This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Thioredoxin Reductase from rat liver
catalog :
T9698
citations: 63
Reference
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Zhang T, Zheng P, Shen X, Shao R, Wang B, Shen H, et al. Curcuminoid WZ26, a TrxR1 inhibitor, effectively inhibits colon cancer cell growth and enhances cisplatin-induced cell death through the induction of ROS. Free Radic Biol Med. 2019;141:93-102 pubmed publisher
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Lothrop A, Snider G, Flemer S, Ruggles E, Davidson R, Lamb A, et al. Compensating for the absence of selenocysteine in high-molecular weight thioredoxin reductases: the electrophilic activation hypothesis. Biochemistry. 2014;53:664-74 pubmed publisher
Rovenko B, Lushchak V, Lushchak O. [Carbohydrate restriction in the larval diet causes oxidative stress in adult insects of Drosophila melanogaster]. Ukr Biokhim Zh (1999). 2013;85:61-72 pubmed
Lothrop A, Snider G, Ruggles E, Patel A, Lees W, Hondal R. Selenium as an electron acceptor during the catalytic mechanism of thioredoxin reductase. Biochemistry. 2014;53:654-63 pubmed publisher
Cao Z, Subramaniam S, Bulleid N. Lack of an efficient endoplasmic reticulum-localized recycling system protects peroxiredoxin IV from hyperoxidation. J Biol Chem. 2014;289:5490-8 pubmed publisher
Parker M, Zhu X, Stubbe J. Bacillus subtilis class Ib ribonucleotide reductase: high activity and dynamic subunit interactions. Biochemistry. 2014;53:766-76 pubmed publisher
Snider G, Dustin C, Ruggles E, Hondal R. A mechanistic investigation of the C-terminal redox motif of thioredoxin reductase from Plasmodium falciparum. Biochemistry. 2014;53:601-9 pubmed publisher
Lothrop A, Snider G, Ruggles E, Hondal R. Why is mammalian thioredoxin reductase 1 so dependent upon the use of selenium?. Biochemistry. 2014;53:554-65 pubmed publisher
Feng D, Dai Q, Xie H, Li R, Zheng G, Wang J, et al. [Protective effect of Pinus massoniana bark extracts against cisplatin-induced nephrotoxicity in human embryonic kidney cells]. Zhongguo Zhong Yao Za Zhi. 2013;38:2868-73 pubmed
Luo Z, Sheng J, Sun Y, Lu C, Yan J, Liu A, et al. Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen. J Med Chem. 2013;56:9089-99 pubmed publisher
Peng X, Zhang M, Conserva F, Hosny G, Selivanova G, Bykov V, et al. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase. Cell Death Dis. 2013;4:e881 pubmed publisher
Randall M, Hristova M, van Der Vliet A. Protein alkylation by the α,β-unsaturated aldehyde acrolein. A reversible mechanism of electrophile signaling?. FEBS Lett. 2013;587:3808-14 pubmed publisher
Jayakumar S, Kunwar A, Sandur S, Pandey B, Chaubey R. Differential response of DU145 and PC3 prostate cancer cells to ionizing radiation: role of reactive oxygen species, GSH and Nrf2 in radiosensitivity. Biochim Biophys Acta. 2014;1840:485-94 pubmed publisher
Joshi R, Kumar A, Manral S, Sinha R, Arora S, Sharma A, et al. Calreticulin transacetylase mediated upregulation of thioredoxin by 7,8-diacetoxy-4-methylcoumarin enhances the antioxidant potential and the expression of vascular endothelial growth factor in peripheral blood mononuclear cells. Chem Biol Interact. 2013;206:327-36 pubmed publisher
Kim S, Kim D, Jung W, Koo J. The expression of redox proteins in phyllodes tumor. Breast Cancer Res Treat. 2013;141:365-74 pubmed publisher
Casagrande N, De Paoli M, Celegato M, Borghese C, Mongiat M, Colombatti A, et al. Preclinical evaluation of a new liposomal formulation of cisplatin, lipoplatin, to treat cisplatin-resistant cervical cancer. Gynecol Oncol. 2013;131:744-52 pubmed publisher
Xu J, Croitoru V, Rutishauser D, Cheng Q, Arner E. Wobble decoding by the Escherichia coli selenocysteine insertion machinery. Nucleic Acids Res. 2013;41:9800-11 pubmed publisher
Cunniff B, Snider G, Fredette N, Hondal R, Heintz N. A direct and continuous assay for the determination of thioredoxin reductase activity in cell lysates. Anal Biochem. 2013;443:34-40 pubmed publisher
Zhu Z, Yang G, Wang Y, Yang J, Gao A, Niu P, et al. Suppression of thioredoxin system contributes to silica-induced oxidative stress and pulmonary fibrogenesis in rats. Toxicol Lett. 2013;222:289-94 pubmed publisher
Marco S, Rullo R, Albino A, Masullo M, De Vendittis E, Amato M. The thioredoxin system in the dental caries pathogen Streptococcus mutans and the food-industry bacterium Streptococcus thermophilus. Biochimie. 2013;95:2145-56 pubmed publisher
Bitar M, Abdel Halim S, Al Mulla F. Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes. Am J Physiol Endocrinol Metab. 2013;305:E951-63 pubmed publisher
Lepistö A, Pakula E, Toivola J, Krieger Liszkay A, Vignols F, Rintamäki E. Deletion of chloroplast NADPH-dependent thioredoxin reductase results in inability to regulate starch synthesis and causes stunted growth under short-day photoperiods. J Exp Bot. 2013;64:3843-54 pubmed publisher
Stangherlin A, Reddy A. Regulation of circadian clocks by redox homeostasis. J Biol Chem. 2013;288:26505-11 pubmed publisher
Fritz Wolf K, Jortzik E, Stumpf M, Preuss J, Iozef R, Rahlfs S, et al. Crystal structure of the Plasmodium falciparum thioredoxin reductase-thioredoxin complex. J Mol Biol. 2013;425:3446-60 pubmed publisher
Dai B, Yoo S, Bartholomeusz G, Graham R, Majidi M, Yan S, et al. KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer. Cancer Res. 2013;73:5532-43 pubmed publisher
Engelman R, Weisman Shomer P, Ziv T, Xu J, Arner E, Benhar M. Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation. J Biol Chem. 2013;288:11312-24 pubmed publisher
Cebula M, Moolla N, Capovilla A, Arner E. The rare TXNRD1_v3 ("v3") splice variant of human thioredoxin reductase 1 protein is targeted to membrane rafts by N-acylation and induces filopodia independently of its redox active site integrity. J Biol Chem. 2013;288:10002-11 pubmed publisher
Schlosser S, Leitsch D, Duch ne M. Entamoeba histolytica: identification of thioredoxin-targeted proteins and analysis of serine acetyltransferase-1 as a prototype example. Biochem J. 2013;451:277-88 pubmed publisher
Van Laer K, Dziewulska A, Fislage M, Wahni K, Hbeddou A, Collet J, et al. NrdH-redoxin of Mycobacterium tuberculosis and Corynebacterium glutamicum dimerizes at high protein concentration and exclusively receives electrons from thioredoxin reductase. J Biol Chem. 2013;288:7942-55 pubmed publisher
Rovenko B, Lushchak O, Lozins kyĭ O, Kubrak O, Lushchak V. [Mild oxidative stress in fruit fly Drosophila melanogaster caused by products of sucrose hydrolysis]. Ukr Biokhim Zh (1999). 2012;84:97-105 pubmed
Liu C, Liu Z, Li M, Li X, Wong Y, Ngai S, et al. Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase. PLoS ONE. 2013;8:e53945 pubmed publisher
Cohen Kutner M, Khomsky L, Trus M, Aisner Y, Niv M, Benhar M, et al. Thioredoxin-mimetic peptides (TXM) reverse auranofin induced apoptosis and restore insulin secretion in insulinoma cells. Biochem Pharmacol. 2013;85:977-90 pubmed publisher
Navakoski de Oliveira K, Andermark V, von Grafenstein S, Onambele L, Dahl G, Rubbiani R, et al. Butyltin(IV) benzoates: inhibition of thioredoxin reductase, tumor cell growth inhibition, and interactions with proteins. ChemMedChem. 2013;8:256-64 pubmed publisher
Fujishiro S, Dodo K, Iwasa E, Teng Y, Sohtome Y, Hamashima Y, et al. Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: reducing cytotoxicity by structural simplification. Bioorg Med Chem Lett. 2013;23:733-6 pubmed publisher
Lu J, Vlamis Gardikas A, Kandasamy K, Zhao R, Gustafsson T, Engstrand L, et al. Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione. FASEB J. 2013;27:1394-403 pubmed publisher
Eweas A, Allam G, Abuelsaad A, Alghamdi A, Maghrabi I. Design, synthesis, anti-schistosomal activity and molecular docking of novel 8-hydroxyquinoline-5-sufonyl 1,4-diazepine derivatives. Bioorg Chem. 2013;46:17-25 pubmed publisher
Fernandes A, Wallenberg M, Gandin V, Misra S, Tisato F, Marzano C, et al. Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systems. PLoS ONE. 2012;7:e50727 pubmed publisher
Lopert P, Day B, Patel M. Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells. PLoS ONE. 2012;7:e50683 pubmed publisher
Wang P, Wu Y, Li X, Ma X, Zhong L. Thioredoxin and thioredoxin reductase control tissue factor activity by thiol redox-dependent mechanism. J Biol Chem. 2013;288:3346-58 pubmed publisher
Pirazzini M, Bordin F, Rossetto O, Shone C, Binz T, Montecucco C. The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals. FEBS Lett. 2013;587:150-5 pubmed publisher
Ekström L, Johansson M, Monostory K, Rundlöf A, Arner E, Björkhem Bergman L. Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells. Biochem Biophys Res Commun. 2013;430:90-4 pubmed publisher
Oehninger L, Stefanopoulou M, Alborzinia H, Schur J, Ludewig S, Namikawa K, et al. Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules. Dalton Trans. 2013;42:1657-66 pubmed publisher
Ibáñez E, Stoedter M, Hofmann P, Plano D, Calvo A, Nguewa P, et al. Structure- and cell-specific effects of imidoselenocarbamates on selenoprotein expression and activity in liver cells in culture. Metallomics. 2012;4:1297-307 pubmed publisher
Debnath A, Ndao M, Reed S. Reprofiled drug targets ancient protozoans: drug discovery for parasitic diarrheal diseases. Gut Microbes. 2013;4:66-71 pubmed publisher
Méplan C, Rohrmann S, Steinbrecher A, Schomburg L, Jansen E, Linseisen J, et al. Polymorphisms in thioredoxin reductase and selenoprotein K genes and selenium status modulate risk of prostate cancer. PLoS ONE. 2012;7:e48709 pubmed publisher
Sobhakumari A, Love Homan L, Fletcher E, Martin S, Parsons A, Spitz D, et al. Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism. PLoS ONE. 2012;7:e48175 pubmed publisher
Ghosh P, Roy S, Chakraborty P, Ghosh S, Bhattacharya S. Effects of organoselenium compound 2-(5-selenocyanato-pentyl)-benzo[de]isoquinoline 1,3-dione on cisplatin induced nephrotoxicity and genotoxicity: an investigation of the influence of the compound on oxidative stress and antioxidant enzyme system. Biometals. 2013;26:61-73 pubmed publisher
Bohrer A, Massot V, Innocenti G, Reichheld J, Issakidis Bourguet E, Vanacker H. New insights into the reduction systems of plastidial thioredoxins point out the unique properties of thioredoxin z from Arabidopsis. J Exp Bot. 2012;63:6315-23 pubmed publisher
Watson M, van Leer L, Vanderlelie J, Perkins A. Selenium supplementation protects trophoblast cells from oxidative stress. Placenta. 2012;33:1012-9 pubmed publisher
Lee Y, Kim S, Lazar P, Moon J, Hwang S, Thangapandian S, et al. Comparative molecular modeling study of Arabidopsis NADPH-dependent thioredoxin reductase and its hybrid protein. PLoS ONE. 2012;7:e46279 pubmed publisher
Jin X, Stamnaes J, Klöck C, Diraimondo T, Sollid L, Khosla C. Activation of extracellular transglutaminase 2 by thioredoxin. J Biol Chem. 2011;286:37866-73 pubmed publisher
May J, Qu Z, Nelson D. Uptake and reduction of alpha-lipoic acid by human erythrocytes. Clin Biochem. 2007;40:1135-42 pubmed
Nordman T, Xia L, Björkhem Bergman L, Damdimopoulos A, Nalvarte I, Arner E, et al. Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase. Biofactors. 2003;18:45-50 pubmed
Moore E, Reichard P, Thelander L. ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOTIDES.V. PURIFICATION AND PROPERTIES OF THIOREDOXIN REDUCTASE FROM ESCHERICHIA COLI B. J Biol Chem. 1964;239:3445-52 pubmed
Arner E, Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem. 2000;267:6102-9 pubmed
Zhong L, Holmgren A. Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations. J Biol Chem. 2000;275:18121-8 pubmed
Speranza M, Ronchi S, Minchiotti L. Purification and characterization of yeast thioredoxin reductase. Biochim Biophys Acta. 1973;327:274-81 pubmed
product information
Catalog Number :
T9698
Product Name :
Thioredoxin Reductase from rat liver
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
buffered aqueous glycerol solution, ?100 units/mg protein (Bradford)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA