This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Terfenadine
catalog :
T9652
citations: 105
Reference
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Xie S, Jia Y, Liu A, Dai R, Huang L. Hypaconitine-induced QT prolongation mediated through inhibition of KCNH2 (hERG) potassium channels in conscious dogs. J Ethnopharmacol. 2015;166:375-9 pubmed publisher
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Yun J, Kim S. Antihistamines modulate the integrin signaling pathway in h9c2 rat cardiomyocytes: Possible association with cardiotoxicity. Hum Exp Toxicol. 2015;34:796-807 pubmed publisher
Tanaka H, Takahashi Y, Hamaguchi S, Iida Tanaka N, Oka T, Nishio M, et al. Effect of terfenadine and pentamidine on the HERG channel and its intracellular trafficking: combined analysis with automated voltage clamp and confocal microscopy. Biol Pharm Bull. 2014;37:1826-30 pubmed
Kim J, Do J, Choi J, Cho S, Kim W, Yoon C. Development and validation of an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistaminics in dietary supplements. Biomed Chromatogr. 2015;29:465-74 pubmed publisher
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Guzman Y. You're the flight surgeon: nasal congestion and Eustachian tube dysfunction. Aviat Space Environ Med. 2013;84:268-9 pubmed
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Shirasaka Y, Shichiri M, Murata Y, Mori T, Nakanishi T, Tamai I. Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption. Drug Metab Dispos. 2013;41:615-21 pubmed publisher
Togami K, Tosaki Y, Chono S, Morimoto K, Hayasaka M, Tada H. Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells. J Pharm Pharmacol. 2013;65:22-9 pubmed publisher
Kusuhara H, Miura M, Yasui Furukori N, Yoshida K, Akamine Y, Yokochi M, et al. Effect of coadministration of single and multiple doses of rifampicin on the pharmacokinetics of fexofenadine enantiomers in healthy subjects. Drug Metab Dispos. 2013;41:206-13 pubmed publisher
Dhaneshwar S, Gautam H. Exploring novel colon-targeting antihistaminic prodrug for colitis. J Physiol Pharmacol. 2012;63:327-37 pubmed
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Nogaki T, Asano K, Furuta A, Kanai K, Suzaki I, Kanei A, et al. Enhancement of clara cell 10-kD protein (CC10) production from nasal epithelial cells by fexofenadine hydrochloride. Asian Pac J Allergy Immunol. 2012;30:139-45 pubmed
Tanaka Y, Yoshikawa Y, Yasui H. Development of a highly sensitive methodology for quantitative determination of fexofenadine in a microdose study by multiple injection method using ultra-high performance liquid chromatography with tandem mass spectrometry. Biol Pharm Bull. 2012;35:698-704 pubmed
Yamada K, Takizawa F, Tamura T, Kanda T. The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. Biol Pharm Bull. 2012;35:693-7 pubmed
Ohura K, Soejima T, Nogata R, Adachi Y, Ninomiya S, Imai T. Effect of intestinal first-pass hydrolysis on the oral bioavailability of an ester prodrug of fexofenadine. J Pharm Sci. 2012;101:3264-74 pubmed publisher
Nguemo F, Saric T, Pfannkuche K, Watzele M, Reppel M, Hescheler J. In vitro model for assessing arrhythmogenic properties of drugs based on high-resolution impedance measurements. Cell Physiol Biochem. 2012;29:819-32 pubmed publisher
Suzuki K, Shitara Y, Fukuda K, Horie T. Long-lasting inhibition of the intestinal absorption of fexofenadine by cyclosporin A in rats. J Pharm Sci. 2012;101:2606-15 pubmed publisher
Mathias S, Tschosik E, Zazzali J. Adaptation and validation of the Urticaria Patient Daily Diary for adolescents. Allergy Asthma Proc. 2012;33:186-90 pubmed publisher
Qiang F, Shin H, Lee B, Han H. Enhanced systemic exposure of fexofenadine via the intranasal administration of chitosan-coated liposome. Int J Pharm. 2012;430:161-6 pubmed publisher
Andoh T, Sakai K, Urashima M, Kitazawa K, Honma A, Kuraishi Y. Involvement of leukotriene B4 in itching in a mouse model of ocular allergy. Exp Eye Res. 2012;98:97-103 pubmed publisher
Fujii M, Ohya S, Yamamura H, Imaizumi Y. Development of recombinant cell line co-expressing mutated Nav1.5, Kir2.1, and hERG for the safety assay of drug candidates. J Biomol Screen. 2012;17:773-84 pubmed publisher
Ali S, Khan S, Crowyn G. Structure determination of fexofenadine-α-cyclodextrin complex by quantitative 2D ROESY analysis and molecular mechanics studies. Magn Reson Chem. 2012;50:299-304 pubmed publisher
Liu X, Limberis J, Su Z, Houseman K, Diaz G, Gintant G, et al. Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers. Life Sci. 2012;90:607-11 pubmed publisher
Saruwatari J, Yasui Furukori N, Niioka T, Akamine Y, Takashima A, Kaneko S, et al. Different effects of the selective serotonin reuptake inhibitors fluvoxamine, paroxetine, and sertraline on the pharmacokinetics of fexofenadine in healthy volunteers. J Clin Psychopharmacol. 2012;32:195-9 pubmed publisher
Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W. Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS Comput Biol. 2011;7:e1002310 pubmed publisher
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Aslanian R, Piwinski J, Zhu X, Priestley T, Sorota S, Du X, et al. Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs. Bioorg Med Chem Lett. 2009;19:5043-7 pubmed publisher
Zachariae U, Giordanetto F, Leach A. Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. J Med Chem. 2009;52:4266-76 pubmed publisher
Imai Y, Ryu S, Oiki S. Docking model of drug binding to the human ether-à-go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach. J Med Chem. 2009;52:1630-8 pubmed publisher
Ermondi G, Visentin S, Caron G. GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers. Eur J Med Chem. 2009;44:1926-32 pubmed publisher
Ahlin G, Karlsson J, Pedersen J, Gustavsson L, Larsson R, Matsson P, et al. Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. J Med Chem. 2008;51:5932-42 pubmed publisher
Pedersen J, Matsson P, Bergström C, Norinder U, Hoogstraate J, Artursson P. Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). J Med Chem. 2008;51:3275-87 pubmed publisher
Jia L, Sun H. Support vector machines classification of hERG liabilities based on atom types. Bioorg Med Chem. 2008;16:6252-60 pubmed publisher
Kornhuber J, Tripal P, Reichel M, Terfloth L, Bleich S, Wiltfang J, et al. Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. J Med Chem. 2008;51:219-37 pubmed
Bergström C, Wassvik C, Johansson K, Hubatsch I. Poorly soluble marketed drugs display solvation limited solubility. J Med Chem. 2007;50:5858-62 pubmed
Chen C. Some pharmacokinetic aspects of the lipophilic terfenadine and zwitterionic fexofenadine in humans. Drugs R D. 2007;8:301-14 pubmed
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
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Rufke C, Nieber K. [Long QT interval. Interaction of terfenadine and itraconazole]. Med Monatsschr Pharm. 2006;29:22-4 pubmed
Wang Y, Li Y, Li Y, Yang S, Yang L. Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorg Med Chem Lett. 2005;15:4076-84 pubmed
Tobita M, Nishikawa T, Nagashima R. A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorg Med Chem Lett. 2005;15:2886-90 pubmed
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product information
Catalog Number :
T9652
Product Name :
Terfenadine
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA