Hacke W. Interventional thrombectomy for major stroke--a step in the right direction. N Engl J Med. 2015;372:76-7 pubmed publisher

Berkhemer O, Fransen P, Beumer D, van den Berg L, Lingsma H, Yoo A, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015;372:11-20 pubmed publisher

Davis F, Rateri D, Balakrishnan A, Howatt D, Strickland D, Muratoglu S, et al. Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms. Arterioscler Thromb Vasc Biol. 2015;35:155-62 pubmed publisher

Elumalai P, Brindha Mercy A, Arunkamar R, Sharmila G, Bhat F, Balakrishnan S, et al. Nimbolide inhibits invasion and migration, and down-regulates uPAR chemokine gene expression, in two breast cancer cell lines. Cell Prolif. 2014;47:540-52 pubmed publisher

Chu S, Yu C, Hsu L, Chen K, Su M, Chen P. Berberine reverses epithelial-to-mesenchymal transition and inhibits metastasis and tumor-induced angiogenesis in human cervical cancer cells. Mol Pharmacol. 2014;86:609-23 pubmed publisher

Duru E, Fu Y, Davies M. Protease-mediated human smooth muscle cell proliferation by urokinase requires epidermal growth factor receptor transactivation by triple membrane signaling. J Surg Res. 2014;192:254-62 pubmed publisher

Lee K, Ye S, Park M, Park B, Lee J, Kim S. p63-Mediated activation of the ?-catenin/c-Myc signaling pathway stimulates esophageal squamous carcinoma cell invasion and metastasis. Cancer Lett. 2014;353:124-32 pubmed publisher

Yen H, Hsieh M, Wu C, Lee F. Effect of systemic urokinase infusion after lower limb percutaneous transluminal angioplasty on limb salvage rate in patients with late-stage critical limb ischemia. Eur J Vasc Endovasc Surg. 2014;48:414-22 pubmed publisher

Varshney A, Ramakrishnan S, Sharma A, Santosh B, Bala J, Yadava P, et al. Global expression profile of telomerase-associated genes in HeLa cells. Gene. 2014;547:211-7 pubmed publisher

Bosse Y. Endocrine regulation of airway contractility is overlooked. J Endocrinol. 2014;222:R61-73 pubmed publisher

Kawao N, Tamura Y, Okumoto K, Yano M, Okada K, Matsuo O, et al. Tissue-type plasminogen activator deficiency delays bone repair: roles of osteoblastic proliferation and vascular endothelial growth factor. Am J Physiol Endocrinol Metab. 2014;307:E278-88 pubmed publisher

Logan J, Pantle H, Huiras P, Bessman E, Bright L. Evidence-based diagnosis and thrombolytic treatment of cardiac arrest or periarrest due to suspected pulmonary embolism. Am J Emerg Med. 2014;32:789-96 pubmed publisher

Van Der Meersch H, De Bacquer D, Vandecasteele S, Van Den Bergh B, Vermeiren P, De Letter J, et al. Hemodialysis catheter design and catheter performance: a randomized controlled trial. Am J Kidney Dis. 2014;64:902-8 pubmed publisher

Vorob eva I, Merkushenkova D, Parfenova E, Makarevich P. [The effect of fibrinolytic therapy for proliferative diabetic retinopathy complications on the angiogenic potential of the eye]. Vestn Oftalmol. 2014;130:31-6 pubmed

Mochizuki A, Pace A, Rockwell C, Roth K, Chow A, O Brien K, et al. Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1?-dependent manner by modulating macrophage phenotype in mice. J Immunol. 2014;192:3847-3857 pubmed publisher

Fleetwood A, Achuthan A, Schultz H, Nansen A, Almholt K, Usher P, et al. Urokinase plasminogen activator is a central regulator of macrophage three-dimensional invasion, matrix degradation, and adhesion. J Immunol. 2014;192:3540-7 pubmed publisher

Venat Bouvet L, Fermeaux V, Léobon S, Saidi N, Monteil J, Mollard J, et al. Adjuvant chemotherapy in node-negative breast cancer: UPA/PAI-1 determinations for 163 cases. Anticancer Res. 2014;34:1213-7 pubmed

Kitley J, Waters P, Woodhall M, Leite M, Murchison A, George J, et al. Neuromyelitis optica spectrum disorders with aquaporin-4 and myelin-oligodendrocyte glycoprotein antibodies: a comparative study. JAMA Neurol. 2014;71:276-83 pubmed publisher

Corcoran J, Rahman N. Point: should fibrinolytics be routinely administered intrapleurally for management of a complicated parapneumonic effusion? Yes. Chest. 2014;145:14-17 pubmed publisher

Fujii T, Horiguchi K, Sunaga H, Moriwaki Y, Misawa H, Kasahara T, et al. SLURP-1, an endogenous ?7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205(+) dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity. J Neuroimmunol. 2014;267:43-9 pubmed publisher

Robertson I, Kessel D, Berridge D. Fibrinolytic agents for peripheral arterial occlusion. Cochrane Database Syst Rev. 2013;:CD001099 pubmed publisher

Riehle K, Johnson M, Johansson F, Bauer R, Hayes B, Gilbertson D, et al. Tissue-type plasminogen activator is not necessary for platelet-derived growth factor-c activation. Biochim Biophys Acta. 2014;1842:318-25 pubmed publisher

Jia Z, Jiang G, Tian F, Zhao J, Li S, Wang K, et al. Early endovascular treatment of superior mesenteric occlusion secondary to thromboemboli. Eur J Vasc Endovasc Surg. 2014;47:196-203 pubmed publisher

Ahn S, Kim J, Hong J, Woo S, Ahn J, Park K, et al. Efficacy and safety of intra-arterial thrombolysis in central retinal artery occlusion. Invest Ophthalmol Vis Sci. 2013;54:7746-55 pubmed publisher

Kosaka K, Hiraga N, Imamura M, Yoshimi S, Murakami E, Nakahara T, et al. A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections. Biochem Biophys Res Commun. 2013;441:230-5 pubmed publisher

Kromann Hansen T, Lund I, Liu Z, Andreasen P, Høyer Hansen G, Sørensen H. Allosteric inactivation of a trypsin-like serine protease by an antibody binding to the 37- and 70-loops. Biochemistry. 2013;52:7114-26 pubmed publisher

Afsharimani B, Baran J, Watanabe S, Lindner D, Cabot P, Parat M. Morphine and breast tumor metastasis: the role of matrix-degrading enzymes. Clin Exp Metastasis. 2014;31:149-58 pubmed publisher

Chou F, Chen Y, Zhao X, Xu Monette Z, Young K, Gartenhaus R, et al. Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas. Am J Pathol. 2013;183:1306-17 pubmed publisher

You J, Chung S, Chung H, Lee H, Park J, Kim H, et al. Predictive value of the Cincinnati Prehospital Stroke Scale for identifying thrombolytic candidates in acute ischemic stroke. Am J Emerg Med. 2013;31:1699-702 pubmed publisher

Lin W, Kao H, Hsueh C, Cheng C. Intrasinus thrombolysis by mechanical and urokinase for severe cerebral venous sinus thrombosis : a case report. Acta Neurol Taiwan. 2013;22:122-6 pubmed

Dun Z, Zhu S, Jiang H. Benefits of a frame-based stereotactic surgical planning system for the treatment of spontaneous intracerebral haematomas. J Int Med Res. 2013;41:1550-9 pubmed publisher

Komissarov A, Florova G, Azghani A, Karandashova S, Kurdowska A, Idell S. Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids. Am J Physiol Lung Cell Mol Physiol. 2013;305:L682-92 pubmed publisher

Chik F, Machnes Z, Szyf M. Synergistic anti-breast cancer effect of a combined treatment with the methyl donor S-adenosyl methionine and the DNA methylation inhibitor 5-aza-2'-deoxycytidine. Carcinogenesis. 2014;35:138-44 pubmed publisher

Chen W, Tang Y, Zheng M, Jiang J, Zhu G, Liang X, et al. Regulation of plasminogen activator activity and expression by cyclic mechanical stress in rat mandibular condylar chondrocytes. Mol Med Rep. 2013;8:1155-62 pubmed publisher

Lee S, Gupta M, Ho Y, Kim T, Lee H. Transgenic chickens expressing human urokinase-type plasminogen activator. Poult Sci. 2013;92:2396-403 pubmed publisher

Chen P, Chang B, Kuo C, Chen P, Cho C, Chang C, et al. Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis. FASEB J. 2013;27:4520-31 pubmed publisher

Enocsson H, Wetterö J, Skogh T, Sjöwall C. Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus. Transl Res. 2013;162:287-96 pubmed publisher

Zhang J, Jiang X, Xie C, Cheng H, Da Dong J, Wang Y, et al. Downregulation of CFTR promotes epithelial-to-mesenchymal transition and is associated with poor prognosis of breast cancer. Biochim Biophys Acta. 2013;1833:2961-2969 pubmed publisher

Roomi M, Kalinovsky T, Niedzwiecki A, Rath M. Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in pediatric human sarcoma cell lines. Int J Oncol. 2013;43:1027-35 pubmed publisher

Asuthkar S, Stepanova V, Lebedeva T, Holterman A, Estes N, Cines D, et al. Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer. Mol Biol Cell. 2013;24:2620-32 pubmed publisher

Furuyama H, Fuji H, Okumura S, Nishigori T, Kadokawa Y, Kondo M, et al. [A case of recurrent colon cancer developed thrombosis in superior mesenteric vein after chemotherapy]. Gan To Kagaku Ryoho. 2013;40:659-61 pubmed

Horvatić Herceg G, Herceg D, Kralik M, Kulić A, Bence Zigman Z, Tomic Brzac H, et al. Urokinase plasminogen activator and its inhibitor type-1 as prognostic factors in differentiated thyroid carcinoma patients. Otolaryngol Head Neck Surg. 2013;149:533-40 pubmed publisher

Sugioka K, Kodama A, Okada K, Iwata M, Yoshida K, Kusaka S, et al. TGF-β2 promotes RPE cell invasion into a collagen gel by mediating urokinase-type plasminogen activator (uPA) expression. Exp Eye Res. 2013;115:13-21 pubmed publisher

Schuliga M, Langenbach S, Xia Y, Qin C, Mok J, Harris T, et al. Plasminogen-stimulated inflammatory cytokine production by airway smooth muscle cells is regulated by annexin A2. Am J Respir Cell Mol Biol. 2013;49:751-8 pubmed publisher

Greco C, Pelliccia F, Tanzilli G, Tinti M, Salenzi P, Cicerchia C, et al. Usefulness of local delivery of thrombolytics before thrombectomy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (the delivery of thrombolytics before thrombectomy in patients with ST. Am J Cardiol. 2013;112:630-5 pubmed publisher

Pelayo Alonso R, Cobo Sánchez J, de Buruaga Perea A, Menezo Viadero R, Gándara Revuelta M, Aja Crespo A, et al. [Comparative study between 20 IU/ml heparin and 5% heparin/urokinase 5000 IU lock in hemodialysis central venous catheters with permeability problems]. Rev Enferm. 2013;36:8-12 pubmed

Tamura T, Morita E, Kawai S, Okada R, Naito M, Wakai K, et al. Significant association of urokinase plasminogen activator Pro141Leu with serum lipid profiles in a Japanese population. Gene. 2013;524:363-7 pubmed publisher

Hamilton B, Whittaker G. Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12. J Biol Chem. 2013;288:17399-407 pubmed publisher

Chen Z, Miao H, Zhu G, Feng H. Intra-arterial thrombolysis of acute cerebral vascular occlusion during endovascular treatment of adjacent aneurysms at the internal carotid artery. JAMA Neurol. 2013;70:406-7 pubmed

Bohm L, Serafin A, Akudugu J, Fernandez P, van der Merwe A, Aziz N. uPA/PAI-1 ratios distinguish benign prostatic hyperplasia and prostate cancer. J Cancer Res Clin Oncol. 2013;139:1221-8 pubmed publisher

Hagelgans A, Menschikowski M, Fuessel S, Nacke B, Arneth B, Wirth M, et al. Deregulated expression of urokinase and its inhibitor type 1 in prostate cancer cells: role of epigenetic mechanisms. Exp Mol Pathol. 2013;94:458-65 pubmed publisher

Ekmekci H, Güngör Öztürk Z, Ekmekci O, Işler Bütün I, Besirli K, Gode S, et al. Significance of vitronectin and PAI-1 activity levels in carotid artery disease: comparison of symptomatic and asymptomatic patients. Minerva Med. 2013;104:215-23 pubmed

Tan Y, Cao Z, Sajja H, Lipowska M, Wang Y, Yang L, et al. DOT corrected fluorescence molecular tomography using targeted contrast agents for small animal tumor imaging. J Xray Sci Technol. 2013;21:43-52 pubmed publisher

Kim N, Sun H, Youn M, Yoo J. IL-1β-specific recruitment of GCN5 histone acetyltransferase induces the release of PAF1 from chromatin for the de-repression of inflammatory response genes. Nucleic Acids Res. 2013;41:4495-506 pubmed publisher

Kenny S, Steele I, Lyons S, Moore A, Murugesan S, Tiszlavicz L, et al. The role of plasminogen activator inhibitor-1 in gastric mucosal protection. Am J Physiol Gastrointest Liver Physiol. 2013;304:G814-22 pubmed publisher

Harbeck N, Schmitt M, Meisner C, Friedel C, Untch M, Schmidt M, et al. Ten-year analysis of the prospective multicentre Chemo-N0 trial validates American Society of Clinical Oncology (ASCO)-recommended biomarkers uPA and PAI-1 for therapy decision making in node-negative breast cancer patients. Eur J Cancer. 2013;49:1825-35 pubmed publisher

Chapnik N, Solomon G, Genzer Y, Miskin R, Gertler A, Froy O. A superactive leptin antagonist alters metabolism and locomotion in high-leptin mice. J Endocrinol. 2013;217:283-90 pubmed publisher

Mandel K, Seidl D, Rades D, Lehnert H, Gieseler F, Hass R, et al. Characterization of spontaneous and TGF-?-induced cell motility of primary human normal and neoplastic mammary cells in vitro using novel real-time technology. PLoS ONE. 2013;8:e56591 pubmed publisher

Du P, Ye L, Yang Y, Jiang W. Candidate of metastasis 1 regulates in vitro growth and invasion of bladder cancer cells. Int J Oncol. 2013;42:1249-56 pubmed publisher

Ren J, Huang G, Ding P, Wu G, Han X, Wang Y. Outcomes of thrombolysis with and without predilation of the inferior vena cava (IVC) in patients with Budd-Chiari syndrome with old IVC thrombosis. Vasc Endovascular Surg. 2013;47:232-8 pubmed publisher

Mani T, Wang F, Knabe W, Sinn A, Khanna M, Jo I, et al. Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis. Bioorg Med Chem. 2013;21:2145-55 pubmed publisher

Castagnola E, Ginocchio F. Rescue therapy of difficult-to-treat indwelling central venous catheter-related bacteremias in cancer patients: a review for practical purposes. Expert Rev Anti Infect Ther. 2013;11:179-86 pubmed publisher

Lee G, Qian W, Wang L, Wang Y, Staley C, Satpathy M, et al. Theranostic nanoparticles with controlled release of gemcitabine for targeted therapy and MRI of pancreatic cancer. ACS Nano. 2013;7:2078-89 pubmed publisher

LeBeau A, Duriseti S, Murphy S, Pepin F, Hann B, Gray J, et al. Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer. Cancer Res. 2013;73:2070-81 pubmed publisher

Sundaram G, Common J, Gopal F, Srikanta S, Lakshman K, Lunny D, et al. 'See-saw' expression of microRNA-198 and FSTL1 from a single transcript in wound healing. Nature. 2013;495:103-6 pubmed publisher

Zhou D, Yang L, Roder C, Kalthoff H, Trauzold A. TRAIL-induced expression of uPA and IL-8 strongly enhanced by overexpression of TRAF2 and Bcl-xL in pancreatic ductal adenocarcinoma cells. Hepatobiliary Pancreat Dis Int. 2013;12:94-8 pubmed

Pilipenko I, Eliava S, Shekhtman O, Kheĭreddin A. [Local fibrinolysis in treatment of non-traumatic intracerebral hematomas and ventricular hemorrhages]. Zh Vopr Neirokhir Im N N Burdenko. 2012;76:3-12; discussion 12-3 pubmed

Imoukhuede P, Dokun A, Annex B, Popel A. Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia. Am J Physiol Heart Circ Physiol. 2013;304:H1085-93 pubmed publisher

Gach K, Wyrebska A, Szemraj J, Janecka A. The influence of opioid peptides on matrix metalloproteinase-9 and urokinase plasminogen activator expression in three cancer cell lines. Mol Biol (Mosk). 2012;46:894-9 pubmed

Agarwal V, Kuchipudi A, Fulde M, Riesbeck K, Bergmann S, Blom A. Streptococcus pneumoniae endopeptidase O (PepO) is a multifunctional plasminogen- and fibronectin-binding protein, facilitating evasion of innate immunity and invasion of host cells. J Biol Chem. 2013;288:6849-63 pubmed publisher

Van Den Broeck T, Van Ammel E, Delforche M, Taveirne S, Kerre T, Vandekerckhove B, et al. Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial ?? T cells. J Immunol. 2013;190:1982-90 pubmed publisher

Pang R, Leung C, Lee C, Lam K, Ye T, Chiu P, et al. MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1. BMC Cancer. 2013;13:25 pubmed publisher

Liu L, Boffa M, Koschinsky M. Apolipoprotein(a) inhibits in vitro tube formation in endothelial cells: identification of roles for Kringle V and the plasminogen activation system. PLoS ONE. 2013;8:e52287 pubmed publisher

Chao S, Hu D, Yang P, Lin C, Nien C, Yang S, et al. Ultraviolet-A irradiation upregulated urokinase-type plasminogen activator in pterygium fibroblasts through ERK and JNK pathways. Invest Ophthalmol Vis Sci. 2013;54:999-1007 pubmed publisher

Małgorzewicz S, Skrzypczak Jankun E, Jankun J. Plasminogen activator inhibitor-1 in kidney pathology (Review). Int J Mol Med. 2013;31:503-10 pubmed publisher

Tang X, Li J, Yu B, Su L, Yu Y, Yan M, et al. Osteopontin splice variants differentially exert clinicopathological features and biological functions in gastric cancer. Int J Biol Sci. 2013;9:55-66 pubmed publisher

Patani N, Martin L, Dowsett M. Biomarkers for the clinical management of breast cancer: international perspective. Int J Cancer. 2013;133:1-13 pubmed publisher

Sehrawat A, Kim S, Vogt A, Singh S. Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells. Carcinogenesis. 2013;34:864-73 pubmed publisher

Pasupuleti N, Leon L, Carraway K, Gorin F. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013;344:600-15 pubmed publisher

Webb S, Sanders A, Mason M, Jiang W. Matriptase-2 inhibits HECV motility and tubule formation in vitro and tumour angiogenesis in vivo. Mol Cell Biochem. 2013;375:207-17 pubmed publisher

Shen Y, Guo Y, Du C, Wilczynska M, Hellstrom S, Ny T. Mice deficient in urokinase-type plasminogen activator have delayed healing of tympanic membrane perforations. PLoS ONE. 2012;7:e51303 pubmed publisher

Kobayashi H, Suzuki M, Tanaka Y, Hirashima Y, Terao T. Suppression of urokinase expression and invasiveness by urinary trypsin inhibitor is mediated through inhibition of protein kinase C- and MEK/ERK/c-Jun-dependent signaling pathways. J Biol Chem. 2001;276:2015-22 pubmed

Lottenberg R, Christensen U, Jackson C, Coleman P. Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates. Methods Enzymol. 1981;80 Pt C:341-61 pubmed

Loskutoff D, Schleef R. Plasminogen activators and their inhibitors. Methods Enzymol. 1988;163:293-302 pubmed

Saksela O, Rifkin D. Cell-associated plasminogen activation: regulation and physiological functions. Annu Rev Cell Biol. 1988;4:93-126 pubmed

Lijnen H, Van Hoef B, Nelles L, Collen D. Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740----Ala) and plasmin-resistant scu-PA (Lys158----Glu). J Biol Chem. 1990;265:5232-6 pubmed