This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
(±)-Verapamil hydrochloride
catalog :
V4629
citations: 147
Reference
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Sadiq M, Uchida Y, Hoshi Y, Tachikawa M, Terasaki T, Hammarlund Udenaes M. Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport. PLoS ONE. 2015;10:e0118638 pubmed publisher
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Uchida Y, Ohtsuki S, Terasaki T. Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models. Drug Metab Dispos. 2014;42:1719-26 pubmed publisher
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McCarthy M, Auda G, Agrawal S, Taylor A, Backstrom Z, Mondal D, et al. In vivo anticancer synergy mechanism of doxorubicin and verapamil combination treatment is impaired in BALB/c mice with metastatic breast cancer. Exp Mol Pathol. 2014;97:6-15 pubmed publisher
Izdes S, Altintas N, Soykut C. Acute respiratory distress syndrome after verapamil intoxication: case report and literature review. Acta Clin Belg. 2014;69:116-9 pubmed publisher
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Canan T, Vaseghi M, Girsky M, Yang E. A complex rhythm treated simply: fascicular ventricular tachycardia. Am J Med. 2014;127:601-4 pubmed publisher
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Tsubaki M, Komai M, Itoh T, Imano M, Sakamoto K, Shimaoka H, et al. By inhibiting Src, verapamil and dasatinib overcome multidrug resistance via increased expression of Bim and decreased expressions of MDR1 and survivin in human multidrug-resistant myeloma cells. Leuk Res. 2014;38:121-30 pubmed publisher
Atabak S, Taziki O, Argani H, Abolghasemi R, Zangneh H, Rahmani L. Effects of oral enalapril and verapamil on dialysis adequacy and solute clearance in chronic ambulatory peritoneal dialysis. Saudi J Kidney Dis Transpl. 2013;24:1170-4 pubmed publisher
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Savage J, Meaney M, Brennan G, Hoey E, Trudgett A, Fairweather I. Increased action of triclabendazole (TCBZ) in vitro against a TCBZ-resistant isolate of Fasciola hepatica following its co-incubation with the P-glycoprotein inhibitor, R(+)-verapamil. Exp Parasitol. 2013;135:642-53 pubmed publisher
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Pfeffer A, Williams S. Annals of Emergency Medicine Journal Club. Treatment of calcium channel blocker poisoning: should we re-prioritize our potpourri of treatment options?. Ann Emerg Med. 2013;62:273-4 pubmed publisher
Bao Q, Niess H, Djafarzadeh R, Zhao Y, Schwarz B, Angele M, et al. Recombinant TIMP-1-GPI inhibits growth of fibrosarcoma and enhances tumor sensitivity to doxorubicin. Target Oncol. 2014;9:251-61 pubmed publisher
Irnaten M, Barry R, Wallace D, Docherty N, Quill B, Clark A, et al. Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells. Exp Eye Res. 2013;115:224-9 pubmed publisher
Sridhar V, Surya Sandeep M, Ravindra Babu P, Naveen Babu K. Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using felodipine and hesperetin in combination in Wistar rats and everted rat gut sacs in vitro. Phytother Res. 2014;28:699-705 pubmed publisher
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Gupta S, Tyagi S, Almeida D, Maiga M, Ammerman N, Bishai W. Acceleration of tuberculosis treatment by adjunctive therapy with verapamil as an efflux inhibitor. Am J Respir Crit Care Med. 2013;188:600-7 pubmed publisher
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Resztak M, Główka F. Stereoselective CZE method for analysis of verapamil and norverapamil in human plasma. Acta Pol Pharm. 2013;70:395-401 pubmed
Calcinaghi N, Wyss M, Jolivet R, Singh A, Keller A, Winnik S, et al. Multimodal imaging in rats reveals impaired neurovascular coupling in sustained hypertension. Stroke. 2013;44:1957-64 pubmed publisher
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Steinbach C, Fedorova G, Prokes M, Grabicova K, Machova J, Grabic R, et al. Toxic effects, bioconcentration and depuration of verapamil in the early life stages of common carp (Cyprinus carpio L.). Sci Total Environ. 2013;461-462:198-206 pubmed publisher
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Wang T, Hu N, Cao J, Wu J, Su K, Wang P. A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell growth and beating. Biosens Bioelectron. 2013;49:9-13 pubmed publisher
McDonough C, Gong Y, Padmanabhan S, Burkley B, Langaee T, Melander O, et al. Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes. Hypertension. 2013;62:48-54 pubmed publisher
Neuhoff S, Yeo K, Barter Z, Jamei M, Turner D, Rostami Hodjegan A. Application of permeability-limited physiologically-based pharmacokinetic models: part II - prediction of P-glycoprotein mediated drug-drug interactions with digoxin. J Pharm Sci. 2013;102:3161-73 pubmed publisher
Levine M, Curry S, Padilla Jones A, Ruha A. Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25-year experience at a single center. Ann Emerg Med. 2013;62:252-8 pubmed publisher
Jia W, Zhu Z, Zhang T, Fan G, Fan P, Liu Y, et al. Treatment of malignant ascites with a combination of chemotherapy drugs and intraperitoneal perfusion of verapamil. Cancer Chemother Pharmacol. 2013;71:1585-90 pubmed publisher
Lautenschläger J, Prell T, Ruhmer J, Weidemann L, Witte O, Grosskreutz J. Overexpression of human mutated G93A SOD1 changes dynamics of the ER mitochondria calcium cycle specifically in mouse embryonic motor neurons. Exp Neurol. 2013;247:91-100 pubmed publisher
Mehta R, Kelleher D, Preece A, Hughes S, Crater G. Effect of verapamil on systemic exposure and safety of umeclidinium and vilanterol: a randomized and open-label study. Int J Chron Obstruct Pulmon Dis. 2013;8:159-67 pubmed publisher
Olson K. What is the best treatment for acute calcium channel blocker overdose?. Ann Emerg Med. 2013;62:259-61 pubmed publisher
Zhang C, Chanteux H, Zuo Z, Kwan P, Baum L. Potential role for human P-glycoprotein in the transport of lacosamide. Epilepsia. 2013;54:1154-60 pubmed publisher
Hung C, Chiou M, Teng Y, Hsieh Y, Huang C, Lane H. Functional impact of ABCB1 variants on interactions between P-glycoprotein and methadone. PLoS ONE. 2013;8:e59419 pubmed publisher
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Macha S, Sennewald R, Rose P, Schoene K, Pinnetti S, Woerle H, et al. Lack of clinically relevant drug-drug interaction between empagliflozin, a sodium glucose cotransporter 2 inhibitor, and verapamil, ramipril, or digoxin in healthy volunteers. Clin Ther. 2013;35:226-35 pubmed publisher
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Li R, Wei M, Shao J. Effects of verapamil on the immediate-early gene expression of bone marrow mesenchymal stem cells stimulated by mechanical strain in vitro. Med Sci Monit Basic Res. 2013;19:68-75 pubmed publisher
Zhang J, Cao H, Zhang Y, Zhang Y, Ma J, Wang J, et al. Nephroprotective effect of calcium channel blockers against toxicity of lead exposure in mice. Toxicol Lett. 2013;218:273-80 pubmed publisher
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Ke A, Eyal S, Chung F, Link J, Mankoff D, Muzi M, et al. Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition. J Nucl Med. 2013;54:437-46 pubmed publisher
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product information
Catalog Number :
V4629
Product Name :
(±)-Verapamil hydrochloride
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥99% (titration), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA