Duru Z, Özsaygılı C. Preservative-free versus preserved brimonidine %0.15 preparations in the treatment of glaucoma and ocular hypertension: short term evaluation of efficacy, safety, and potential advantages. Cutan Ocul Toxicol. 2020;39:21-24 pubmed publisher

Montes Mico R, Charman W. Pharmacological Strategies for Presbyopia Correction. J Refract Surg. 2019;35:803-814 pubmed publisher

Horrillo I, Ortega J, Diez Alarcia R, Urigüen L, Meana J. Chronic fluoxetine reverses the effects of chronic corticosterone treatment on α2-adrenoceptors in the rat frontal cortex but not locus coeruleus. Neuropharmacology. 2019;158:107731 pubmed publisher

Yokoyama Y, Kawasaki R, Takahashi H, Maekawa S, Tsuda S, Omodaka K, et al. Effects of Brimonidine and Timolol on the Progression of Visual Field Defects in Open-angle Glaucoma: A Single-center Randomized Trial. J Glaucoma. 2019;28:575-583 pubmed publisher

Joh H, Jin S. Comparison of different combinations of maximum medical therapy for lowering intraocular pressure in primary open angle glaucoma: 12-month retrospective consecutive case series. Jpn J Ophthalmol. 2019;: pubmed publisher

Obradović D, Stavrianidi A, Ustinovich K, Parenago O, Shpigun O, Agbaba D. The comparison of retention behaviour of imidazoline and serotonin receptor ligands in non-aqueous hydrophilic interaction chromatography and supercritical fluid chromatography. J Chromatogr A. 2019;: pubmed publisher

Feng J, Zhang C, Lischinsky J, Jing M, Zhou J, Wang H, et al. A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron. 2019;: pubmed publisher

Fan K, Baskaran M, Nongpiur M, Htoon H, de Leon J, Perera S, et al. Investigating the neuroprotective effect of Copolymer-1 in acute primary angle closure - Interim report of a randomized placebo-controlled double-masked clinical trial. Acta Ophthalmol. 2019;97:e827-e832 pubmed publisher

Carr B, Nguyen C, Stell W. Alpha2 -adrenoceptor agonists inhibit form-deprivation myopia in the chick. Clin Exp Optom. 2019;102:418-425 pubmed publisher

Obradović D, Oljacic S, Nikolic K, Agbaba D. Investigation and prediction of retention characteristics of imidazoline and serotonin receptor ligands and their related compounds on mixed-mode stationary phase. J Chromatogr A. 2019;1585:92-104 pubmed publisher

Thongon N, Chamniansawat S. The inhibitory role of purinergic P2Y receptor on Mg2+ transport across intestinal epithelium-like Caco-2 monolayer. J Physiol Sci. 2019;69:129-141 pubmed publisher

Cho H, Lee M, Kee C. Association between the Frequency of Optic Disk Hemorrhage and Progression of NTG Related with the Initial Location of RNFL Defect. Ophthalmic Res. 2018;60:152-160 pubmed publisher

Hsia E, Tian M, Gil D. Reduction in ultraviolet B light-induced erythema by oxymetazoline and brimonidine is mediated by different α-adrenoceptors. Exp Dermatol. 2018;27:763-768 pubmed publisher

Han X, Liu Y, Kam W, Sullivan D. Effect of brimonidine, an α2 adrenergic agonist, on human meibomian gland epithelial cells. Exp Eye Res. 2018;170:20-28 pubmed publisher

De la Cruz S, Medina Terol G, Beltrán Ornelas J, Gomez C, Morato Valderrama Y, Sánchez López A, et al. Pharmacological evidence that metformin blocks the vasopressor responses mediated by stimulation of ?1- and ?2-adrenoceptors in pithed rats. Eur J Pharmacol. 2018;820:130-137 pubmed publisher

Kotańska M, Kulig K, Marcinkowska M, Bednarski M, Malawska K, Zaręba P. Metabolic benefits of 1-(3-(4-(o-tolyl)piperazin-1-yl)propyl)pyrrolidin-2-one: a non-selective α-adrenoceptor antagonist. J Endocrinol Invest. 2018;41:609-619 pubmed publisher

Wang J, Williamson G, Lancina M, Yang H. Mildly Cross-Linked Dendrimer Hydrogel Prepared via Aza-Michael Addition Reaction for Topical Brimonidine Delivery. J Biomed Nanotechnol. 2017;13:1089-1096 pubmed publisher

Lin H, Lee C, Huang J, Yang S, Chao S. Concurrent injection of dexamethasone intravitreal implant and anti-angiogenic agent in patients with macular edema: A retrospective cohort study. Medicine (Baltimore). 2017;96:e8868 pubmed publisher

Feng Z, Zhang X, Zhao J, Ma J. Involvement of Rho-associated coiled-coil kinase signaling inhibition in TGF-β1/Smad2, 3 signal transduction in vitro. Int J Ophthalmol. 2017;10:1805-1811 pubmed publisher

Raczak Gutknecht J, Nasal A, Frackowiak T, Kornicka A, Saczewski F, Wawrzyniak R, et al. Comparative pharmacodynamic analysis of imidazoline compounds using rat model of ocular mydriasis with a test of quantitative structure-activity relationships. J Pharm Biomed Anal. 2017;144:122-128 pubmed publisher

Nizari S, Guo L, Davis B, Normando E, Galvão J, Turner L, et al. Non-amyloidogenic effects of α2 adrenergic agonists: implications for brimonidine-mediated neuroprotection. Cell Death Dis. 2016;7:e2514 pubmed publisher

Zeltner N, Fattahi F, Dubois N, Saurat N, Lafaille F, Shang L, et al. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Nat Med. 2016;22:1421-1427 pubmed publisher

Filipic S, Antic A, Vujovic M, Nikolic K, Agbaba D. A Comparative Study of Chromatographic Behavior and Lipophilicity of Selected Imidazoline Derivatives. J Chromatogr Sci. 2016;54:1137-45 pubmed publisher

Dudek M, Knutelska J, Bednarski M, Nowiński L, Zygmunt M, Mordyl B, et al. A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity. PLoS ONE. 2015;10:e0141327 pubmed publisher

Shin H, Lee H, Lee Y, Kim S. Effect of Brimonidine on the B Cells, T Cells, and Cytokines of the Ocular Surface and Aqueous Humor in Rat Eyes. J Ocul Pharmacol Ther. 2015;31:623-6 pubmed publisher

Rho S, Sung Y, Ma K, Rho S, Kim C. Bleb Analysis and Short-Term Results of Biodegradable Collagen Matrix-Augmented Ahmed Glaucoma Valve Implantation: 6-Month Follow-up. Invest Ophthalmol Vis Sci. 2015;56:5896-903 pubmed publisher

Dave P, Villarreal G, Friedman D, Kahook M, Ramulu P. Ability of Bottle Cap Color to Facilitate Accurate Patient-Physician Communication Regarding Medication Identity in Patients with Glaucoma. Ophthalmology. 2015;122:2373-9 pubmed publisher

Li N, Shi H, Cong L, Lu Z, Ye W, Zhang Y. Outflow facility efficacy of five drugs in enucleated porcine eyes by a method of constant-pressure perfusion. Int J Clin Exp Med. 2015;8:7184-91 pubmed

Zhu W, Kong X, Xu J, Sun X. Effects of Long-Term Antiglaucoma Eye Drops on Conjunctival Structures: An In Vivo Confocal Microscopy Study. J Ophthalmol. 2015;2015:165475 pubmed publisher

Mansouri K, Medeiros F, Weinreb R. Effect of glaucoma medications on 24-hour intraocular pressure-related patterns using a contact lens sensor. Clin Exp Ophthalmol. 2015;43:787-95 pubmed publisher

Cho H, Suh W, Kee C. Visual and structural prognosis of the untreated fellow eyes of unilateral normal tension glaucoma patients. Graefes Arch Clin Exp Ophthalmol. 2015;253:1547-55 pubmed publisher

Hong S, Han S, Kim C, Kim K, Song Y, Seong G. Brimonidine reduces TGF-beta-induced extracellular matrix synthesis in human Tenon's fibroblasts. BMC Ophthalmol. 2015;15:54 pubmed publisher

Saini M, Dhiman R, Dada T, Tandon R, Vanathi M. Topical cyclosporine to control ocular surface disease in patients with chronic glaucoma after long-term usage of topical ocular hypotensive medications. Eye (Lond). 2015;29:808-14 pubmed publisher

Du Y, Cramer M, Lee C, Tang J, Muthusamy A, Antonetti D, et al. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015;29:2194-204 pubmed publisher

Lee J, Liu C, Chan J, Lai J. Predictors of success in selective laser trabeculoplasty for normal tension glaucoma. Medicine (Baltimore). 2014;93:e236 pubmed publisher

Aung T, Laganovska G, Hernandez Paredes T, Branch J, Tsorbatzoglou A, Goldberg I. Twice-daily brinzolamide/brimonidine fixed combination versus brinzolamide or brimonidine in open-angle glaucoma or ocular hypertension. Ophthalmology. 2014;121:2348-55 pubmed publisher

Fedorchak M, Conner I, Medina C, Wingard J, Schuman J, Little S. 28-day intraocular pressure reduction with a single dose of brimonidine tartrate-loaded microspheres. Exp Eye Res. 2014;125:210-6 pubmed publisher

Ilkovitch D, Pomerantz R. Brimonidine effective but may lead to significant rebound erythema. J Am Acad Dermatol. 2014;70:e109-10 pubmed publisher

Feke G, Bex P, Taylor C, Rhee D, Turalba A, Chen T, et al. Effect of brimonidine on retinal vascular autoregulation and short-term visual function in normal tension glaucoma. Am J Ophthalmol. 2014;158:105-112.e1 pubmed publisher

Furlanetto R, De Moraes C, Teng C, Liebmann J, Greenfield D, Gardiner S, et al. Risk factors for optic disc hemorrhage in the low-pressure glaucoma treatment study. Am J Ophthalmol. 2014;157:945-52 pubmed publisher

Benkali K, Leoni M, Rony F, Bouer R, Fernando A, Graeber M, et al. Comparative pharmacokinetics and bioavailability of brimonidine following ocular and dermal administration of brimonidine tartrate ophthalmic solution and gel in patients with moderate-to-severe facial erythema associated with rosacea. Br J Dermatol. 2014;171:162-9 pubmed publisher

Fukuchi T. [Current trend of glaucoma medication with various eye drops]. Nippon Ganka Gakkai Zasshi. 2013;117:781-3 pubmed

Del Rosso J. Management of facial erythema of rosacea: what is the role of topical ?-adrenergic receptor agonist therapy?. J Am Acad Dermatol. 2013;69:S44-56 pubmed publisher

. Brimonidine gel (Mirvaso) for rosacea. Med Lett Drugs Ther. 2013;55:82-3 pubmed

. Brinzolamide/brimonidine (Simbrinza) for glaucoma. Med Lett Drugs Ther. 2013;55:57-8 pubmed

Pasquali T, Aufderheide A, Brinton J, Avila M, Stahl E, Durrie D. Dilute brimonidine to improve patient comfort and subconjunctival hemorrhage after LASIK. J Refract Surg. 2013;29:469-75 pubmed publisher

Shah A, Modi Y, Thomas B, Wellik S, Galor A. Brimonidine allergy presenting as vernal-like keratoconjunctivitis. J Glaucoma. 2015;24:89-91 pubmed publisher

Katz G, Dubiner H, Samples J, Vold S, Sall K. Three-month randomized trial of fixed-combination brinzolamide, 1%, and brimonidine, 0.2%. JAMA Ophthalmol. 2013;131:724-30 pubmed publisher

Chen Y, Kardon R. Studying the effect of iris mechanics on the pupillary light reflex using brimonidine-induced anisocoria. Invest Ophthalmol Vis Sci. 2013;54:2951-8 pubmed publisher

Sena D, Lindsley K. Neuroprotection for treatment of glaucoma in adults. Cochrane Database Syst Rev. 2013;:CD006539 pubmed publisher

Nguyen Q, McMenemy M, Realini T, Whitson J, Goode S. Phase 3 randomized 3-month trial with an ongoing 3-month safety extension of fixed-combination brinzolamide 1%/brimonidine 0.2%. J Ocul Pharmacol Ther. 2013;29:290-7 pubmed publisher

Araie M, Yamazaki Y, Sugiyama K, Kuwayama Y, Tanihara H. [Phase III clinical trial of brimonidine in patients with primary open-angle glaucoma and ocular hypertension--comparison of the effects of brimonidine monotherapy versus timolol monotherapy, or combination brimonidine/prostaglandins therapy versus c. Nippon Ganka Gakkai Zasshi. 2012;116:955-66 pubmed

Fallen R, Gooderham M. Rosacea: update on management and emerging therapies. Skin Therapy Lett. 2012;17:1-4 pubmed

Cai J, Li J, Liu W, Han Y, Wang H. α2-adrenergic receptors in spiral ganglion neurons may mediate protective effects of brimonidine and yohimbine against glutamate and hydrogen peroxide toxicity. Neuroscience. 2013;228:23-35 pubmed publisher

Kaneko E, Wada T, Minagawa Y, Inoue Y. [Pharmacological profile and clinical efficacy of brimonidine tartrate (AIPHAGAN(®) ophthalmic solution 0.1%)]. Nihon Yakurigaku Zasshi. 2012;140:177-82 pubmed

Lee D, Kim K, Noh Y, Chai S, Lindsey J, Ellisman M, et al. Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor a in ischemic retinal injury. PLoS ONE. 2012;7:e47098 pubmed publisher

Horng C, Tsai M, Chien S, Kao W, Tsai M, Chang T, et al. The activity of lowering intraocular pressure of cassiae seed extract in a DBA/2J mouse glaucoma model. J Ocul Pharmacol Ther. 2013;29:48-54 pubmed publisher

Cho H, Kee C. Comparison of the progression rates of the superior, inferior, and both hemifield defects in normal-tension glaucoma patients. Am J Ophthalmol. 2012;154:958-968.e1 pubmed publisher

Gatzioufas Z, Labiris G, Stachs O, Hovakimyan M, Schnaidt A, Viestenz A, et al. Biomechanical profile of the cornea in primary congenital glaucoma. Acta Ophthalmol. 2013;91:e29-34 pubmed publisher

Lehner Z, Stadlbauer K, Adorjan I, Rustenbeck I, Belz M, Fenzl A, et al. Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?. Diabetologia. 2012;55:3071-82 pubmed publisher

Araie M, Adachi M. [Effect of topical 0.1% brimonidine tartrate and 0.5% timolol maleate on pulmonary and cardiovascular functions]. Nippon Ganka Gakkai Zasshi. 2012;116:623-34 pubmed

De Moraes C, Liebmann J, Greenfield D, Gardiner S, Ritch R, Krupin T. Risk factors for visual field progression in the low-pressure glaucoma treatment study. Am J Ophthalmol. 2012;154:702-11 pubmed publisher

El Chehab H, Le Corre A, Giraud J, Ract Madoux G, Swalduz B, Dot C. [Efficacy of prophylactic treatment of intraocular pressure spikes due to intravitreal injections]. J Fr Ophtalmol. 2012;35:614-21 pubmed publisher

Oner V, Alakus M, Taş M, Turkyilmaz K, Işcan Y. Fixed combination brimonidine-timolol versus brimonidine for treatment of intraocular pressure elevation after neodymium:YAG laser posterior capsulotomy. J Ocul Pharmacol Ther. 2012;28:576-80 pubmed publisher

Hommer A, Sperl P, Resch H, Popa Cherecheanu A, Qiao C, Schmetterer L, et al. A double-masked randomized crossover study comparing the effect of latanoprost/timolol and brimonidine/timolol fixed combination on intraocular pressure and ocular blood flow in patients with primary open-angle glaucoma or ocular hypertension. J Ocul Pharmacol Ther. 2012;28:569-75 pubmed publisher

Deokule S, Baffi J, Guo H, Nazzaro M, Kaneko H. Evaluation of extended release brimonidine intravitreal device in normotensive rabbit eyes. Acta Ophthalmol. 2012;90:e344-8 pubmed publisher

Elzanfaly E, Saad A, Abd Elaleem A. Combining the isoabsorptive point in the ratio spectrum and the smart ratio difference methods for a single step determination of compounds with overlapped spectra. Spectrochim Acta A Mol Biomol Spectrosc. 2012;95:188-92 pubmed publisher

Saigusa T, Aono Y, Uchida T, Takada K, Verheij M, Koshikawa N, et al. The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats. Eur J Pharmacol. 2012;688:35-41 pubmed publisher

Yang Q, Cho K, Chen H, Yu D, Wang W, Luo G, et al. Microbead-induced ocular hypertensive mouse model for screening and testing of aqueous production suppressants for glaucoma. Invest Ophthalmol Vis Sci. 2012;53:3733-41 pubmed publisher

Congdon N, Krishnadas R, Friedman D, Goggins W, Ramakrishnan R, Kader M, et al. A study of initial therapy for glaucoma in southern India: India Glaucoma Outcomes and Treatment (INGOT) Study. Ophthalmic Epidemiol. 2012;19:149-58 pubmed publisher

Jimenez Rivera C, Figueroa J, Vázquez Torres R, Vélez Hernández M, Schwarz D, Velásquez Martínez M, et al. Presynaptic inhibition of glutamate transmission by α2 receptors in the VTA. Eur J Neurosci. 2012;35:1406-15 pubmed publisher

Näreoja K, Näsman J. Characterization of α(2B)-adrenoceptor ligand binding in the presence of muscarinic toxin α and delineation of structural features of receptor binding selectivity. Eur J Pharmacol. 2012;683:63-70 pubmed publisher

Katz L, Rauchman S, Cottingham A, Simmons S, Williams J, Schiffman R, et al. Fixed-combination brimonidine-timolol versus latanoprost in glaucoma and ocular hypertension: a 12-week, randomized, comparison study. Curr Med Res Opin. 2012;28:781-8 pubmed publisher

Jensen B, Swigart P, Montgomery M, Simpson P. Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2010;382:475-82 pubmed publisher

Bian X, Galligan J. Alpha2-adrenoceptors couple to inhibition of R-type calcium currents in myenteric neurons. Neurogastroenterol Motil. 2007;19:845-55 pubmed

Xu J, He J, Castleberry A, Balasubramanian S, Lau A, Hall R. Heterodimerization of alpha 2A- and beta 1-adrenergic receptors. J Biol Chem. 2003;278:10770-7 pubmed

Andorn A, Carlson M, Gilkeson R. Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci. 1988;43:1805-12 pubmed

Turner J, Ray Prenger C, Bylund D. Alpha 2-adrenergic receptors in the human cell line, HT29. Characterization with the full agonist radioligand [3H]UK-14,304 and inhibition of adenylate cyclase. Mol Pharmacol. 1985;28:422-30 pubmed

Paris H, Galitzky J, Senard J. Interactions of full and partial agonists with HT29 cell alpha 2-adrenoceptor: comparative study of [3H]UK-14,304 and [3H]clonidine binding. Mol Pharmacol. 1989;35:345-54 pubmed