2014;21:221-8 pubmed publisher

Schaper K, Kietzmann M, Baumer W. Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells. Mol Immunol. 2014;59:10-8 pubmed publisher

Cilvik S, Wang J, Lavine K, Uchida K, Castro A, Gierasch C, et al. Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy. PLoS ONE. 2013;8:e82979 pubmed publisher

Jozefowski S, Biedroń R, Sróttek M, Chadzinska M, Marcinkiewicz J. The class A scavenger receptor SR-A/CD204 and the class B scavenger receptor CD36 regulate immune functions of macrophages differently. Innate Immun. 2014;20:826-47 pubmed publisher

Hsieh Y, van der Heyde H, Oh E, Guan J, Chang P. Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: an Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis. Mol Carcinog. 2015;54:379-92 pubmed publisher

Mimura K, Shiraishi K, Mueller A, Izawa S, Kua L, So J, et al. The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer. J Immunol. 2013;191:6261-72 pubmed publisher

Schlatter E, Klassen P, Massmann V, Holle S, Guckel D, Edemir B, et al. Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules. Pflugers Arch. 2014;466:1581-9 pubmed

Secreto F, Manske M, Price Troska T, Ziesmer S, Hodge L, Ansell S, et al. B-cell activating factor-receptor specific activation of tumor necrosis factor receptor associated factor 6 and the phosphatidyl inositol 3-kinase pathway in lymphoma B cells. Leuk Lymphoma. 2014;55:1884-92 pubmed publisher

Jemal I, Soriano S, Conte A, Morenilla C, Gomis A. G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels. Pflugers Arch. 2014;466:1635-46 pubmed publisher

Tsuchiya A, Kanno T, Nishizaki T. PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway. J Endocrinol. 2014;220:49-59 pubmed publisher

Shugg R, Thomson A, Tanabe N, Kashishian A, Steiner B, Puri K, et al. Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption. J Biol Chem. 2013;288:35346-57 pubmed publisher

Roviezzo F, De Angelis A, De Gruttola L, Bertolino A, Sullo N, Brancaleone V, et al. Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate. Clin Sci (Lond). 2014;126:545-56 pubmed publisher

Clark S, Rainville J, Zhao X, Katzenellenbogen B, Pfaff D, Vasudevan N. Estrogen receptor-mediated transcription involves the activation of multiple kinase pathways in neuroblastoma cells. J Steroid Biochem Mol Biol. 2014;139:45-53 pubmed publisher

Quast S, Berger A, Eberle J. ROS-dependent phosphorylation of Bax by wortmannin sensitizes melanoma cells for TRAIL-induced apoptosis. Cell Death Dis. 2013;4:e839 pubmed publisher

Sung C, Im H, Park N, Kwon Y, Shin S, Ye D, et al. Induction of steroid sulfatase expression in PC-3 human prostate cancer cells by insulin-like growth factor II. Toxicol Lett. 2013;223:109-15 pubmed publisher

Solodushko V, Khader H, Fouty B. Serum can overcome contact inhibition in confluent human pulmonary artery smooth muscle cells. PLoS ONE. 2013;8:e71490 pubmed publisher

McCarthy N, Wetherill L, Lovely C, Swartz M, Foroud T, Eberhart J. Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. Development. 2013;140:3254-65 pubmed publisher

Su N, Peng T, Tsai P, Huang C. Phosphoinositide 3-kinase/Akt pathway is involved in mediating the anti-inflammation effects of magnesium sulfate. J Surg Res. 2013;185:726-32 pubmed publisher

Akiyama M, Ozaki K, Kawano T, Yamada O, Kawauchi K, Ida H, et al. Telomerase activation as a repair response to radiation-induced DNA damage in Y79 retinoblastoma cells. Cancer Lett. 2013;340:82-7 pubmed publisher

Münzer P, Tolios A, Pelzl L, Schmid E, Schmidt E, Walker B, et al. Thrombin-sensitive expression of the store operated Ca(2+) channel Orai1 in platelets. Biochem Biophys Res Commun. 2013;436:25-30 pubmed publisher

Zou Y, Zhong W. A likely role for a novel PH-domain containing protein, PEPP2, in connecting membrane and cytoskeleton. Biocell. 2012;36:127-32 pubmed

Thirkettle S, Decock J, Arnold H, Pennington C, Jaworski D, Edwards D. Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells. J Biol Chem. 2013;288:16282-94 pubmed publisher

Caldas L, Seabra S, Attias M, de Souza W. The effect of kinase, actin, myosin and dynamin inhibitors on host cell egress by Toxoplasma gondii. Parasitol Int. 2013;62:475-82 pubmed publisher

Krafft P, Caner B, Klebe D, Rolland W, Tang J, Zhang J. PHA-543613 preserves blood-brain barrier integrity after intracerebral hemorrhage in mice. Stroke. 2013;44:1743-7 pubmed publisher

Meng Y, Yong Y, Yang G, Ding H, Fan Z, Tang Y, et al. Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism. J Neurochem. 2013;126:805-18 pubmed publisher

Liu J, Liao Y, Ma K, Wang Y, Zhang G, Yang R, et al. PI3K is required for the physical interaction and functional inhibition of NF-?B by ?-catenin in colorectal cancer cells. Biochem Biophys Res Commun. 2013;434:760-6 pubmed publisher

Brennan Minnella A, Shen Y, el Benna J, Swanson R. Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death. Cell Death Dis. 2013;4:e580 pubmed publisher

Hong D, Choi I, Son Y, Kim D, Na S, Jung W, et al. The effect of PI3 kinase inhibitor LY294002 on voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells. Life Sci. 2013;92:916-22 pubmed publisher

Song J, Chen Q, Xing D. Enhanced apoptotic effects by downregulating Mcl-1: evidence for the improvement of photodynamic therapy with Celecoxib. Exp Cell Res. 2013;319:1491-504 pubmed publisher

Mukaro V, Bylund J, Hodge G, Holmes M, Jersmann H, Reynolds P, et al. Lectins offer new perspectives in the development of macrophage-targeted therapies for COPD/emphysema. PLoS ONE. 2013;8:e56147 pubmed publisher

Li X, Luo R, Jiang R, Meng X, Wu X, Zhang S, et al. The role of the Hsp90/Akt pathway in myocardial calpain-induced caspase-3 activation and apoptosis during sepsis. BMC Cardiovasc Disord. 2013;13:8 pubmed publisher

Stergiou L, Bauer M, Mair W, Bausch Fluck D, Drayman N, Wollscheid B, et al. Integrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane. PLoS ONE. 2013;8:e55799 pubmed publisher

Wang D, Lu J, Tindall D. Androgens regulate TRAIL-induced cell death in prostate cancer cells via multiple mechanisms. Cancer Lett. 2013;335:136-44 pubmed publisher

Vivas O, Castro H, Arenas I, Elías Viñas D, Garcia D. PIP? hydrolysis is responsible for voltage independent inhibition of CaV2.2 channels in sympathetic neurons. Biochem Biophys Res Commun. 2013;432:275-80 pubmed publisher

Leto D, Uhm M, Williams A, Chen X, Saltiel A. Negative regulation of the RalGAP complex by 14-3-3. J Biol Chem. 2013;288:9272-83 pubmed publisher

Buffen K, Oosting M, Mennens S, Anand P, Plantinga T, Sturm P, et al. Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1? (IL-1?). J Biol Chem. 2013;288:8658-66 pubmed publisher

Yang P, Han Y, Gui L, Sun J, Chen Y, Song R, et al. Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-κB and MAPKs activation via the phosphatidylinositol 3-kinase signaling. Biochem Pharmacol. 2013;85:1124-33 pubmed publisher

Fan R, Kim N, Gumbiner B. Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1. Proc Natl Acad Sci U S A. 2013;110:2569-74 pubmed publisher

Walton J, Bourdolle A, Butler S, Soulie M, Delbianco M, McMahon B, et al. Very bright europium complexes that stain cellular mitochondria. Chem Commun (Camb). 2013;49:1600-2 pubmed publisher

Quan J, Cha G, Zhou W, Chu J, Nishikawa Y, Lee Y. Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis. Exp Parasitol. 2013;133:462-71 pubmed publisher

Strande J, Routhu K, Lecht S, Lazarovici P. Nerve growth factor reduces myocardial ischemia/reperfusion injury in rat hearts. J Basic Clin Physiol Pharmacol. 2013;24:81-4 pubmed publisher

Li Z, Shen J, Wu W, Yu X, Liang J, Qiu G, et al. Leptin induces cyclin D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT, PI3K/Akt and MEK/ERK pathways. PLoS ONE. 2012;7:e53176 pubmed publisher

Chang B, Sang L, Wang Y, Tong J, Wang B. The role of FoxO4 in the relationship between alcohol-induced intestinal barrier dysfunction and liver injury. Int J Mol Med. 2013;31:569-76 pubmed publisher

McAlpine F, Williamson L, Tooze S, Chan E. Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2. Autophagy. 2013;9:361-73 pubmed publisher

Tsai C, Chiang Y, Chen H, Huang P, Hsu H, Tang C. High glucose induces vascular endothelial growth factor production in human synovial fibroblasts through reactive oxygen species generation. Biochim Biophys Acta. 2013;1830:2649-58 pubmed

Dai C, Zheng C, Meng F, Zhou Z, Sang L, Jiang M. VSL#3 probiotics exerts the anti-inflammatory activity via PI3k/Akt and NF-κB pathway in rat model of DSS-induced colitis. Mol Cell Biochem. 2013;374:1-11 pubmed publisher

Shin H, Ryu J, Kim S, Zuo Z, Do S. Caffeine-induced inhibition of the activity of glutamate transporter type 3 expressed in Xenopus oocytes. Toxicol Lett. 2013;217:143-8 pubmed publisher

Alba Betancourt C, Luna Acosta J, Ramírez Martínez C, Avila González D, Granados Ávalos E, Carranza M, et al. Neuro-protective effects of growth hormone (GH) after hypoxia-ischemia injury in embryonic chicken cerebellum. Gen Comp Endocrinol. 2013;183:17-31 pubmed publisher

Engelhardt S, Boevink P, Armstrong M, Ramos M, Hein I, Birch P. Relocalization of late blight resistance protein R3a to endosomal compartments is associated with effector recognition and required for the immune response. Plant Cell. 2012;24:5142-58 pubmed publisher

Ishida E, Hashimoto K, Shimizu H, Okada S, Satoh T, Kato I, et al. Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line. PLoS ONE. 2012;7:e50918 pubmed publisher

Binu S, Soumya S, Sudhakaran P. Metabolite control of angiogenesis: angiogenic effect of citrate. J Physiol Biochem. 2013;69:383-95 pubmed publisher

Abcejo A, Sathish V, Smelter D, Aravamudan B, Thompson M, Hartman W, et al. Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle. PLoS ONE. 2012;7:e44343 pubmed publisher

Pais R, Bhowmick S, Chattopadhyay S, Lemire Y, Sharafieh R, Yadav R, et al. An intracameral injection of antigen induces in situ chemokines and cytokines required for the generation of circulating immunoregulatory monocytes. PLoS ONE. 2012;7:e43182 pubmed publisher

Romagnoli A, Etna M, Giacomini E, Pardini M, Remoli M, Corazzari M, et al. ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells. Autophagy. 2012;8:1357-70 pubmed publisher

Zhang L, Zhang H, Liu P, Hao H, Jin J, Lin J. Arabidopsis R-SNARE proteins VAMP721 and VAMP722 are required for cell plate formation. PLoS ONE. 2011;6:e26129 pubmed publisher

Müller K, Tveteraas I, Aasrum M, Ødegård J, Dawood M, Dajani O, et al. Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells. BMC Cancer. 2011;11:421 pubmed publisher

Tian Y, Zhang W, Xia D, Modi P, Liang D, Wei M. Postconditioning inhibits myocardial apoptosis during prolonged reperfusion via a JAK2-STAT3-Bcl-2 pathway. J Biomed Sci. 2011;18:53 pubmed publisher

Crawford A, Liekens S, Kamuhabwa A, Maes J, Munck S, Busson R, et al. Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants. PLoS ONE. 2011;6:e14694 pubmed publisher

Giordanetto F, Kull B, Dellsén A. Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening. Bioorg Med Chem Lett. 2011;21:829-35 pubmed publisher

Chen S, Evans H, Evans D. FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells. J Biol Chem. 2011;286:10201-9 pubmed publisher

Rode H, Sos M, Grütter C, Heynck S, Simard J, Rauh D. Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor. Bioorg Med Chem. 2011;19:429-39 pubmed publisher

Pereira A, Strangman W, Marion F, Feldberg L, Roll D, Mallon R, et al. Synthesis of phosphatidylinositol 3-kinase (PI3K) inhibitory analogues of the sponge meroterpenoid liphagal. J Med Chem. 2010;53:8523-33 pubmed publisher

Kularatne S, Venkatesh C, Santhapuram H, Wang K, Vaitilingam B, Henne W, et al. Synthesis and biological analysis of prostate-specific membrane antigen-targeted anticancer prodrugs. J Med Chem. 2010;53:7767-77 pubmed publisher

Pondugula S, Raveendran N, Marcus D. Ion transport regulation by P2Y receptors, protein kinase C and phosphatidylinositol 3-kinase within the semicircular canal duct epithelium. BMC Res Notes. 2010;3:100 pubmed publisher

Li S, Brown M, Goldstein J. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A. 2010;107:3441-6 pubmed publisher

Heikkilä O, Susi P, Tevaluoto T, Härmä H, Marjomaki V, Hyypia T, et al. Internalization of coxsackievirus A9 is mediated by {beta}2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin. J Virol. 2010;84:3666-81 pubmed publisher

PERRON J, Dodd J. ActRIIA and BMPRII Type II BMP receptor subunits selectively required for Smad4-independent BMP7-evoked chemotaxis. PLoS ONE. 2009;4:e8198 pubmed publisher

Florian M, Jankowski M, Gutkowska J. Oxytocin increases glucose uptake in neonatal rat cardiomyocytes. Endocrinology. 2010;151:482-91 pubmed publisher

Gabrielli E, Pericolini E, Cenci E, Ortelli F, Magliani W, Ciociola T, et al. Antibody complementarity-determining regions (CDRs): a bridge between adaptive and innate immunity. PLoS ONE. 2009;4:e8187 pubmed publisher

Tureckova J, Vojtechova M, Krausova M, Sloncova E, Korinek V. Focal adhesion kinase functions as an akt downstream target in migration of colorectal cancer cells. Transl Oncol. 2009;2:281-90 pubmed

Hsieh C, Nickel E, Hsu J, Schwacha M, Bland K, Chaudry I. Trauma-hemorrhage and hypoxia differentially influence kupffer cell phagocytic capacity: role of hypoxia-inducible-factor-1alpha and phosphoinositide 3-kinase/Akt activation. Ann Surg. 2009;250:995-1001 pubmed publisher

Kwon H, Jeong K, Pak Y. Identification of pY19-caveolin-2 as a positive regulator of insulin-stimulated actin cytoskeleton-dependent mitogenesis. J Cell Mol Med. 2009;13:1549-64 pubmed publisher

Sasai N, Agata N, Inoue Miyazu M, Kawakami K, Kobayashi K, Sokabe M, et al. Involvement of PI3K/Akt/TOR pathway in stretch-induced hypertrophy of myotubes. Muscle Nerve. 2010;41:100-6 pubmed publisher

Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher

Stephan H, Concannon C, Kremmer E, Carty M, Nasheuer H. Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis. Nucleic Acids Res. 2009;37:6028-41 pubmed publisher

Doherty G, Byrne S, Molloy E, Malhotra V, Austin S, Kay E, et al. Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer. BMC Cancer. 2009;9:207 pubmed publisher

Yuan H, Pupo M, Blois J, Smith A, Weissleder R, Clardy J, et al. A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorg Med Chem Lett. 2009;19:4223-7 pubmed publisher

Clyde R, Craig A, de Breed L, Bown J, Forrester L, Vojtesek B, et al. A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells. J R Soc Interface. 2009;6:1167-77 pubmed publisher

Bhaskar K, Miller M, Chludzinski A, Herrup K, Zagorski M, Lamb B. The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Mol Neurodegener. 2009;4:14 pubmed publisher

Han S, Polizzano C, Nielsen G, Hornicek F, Rosenberg A, Ramesh V. Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas. Clin Cancer Res. 2009;15:1940-6 pubmed publisher

Uzan B, Figeac F, Portha B, Movassat J. Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation. PLoS ONE. 2009;4:e4734 pubmed publisher

Ponpuak M, Delgado M, Elmaoued R, Deretic V. Monitoring autophagy during Mycobacterium tuberculosis infection. Methods Enzymol. 2009;452:345-61 pubmed publisher

Davis R, Barnes E, Longden J, Avery V, Healy P. Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum. Bioorg Med Chem. 2009;17:1387-92 pubmed publisher

Nowak J, Archange C, Tardivel Lacombe J, Pontarotti P, Pébusque M, Vaccaro M, et al. The TP53INP2 protein is required for autophagy in mammalian cells. Mol Biol Cell. 2009;20:870-81 pubmed publisher

Hein J, Boichuk S, Wu J, Cheng Y, Freire R, Jat P, et al. Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol. 2009;83:117-27 pubmed publisher

Itakura E, Kishi C, Inoue K, Mizushima N. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell. 2008;19:5360-72 pubmed publisher

Bulat N, Waeber G, Widmann C. LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase. J Lipid Res. 2009;50:81-9 pubmed publisher

Liu L, Zhu S, Gong Z, Low B. K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis. PLoS ONE. 2008;3:e2850 pubmed publisher

Blois J, Yuan H, Smith A, Pacold M, Weissleder R, Cantley L, et al. Slow self-activation enhances the potency of viridin prodrugs. J Med Chem. 2008;51:4699-707 pubmed publisher

Rogers P, Mashtalir N, Rathod M, Dubuisson O, Wang Z, Dasuri K, et al. Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36. Diabetes. 2008;57:2321-31 pubmed publisher

Schiekofer S, Belisle K, Galasso G, Schneider J, Boehm B, Burster T, et al. Angiogenic-regulatory network revealed by molecular profiling heart tissue following Akt1 induction in endothelial cells. Angiogenesis. 2008;11:289-99 pubmed publisher

Chekenya M, Krakstad C, Svendsen A, Netland I, Staalesen V, Tysnes B, et al. The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. Oncogene. 2008;27:5182-94 pubmed publisher

Triola G, Wetzel S, Ellinger B, Koch M, Hübel K, Rauh D, et al. ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds. Bioorg Med Chem. 2009;17:1079-87 pubmed publisher

van der Heijden M, Versteilen A, Sipkema P, van Nieuw Amerongen G, Musters R, Groeneveld A. Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis. Apoptosis. 2008;13:404-12 pubmed publisher

Bain J, Plater L, Elliott M, Shpiro N, Hastie C, McLauchlan H, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007;408:297-315 pubmed

Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed

Liu Y, Jiang N, Wu J, Dai W, Rosenblum J. Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects. J Biol Chem. 2007;282:2505-11 pubmed

Lanni T, Greene K, Kolz C, Para K, Visnick M, Mobley J, et al. Design and synthesis of phenethyl benzo[1,4]oxazine-3-ones as potent inhibitors of PI3Kinasegamma. Bioorg Med Chem Lett. 2007;17:756-60 pubmed

Pomel V, Klicic J, Covini D, Church D, Shaw J, Roulin K, et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J Med Chem. 2006;49:3857-71 pubmed

MacDonald M, Lamerdin J, Owens S, Keon B, Bilter G, Shang Z, et al. Identifying off-target effects and hidden phenotypes of drugs in human cells. Nat Chem Biol. 2006;2:329-37 pubmed

Jayasinghe L, Abbas H, Jacob M, Herath W, Nanayakkara N. N-Methyl-4-hydroxy-2-pyridinone analogues from Fusarium oxysporum. J Nat Prod. 2006;69:439-42 pubmed

Giner J, Kehbein K, Cook J, Smith M, Vlahos C, Badwey J. Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase. Bioorg Med Chem Lett. 2006;16:2518-21 pubmed

Ding H, Zhang C, Wu X, Yang C, Zhang X, Ding J, et al. Novel indole alpha-methylene-gamma-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases. Bioorg Med Chem Lett. 2005;15:4799-802 pubmed

Griffin R, Fontana G, Golding B, Guiard S, Hardcastle I, Leahy J, et al. Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. J Med Chem. 2005;48:569-85 pubmed

Krasilnikov M, Adler V, Fuchs S, Dong Z, Haimovitz Friedman A, Herlyn M, et al. Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells. Mol Carcinog. 1999;24:64-9 pubmed

Allen M, Zeng C, Schneider K, Xiong X, Meintzer M, Bellosta P, et al. Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt. Mol Endocrinol. 1999;13:191-201 pubmed

Morita Y, Manganaro T, Tao X, Martimbeau S, Donahoe P, Tilly J. Requirement for phosphatidylinositol-3'-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse. Endocrinology. 1999;140:941-9 pubmed

Manna S, Aggarwal B. Interleukin-4 down-regulates both forms of tumor necrosis factor receptor and receptor-mediated apoptosis, NF-kappaB, AP-1, and c-Jun N-terminal kinase. Comparison with interleukin-13. J Biol Chem. 1998;273:33333-41 pubmed

Crowder R, Freeman R. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J Neurosci. 1998;18:2933-43 pubmed

Moule S, Denton R. Multiple signaling pathways involved in the metabolic effects of insulin. Am J Cardiol. 1997;80:41A-49A pubmed

Hazeki O, Hazeki K, Katada T, Ui M. Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events. J Lipid Mediat Cell Signal. 1996;14:259-61 pubmed

Wymann M, Bulgarelli Leva G, Zvelebil M, Pirola L, Vanhaesebroeck B, Waterfield M, et al. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol Cell Biol. 1996;16:1722-33 pubmed

Powis G, Bonjouklian R, Berggren M, Gallegos A, Abraham R, Ashendel C, et al. Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 1994;54:2419-23 pubmed

Hazeki O. [Wortmannin, an inhibitor of phosphatidylinositol 3-kinase]. Seikagaku. 1995;67:33-6 pubmed

Ui M, Okada T, Hazeki K, Hazeki O. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem Sci. 1995;20:303-7 pubmed

Nakanishi S, Kakita S, Takahashi I, Kawahara K, Tsukuda E, Sano T, et al. Wortmannin, a microbial product inhibitor of myosin light chain kinase. J Biol Chem. 1992;267:2157-63 pubmed