product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse
catalog :
V9134
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
KDR-1
reactivity :
human
application :
flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other
more info or order :
citations: 30
Published Application/Species/Sample/DilutionReference
  • other; human; loading ...; fig s1
Shah F, Stepan A, O Mahony A, Velichko S, Folias A, Houle C, et al. Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. Cell Chem Biol. 2017;24:858-869.e5 pubmed publisher
  • flow cytometry; human; tbl 1
Zomerman W, Plasschaert S, Diks S, Lourens H, Meeuwsen de Boer T, Hoving E, et al. Exogenous HGF Bypasses the Effects of ErbB Inhibition on Tumor Cell Viability in Medulloblastoma Cell Lines. PLoS ONE. 2015;10:e0141381 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 1b
Gaumann A, Drexler H, Lang S, Stoeltzing O, Diermeier Daucher S, Buchdunger E, et al. The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib®). Int J Oncol. 2014;45:2267-77 pubmed publisher
Peach C, Kilpatrick L, Friedman Ohana R, Zimmerman K, Robers M, Wood K, et al. Real-Time Ligand Binding of Fluorescent VEGF-A Isoforms that Discriminate between VEGFR2 and NRP1 in Living Cells. Cell Chem Biol. 2018;25:1208-1218.e5 pubmed publisher
Chen G, Ke Y, Qin K, Dong M, Zeng S, Lin X, et al. Analysis of the Expression of Angioarchitecture-related Factors in Patients with Cerebral Arteriovenous Malformation. Chin Med J (Engl). 2017;130:2465-2472 pubmed publisher
Sun Q, Zhou J, Zhang Z, Guo M, Liang J, Zhou F, et al. Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy. Cancer Biol Ther. 2014;15:1635-45 pubmed publisher
Stacchiotti S, Tortoreto M, Baldi G, Grignani G, Toss A, Badalamenti G, et al. Preclinical and clinical evidence of activity of pazopanib in solitary fibrous tumour. Eur J Cancer. 2014;50:3021-8 pubmed publisher
Shen W, Chung S, Irhimeh M, Li S, Lee S, Gillies M. Systemic administration of erythropoietin inhibits retinopathy in RCS rats. PLoS ONE. 2014;9:e104759 pubmed publisher
Cho Y, Kim J, Kim J, Ahn E, Ko H, In J, et al. Broussonetia kazinoki modulates the expression of VEGFR-2 and MMP-2 through the inhibition of ERK, Akt and p70S6K‑dependent signaling pathways: Its implication in endothelial cell proliferation, migration and tubular formation. Oncol Rep. 2014;32:1531-6 pubmed publisher
Kere M, Siriboon C, Liao J, Lo N, Chiang H, Fan Y, et al. Vascular endothelial growth factor A improves quality of matured porcine oocytes and developing parthenotes. Domest Anim Endocrinol. 2014;49:60-9 pubmed publisher
Hu J, Cheng Y, Li Y, Jin Z, Pan Y, Liu G, et al. microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C. Eur J Cancer. 2014;50:2336-50 pubmed publisher
Rathore K, Cekanova M. Animal model of naturally occurring bladder cancer: characterization of four new canine transitional cell carcinoma cell lines. BMC Cancer. 2014;14:465 pubmed publisher
Ardelean D, Yin M, Jerkic M, Peter M, Ngan B, Kerbel R, et al. Anti-VEGF therapy reduces intestinal inflammation in Endoglin heterozygous mice subjected to experimental colitis. Angiogenesis. 2014;17:641-59 pubmed publisher
Zhou Y, Guan X, Yu M, Wang X, Zhu W, Wang C, et al. Angiogenic/osteogenic response of BMMSCs on bone-derived scaffold: effect of hypoxia and role of PI3K/Akt-mediated VEGF-VEGFR pathway. Biotechnol J. 2014;9:944-53 pubmed publisher
Sinka L, Biasch K, Khazaal I, Peault B, Tavian M. Angiotensin-converting enzyme (CD143) specifies emerging lympho-hematopoietic progenitors in the human embryo. Blood. 2012;119:3712-23 pubmed publisher
Dragoni S, Laforenza U, Bonetti E, Lodola F, Bottino C, Berra Romani R, et al. Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration. Stem Cells. 2011;29:1898-907 pubmed publisher
Ballmer Hofer K, Andersson A, Ratcliffe L, Berger P. Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output. Blood. 2011;118:816-26 pubmed publisher
Simons D, Grieb G, Hristov M, Pallua N, Weber C, Bernhagen J, et al. Hypoxia-induced endothelial secretion of macrophage migration inhibitory factor and role in endothelial progenitor cell recruitment. J Cell Mol Med. 2011;15:668-78 pubmed publisher
Chen C, Lee M, Huang J, Aplin J, Wu Y, Hu C, et al. Trafficking of multipotent mesenchymal stromal cells from maternal circulation through the placenta involves vascular endothelial growth factor receptor-1 and integrins. Stem Cells. 2008;26:550-61 pubmed
Masuda H, Kalka C, Takahashi T, Yoshida M, Wada M, Kobori M, et al. Estrogen-mediated endothelial progenitor cell biology and kinetics for physiological postnatal vasculogenesis. Circ Res. 2007;101:598-606 pubmed
Murakami Y, Yamagoe S, Noguchi K, Takebe Y, Takahashi N, Uehara Y, et al. Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx. J Biol Chem. 2006;281:28113-21 pubmed
Ishikawa T, Eguchi M, Wada M, Iwami Y, Tono K, Iwaguro H, et al. Establishment of a functionally active collagen-binding vascular endothelial growth factor fusion protein in situ. Arterioscler Thromb Vasc Biol. 2006;26:1998-2004 pubmed
Olsson A, Dimberg A, Kreuger J, Claesson Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol. 2006;7:359-71 pubmed
Shibuya M, Claesson Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res. 2006;312:549-60 pubmed
Takahashi H, Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond). 2005;109:227-41 pubmed
Meissner M, Stein M, Urbich C, Reisinger K, Suske G, Staels B, et al. PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation. Circ Res. 2004;94:324-32 pubmed
Nagaya N, Kangawa K, Kanda M, Uematsu M, Horio T, Fukuyama N, et al. Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells. Circulation. 2003;108:889-95 pubmed
Ferrara N, Gerber H, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9:669-76 pubmed
Murohara T, Ikeda H, Duan J, Shintani S, Sasaki K, Eguchi H, et al. Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization. J Clin Invest. 2000;105:1527-36 pubmed
Simon M, Rockl W, Hornig C, Gröne E, Theis H, Weich H, et al. Receptors of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in fetal and adult human kidney: localization and [125I]VEGF binding sites. J Am Soc Nephrol. 1998;9:1032-44 pubmed
product information
Product No. :
V9134
Product Name :
Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse
Host :
mouse
Conjugate :
unconjugated
Antibody Type :
monoclonal
Clone Number (if monoclonal) :
KDR-1
Applications/Description :
Suitable for immunohistochemistry (frozen sections): 1:800 using human placenta; indirect ELISA
Species Reactivity :
human
Isotype :
IgG1
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA