product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Anti-Tau antibody, Mouse monoclonal
catalog :
T9450
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Tau46
reactivity :
human, mouse
application :
western blot, western blot knockout validation
more info or order :
citations: 35
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:500; loading ...; fig 1b
Geiszler P, Barron M, Pardon M. Impaired burrowing is the most prominent behavioral deficit of aging htau mice. Neuroscience. 2016;329:98-111 pubmed publisher
  • western blot; mouse; 1:4000; loading ...; fig 5b
Pajares M, Jiménez Moreno N, García Yagüe A, Escoll M, De Ceballos M, Van Leuven F, et al. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 2016;12:1902-1916 pubmed
  • western blot; mouse
Iliff J, Chen M, Plog B, Zeppenfeld D, Soltero M, Yang L, et al. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci. 2014;34:16180-93 pubmed publisher
  • western blot; mouse
Liao C, Fan C, Kao T, Ji D, Su K, Lin Y, et al. Brain injury-associated biomarkers of TGF-beta1, S100B, GFAP, NF-L, tTG, AbetaPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canis in mice. BMC Infect Dis. 2008;8:84 pubmed publisher
Wang S, Cho Y. Yeast surface display of full-length human microtubule-associated protein tau. Biotechnol Prog. 2020;36:e2920 pubmed publisher
Lin S, Lin K, Lin P, Huang C, Chang C, Lee Y, et al. Plasma amyloid assay as a pre-screening tool for amyloid positron emission tomography imaging in early stage Alzheimer's disease. Alzheimers Res Ther. 2019;11:111 pubmed publisher
Lue L, Kuo Y, Sabbagh M. Advance in Plasma AD Core Biomarker Development: Current Findings from Immunomagnetic Reduction-Based SQUID Technology. Neurol Ther. 2019;8:95-111 pubmed publisher
Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson E, et al. Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization. Nat Commun. 2019;10:5583 pubmed publisher
Wang Y, Huang Y, Liu J, Zhang J, Xu M, You Z, et al. Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB. EMBO Rep. 2019;:e48335 pubmed publisher
Schiapparelli L, Shah S, Ma Y, McClatchy D, Sharma P, Li J, et al. The Retinal Ganglion Cell Transportome Identifies Proteins Transported to Axons and Presynaptic Compartments in the Visual System In Vivo. Cell Rep. 2019;28:1935-1947.e5 pubmed publisher
Mietelska Porowska A, Gasiorowska A, Palasz E, Koss D, Riedel G, Niewiadomska G. Pore-former enabled seeding of tau in rats: Alleviation by memantine and lithium chloride. J Neurosci Methods. 2019;319:47-59 pubmed publisher
Boban M, Babić Leko M, Miškić T, Hof P, Simic G. Human neuroblastoma SH-SY5Y cells treated with okadaic acid express phosphorylated high molecular weight tau-immunoreactive protein species. J Neurosci Methods. 2018;: pubmed publisher
Fan L, Tzen K, Chen Y, Chen T, Lai Y, Yen R, et al. The Relation Between Brain Amyloid Deposition, Cortical Atrophy, and Plasma Biomarkers in Amnesic Mild Cognitive Impairment and Alzheimer's Disease. Front Aging Neurosci. 2018;10:175 pubmed publisher
Huang G, Guo L, Zhu L, Liu X, Sun Z, Li H, et al. Neuronal GAP-Porf-2 transduces EphB1 signaling to brake axon growth. Cell Mol Life Sci. 2018;75:4207-4222 pubmed publisher
Lin C, Yang S, Horng H, Yang C, Chieh J, Chen H, et al. Plasma Biomarkers Differentiate Parkinson's Disease From Atypical Parkinsonism Syndromes. Front Aging Neurosci. 2018;10:123 pubmed publisher
Oka M, Fujisaki N, Maruko Otake A, Ohtake Y, Shimizu S, Saito T, et al. Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy. J Biochem. 2017;162:335-342 pubmed publisher
Qu X, Yuan F, Corona C, Pasini S, Pero M, Gundersen G, et al. Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1-42 synaptotoxicity. J Cell Biol. 2017;216:3161-3178 pubmed publisher
Yang S, Chiu M, Chen T, Lin C, Jeng J, Tang S, et al. Analytical performance of reagent for assaying tau protein in human plasma and feasibility study screening neurodegenerative diseases. Sci Rep. 2017;7:9304 pubmed publisher
Lue L, Guerra A, Walker D. Amyloid Beta and Tau as Alzheimer's Disease Blood Biomarkers: Promise From New Technologies. Neurol Ther. 2017;6:25-36 pubmed publisher
Yang S, Chiu M, Chen T, Horng H. Detection of Plasma Biomarkers Using Immunomagnetic Reduction: A Promising Method for the Early Diagnosis of Alzheimer's Disease. Neurol Ther. 2017;6:37-56 pubmed publisher
Du X, West M, Cai Q, Cheng W, EWERT D, Li W, et al. Antioxidants reduce neurodegeneration and accumulation of pathologic Tau proteins in the auditory system after blast exposure. Free Radic Biol Med. 2017;108:627-643 pubmed publisher
Chiu M, Fan L, Chen T, Chen Y, Chieh J, Horng H. Plasma Tau Levels in Cognitively Normal Middle-Aged and Older Adults. Front Aging Neurosci. 2017;9:51 pubmed publisher
Lago L, Nunes E, Vigato A, Souza V, Barbosa F, Sato J, et al. Flow of essential elements in subcellular fractions during oxidative stress. Biometals. 2017;30:83-96 pubmed publisher
Cuadrado Tejedor M, Garcia Barroso C, Sánchez Arias J, Rabal O, Pérez González M, Mederos S, et al. A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice. Neuropsychopharmacology. 2017;42:524-539 pubmed publisher
Chaves R, Kazi A, Silva C, Almeida M, Lima R, Carrettiero D, et al. Presence of insoluble Tau following rotenone exposure ameliorates basic pathways associated with neurodegeneration. IBRO Rep. 2016;1:32-45 pubmed publisher
Zhang J, Michel U, Lenz C, Friedel C, Köster S, D Hedouville Z, et al. Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration. Sci Rep. 2016;6:37050 pubmed publisher
McInnis C, Bonthuis P, Rissman E, Park J. Inheritance of steroid-independent male sexual behavior in male offspring of B6D2F1 mice. Horm Behav. 2016;80:132-138 pubmed publisher
Kajabadi N, Ghoochani A, Peymani M, Ghaedi K, Kiani Esfahani A, Hashemi M, et al. The Synergistic Enhancement of Cloning Efficiency in Individualized Human Pluripotent Stem Cells by Peroxisome Proliferative-activated Receptor-γ (PPARγ) Activation and Rho-associated Kinase (ROCK) Inhibition. J Biol Chem. 2015;290:26303-13 pubmed publisher
Adwan L, Subaiea G, Basha R, Zawia N. Tolfenamic acid reduces tau and CDK5 levels: implications for dementia and tauopathies. J Neurochem. 2015;133:266-72 pubmed publisher
Chiu M, Yang S, Horng H, Yang C, Chen T, Chieh J, et al. Combined plasma biomarkers for diagnosing mild cognition impairment and Alzheimer's disease. ACS Chem Neurosci. 2013;4:1530-6 pubmed publisher
Bharadwaj P, McInnis C, Madden A, Bonthuis P, Zup S, Rissman E, et al. Increased dendritic spine density and tau expression are associated with individual differences in steroidal regulation of male sexual behavior. PLoS ONE. 2013;8:e69672 pubmed publisher
Corredor R, Trakhtenberg E, Pita Thomas W, Jin X, Hu Y, Goldberg J. Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth. J Neurosci. 2012;32:7734-44 pubmed publisher
Green M, Scott J, Steel R, Oakhill J, Kemp B, Means A. Ca2+/Calmodulin-dependent protein kinase kinase beta is regulated by multisite phosphorylation. J Biol Chem. 2011;286:28066-79 pubmed publisher
Zhukareva V, Shah K, Uryu K, Braak H, Del Tredici K, Sundarraj S, et al. Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease : a comparative study. Am J Pathol. 2002;161:1135-41 pubmed
Mawal Dewan M, Henley J, Van De Voorde A, Trojanowski J, Lee V. The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases. J Biol Chem. 1994;269:30981-7 pubmed
product information
Catalog Number :
T9450
Product Name :
Anti-Tau antibody, Mouse monoclonal
Product Type :
ANTIBODIES - SIAL
Product Group :
Protein & Pathway Technologies
Clonality :
monoclonal
Conjugation :
unconjugated
Clone Name :
Tau46
Isotype :
IgG1
Product Description :
clone Tau46, purified from hybridoma cell culture
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA