This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Topoisomerase I human
catalog :
T9069
citations: 53
Reference
Bocquet N, Bizard A, Abdulrahman W, Larsen N, Faty M, Cavadini S, et al. Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase III? and RMI1. Nat Struct Mol Biol. 2014;21:261-8 pubmed publisher
Yang Y, McBride K, Hensley S, Lu Y, Chedin F, Bedford M. Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Mol Cell. 2014;53:484-97 pubmed publisher
Jamroze A, Perugino G, Valenti A, Rashid N, Rossi M, Akhtar M, et al. The reverse gyrase from Pyrobaculum calidifontis, a novel extremely thermophilic DNA topoisomerase endowed with DNA unwinding and annealing activities. J Biol Chem. 2014;289:3231-43 pubmed publisher
Alagoz M, Wells O, El Khamisy S. TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. Nucleic Acids Res. 2014;42:3089-103 pubmed publisher
Minchew C, Didenko V. Selective transport of cationized fluorescent topoisomerase into nuclei of live cells for DNA damage studies. Methods Mol Biol. 2014;1094:167-75 pubmed publisher
Asano Y, Sato S. Animal models of scleroderma: current state and recent development. Curr Rheumatol Rep. 2013;15:382 pubmed publisher
Saha S, Mukherjee T, Chowdhury S, Mishra A, Chowdhury S, Jaisankar P, et al. The lignan glycosides lyoniside and saracoside poison the unusual type IB topoisomerase of Leishmania donovani and kill the parasite both in vitro and in vivo. Biochem Pharmacol. 2013;86:1673-87 pubmed publisher
Saikia N, Deka R. Ab initio study on the noncovalent adsorption of camptothecin anticancer drug onto graphene, defect modified graphene and graphene oxide. J Comput Aided Mol Des. 2013;27:807-21 pubmed publisher
Guo W, Dong G, Zhu L, Liu W, Zhuang C, Guo Z, et al. Synthesis and biological assays of 9-(acylamino) homocamptothecins as DNA topoisomerase I inhibitors. Chem Biodivers. 2013;10:1804-15 pubmed publisher
Negri F, Azzoni C, Bottarelli L, Campanini N, Mandolesi A, Wotherspoon A, et al. Thymidylate synthase, topoisomerase-1 and microsatellite instability: relationship with outcome in mucinous colorectal cancer treated with fluorouracil. Anticancer Res. 2013;33:4611-7 pubmed
Meng J, Xu J, Qin D, He Y, Xiao X, Wang F. Genetic and functional properties of uncultivated MCG archaea assessed by metagenome and gene expression analyses. ISME J. 2014;8:650-9 pubmed publisher
Pradhan A, Singh T, Ali A, Wahengbam K, Meetei A. Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III ?-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation. J Biol Chem. 2013;288:33500-8 pubmed publisher
Christodoulou M, Sacchetti A, Ronchetti V, Caufin S, Silvani A, Lesma G, et al. Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins. Bioorg Med Chem. 2013;21:6920-8 pubmed publisher
D Annessa I, Tesauro C, Wang Z, Arnò B, Zuccaro L, Fiorani P, et al. The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation. Biochim Biophys Acta. 2013;1834:2712-21 pubmed publisher
Lee C, Chang D, Huang K, Chen C, Chen T, Lo Y, et al. Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase I inhibitory properties. Bioorg Med Chem. 2013;21:7125-33 pubmed publisher
Saw J, Curtis D, Hussey D, Dobrovic A, Aplan P, Slape C. The fusion partner specifies the oncogenic potential of NUP98 fusion proteins. Leuk Res. 2013;37:1668-73 pubmed publisher
Carballeira N, Montano N, Alvarez Velilla R, Prada C, Reguera R, Balaña Fouce R. Synthesis of marine α-methoxylated fatty acid analogs that effectively inhibit the topoisomerase IB from Leishmania donovani with a mechanism different from that of camptothecin. Mar Drugs. 2013;11:3661-75 pubmed publisher
Miao Z, Zhu L, Dong G, Zhuang C, Wu Y, Wang S, et al. A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors. J Med Chem. 2013;56:7902-10 pubmed publisher
Dejosez M, Ura H, Brandt V, Zwaka T. Safeguards for cell cooperation in mouse embryogenesis shown by genome-wide cheater screen. Science. 2013;341:1511-4 pubmed publisher
Acevedo Morantes C, Acevedo Morantes M, Suleiman Rosado D, RAMIREZ VICK J. Evaluation of the cytotoxic effect of camptothecin solid lipid nanoparticles on MCF7 cells. Drug Deliv. 2013;20:338-48 pubmed publisher
Prada C, Alvarez Velilla R, Díaz Gozález R, Pérez Pertejo Y, Balaña Fouce R, Reguera R. Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB. PLoS ONE. 2013;8:e73565 pubmed publisher
Siu F, Pommier Y. Sequence selectivity of the cleavage sites induced by topoisomerase I inhibitors: a molecular dynamics study. Nucleic Acids Res. 2013;41:10010-9 pubmed publisher
Malkki H. Genetics: RNA topoisomerase involved in neurodevelopmental disorders. Nat Rev Neurol. 2013;9:542 pubmed publisher
Lee S, Siaw G, Willcox S, Griffith J, Hsieh T. Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases. Proc Natl Acad Sci U S A. 2013;110:E3587-94 pubmed publisher
Coletta A, Desideri A. Role of the protein in the DNA sequence specificity of the cleavage site stabilized by the camptothecin topoisomerase IB inhibitor: a metadynamics study. Nucleic Acids Res. 2013;41:9977-86 pubmed publisher
Kiianitsa K, Maizels N. A rapid and sensitive assay for DNA-protein covalent complexes in living cells. Nucleic Acids Res. 2013;41:e104 pubmed publisher
Norman Axelsson U, Durand Dubief M, Prasad P, Ekwall K. DNA topoisomerase III localizes to centromeres and affects centromeric CENP-A levels in fission yeast. PLoS Genet. 2013;9:e1003371 pubmed publisher
Szafran M, Zakrzewska Czerwinska J, Jakimowicz D. [Bacterial type I topoisomerases - biological function and potential use as targets for antibiotic treatments]. Postepy Hig Med Dosw (Online). 2013;67:130-42 pubmed
Prada C, Alvarez Velilla R, Balaña Fouce R, Prieto C, Calvo Álvarez E, Escudero Martínez J, et al. Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect. Biochem Pharmacol. 2013;85:1433-40 pubmed publisher
Seol Y, Hardin A, Strub M, Charvin G, Neuman K. Comparison of DNA decatenation by Escherichia coli topoisomerase IV and topoisomerase III: implications for non-equilibrium topology simplification. Nucleic Acids Res. 2013;41:4640-9 pubmed publisher
Kouzine F, Gupta A, Baranello L, Wójtowicz D, Ben Aissa K, Liu J, et al. Transcription-dependent dynamic supercoiling is a short-range genomic force. Nat Struct Mol Biol. 2013;20:396-403 pubmed publisher
Naughton C, Avlonitis N, Corless S, Prendergast J, Mati I, Eijk P, et al. Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures. Nat Struct Mol Biol. 2013;20:387-95 pubmed publisher
Calderón Montaño J, Burgos Morón E, Orta M, Pastor N, Pérez Guerrero C, Austin C, et al. Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death. Pharmacol Rep. 2012;64:1515-25 pubmed
Usongo V, Tanguay C, Nolent F, Bessong J, Drolet M. Interplay between type 1A topoisomerases and gyrase in chromosome segregation in Escherichia coli. J Bacteriol. 2013;195:1758-68 pubmed publisher
Berti M, Ray Chaudhuri A, Thangavel S, Gomathinayagam S, Kenig S, Vujanovic M, et al. Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nat Struct Mol Biol. 2013;20:347-54 pubmed publisher
Montariello D, Troiano A, Malanga M, Calabrò V, Quesada P. p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells. Biochem Pharmacol. 2013;85:999-1006 pubmed publisher
Williams J, Smith D, Marjavaara L, Lujan S, Chabes A, Kunkel T. Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA. Mol Cell. 2013;49:1010-5 pubmed publisher
Kim S, Sakchaisri K, Thimmegowda N, N R T, Soung N, Jang J, et al. STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage. PLoS ONE. 2013;8:e53908 pubmed publisher
Barros F, Bezerra D, Ferreira P, Cavalcanti B, Silva T, Pitta M, et al. Inhibition of DNA topoisomerase I activity and induction of apoptosis by thiazacridine derivatives. Toxicol Appl Pharmacol. 2013;268:37-46 pubmed publisher
Yakovleva L, Shuman S. Chemical mutagenesis of vaccinia DNA topoisomerase lysine 167 provides insights to the catalysis of DNA transesterification. Biochemistry. 2013;52:984-91 pubmed publisher
Nanbu T, Takahashi K, Murray J, Hirata N, Ukimori S, Kanke M, et al. Fission yeast RecQ helicase Rqh1 is required for the maintenance of circular chromosomes. Mol Cell Biol. 2013;33:1175-87 pubmed publisher
Pfister T, Hollingshead M, Kinders R, Zhang Y, Evrard Y, JI J, et al. Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues. PLoS ONE. 2012;7:e50494 pubmed publisher
Esselen M, Barth S, Winkler S, Baechler S, Briviba K, Watzl B, et al. Anthocyanins suppress the cleavable complex formation by irinotecan and diminish its DNA-strand-breaking activity in the colon of Wistar rats. Carcinogenesis. 2013;34:835-40 pubmed publisher
Chang C, Wang Y, Chen S, Wu C, Chan N. New insights into DNA-binding by type IIA topoisomerases. Curr Opin Struct Biol. 2013;23:125-33 pubmed publisher
Castelli S, Vieira S, D Annessa I, Katkar P, Musso L, Dallavalle S, et al. A derivative of the natural compound kakuol affects DNA relaxation of topoisomerase IB inhibiting the cleavage reaction. Arch Biochem Biophys. 2013;530:7-12 pubmed publisher
Conda Sheridan M, Reddy P, Morrell A, Cobb B, Marchand C, Agama K, et al. Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1). J Med Chem. 2013;56:182-200 pubmed publisher
Cinelli M, Reddy P, Lv P, Liang J, Chen L, Agama K, et al. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I . J Med Chem. 2012;55:10844-62 pubmed publisher
Bar J, Grelewski P, Noga L, Rabczynski J, Grybos M, Jeleń M. The association between the p53/topoisomerase I and p53/ topoisomerase IIalpha immunophenotypes and the progression of ovarian carcinomas. Adv Clin Exp Med. 2012;21:35-42 pubmed
Rudolph M, del Toro Duany Y, Jungblut S, Ganguly A, Klostermeier D. Crystal structures of Thermotoga maritima reverse gyrase: inferences for the mechanism of positive DNA supercoiling. Nucleic Acids Res. 2013;41:1058-70 pubmed publisher
Zhi X, Leng F. Dependence of transcription-coupled DNA supercoiling on promoter strength in Escherichia coli topoisomerase I deficient strains. Gene. 2013;514:82-90 pubmed publisher
Yoo B, Berezkin A, Wang Y, Zagryazhskaya A, Rosen K. Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells. Int J Cancer. 2012;131:357-66 pubmed publisher
Lisby M, Olesen J, Skouboe C, Krogh B, Straub T, Boege F, et al. Residues within the N-terminal domain of human topoisomerase I play a direct role in relaxation. J Biol Chem. 2001;276:20220-7 pubmed
Gellert M. DNA topoisomerases. Annu Rev Biochem. 1981;50:879-910 pubmed
product information
Catalog Number :
T9069
Product Name :
Topoisomerase I human
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
buffered aqueous glycerol solution, ?2 units/?L
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA