Horie T, Nakao T, Miyasaka Y, Nishino T, Matsumura S, Nakazeki F, et al. microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity. Nat Commun. 2021;12:843 pubmed publisher

Velázquez Villegas L, Perino A, Lemos V, Zietak M, Nomura M, Pols T, et al. TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue. Nat Commun. 2018;9:245 pubmed publisher

Wang Y, Lin S, Hsieh P, Hung S. Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes. Biochem Biophys Res Commun. 2016;478:689-95 pubmed publisher

Wang S, Zhang Q, Zhang Y, Shen C, Wang Z, Wu Q, et al. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. Biochem Biophys Res Commun. 2016;477:454-60 pubmed publisher

Moschinger M, Hilse K, Rupprecht A, Zeitz U, Erben R, Rülicke T, et al. Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice. Biol Sex Differ. 2019;10:56 pubmed publisher

Liu J, Kuipers E, Sips H, Dorleijn J, van Dam A, Christodoulides C, et al. Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:158511 pubmed publisher

Sharma M, Schlegel M, Brown E, Sansbury B, Weinstock A, Afonso M, et al. Netrin-1 Alters Adipose Tissue Macrophage Fate and Function in Obesity. Immunometabolism. 2019;1: pubmed publisher

Vas V, Háhner T, Kudlik G, Ernszt D, Kvell K, Kuti D, et al. Analysis of Tks4 Knockout Mice Suggests a Role for Tks4 in Adipose Tissue Homeostasis in the Context of Beigeing. Cells. 2019;8: pubmed publisher

Wang N, Ma Y, Liu Z, Liu L, Yang K, Wei Y, et al. Hydroxytyrosol prevents PM2.5-induced adiposity and insulin resistance by restraining oxidative stress related NF-κB pathway and modulation of gut microbiota in a murine model. Free Radic Biol Med. 2019;141:393-407 pubmed publisher

Hemmeryckx B, Vranckx C, Bauters D, Lijnen H, Scroyen I. Does butein affect adipogenesis?. Adipocyte. 2019;8:209-222 pubmed publisher

Sebaa R, Johnson J, Pileggi C, Norgren M, Xuan J, Sai Y, et al. SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1. Mol Metab. 2019;: pubmed publisher

Chen S, Ding L, Zeng N, Liu H, Zheng S, Xu J, et al. Icariin induces irisin/FNDC5 expression in C2C12 cells via the AMPK pathway. Biomed Pharmacother. 2019;115:108930 pubmed publisher

Klusóczki Á, Veréb Z, Vámos A, Fischer Posovszky P, Wabitsch M, Bacso Z, et al. Differentiating SGBS adipocytes respond to PPARγ stimulation, irisin and BMP7 by functional browning and beige characteristics. Sci Rep. 2019;9:5823 pubmed publisher

Hao L, Scott S, Abbasi M, Zu Y, Khan M, Yang Y, et al. Beneficial Metabolic Effects of Mirabegron In Vitro and in High-Fat Diet-Induced Obese Mice. J Pharmacol Exp Ther. 2019;369:419-427 pubmed publisher

Clookey S, Welly R, Shay D, Woodford M, Fritsche K, Rector R, et al. Beta 3 Adrenergic Receptor Activation Rescues Metabolic Dysfunction in Female Estrogen Receptor Alpha-Null Mice. Front Physiol. 2019;10:9 pubmed publisher

Krois C, Vuckovic M, Huang P, Zaversnik C, Liu C, Gibson C, et al. RDH1 suppresses adiposity by promoting brown adipose adaptation to fasting and re-feeding. Cell Mol Life Sci. 2019;76:2425-2447 pubmed publisher

Rabasa C, Askevik K, Schéle E, Hu M, Vogel H, Dickson S. Divergent Metabolic Effects of Acute Versus Chronic Repeated Forced Swim Stress in the Rat. Obesity (Silver Spring). 2019;27:427-433 pubmed publisher

Hedesan O, Fenzl A, Digruber A, Spirk K, Baumgartner Parzer S, Bilban M, et al. Parathyroid hormone induces a browning program in human white adipocytes. Int J Obes (Lond). 2019;43:1319-1324 pubmed publisher

Ricca C, Aillon A, Viano M, Bergandi L, Aldieri E, Silvagno F. Vitamin D inhibits the epithelial-mesenchymal transition by a negative feedback regulation of TGF-β activity. J Steroid Biochem Mol Biol. 2019;187:97-105 pubmed publisher

Bhattacharya A, Sun S, Wang H, Liu M, Long Q, Yin L, et al. Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH. EMBO J. 2018;37: pubmed publisher

Pinol R, Zahler S, Li C, Saha A, Tan B, Skop V, et al. Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake. Nat Neurosci. 2018;21:1530-1540 pubmed publisher

Lemecha M, Morino K, Imamura T, Iwasaki H, Ohashi N, Ida S, et al. MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes. Sci Rep. 2018;8:15096 pubmed publisher

He L, Tang M, Xiao T, Liu H, Liu W, Li G, et al. Obesity-Associated miR-199a/214 Cluster Inhibits Adipose Browning via PRDM16-PGC-1α Transcriptional Network. Diabetes. 2018;67:2585-2600 pubmed publisher

Drareni K, Ballaire R, Barilla S, Mathew M, Toubal A, Fan R, et al. GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation. Cell Rep. 2018;24:2957-2971.e6 pubmed publisher

Giudetti A, Testini M, Vergara D, Priore P, Damiano F, Gallelli C, et al. Chronic psychosocial defeat differently affects lipid metabolism in liver and white adipose tissue and induces hepatic oxidative stress in mice fed a high-fat diet. FASEB J. 2019;33:1428-1439 pubmed publisher

Paulo E, Wu D, Hecker P, Zhang Y, Wang B. Adipocyte HDAC4 activation leads to beige adipocyte expansion and reduced adiposity. J Endocrinol. 2018;: pubmed publisher

Clookey S, Welly R, Zidon T, Gastecki M, Woodford M, Grunewald Z, et al. Increased susceptibility to OVX-associated metabolic dysfunction in UCP1-null mice. J Endocrinol. 2018;: pubmed publisher

Lemecha M, Morino K, Seifu D, Imamura T, Nakagawa F, Nagata A, et al. Improved glucose metabolism by Eragrostis tef potentially through beige adipocyte formation and attenuating adipose tissue inflammation. PLoS ONE. 2018;13:e0201661 pubmed publisher

Paulo E, Wu D, Wang Y, Zhang Y, Wu Y, Swaney D, et al. Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis. Sci Rep. 2018;8:11001 pubmed publisher

Xiong W, Zhao X, Villacorta L, Rom O, Garcia Barrio M, Guo Y, et al. Brown Adipocyte-Specific PPAR? (Peroxisome Proliferator-Activated Receptor ?) Deletion Impairs Perivascular Adipose Tissue Development and Enhances Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2018;: pubmed publisher

Kuipers E, Dam A, Held N, Mol I, Houtkooper R, Rensen P, et al. Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice. Int J Mol Sci. 2018;19: pubmed publisher

Ahn J, Kim D, Suh Y, Lee J, Lee K. Adipose-specific expression of mouse Rbp7 gene and its developmental and metabolic changes. Gene. 2018;670:38-45 pubmed publisher

Blumenfeld N, Kang H, Fenzl A, Song Z, Chung J, Singh R, et al. A direct tissue-grafting approach to increasing endogenous brown fat. Sci Rep. 2018;8:7957 pubmed publisher

Mukherjee S, Zhang T, Lacko L, Tan L, Xiang J, Butler J, et al. Derivation and characterization of a UCP1 reporter human ES cell line. Stem Cell Res. 2018;30:12-21 pubmed publisher

Lu X, Altshuler Keylin S, Wang Q, Chen Y, Henrique Sponton C, Ikeda K, et al. Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism. Sci Signal. 2018;11: pubmed publisher

Rodriguez Lanzi C, Perdicaro D, Landa M, Fontana A, Antoniolli A, Miatello R, et al. Grape pomace extract induced beige cells in white adipose tissue from rats and in 3T3-L1 adipocytes. J Nutr Biochem. 2018;56:224-233 pubmed publisher

Chen Q, Huang L, Pan D, Zhu L, Wang Y. Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis. Cell Rep. 2018;22:2860-2872 pubmed publisher

Masand R, Paulo E, Wu D, Wang Y, Swaney D, Jimenez Morales D, et al. Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits. Cell Metab. 2018;27:616-629.e4 pubmed publisher

Tharp K, Kang M, Timblin G, Dempersmier J, Dempsey G, Zushin P, et al. Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues. Cell Metab. 2018;27:602-615.e4 pubmed publisher

Grunewald Z, Winn N, Gastecki M, Woodford M, Ball J, Hansen S, et al. Removal of interscapular brown adipose tissue increases aortic stiffness despite normal systemic glucose metabolism in mice. Am J Physiol Regul Integr Comp Physiol. 2018;314:R584-R597 pubmed publisher

Schilperoort M, van Dam A, Hoeke G, Shabalina I, Okolo A, Hanyaloglu A, et al. The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat. EMBO Mol Med. 2018;10: pubmed publisher

Viano M, Alotto D, Aillon A, Castagnoli C, Silvagno F. A thermal gradient modulates the oxidative metabolism and growth of human keratinocytes. FEBS Open Bio. 2017;7:1843-1853 pubmed publisher

Gonzalez Hurtado E, Lee J, Choi J, Wolfgang M. Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing. Mol Metab. 2018;7:45-56 pubmed publisher

Gao Z, Daquinag A, Su F, Snyder B, Kolonin M. PDGFRα/PDGFRβ signaling balance modulates progenitor cell differentiation into white and beige adipocytes. Development. 2018;145: pubmed publisher

Ikeda K, Kang Q, Yoneshiro T, Camporez J, Maki H, Homma M, et al. UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat Med. 2017;23:1454-1465 pubmed publisher

Wang N, Liu Y, Ma Y, Wen D. High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice. Life Sci. 2017;191:122-131 pubmed publisher

McQueen A, Kanamaluru D, Yan K, Gray N, Wu L, Li M, et al. The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure. J Biol Chem. 2017;292:16122-16134 pubmed publisher

Huang L, Pan D, Chen Q, Zhu L, Ou J, Wabitsch M, et al. Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation. Nat Commun. 2017;8:68 pubmed publisher

Winn N, Grunewald Z, Gastecki M, Woodford M, Welly R, Clookey S, et al. Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction. Am J Physiol Endocrinol Metab. 2017;313:E402-E412 pubmed publisher

Ohashi N, Morino K, Ida S, Sekine O, Lemecha M, Kume S, et al. Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis. Diabetes. 2017;66:2351-2362 pubmed publisher

Nam M, Akie T, Sanosaka M, Craige S, Kant S, Keaney J, et al. Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression. Sci Rep. 2017;7:2013 pubmed publisher

Oguri Y, Fujita Y, Abudukadier A, Ohashi A, Goto T, Furuya F, et al. Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism. JCI Insight. 2017;2: pubmed publisher

Soofi A, Wolf K, Emont M, Qi N, Martinez Santibañez G, Grimley E, et al. The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice. J Biol Chem. 2017;292:9051-9062 pubmed publisher

Goto T, Hirata M, Aoki Y, Iwase M, Takahashi H, Kim M, et al. The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-? agonist-induced amelioration of metabolic disorders in obese mice. J Biol Chem. 2017;292:9175-9190 pubmed publisher

Zhu Q, Ghoshal S, Tyagi R, Chakraborty A. Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain. Mol Metab. 2017;6:73-85 pubmed publisher

Kristof E, Doan Xuan Q, Sárvári A, Klusóczki Á, Fischer Posovszky P, Wabitsch M, et al. Clozapine modifies the differentiation program of human adipocytes inducing browning. Transl Psychiatry. 2016;6:e963 pubmed publisher

Winn N, Vieira Potter V, Gastecki M, Welly R, Scroggins R, Zidon T, et al. Loss of UCP1 exacerbates Western diet-induced glycemic dysregulation independent of changes in body weight in female mice. Am J Physiol Regul Integr Comp Physiol. 2017;312:R74-R84 pubmed publisher

Sulston R, Learman B, Zhang B, Scheller E, Parlee S, Simon B, et al. Increased Circulating Adiponectin in Response to Thiazolidinediones: Investigating the Role of Bone Marrow Adipose Tissue. Front Endocrinol (Lausanne). 2016;7:128 pubmed

Zhu Q, Ghoshal S, Rodrigues A, Gao S, Asterian A, Kamenecka T, et al. Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis. J Clin Invest. 2016;126:4273-4288 pubmed publisher

Lacraz G, Rakotoarivelo V, Labbé S, Vernier M, Noll C, Mayhue M, et al. Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues. PLoS ONE. 2016;11:e0162995 pubmed publisher

Soofi A, Wolf K, Ranghini E, Amin M, Dressler G. The kielin/chordin-like protein KCP attenuates nonalcoholic fatty liver disease in mice. Am J Physiol Gastrointest Liver Physiol. 2016;311:G587-G598 pubmed publisher

Morton T, Galior K, McGrath C, Wu X, Uzer G, Uzer G, et al. Exercise Increases and Browns Muscle Lipid in High-Fat Diet-Fed Mice. Front Endocrinol (Lausanne). 2016;7:80 pubmed publisher

. Short-Chain Fatty Acid Acetate Stimulates Adipogenesis and Mitochondrial Biogenesis via GPR43 in Brown Adipocytes. Endocrinology. 2016;157:1881-94 pubmed publisher

Takahashi A, Adachi S, Morita M, Tokumasu M, Natsume T, Suzuki T, et al. Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity. Cell Rep. 2015;13:2756-67 pubmed publisher

Avau B, Bauters D, Steensels S, Vancleef L, Laermans J, Lesuisse J, et al. The Gustatory Signaling Pathway and Bitter Taste Receptors Affect the Development of Obesity and Adipocyte Metabolism in Mice. PLoS ONE. 2015;10:e0145538 pubmed publisher

Patil Y, Dille K, Burk D, Cortez C, Gettys T. Cellular and molecular remodeling of inguinal adipose tissue mitochondria by dietary methionine restriction. J Nutr Biochem. 2015;26:1235-47 pubmed publisher

Gaborit B, Venteclef N, Ancel P, Pelloux V, Gariboldi V, Leprince P, et al. Human epicardial adipose tissue has a specific transcriptomic signature depending on its anatomical peri-atrial, peri-ventricular, or peri-coronary location. Cardiovasc Res. 2015;108:62-73 pubmed publisher

Lisboa P, Conceição E, de Oliveira E, Moura E. Postnatal overnutrition programs the thyroid hormone metabolism and function in adulthood. J Endocrinol. 2015;226:219-26 pubmed publisher

Tsai S, Sitzmann J, Dastidar S, Rodriguez A, Vu S, McDonald C, et al. Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity. J Clin Invest. 2015;125:2952-64 pubmed publisher

Xiao C, Goldgof M, Gavrilova O, Reitman M. Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C. Obesity (Silver Spring). 2015;23:1450-9 pubmed publisher

Porter C, Herndon D, Bhattarai N, Ogunbileje J, Szczesny B, Szabo C, et al. Severe Burn Injury Induces Thermogenically Functional Mitochondria in Murine White Adipose Tissue. Shock. 2015;44:258-64 pubmed publisher

Meyer G, Gibbons M, Sato E, Lane J, Ward S, Engler A. Epimuscular Fat in the Human Rotator Cuff Is a Novel Beige Depot. Stem Cells Transl Med. 2015;4:764-74 pubmed publisher

Chondronikola M, Annamalai P, Chao T, Porter C, Saraf M, Cesani F, et al. A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans. Int J Obes (Lond). 2015;39:1561-4 pubmed publisher

Shinoda K, Luijten I, Hasegawa Y, Hong H, Sonne S, Kim M, et al. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med. 2015;21:389-94 pubmed publisher

Lisboa P, de Oliveira E, Manhães A, Santos Silva A, Pinheiro C, Younes Rapozo V, et al. Effects of maternal nicotine exposure on thyroid hormone metabolism and function in adult rat progeny. J Endocrinol. 2015;224:315-25 pubmed publisher

Vieira Potter V, Padilla J, Park Y, Welly R, Scroggins R, Britton S, et al. Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction. Am J Physiol Regul Integr Comp Physiol. 2015;308:R530-42 pubmed publisher