product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-1 antibody produced in mouse
catalog :
V4262
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
FLT-11
reactivity :
human
more info or order :
citations: 25
Reference
Deepak V, Sahu M, Yu J, Jones J, KANE M, Taylor R, et al. Retinoic Acid Is a Negative Regulator of sFLT1 Expression in Decidual Stromal Cells, and Its Levels Are Reduced in Preeclamptic Decidua. Hypertension. 2019;73:1104-1111 pubmed publisher
Ji S, Xin H, Li Y, Su E. FMS-like tyrosine kinase 1 (FLT1) is a key regulator of fetoplacental endothelial cell migration and angiogenesis. Placenta. 2018;70:7-14 pubmed publisher
Souders C, Maynard S, Yan J, Wang Y, Boatright N, Sedan J, et al. Circulating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of Preeclampsia. Int J Mol Sci. 2015;16:12436-53 pubmed publisher
Rana S, Rajakumar A, Geahchan C, Salahuddin S, Cerdeira A, Burke S, et al. Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1? pathway. FASEB J. 2014;28:4324-34 pubmed publisher
Govender N, Moodley J, Gathiram P, Naicker T. Soluble fms-like tyrosine kinase-1 in HIV infected pre-eclamptic South African Black women. Placenta. 2014;35:618-24 pubmed publisher
Zhang M, He Y, Sun X, Li Q, Wang W, Zhao A, et al. A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients. J Ovarian Res. 2014;7:19 pubmed publisher
Rajakumar A, Myerski A, Edmunds L, Powers R, Roberts J, Gandley R, et al. Vascular pool of releasable soluble VEGF receptor-1 (sFLT1) in women with previous preeclampsia and uncomplicated pregnancy. J Clin Endocrinol Metab. 2014;99:978-87 pubmed publisher
Mendonça M, Soares E, Stávale L, Raposo C, Coope A, Kalapothakis E, et al. Expression of VEGF and Flk-1 and Flt-1 receptors during blood-brain barrier (BBB) impairment following Phoneutria nigriventer spider venom exposure. Toxins (Basel). 2013;5:2572-88 pubmed publisher
Bazan Peregrino M, Sainson R, Carlisle R, Thoma C, Waters R, Arvanitis C, et al. Combining virotherapy and angiotherapy for the treatment of breast cancer. Cancer Gene Ther. 2013;20:461-8 pubmed publisher
Rajakumar A, Cerdeira A, Rana S, Zsengeller Z, Edmunds L, Jeyabalan A, et al. Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia. Hypertension. 2012;59:256-64 pubmed publisher
Searle J, Mockel M, Gwosc S, Datwyler S, Qadri F, Albert G, et al. Heparin strongly induces soluble fms-like tyrosine kinase 1 release in vivo and in vitro--brief report. Arterioscler Thromb Vasc Biol. 2011;31:2972-4 pubmed publisher
Sela S, Natanson Yaron S, Zcharia E, Vlodavsky I, Yagel S, Keshet E. Local retention versus systemic release of soluble VEGF receptor-1 are mediated by heparin-binding and regulated by heparanase. Circ Res. 2011;108:1063-70 pubmed publisher
Mezquita B, Mezquita J, Pau M, Mezquita C. A novel intracellular isoform of VEGFR-1 activates Src and promotes cell invasion in MDA-MB-231 breast cancer cells. J Cell Biochem. 2010;110:732-42 pubmed publisher
Thomas C, Andrews J, Raikwar N, Kelley E, Herse F, Dechend R, et al. A recently evolved novel trophoblast-enriched secreted form of fms-like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia. J Clin Endocrinol Metab. 2009;94:2524-30 pubmed publisher
Rajakumar A, Powers R, Hubel C, Shibata E, von Versen Höynck F, Plymire D, et al. Novel soluble Flt-1 isoforms in plasma and cultured placental explants from normotensive pregnant and preeclamptic women. Placenta. 2009;30:25-34 pubmed publisher
Jin P, Zhang J, Sumariwalla P, Ni I, Jorgensen B, Crawford D, et al. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. Arthritis Res Ther. 2008;10:R73 pubmed publisher
Nishi J, Minamino T, Miyauchi H, Nojima A, Tateno K, Okada S, et al. Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt. Circ Res. 2008;103:261-8 pubmed publisher
Sela S, Itin A, Natanson Yaron S, Greenfield C, Goldman Wohl D, Yagel S, et al. A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia. Circ Res. 2008;102:1566-74 pubmed publisher
Rajakumar A, Jeyabalan A, Markovic N, Ness R, Gilmour C, Conrad K. Placental HIF-1 alpha, HIF-2 alpha, membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2007;293:R766-74 pubmed
Murakami Y, Yamagoe S, Noguchi K, Takebe Y, Takahashi N, Uehara Y, et al. Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx. J Biol Chem. 2006;281:28113-21 pubmed
Krysiak O, Bretschneider A, Zhong E, Webb J, Hopp H, Verlohren S, et al. Soluble vascular endothelial growth factor receptor-1 (sFLT-1) mediates downregulation of FLT-1 and prevents activated neutrophils from women with preeclampsia from additional migration by VEGF. Circ Res. 2005;97:1253-61 pubmed
Rajakumar A, Michael H, Rajakumar P, Shibata E, Hubel C, Karumanchi S, et al. Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women. Placenta. 2005;26:563-73 pubmed
Neagoe P, Lemieux C, Sirois M. Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer. J Biol Chem. 2005;280:9904-12 pubmed
Mahendra G, Kumar S, Isayeva T, Mahasreshti P, Curiel D, Stockardt C, et al. Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptor. Cancer Gene Ther. 2005;12:26-34 pubmed
Vaisman N, Gospodarowicz D, Neufeld G. Characterization of the receptors for vascular endothelial growth factor. J Biol Chem. 1990;265:19461-6 pubmed
product information
Catalog Number :
V4262
Product Name :
Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-1 antibody produced in mouse
Product Type :
ANTIBODIES - SIAL
Product Group :
Protein & Pathway Technologies
Host Species :
mouse
Clonality :
monoclonal
Conjugation :
unconjugated
Clone Name :
FLT-11
Isotype :
IgG1
Product Description :
clone FLT-11, ascites fluid
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA