This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
TRAIL human
catalog :
T9701
citations: 43
Reference
Refaat A, Abdelhamed S, Saiki I, Sakurai H. Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy. Oncol Lett. 2015;10:1907-1911 pubmed
Sophonnithiprasert T, Nilwarangkoon S, Nakamura Y, Watanapokasin R. Goniothalamin enhances TRAIL-induced apoptosis in colorectal cancer cells through DR5 upregulation and cFLIP downregulation. Int J Oncol. 2015;47:2188-96 pubmed publisher
Pietkiewicz S, Eils R, Krammer P, Giese N, Lavrik I. Combinatorial treatment of CD95L and gemcitabine in pancreatic cancer cells induces apoptotic and RIP1-mediated necroptotic cell death network. Exp Cell Res. 2015;339:1-9 pubmed publisher
Ambroise G, Portier A, Roders N, Arnoult D, Vazquez A. Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells. Oncotarget. 2015;6:38181-94 pubmed publisher
Yao W, Yue P, Khuri F, Sun S. The BET bromodomain inhibitor, JQ1, facilitates c-FLIP degradation and enhances TRAIL-induced apoptosis independent of BRD4 and c-Myc inhibition. Oncotarget. 2015;6:34669-79 pubmed publisher
Chang C, Kuan C, Lin J, Lai J, Ho T. Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines. Chem Res Toxicol. 2015;28:1574-83 pubmed publisher
Minker C, Duban L, Karas D, Järvinen P, Lobstein A, Muller C. Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer. Oxid Med Cell Longev. 2015;2015:154164 pubmed publisher
Jiang C, Long J, Liu B, Xie X, Kuang M. Mcl-1 Is a Novel Target of miR-26b That Is Associated with the Apoptosis Induced by TRAIL in HCC Cells. Biomed Res Int. 2015;2015:572738 pubmed publisher
Lee M, Kim D, Eom J, Ko Y, Sung K, Koo H, et al. RAD001 (everolimus) enhances TRAIL cytotoxicity in human leukemic Jurkat T cells by upregulating DR5. Biochem Biophys Res Commun. 2015;463:894-9 pubmed publisher
Suzuki Karasaki Y, Fujiwara K, Saito K, Suzuki Karasaki M, Ochiai T, Soma M. Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization. Oncotarget. 2015;6:21572-88 pubmed
Han B, Yao W, Oh Y, Tong J, Li S, Deng J, et al. The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5. Oncotarget. 2015;6:17532-42 pubmed
Fauster A, Rebsamen M, Huber K, Bigenzahn J, Stukalov A, Lardeau C, et al. A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis. Cell Death Dis. 2015;6:e1767 pubmed publisher
Li J, Sharkey C, King M. Piperlongumine and immune cytokine TRAIL synergize to promote tumor death. Sci Rep. 2015;5:9987 pubmed publisher
Convertini P, Tramutola F, Iacobazzi V, Lupattelli P, Chiummiento L, Infantino V. Permethylated Anigopreissin A inhibits human hepatoma cell proliferation by mitochondria-induced apoptosis. Chem Biol Interact. 2015;237:1-8 pubmed publisher
Tanaka R, Tomosugi M, Horinaka M, Sowa Y, Sakai T. Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells. PLoS ONE. 2015;10:e0125779 pubmed publisher
Yuan Z, Kolluri K, Sage E, Gowers K, Janes S. Mesenchymal stromal cell delivery of full-length tumor necrosis factor-related apoptosis-inducing ligand is superior to soluble type for cancer therapy. Cytotherapy. 2015;17:885-96 pubmed publisher
Merz C, Strecker A, Sykora J, Hill O, Fricke H, Angel P, et al. Neutralization of the CD95 ligand by APG101 inhibits invasion of glioma cells in vitro. Anticancer Drugs. 2015;26:716-27 pubmed publisher
Woo S, Seo B, Min K, Kwon T. FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells. Oncotarget. 2015;6:11614-26 pubmed
Lv X, Tan G, Yao Y, Lv L, Deng X, Dong L, et al. Somatic mutations in myeloid cell leukemia-1 contribute to the pathogenesis of glioma by prolonging its half-life. Mol Med Rep. 2015;12:1265-71 pubmed publisher
Hanikoglu F, Cort A, Ozben H, Hanikoglu A, Ozben T. Epoxomicin Sensitizes Resistant Osteosarcoma Cells to TRAIL Induced Apoptosis. Anticancer Agents Med Chem. 2015;15:527-33 pubmed
Higgs J, Jarboe J, Lee J, Chanda D, Lee C, Deivanayagam C, et al. Variants of Osteoprotegerin Lacking TRAIL Binding for Therapeutic Bone Remodeling in Osteolytic Malignancies. Mol Cancer Res. 2015;13:819-27 pubmed publisher
Yang M, Liu L, Xie M, Sun X, Yu Y, Kang R, et al. Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy. Autophagy. 2015;11:214-24 pubmed publisher
Jung K, Min K, Bae J, Kwon T. Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells. Oncotarget. 2015;6:1556-68 pubmed
Chandrasekaran S, Marshall J, Messing J, Hsu J, King M. TRAIL-mediated apoptosis in breast cancer cells cultured as 3D spheroids. PLoS ONE. 2014;9:e111487 pubmed publisher
Bozza W, Di X, Takeda K, Rivera Rosado L, Pariser S, Zhang B. The use of a stably expressed FRET biosensor for determining the potency of cancer drugs. PLoS ONE. 2014;9:e107010 pubmed publisher
Akita M, Suzuki Karasaki M, Fujiwara K, Nakagawa C, Soma M, Yoshida Y, et al. Mitochondrial division inhibitor-1 induces mitochondrial hyperfusion and sensitizes human cancer cells to TRAIL-induced apoptosis. Int J Oncol. 2014;45:1901-12 pubmed publisher
Wang D, Upadhyaya B, Liu Y, Knudsen D, Dey M. Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells. BMC Cancer. 2014;14:591 pubmed publisher
Horinaka M, Yoshida T, Tomosugi M, Yasuda S, Sowa Y, Sakai T. Myeloid zinc finger 1 mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells. Sci Rep. 2014;4:6000 pubmed publisher
Zhu K, Fang W, Chen Y, Lin S, Chen X. TNF-related apoptosis-inducing ligand enhances vinorelbine-induced apoptosis and antitumor activity in a preclinical model of non-small cell lung cancer. Oncol Rep. 2014;32:1234-42 pubmed publisher
Park S, Shim S, Nam S, Andera L, Suh N, Kim I. CGP74514A enhances TRAIL-induced apoptosis in breast cancer cells by reducing X-linked inhibitor of apoptosis protein. Anticancer Res. 2014;34:3557-62 pubmed
McCray A, Desai S, Acevedo Duncan M. The interruption of PKC-ι signaling and TRAIL combination therapy against glioblastoma cells. Neurochem Res. 2014;39:1691-701 pubmed publisher
Hong M, Kim H, Kim I. Ribosomal protein L19 overexpression activates the unfolded protein response and sensitizes MCF7 breast cancer cells to endoplasmic reticulum stress-induced cell death. Biochem Biophys Res Commun. 2014;450:673-8 pubmed publisher
Jang J, Kim S, Cho E, Jeong S, Park E, Lee W, et al. TRAIL enhances apoptosis of human hepatocellular carcinoma cells sensitized by hepatitis C virus infection: therapeutic implications. PLoS ONE. 2014;9:e98171 pubmed publisher
Zang F, Wei X, Leng X, Yu M, Sun B. C-FLIP(L) contributes to TRAIL resistance in HER2-positive breast cancer. Biochem Biophys Res Commun. 2014;450:267-73 pubmed publisher
Beyer K, Poetschke C, Partecke L, von Bernstorff W, Maier S, Broeker B, et al. TRAIL induces neutrophil apoptosis and dampens sepsis-induced organ injury in murine colon ascendens stent peritonitis. PLoS ONE. 2014;9:e97451 pubmed publisher
Xu L, Qu X, Li H, Li C, Liu J, Zheng H, et al. Src/caveolin-1-regulated EGFR activation antagonizes TRAIL-induced apoptosis in gastric cancer cells. Oncol Rep. 2014;32:318-24 pubmed publisher
Condamine T, Kumar V, Ramachandran I, Youn J, Celis E, Finnberg N, et al. ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis. J Clin Invest. 2014;124:2626-39 pubmed publisher
Calzolari A, Saulle E, De Angelis M, Pasquini L, Boe A, Pelacchi F, et al. Salinomycin potentiates the cytotoxic effects of TRAIL on glioblastoma cell lines. PLoS ONE. 2014;9:e94438 pubmed publisher
Zhang T, Wang X, He D, Jin X, Guo P. Metformin sensitizes human bladder cancer cells to TRAIL-induced apoptosis through mTOR/S6K1-mediated downregulation of c-FLIP. Anticancer Drugs. 2014;25:887-97 pubmed publisher
He T, Haapa Paananen S, Kaminskyy V, Kohonen P, Fey V, Zhivotovsky B, et al. Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis. Oncogene. 2014;33:3538-49 pubmed publisher
Carette J, Guimaraes C, Wuethrich I, Blomen V, Varadarajan M, Sun C, et al. Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nat Biotechnol. 2011;29:542-6 pubmed publisher
Ovcharenko D, Kelnar K, Johnson C, Leng N, Brown D. Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis pathway. Cancer Res. 2007;67:10782-8 pubmed
Pitti R, Marsters S, Ruppert S, Donahue C, Moore A, Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem. 1996;271:12687-90 pubmed
product information
Catalog Number :
T9701
Product Name :
TRAIL human
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA