This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Thapsigargin
catalog :
T9033
citations: 1109
Reference
Yang X, Guo Q, Feng T, Lu Q, Ge L, Pan J, et al. IL13Rα1 protects against rheumatoid arthritis by combating the apoptotic resistance of fibroblast-like synoviocytes. Arthritis Res Ther. 2020;22:184 pubmed publisher
Leite N, Sintov E, Meissner T, Brehm M, Greiner D, Harlan D, et al. Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells. Cell Rep. 2020;32:107894 pubmed publisher
Park H, Shin D, Sim J, Aum S, Lee M. IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin. Sci Adv. 2020;6:eaax9914 pubmed publisher
Saini N, Sarin A. Nucleolar localization of the Notch4 intracellular domain underpins its regulation of the cellular response to genotoxic stressors. Cell Death Discov. 2020;6:7 pubmed publisher
Sarcinelli C, Dragic H, Piecyk M, Barbet V, Duret C, Barthelaix A, et al. ATF4-Dependent NRF2 Transcriptional Regulation Promotes Antioxidant Protection during Endoplasmic Reticulum Stress. Cancers (Basel). 2020;12: pubmed publisher
Xiong Y, Yin Q, Jin E, Chen H, He S. Selenium Attenuates Chronic Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in Mouse Granulosa Cells. Molecules. 2020;25: pubmed publisher
Chen Y, Mains R, Eipper B, Hoffman B, Czyzyk T, Pintar J, et al. PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice. Diabetologia. 2020;63:561-576 pubmed publisher
Mishra R, Amanullah A, Upadhyay A, Dhiman R, Dubey A, Singh S, et al. Ubiquitin ligase LRSAM1 suppresses neurodegenerative diseases linked aberrant proteins induced cell death. Int J Biochem Cell Biol. 2020;120:105697 pubmed publisher
Liu Y, Tao S, Liao L, Li Y, Li H, Li Z, et al. TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. Nat Commun. 2020;11:348 pubmed publisher
McDonough C, Bernhardt M, Williams C. Mouse strain-dependent egg factors regulate calcium signals at fertilization. Mol Reprod Dev. 2020;87:284-292 pubmed publisher
Abbasian N, Millington Burgess S, Chabra S, Malcor J, Harper M. Supramaximal calcium signaling triggers procoagulant platelet formation. Blood Adv. 2020;4:154-164 pubmed publisher
Shen T, Li Y, Chen Z, Liang S, Qiu Y, Zhu L, et al. Activating transcription factor 6 (ATF6) negatively regulates Polo-like kinase 4 expression via recruiting C/EBPβ to the upstream-promoter during ER stress. Biochim Biophys Acta Gene Regul Mech. 2020;1863:194488 pubmed publisher
Matsuhisa K, Saito A, Cai L, Kaneko M, Okamoto T, Sakaue F, et al. Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis. FASEB J. 2020;34:865-880 pubmed publisher
Larpin Y, Besançon H, Iacovache M, Babiychuk V, Babiychuk E, Zuber B, et al. Bacterial pore-forming toxin pneumolysin: Cell membrane structure and microvesicle shedding capacity determines differential survival of cell types. FASEB J. 2020;34:1665-1678 pubmed publisher
Zhang W, Sakoda H, Nakazato M. Neuromedin U suppresses insulin secretion by triggering mitochondrial dysfunction and endoplasmic reticulum stress in pancreatic β-cells. FASEB J. 2020;34:133-147 pubmed publisher
Kim D, Hogan J, White C. Ca2+ oscillations in rat carotid body type 1 cells in normoxia and hypoxia. Am J Physiol Cell Physiol. 2020;318:C430-C438 pubmed publisher
Rembetski B, Sanders K, Drumm B. Contribution of Cav1.2 Ca2+ channels and store-operated Ca2+ entry to pig urethral smooth muscle contraction. Am J Physiol Renal Physiol. 2020;318:F496-F505 pubmed publisher
Funsten J, Murillo Brizuela K, Swatzel H, Ward A, Scott T, Eikenbusch S, et al. PKC signaling contributes to chromatin decondensation and is required for competence to respond to IL-2 during T cell activation. Cell Immunol. 2020;347:104027 pubmed publisher
Zou H, Wang T, Yuan J, Sun J, Yuan Y, Gu J, et al. Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes. Toxicol Lett. 2020;321:32-43 pubmed publisher
Clark E, Nonarath H, Bostrom J, Link B. Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease. Dis Model Mech. 2020;13: pubmed publisher
Ye L, Zeng Q, Dai H, Zhang W, Wang X, Ma R, et al. Endoplasmic reticulum stress is involved in ventilator-induced lung injury in mice via the IRE1α-TRAF2-NF-κB pathway. Int Immunopharmacol. 2020;78:106069 pubmed publisher
Obiedat A, Charpak Amikam Y, Tai Schmiedel J, Seidel E, Mahameed M, Avril T, et al. The integrated stress response promotes B7H6 expression. J Mol Med (Berl). 2020;98:135-148 pubmed publisher
Lee S, Lee M, Jeong S, Qin X, Lee A, Park H, et al. The inactivation domain of STIM1 acts through intramolecular binding to the coiled-coil domain in the resting state. J Cell Sci. 2020;133: pubmed publisher
De la Cruz L, TRAYNOR KAPLAN A, Vivas O, Hille B, Jensen J. Plasma membrane processes are differentially regulated by type I phosphatidylinositol phosphate 5-kinases and RASSF4. J Cell Sci. 2020;133: pubmed publisher
Cardner M, Yalcınkaya M, Goetze S, Luca E, Balaz M, Hunjadi M, et al. Structure-function relationships of HDL in diabetes and coronary heart disease. JCI Insight. 2020;5: pubmed publisher
Schulien I, Hockenjos B, Van Marck V, Ayata C, Follo M, Thimme R, et al. Extracellular ATP and Purinergic P2Y2 Receptor Signaling Promote Liver Tumorigenesis in Mice by Exacerbating DNA Damage. Cancer Res. 2020;80:699-708 pubmed publisher
Qin X, Liu L, Lee S, Alsina A, Liu T, Wu C, et al. Increased Confinement and Polydispersity of STIM1 and Orai1 after Ca2+ Store Depletion. Biophys J. 2020;118:70-84 pubmed publisher
Drumm B, Rembetski B, Messersmith K, Manierka M, Baker S, Sanders K. Pacemaker function and neural responsiveness of subserosal interstitial cells of Cajal in the mouse colon. J Physiol. 2020;598:651-681 pubmed publisher
Oshima M, Pechberty S, Bellini L, Gopel S, Campana M, Rouch C, et al. Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity. Diabetologia. 2020;63:395-409 pubmed publisher
Bella P, Farini A, Banfi S, Parolini D, Tonna N, Meregalli M, et al. Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy. EMBO Mol Med. 2020;12:e11019 pubmed publisher
Zhong W, Darmani N. The pivotal role of glycogen synthase kinase 3 (GSK-3) in vomiting evoked by specific emetogens in the least shrew (Cryptotis parva). Neurochem Int. 2020;132:104603 pubmed publisher
Christ W, Tynell J, Klingstrom J. Puumala and Andes Orthohantaviruses Cause Transient Protein Kinase R-Dependent Formation of Stress Granules. J Virol. 2020;94: pubmed publisher
Shu W, Guo Z, Li L, Xiong Z, Wang Z, Yang Y, et al. Regulation of Molecular Chaperone GRP78 by Hepatitis B Virus: Control of Viral Replication and Cell Survival. Mol Cell Biol. 2020;40: pubmed publisher
Dolfini D, Minuzzo M, Sertic S, Mantovani R. NF-YA overexpression protects from glutamine deprivation. Biochim Biophys Acta Mol Cell Res. 2020;1867:118571 pubmed publisher
Miyazawa S, Moriya S, Kokuba H, Hino H, Takano N, Miyazawa K. Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines. Breast Cancer. 2020;27:225-235 pubmed publisher
Van Ziel A, Wolzak K, Nölle A, Hoetjes P, Berenjeno Correa E, van Anken E, et al. No evidence for cell-to-cell transmission of the unfolded protein response in cell culture. J Neurochem. 2020;152:208-220 pubmed publisher
Stewart T, Azimi I, Marcial D, Peters A, Chalmers S, Yapa K, et al. Differential engagement of ORAI1 and TRPC1 in the induction of vimentin expression by different stimuli. Lab Invest. 2020;100:224-233 pubmed publisher
Dráberová L, Draberova H, Potůčková L, Hálová I, Bambousková M, Mohandas N, et al. Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells. Front Immunol. 2019;10:3068 pubmed publisher
Vajente N, Norante R, Redolfi N, Daga A, Pizzo P, Pendin D. Microtubules Stabilization by Mutant Spastin Affects ER Morphology and Ca2+ Handling. Front Physiol. 2019;10:1544 pubmed publisher
Kikuta S, Iguchi Y, Kakizaki T, Kobayashi K, Yanagawa Y, Takada M, et al. Store-Operated Calcium Channels Are Involved in Spontaneous Slow Calcium Oscillations in Striatal Neurons. Front Cell Neurosci. 2019;13:547 pubmed publisher
Harlen K, Roush E, Clayton J, Martinka S, Hughes T. Live-Cell Assays for Cell Stress Responses Reveal New Patterns of Cell Signaling Caused by Mutations in Rhodopsin, α-Synuclein and TDP-43. Front Cell Neurosci. 2019;13:535 pubmed publisher
Kakinoki A, Kameo T, Yamashita S, Furuta K, Tanaka S. Establishment and Characterization of a Murine Mucosal Mast Cell Culture Model. Int J Mol Sci. 2019;21: pubmed publisher
Taverner W, Jacobus E, Christianson J, Champion B, Paton A, Paton J, et al. Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKCα Activation. Mol Ther Oncolytics. 2019;15:117-130 pubmed publisher
Jin S, Lee G, Pham H, Choi J, Jeong H. Polyhexamethylene Guanidine Phosphate Damages Tight Junctions and the F-Actin Architecture by Activating Calpain-1 via the P2RX7/Ca2+ Signaling Pathway. Cells. 2019;9: pubmed publisher
Stoyas C, Bushart D, Switonski P, Ward J, Alaghatta A, Tang M, et al. Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7. Neuron. 2019;: pubmed publisher
Stevens A, Xiang M, Heppler L, Tošić I, Jiang K, Munoz J, et al. Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation. Blood Adv. 2019;3:4215-4227 pubmed publisher
Fukushima T, Tanaka Y, Hamey F, Chang C, Oki T, Asada S, et al. Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium. Cell Rep. 2019;29:4144-4158.e7 pubmed publisher
Harvey R, Pöyry T, Stoneley M, Willis A. Signaling from mTOR to eIF2α mediates cell migration in response to the chemotherapeutic doxorubicin. Sci Signal. 2019;12: pubmed publisher
Lee D, Hokinson D, Park S, Elvira R, Kusuma F, Lee J, et al. ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α. Int J Mol Sci. 2019;20: pubmed publisher
Alansary D, Peckys D, Niemeyer B, de Jonge N. Detecting single ORAI1 proteins within the plasma membrane reveals higher order channel complexes. J Cell Sci. 2019;: pubmed publisher
Gokhale N, McIntyre A, Mattocks M, Holley C, Lazear H, Mason C, et al. Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection. Mol Cell. 2019;: pubmed publisher
Stein B, Calzolari D, Hellberg K, Hu Y, He L, Hung C, et al. Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks. Cell Rep. 2019;29:3331-3348.e7 pubmed publisher
Ye L, Mueller O, Bagwell J, Bagnat M, Liddle R, Rawls J. High fat diet induces microbiota-dependent silencing of enteroendocrine cells. elife. 2019;8: pubmed publisher
Johnston B, Pringle E, McCormick C. KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication. PLoS Pathog. 2019;15:e1008185 pubmed publisher
Song J, Chen M, Li Z, Zhang J, Hu H, Tong X, et al. Astragalus Polysaccharide Extends Lifespan via Mitigating Endoplasmic Reticulum Stress in the Silkworm, Bombyx mori. Aging Dis. 2019;10:1187-1198 pubmed publisher
Kobayashi T, Piao W, Takamura T, Kori H, Miyachi H, Kitano S, et al. Enhanced lysosomal degradation maintains the quiescent state of neural stem cells. Nat Commun. 2019;10:5446 pubmed publisher
Li J, Song M, Moh S, Kim H, Kim D. Cytoplasmic Restriction of Mutated SOD1 Impairs the DNA Repair Process in Spinal Cord Neurons. Cells. 2019;8: pubmed publisher
Malintan N, Buckingham S, Lomas D, Sattelle D. Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin. Sci Rep. 2019;9:17293 pubmed publisher
Wang Y, Sherrard A, Zhao B, Melak M, Trautwein J, Kleinschnitz E, et al. GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics. Nat Commun. 2019;10:5271 pubmed publisher
Gao P, Chai Y, Song J, Liu T, Chen P, Zhou L, et al. Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus. PLoS Pathog. 2019;15:e1008169 pubmed publisher
Kashiwagi S, Fujioka Y, Kondo T, Satoh A, Yoshida A, Fujioka M, et al. Localization of BCR-ABL to Stress Granules Contributes to Its Oncogenic Function. Cell Struct Funct. 2019;44:195-204 pubmed publisher
Price J, Russo D, Ji D, Chavez R, DiPeso L, Lee A, et al. IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila. MBio. 2019;10: pubmed publisher
Lu A, Chu C, Mulvihill E, Wang R, Liang W. ATP-sensitive K+ channels and mitochondrial permeability transition pore mediate effects of hydrogen sulfide on cytosolic Ca2+ homeostasis and insulin secretion in β-cells. Pflugers Arch. 2019;471:1551-1564 pubmed publisher
He S, Wu W, Wan Y, Nandakumar K, Cai X, Tang X, et al. GLP-1 Receptor Activation Abrogates β-Cell Dysfunction by PKA Cα-Mediated Degradation of Thioredoxin Interacting Protein. Front Pharmacol. 2019;10:1230 pubmed publisher
Kim J, Kaufman R, Back S, Moon J. Development of a Reporter System Monitoring Regulated Intramembrane Proteolysis of the Transmembrane bZIP Transcription Factor ATF6α. Mol Cells. 2019;42:783-793 pubmed publisher
Sperduti S, Limoncella S, Lazzaretti C, Paradiso E, Riccetti L, Turchi S, et al. GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors. Int J Mol Sci. 2019;20: pubmed publisher
Habib P, Stamm A, Schulz J, Reich A, Slowik A, Capellmann S, et al. EPO and TMBIM3/GRINA Promote the Activation of the Adaptive Arm and Counteract the Terminal Arm of the Unfolded Protein Response after Murine Transient Cerebral Ischemia. Int J Mol Sci. 2019;20: pubmed publisher
Li H, Seo M, An J, Jung H, Ha K, Han E, et al. Dipeptidyl peptidase-4 inhibitor sitagliptin induces vasorelaxation via the activation of Kv channels and PKA. Toxicol Appl Pharmacol. 2019;384:114799 pubmed publisher
Kumar S, O Malley J, Chaudhary A, Inigo J, Yadav N, Kumar R, et al. Hsp60 and IL-8 axis promotes apoptosis resistance in cancer. Br J Cancer. 2019;121:934-943 pubmed publisher
Moore P, Qi J, Thamsen M, Ghosh R, Peng J, Gliedt M, et al. Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Cancer Res. 2019;79:6190-6203 pubmed publisher
Grune T, Ott C, Häseli S, Höhn A, Jung T. The "MYOCYTER" - Convert cellular and cardiac contractions into numbers with ImageJ. Sci Rep. 2019;9:15112 pubmed publisher
Ko P, Woodrow C, Dubreuil M, Martin B, Skouta R, Bassik M, et al. A ZDHHC5-GOLGA7 Protein Acyltransferase Complex Promotes Nonapoptotic Cell Death. Cell Chem Biol. 2019;26:1716-1724.e9 pubmed publisher
Itzhak D, Sacco F, Nagaraj N, Tyanova S, Mann M, Murgia M. SILAC-based quantitative proteomics using mass spectrometry quantifies endoplasmic reticulum stress in whole HeLa cells. Dis Model Mech. 2019;12: pubmed publisher
Fu D, Li P, Sheng Q, Lv Z. β-arrestin-2 enhances intestinal epithelial apoptosis in necrotizing enterocolitis. Aging (Albany NY). 2019;11:8294-8312 pubmed publisher
Denu R, Kaur G, Sass M, Lakkaraju A, Burkard M. Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition. Mol Cancer Res. 2019;: pubmed publisher
Tao T, Wang J, Wang X, Wang Y, Mao H, Liu X. The PERK/Nrf2 pathway mediates endoplasmic reticulum stress-induced injury by upregulating endoplasmic reticulophagy in H9c2 cardiomyoblasts. Life Sci. 2019;237:116944 pubmed publisher
Oh S, Lee J, Kim H, Lee J, Han S, Bae J, et al. Ultrasonic Neuromodulation via Astrocytic TRPA1. Curr Biol. 2019;29:3386-3401.e8 pubmed publisher
Nardin C, Peres C, Mazzarda F, Ziraldo G, Salvatore A, Mammano F. Photosensitizer Activation Drives Apoptosis by Interorganellar Ca2+ Transfer and Superoxide Production in Bystander Cancer Cells. Cells. 2019;8: pubmed publisher
Cui Y, Li X, Zeljic K, Shan S, Qiu Z, Wang Z. Effect of PEGylated Magnetic PLGA-PEI Nanoparticles on Primary Hippocampal Neurons: Reduced Nanoneurotoxicity and Enhanced Transfection Efficiency with Magnetofection. ACS Appl Mater Interfaces. 2019;11:38190-38204 pubmed publisher
Vo D, Hartig R, Weinert S, Haybaeck J, Nass N. G-Protein-Coupled Estrogen Receptor (GPER)-Specific Agonist G1 Induces ER Stress Leading to Cell Death in MCF-7 Cells. Biomolecules. 2019;9: pubmed publisher
Kruglova N, Filatov A. T cell receptor signaling results in ERK-dependent Ser163 phosphorylation of lymphocyte phosphatase-associated phosphoprotein. Biochem Biophys Res Commun. 2019;519:559-565 pubmed publisher
Merola J, Reschke M, Pierce R, Qin L, Spindler S, Baltazar T, et al. Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression. JCI Insight. 2019;4: pubmed publisher
Park Y, Kim D, Kim H, Lee D, Lee M, Min K, et al. WZ3146 inhibits mast cell Lyn and Fyn to reduce IgE-mediated allergic responses in vitro and in vivo. Toxicol Appl Pharmacol. 2019;383:114763 pubmed publisher
Thekkinghat A, Yadav K, Rangarajan P. Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution. Biol Open. 2019;8: pubmed publisher
Escoula Q, Bellenger S, Narce M, Bellenger J. Docosahexaenoic and Eicosapentaenoic Acids Prevent Altered-Muc2 Secretion Induced by Palmitic Acid by Alleviating Endoplasmic Reticulum Stress in LS174T Goblet Cells. Nutrients. 2019;11: pubmed publisher
Yong J, Bischof H, Burgstaller S, Siirin M, Murphy A, Malli R, et al. Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2. elife. 2019;8: pubmed publisher
Rohde C, Becker S, Krähling V. Marburg virus regulates the IRE1/XBP1-dependent unfolded protein response to ensure efficient viral replication. Emerg Microbes Infect. 2019;8:1300-1313 pubmed publisher
Leu Y, Chen Y, Chen C, Huang H. Induction of Autophagic Death of Human Hepatocellular Carcinoma Cells by Armillaridin from Armillaria mellea. Am J Chin Med. 2019;47:1365-1380 pubmed publisher
Makarenko V, Peng Y, Khan S, Nanduri J, Fox A, Prabhakar N. Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia. J Neurophysiol. 2019;122:1874-1883 pubmed publisher
Zhang H, Alsaleh G, Feltham J, Sun Y, Napolitano G, Riffelmacher T, et al. Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. Mol Cell. 2019;76:110-125.e9 pubmed publisher
Roca F, Whitworth L, Redmond S, Jones A, Ramakrishnan L. TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit. Cell. 2019;178:1344-1361.e11 pubmed publisher
Nishikawa S, Itoh Y, Tokugawa M, Inoue Y, Nakashima K, Hori Y, et al. Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation. Molecules. 2019;24: pubmed publisher
Dér B, Molnár P, Ruisanchez E, Orsy P, Kerék M, Farago B, et al. NK2 receptor-mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent Ca2+ channels and the RhoA-Rho kinase pathway. Am J Physiol Renal Physiol. 2019;317:F1154-F1163 pubmed publisher
Falcón Moya R, Losada Ruiz P, Rodríguez Moreno A. Kainate Receptor-Mediated Depression of Glutamate Release Involves Protein Kinase A in the Cerebellum. Int J Mol Sci. 2019;20: pubmed publisher
Song M, Peng H, Guo W, Luo M, Duan W, Chen P, et al. Cigarette Smoke Extract Promotes Human Lung Myofibroblast Differentiation by the Induction of Endoplasmic Reticulum Stress. Respiration. 2019;98:347-356 pubmed publisher
Nakashima A, Cheng S, Kusabiraki T, Motomura K, Aoki A, Ushijima A, et al. Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts. Sci Rep. 2019;9:11466 pubmed publisher
Liu L, Huang X, Yang H, Kuang S, Lian F, Zhang M, et al. Comparison of Ca2+ Handling for the Regulation of Vasoconstriction between Rat Coronary and Renal Arteries. J Vasc Res. 2019;56:191-203 pubmed publisher
Ma K, Liu P, Al Maghout T, Sukkar B, Cao H, Voelkl J, et al. Phosphate-induced ORAI1 expression and store-operated Ca2+ entry in aortic smooth muscle cells. J Mol Med (Berl). 2019;97:1465-1475 pubmed publisher
Estaras M, Ameur F, Roncero V, Fernandez Bermejo M, Blanco G, Lopez D, et al. The melatonin receptor antagonist luzindole induces Ca2+ mobilization, reactive oxygen species generation and impairs trypsin secretion in mouse pancreatic acinar cells. Biochim Biophys Acta Gen Subj. 2019;1863:129407 pubmed publisher
Nelson M, Parker B, Burchfield J, Hoffman N, Needham E, Cooke K, et al. Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry. EMBO J. 2019;38:e102578 pubmed publisher
Ji C, Kim H, Heo A, Lee S, Lee M, Kim S, et al. The N-Degron Pathway Mediates ER-phagy. Mol Cell. 2019;75:1058-1072.e9 pubmed publisher
Harnoss J, Le Thomas A, Shemorry A, Marsters S, Lawrence D, Lu M, et al. Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proc Natl Acad Sci U S A. 2019;116:16420-16429 pubmed publisher
Takeda K, Nagashima S, Shiiba I, Uda A, Tokuyama T, Ito N, et al. MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites. EMBO J. 2019;38:e100999 pubmed publisher
Moriguchi M, Watanabe T, Fujimuro M. Capsaicin Induces ATF4 Translation with Upregulation of CHOP, GADD34 and PUMA. Biol Pharm Bull. 2019;42:1428-1432 pubmed publisher
Dvela Levitt M, Kost Alimova M, Emani M, Kohnert E, Thompson R, Sidhom E, et al. Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Cell. 2019;178:521-535.e23 pubmed publisher
Tedeschi V, Petrozziello T, Sisalli M, Boscia F, Canzoniero L, Secondo A. The activation of Mucolipin TRP channel 1 (TRPML1) protects motor neurons from L-BMAA neurotoxicity by promoting autophagic clearance. Sci Rep. 2019;9:10743 pubmed publisher
Akhter M, Uddin M, Barabutis N. Unfolded protein response regulates P53 expression in the pulmonary endothelium. J Biochem Mol Toxicol. 2019;33:e22380 pubmed publisher
Salati S, Genovese E, Carretta C, Zini R, Bartalucci N, Prudente Z, et al. Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants. Sci Rep. 2019;9:10558 pubmed publisher
Kawatkar A, Schefter M, Hermansson N, Snijder A, Dekker N, Brown D, et al. CETSA beyond Soluble Targets: a Broad Application to Multipass Transmembrane Proteins. ACS Chem Biol. 2019;14:1913-1920 pubmed publisher
Shin G, Moon S, Kang H, Choi H, Han H, Kim K. PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway. Nat Commun. 2019;10:3185 pubmed publisher
Mirvis M, Siemers K, Nelson W, Stearns T. Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding. PLoS Biol. 2019;17:e3000381 pubmed publisher
Bartoszewska S, Cabaj A, Dąbrowski M, Collawn J, Bartoszewski R. miR-34c-5p modulates X-box-binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response. FASEB J. 2019;33:11541-11554 pubmed publisher
Pällmann N, Livgård M, Tesikova M, Zeynep Nenseth H, Akkus E, Sikkeland J, et al. Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer. Oncogene. 2019;38:6301-6318 pubmed publisher
Jaña F, Bustos G, Rivas J, Cruz P, Urra F, Basualto Alarcón C, et al. Complex I and II are required for normal mitochondrial Ca2+ homeostasis. Mitochondrion. 2019;49:73-82 pubmed publisher
Ávila Pérez G, Diaz Beneitez E, Cubas Gaona L, Nieves Molina G, Rodríguez J, Rodriguez J, et al. Activation of the autophagy pathway by Torovirus infection is irrelevant for virus replication. PLoS ONE. 2019;14:e0219428 pubmed publisher
Grossmann D, Berenguer Escuder C, Bellet M, Scheibner D, Bohler J, Massart F, et al. Mutations in RHOT1 Disrupt Endoplasmic Reticulum-Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease. Antioxid Redox Signal. 2019;31:1213-1234 pubmed publisher
Mitchell S, Mercado E, Adelaja A, Ho J, Cheng Q, Ghosh G, et al. An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms. Front Immunol. 2019;10:1425 pubmed publisher
Mishra N, Schwerdtner L, Sams K, Mondal S, Ahmad F, Schmidt R, et al. Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1β Maturation and ASC Speck Formation in Macrophages. J Immunol. 2019;203:795-800 pubmed publisher
Oh hashi K, Takahashi K, Hirata Y. Regulation of the ER-bound transcription factor Luman/CREB3 in HEK293 cells. FEBS Lett. 2019;: pubmed publisher
Herrmann A, Wüllner V, Moos S, Graf J, Chen J, Kieseier B, et al. Dimethyl fumarate alters intracellular Ca2+ handling in immune cells by redox-mediated pleiotropic effects. Free Radic Biol Med. 2019;141:338-347 pubmed publisher
Wang X, Peng P, Pan Z, Fang Z, Lu W, Liu X. Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells. Biol Res. 2019;52:34 pubmed publisher
Liu K, Chen P, Lu J, Zhu Y, Xu Y, Liu Y, et al. Protective Effect of Purple Tomato Anthocyanidin on Chromium(VI)-Induced Autophagy in LMH Cells by Inhibiting Endoplasmic Reticulum Stress. Biol Trace Elem Res. 2019;: pubmed publisher
Tian X, Zheng P, Zhou C, Wang X, Ma H, Ma W, et al. DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B. Autophagy. 2019;:1-14 pubmed publisher
Liu Y, Zhang H, Men H, Du Y, Xiao Z, Zhang F, et al. Volume-regulated Cl- current: contributions of distinct Cl- channels and localized Ca2+ signals. Am J Physiol Cell Physiol. 2019;317:C466-C480 pubmed publisher
Fujiki T, Ando F, Murakami K, Isobe K, Mori T, Susa K, et al. Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation. Sci Rep. 2019;9:9245 pubmed publisher
Shiou Y, Lin H, Ke L, Wu B, Shin S, Chen C, et al. Very Low-Density Lipoproteins of Metabolic Syndrome Modulates STIM1, Suppresses Store-Operated Calcium Entry, and Deranges Myofilament Proteins in Atrial Myocytes. J Clin Med. 2019;8: pubmed publisher
Saul S, Castelbou C, Fickentscher C, Demaurex N. Signaling and functional competency of neutrophils derived from bone-marrow cells expressing the ER-HOXB8 oncoprotein. J Leukoc Biol. 2019;106:1101-1115 pubmed publisher
Yadav V, Singh P, Sharma D, Singh S, Agarwal V. Mechanism underlying N-(3-oxo-dodecanoyl)-L-homoserine lactone mediated intracellular calcium mobilization in human platelets. Blood Cells Mol Dis. 2019;79:102340 pubmed publisher
Li M, Zhang C, Zong Y, Feng J, Ma T, Hu M, et al. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. Cell Metab. 2019;: pubmed publisher
Youn D, Weon H. Endogenous TRPC channels mediate Ca2+ signals and trigeminal synaptic plasticity induced by mGluR5a. Life Sci. 2019;:116567 pubmed publisher
Paliienko K, Veklich T, Shatursky O, Shkrabak O, Pastukhov A, Galkin M, et al. Membrane action of polyhexamethylene guanidine hydrochloride revealed on smooth muscle cells, nerve tissue and rat blood platelets: A biocide driven pore-formation in phospholipid bilayers. Toxicol In Vitro. 2019;: pubmed publisher
Favaro G, Romanello V, Varanita T, Andrea Desbats M, Morbidoni V, Tezze C, et al. DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass. Nat Commun. 2019;10:2576 pubmed publisher
Mehta N, Gava A, Zhang D, Gao B, Krepinsky J. Follistatin Protects against Glomerular Mesangial Cell Apoptosis and Oxidative Stress to Ameliorate Chronic Kidney Disease. Antioxid Redox Signal. 2019;: pubmed publisher
Lee J, Hong S, Kwon H, Park S, Rhee E, Park C, et al. Resveratrol, an activator of SIRT1, improves ER stress by increasing clusterin expression in HepG2 cells. Cell Stress Chaperones. 2019;: pubmed publisher
Shimomura T, Kubo Y. Phosphoinositides modulate the voltage dependence of two-pore channel 3. J Gen Physiol. 2019;: pubmed publisher
Ye J, Qi L, Chen K, Li R, Song S, Zhou C, et al. Metformin induces TPC-1 cell apoptosis through endoplasmic reticulum stress-associated pathways in vitro and in vivo. Int J Oncol. 2019;55:331-339 pubmed publisher
Lu J, Zheng Y, Yang J, Zhang J, Cao W, Chen X, et al. Resveratrol alleviates inflammatory injury and enhances the apoptosis of fibroblast‑like synoviocytes via mitochondrial dysfunction and ER stress in rats with adjuvant arthritis. Mol Med Rep. 2019;20:463-472 pubmed publisher
Hong T, Ge Z, Zhang B, Meng R, Zhu D, Bi Y. Erythropoietin suppresses hepatic steatosis and obesity by inhibiting endoplasmic reticulum stress and upregulating fibroblast growth factor 21. Int J Mol Med. 2019;44:469-478 pubmed publisher
Besio R, Garibaldi N, Leoni L, Cipolla L, Sabbioneda S, Biggiogera M, et al. Cellular stress due to impairment of collagen prolyl hydroxylation complex is rescued by the chaperone 4-phenylbutyrate. Dis Model Mech. 2019;: pubmed publisher
Stamm C, Pasko B, Chaisavaneeyakorn S, Franco L, Nair V, Weigele B, et al. Screening Mycobacterium tuberculosis Secreted Proteins Identifies Mpt64 as a Eukaryotic Membrane-Binding Bacterial Effector. mSphere. 2019;4: pubmed publisher
Han S, Mao L, Liao Y, Sun S, Zhang Z, Mo Y, et al. Sec62 Suppresses Foot-and-Mouth Disease Virus Proliferation by Promotion of IRE1α-RIG-I Antiviral Signaling. J Immunol. 2019;: pubmed publisher
Ge C, Xu M, Qin Y, Gu T, Lou D, Li Q, et al. Endoplasmic reticulum stress-induced iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: Intervention of fisetin and metformin. Free Radic Biol Med. 2019;141:67-83 pubmed publisher
Hsu S, Jan C, Liang W. Uncovering malathion (an organophosphate insecticide) action on Ca2+ signal transduction and investigating the effects of BAPTA-AM (a cell-permeant Ca2+ chelator) on protective responses in glial cells. Pestic Biochem Physiol. 2019;157:152-160 pubmed publisher
Medina Navarro R, Torres Ramos Y, Guzman Grenfell A, Díaz Flores M, León Reyes G, Hicks G J. Lysosomal dysfunction induced by changes in albumin's tertiary structure: Potential key factor in protein toxicity during diabetic nephropathy. Life Sci. 2019;230:197-207 pubmed publisher
Truong K, Cherednichenko G, Pessah I. Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1. Toxicol Sci. 2019;170:509-524 pubmed publisher
Duan J, Navarro Dorado J, Clark J, Kinnear N, Meinke P, Schirmer E, et al. The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses. Nat Commun. 2019;10:2299 pubmed publisher
Drumm B, Hwang S, Baker S, Ward S, Sanders K. Ca2+ signalling behaviours of intramuscular interstitial cells of Cajal in the murine colon. J Physiol. 2019;597:3587-3617 pubmed publisher
Wong V, Qiu C, Xu S, Law B, Zeng W, Wang H, et al. Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats. Br J Pharmacol. 2019;176:2922-2944 pubmed publisher
O BRIEN R, Buckley M, Kelliher A, O Malley D. PI 3-kinase- and ERK-MAPK-dependent mechanisms underlie Glucagon-Like Peptide-1-mediated activation of Sprague Dawley colonic myenteric neurons. Neurogastroenterol Motil. 2019;31:e13631 pubmed publisher
Guan G, Yang L, Huang W, Zhang J, Zhang P, Yu H, et al. Mechanism of interactions between endoplasmic reticulum stress and autophagy in hypoxia/reoxygenation‑induced injury of H9c2 cardiomyocytes. Mol Med Rep. 2019;20:350-358 pubmed publisher
Shiki A, Inoh Y, Yokawa S, Furuno T. Inhibition of degranulation in mast cells attached to a hydrogel through defective microtubule tracts. Exp Cell Res. 2019;: pubmed publisher
Mendez J, Kolora L, Lemon J, Dupree S, Keestra Gounder A. Activation of the endoplasmic reticulum stress response impacts the NOD1 signaling pathway. Infect Immun. 2019;: pubmed publisher
Gopal S, Lee Y, Stepanyan R, McDermott B, Alagramam K. Unconventional secretory pathway activation restores hair cell mechanotransduction in an USH3A model. Proc Natl Acad Sci U S A. 2019;116:11000-11009 pubmed publisher
Zavodszky E, Hegde R. Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors. elife. 2019;8: pubmed publisher
Jetta D, Gottlieb P, Verma D, Sachs F, Hua S. Shear stress-induced nuclear shrinkage through activation of Piezo1 channels in epithelial cells. J Cell Sci. 2019;132: pubmed publisher
Ontiveros M, Rinaldi D, Marder M, Espelt M, Mangialavori I, Vigil M, et al. Natural flavonoids inhibit the plasma membrane Ca2+-ATPase. Biochem Pharmacol. 2019;166:1-11 pubmed publisher
Yang Y, Cong H, Du N, Han X, Song L, Zhang W, et al. Mitochondria Redistribution in Enterovirus A71 Infected Cells and Its Effect on Virus Replication. Virol Sin. 2019;: pubmed publisher
Meixiong J, Vasavda C, Snyder S, Dong X. MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus. Proc Natl Acad Sci U S A. 2019;116:10525-10530 pubmed publisher
Kalinski A, Kar A, Craver J, Tosolini A, Sleigh J, Lee S, et al. Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition. J Cell Biol. 2019;218:1871-1890 pubmed publisher
Yu F, Hubrack S, Chakraborty S, Sun L, Alcantara Adap E, Kulkarni R, et al. Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca2+ influx in mitosis. Proc Natl Acad Sci U S A. 2019;116:10392-10401 pubmed publisher
Ota K, Okuma T, Lorenzo A, Yokota A, Hino H, Kazama H, et al. Fingolimod sensitizes EGFR wild‑type non‑small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest. Oncol Rep. 2019;42:231-242 pubmed publisher
Alim I, Caulfield J, Chen Y, Swarup V, Geschwind D, Ivanova E, et al. Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke. Cell. 2019;177:1262-1279.e25 pubmed publisher
Yang G, Ma H, Wu Y, Zhou B, Zhang C, Chai C, et al. Activation of TRPC6 channels contributes to (+)-conocarpan-induced apoptotic cell death in HK-2 cells. Food Chem Toxicol. 2019;129:281-290 pubmed publisher
Zhang L, Xia Q, Zhou Y, Li J. Endoplasmic reticulum stress and autophagy contribute to cadmium-induced cytotoxicity in retinal pigment epithelial cells. Toxicol Lett. 2019;311:105-113 pubmed publisher
Arichi S, Sasaki Hamada S, Kadoya Y, Ogata M, Ishibashi H. Excitatory effect of bradykinin on intrinsic neurons of the rat heart. Neuropeptides. 2019;: pubmed publisher
Koval O, Nguyen E, Santhana V, Fidler T, Sebag S, Rasmussen T, et al. Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation. Sci Signal. 2019;12: pubmed publisher
Maurel M, Obacz J, Avril T, Ding Y, Papadodima O, Treton X, et al. Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation. EMBO Mol Med. 2019;11: pubmed publisher
Lossos C, Liu Y, Kolb K, Christie A, Van Scoyk A, Prakadan S, et al. Mechanisms of lymphoma clearance induced by high-dose alkylating agents. Cancer Discov. 2019;: pubmed publisher
Liu C, Li X, Nan F, Jiang S, Gao X, Guo S, et al. Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity. Cell. 2019;177:865-880.e21 pubmed publisher
Yarapureddy S, Abril J, Foote J, Kumar S, Asad O, Sharath V, et al. ATF6α Activation Enhances Survival against Chemotherapy and Serves as a Prognostic Indicator in Osteosarcoma. Neoplasia. 2019;21:516-532 pubmed publisher
Li Y, Xia Y, Cheng X, Kleiner D, Hewitt S, Sproch J, et al. Hepatitis B Surface Antigen Activates Unfolded Protein Response in Forming Ground Glass Hepatocytes of Chronic Hepatitis B. Viruses. 2019;11: pubmed publisher
Pavez M, Thompson A, Arnott H, Mitchell C, D Atri I, Don E, et al. STIM1 is required for remodelling of the endoplasmic reticulum and microtubule cytoskeleton in steering growth cones. J Neurosci. 2019;: pubmed publisher
Yang Z, Yan H, Dai W, Jing J, Yang Y, Mahajan S, et al. Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1. J Autoimmun. 2019;101:94-108 pubmed publisher
Li Z, Zhou J, Li Y, Yang F, Lian X, Liu W. Mitochondrial TRPC3 promotes cell proliferation by regulating the mitochondrial calcium and metabolism in renal polycystin-2 knockdown cells. Int Urol Nephrol. 2019;51:1059-1070 pubmed publisher
Poulsen K, McMullen M, Huang E, Kibler C, Sheehan M, Leng L, et al. Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response After Ethanol Feeding in Mice. Alcohol Clin Exp Res. 2019;43:1439-1451 pubmed publisher
Wang F, Pulinilkunnil T, Flibotte S, Nislow C, Vlodavsky I, Hussein B, et al. Heparanase protects the heart against chemical or ischemia/reperfusion injury. J Mol Cell Cardiol. 2019;131:29-40 pubmed publisher
Yang G, Wang Y, Yu Y, Zheng J, Chen J, Li S, et al. Schekwanglupaside C, a new lupane saponin from Schefflera kwangsiensis, is a potent activator of sarcoplasmic reticulum Ca2+-ATPase. Fitoterapia. 2019;137:104150 pubmed publisher
Hinze L, Pfirrmann M, Karim S, Degar J, McGuckin C, Vinjamur D, et al. Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 2019;35:664-676.e7 pubmed publisher
Sakurada R, Odagiri K, Hakamata A, Kamiya C, Wei J, Watanabe H. Calcium Release from Endoplasmic Reticulum Involves Calmodulin-Mediated NADPH Oxidase-Derived Reactive Oxygen Species Production in Endothelial Cells. Int J Mol Sci. 2019;20: pubmed publisher
Schulman J, Szczesniak L, Bunker E, Nelson H, Roe M, Wagner L, et al. Bok regulates mitochondrial fusion and morphology. Cell Death Differ. 2019;: pubmed publisher
Rey D, Miranda Sulis P, Alves Fernandes T, Gonçalves R, Silva Frederico M, Costa G, et al. Astragalin augments basal calcium influx and insulin secretion in rat pancreatic islets. Cell Calcium. 2019;80:56-62 pubmed publisher
Li J, Liu C, Li Y, Zheng Q, Xu Y, Liu B, et al. TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling. Nat Commun. 2019;10:1589 pubmed publisher
Malette J, Degrandmaison J, Giguère H, Berthiaume J, Frappier M, Parent J, et al. MURC/CAVIN-4 facilitates store-operated calcium entry in neonatal cardiomyocytes. Biochim Biophys Acta Mol Cell Res. 2019;1866:1249-1259 pubmed publisher
Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, et al. Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice. Nat Commun. 2019;10:1492 pubmed publisher
Luhr M, Torgersen M, Szalai P, Hashim A, Brech A, Staerk J, et al. The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress. J Biol Chem. 2019;294:8197-8217 pubmed publisher
Gualdani R, de Clippele M, Ratbi I, Gailly P, Tajeddine N. Store-Operated Calcium Entry Contributes to Cisplatin-Induced Cell Death in Non-Small Cell Lung Carcinoma. Cancers (Basel). 2019;11: pubmed publisher
Stone S, Abreu D, Mahadevan J, Asada R, Kries K, Graf R, et al. Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells. Sci Rep. 2019;9:5199 pubmed publisher
Lee S, Jeong Y, Yu A, Kwak H, Cha J, Kang I, et al. Carfilzomib enhances cisplatin-induced apoptosis in SK-N-BE(2)-M17 human neuroblastoma cells. Sci Rep. 2019;9:5039 pubmed publisher
McDonough R, Shoga J, Price C. DREADD-based synthetic control of chondrocyte calcium signaling in vitro. J Orthop Res. 2019;37:1518-1529 pubmed publisher
Srinivasan P. Detecting In-Situ oligomerization of engineered STIM1 proteins by diffraction-limited optical imaging. PLoS ONE. 2019;14:e0213655 pubmed publisher
Abdelazeem K, Droppova B, Sukkar B, Al Maghout T, Pelzl L, Zacharopoulou N, et al. Upregulation of Orai1 and STIM1 expression as well as store-operated Ca2+ entry in ovary carcinoma cells by placental growth factor. Biochem Biophys Res Commun. 2019;512:467-472 pubmed publisher
Cao X, He Y, Li X, Xu Y, Liu X. The IRE1α-XBP1 pathway function in hypoxia-induced pulmonary vascular remodeling, is upregulated by quercetin, inhibits apoptosis and partially reverses the effect of quercetin in PASMCs. Am J Transl Res. 2019;11:641-654 pubmed
Bramini M, Chiacchiaretta M, Armirotti A, Rocchi A, Kale D, Martin C, et al. An Increase in Membrane Cholesterol by Graphene Oxide Disrupts Calcium Homeostasis in Primary Astrocytes. Small. 2019;15:e1900147 pubmed publisher
Pickard A, Chang J, Alachkar N, Calverley B, Garva R, Arvan P, et al. Preservation of circadian rhythms by the protein folding chaperone, BiP. FASEB J. 2019;33:7479-7489 pubmed publisher
Munder A, Moskovitz Y, Meir A, Kahremany S, Levy L, Kolitz Domb M, et al. Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions. Medchemcomm. 2019;10:280-293 pubmed publisher
Ouyang Y, Xu L, Lv J, Hou Y, Fan Z, Xu P, et al. Porcine circovirus type 2 ORF5 protein induces endoplasmic reticulum stress and unfolded protein response in porcine alveolar macrophages. Arch Virol. 2019;164:1323-1334 pubmed publisher
Wu C, Hsu W, Tsai M, Chai C, Yen C, Chen C, et al. A potential new approach for treating systemic sclerosis: Dedifferentiation of SSc fibroblasts and change in the microenvironment by blocking store-operated Ca2+ entry. PLoS ONE. 2019;14:e0213400 pubmed publisher
Estaras M, Moreno N, Santofimia Castaño P, Martínez Morcillo S, Roncero V, Blanco G, et al. Melatonin induces reactive oxygen species generation and changes in glutathione levels and reduces viability in human pancreatic stellate cells. J Physiol Biochem. 2019;: pubmed publisher
Drumm B, Rembetski B, Baker S, Sanders K. Tonic inhibition of murine proximal colon is due to nitrergic suppression of Ca2+ signaling in interstitial cells of Cajal. Sci Rep. 2019;9:4402 pubmed publisher
Guan G, Lei L, Lv Q, Gong Y, Yang L. Curcumin attenuates palmitic acid-induced cell apoptosis by inhibiting endoplasmic reticulum stress in H9C2 cardiomyocytes. Hum Exp Toxicol. 2019;38:655-664 pubmed publisher
Subramanian A, Capalbo A, Iyengar N, Rizzo R, Di Campli A, Di Martino R, et al. Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum. Cell. 2019;176:1461-1476.e23 pubmed publisher
Piccolis M, Bond L, Kampmann M, Pulimeno P, Chitraju C, Jayson C, et al. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. Mol Cell. 2019;74:32-44.e8 pubmed publisher
Llinàs Arias P, Rosselló Tortella M, López Serra P, Pérez Salvia M, Setien F, Marin S, et al. Epigenetic loss of the endoplasmic reticulum-associated degradation inhibitor SVIP induces cancer cell metabolic reprogramming. JCI Insight. 2019;5: pubmed publisher
Jung K, Park J, Kim S, Jeon N, Cho S, Hyung S. Optogenetic stimulation promotes Schwann cell proliferation, differentiation, and myelination in vitro. Sci Rep. 2019;9:3487 pubmed publisher
Latour S, Zanese M, Le Morvan V, Vacher A, Menard N, Bijou F, et al. Role of Calcium Signaling in GA101-Induced Cell Death in Malignant Human B Cells. Cancers (Basel). 2019;11: pubmed publisher
Moss S, Taylor I, Ruggero D, Gestwicki J, Shokat K, Mukherjee S. A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis. Cell Host Microbe. 2019;25:454-462.e6 pubmed publisher
Wang C, Chidiac P. RGS2 promotes the translation of stress-associated proteins ATF4 and CHOP via its eIF2B-inhibitory domain. Cell Signal. 2019;59:163-170 pubmed publisher
Takahashi T, Nakagawa K, Tada S, Tsukamoto A. Low-energy shock waves evoke intracellular Ca2+ increases independently of sonoporation. Sci Rep. 2019;9:3218 pubmed publisher
Greotti E, Capitanio P, Wong A, Pozzan T, Pizzo P, Pendin D. Familial Alzheimer's disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis. Cell Calcium. 2019;79:44-56 pubmed publisher
Grandjean J, Plate L, Morimoto R, Bollong M, Powers E, Wiseman R. Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing. ACS Chem Biol. 2019;14:784-795 pubmed publisher
Li C, Huang L, Sun W, Chen Y, He M, Yue J, et al. Saikosaponin D suppresses enterovirus A71 infection by inhibiting autophagy. Signal Transduct Target Ther. 2019;4:4 pubmed publisher
Hirata Y, Iwasaki T, Makimura Y, Okajima S, Oh hashi K, Takemori H. Inhibition of double-stranded RNA-dependent protein kinase prevents oxytosis and ferroptosis in mouse hippocampal HT22 cells. Toxicology. 2019;418:1-10 pubmed publisher
Sasako T, Ohsugi M, Kubota N, Itoh S, Okazaki Y, Terai A, et al. Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism. Nat Commun. 2019;10:947 pubmed publisher
Zhao X, Chang S, Long J, Li J, Li X, Cao Y. The toxicity of multi-walled carbon nanotubes (MWCNTs) to human endothelial cells: The influence of diameters of MWCNTs. Food Chem Toxicol. 2019;126:169-177 pubmed publisher
Shan A, Lu J, Xu Z, Li X, Xu Y, Li W, et al. Polypeptide N-acetylgalactosaminyltransferase 18 non-catalytically regulates the ER homeostasis and O-glycosylation. Biochim Biophys Acta Gen Subj. 2019;: pubmed publisher
Chou X, Ding F, Zhang X, Ding X, Gao H, Wu Q. Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells. Arch Toxicol. 2019;93:965-986 pubmed publisher
Barandov A, Bartelle B, Williamson C, Loucks E, Lippard S, Jasanoff A. Sensing intracellular calcium ions using a manganese-based MRI contrast agent. Nat Commun. 2019;10:897 pubmed publisher
Chen W, Do K, Saxton B, Leng S, Filipczak P, Tessema M, et al. Inhibition of the hexosamine biosynthesis pathway potentiates cisplatin cytotoxicity by decreasing BiP expression in non-small-cell lung cancer cells. Mol Carcinog. 2019;58:1046-1055 pubmed publisher
Fatsis Kavalopoulos N, O Callaghan P, Xie B, Hernández Vera R, Idevall Hagren O, Kreuger J. Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution. Lab Chip. 2019;19:1071-1081 pubmed publisher
Liu L, Zhao M, Jin X, Ney G, Yang K, Peng F, et al. Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells. Nat Cell Biol. 2019;21:328-337 pubmed publisher
Zhang L, Wang Y, Zhang L, Xia X, Chao Y, He R, et al. ZBTB7A, a miR-663a target gene, protects osteosarcoma from endoplasmic reticulum stress-induced apoptosis by suppressing LncRNA GAS5 expression. Cancer Lett. 2019;448:105-116 pubmed publisher
Sun X, Zhao D, Lu F, Peng S, Yu M, Liu N, et al. Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys44 to prevent cardiac structural damage in diabetic cardiomyopathy. Br J Pharmacol. 2019;: pubmed publisher
van Ziel A, Largo Barrientos P, Wolzak K, Verhage M, Scheper W. Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons. Sci Rep. 2019;9:1567 pubmed publisher
Harmatha J, Budesinsky M, Jurášek M, Zimmermann T, Drasar P, Zidek Z, et al. Structural modification of trilobolide for upgrading its immunobiological properties and reducing its cytotoxic action. Fitoterapia. 2019;134:88-95 pubmed publisher
Cai Y, Lei Y, Chen J, Cao L, Yang X, Zhang K, et al. Erythromycin relaxes BALB/c mouse airway smooth muscle. Life Sci. 2019;221:135-142 pubmed publisher
Cao J, Poddar A, Magtanong L, Lumb J, Mileur T, Reid M, et al. A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cell Rep. 2019;26:1544-1556.e8 pubmed publisher
Yamada K, Sato H, Sakamaki K, Kamada M, Okuno Y, Fukuishi N, et al. Suppression of IgE-Independent Degranulation of Murine Connective Tissue-Type Mast Cells by Dexamethasone. Cells. 2019;8: pubmed publisher
Alves Santos T, Xavier F, Duarte G, Dos Santos Borges R, Magalhães P, Lahlou S. Mechanisms underlying the vasorelaxant effect of trans-4-methoxy-β-nitrostyrene in the rat mesenteric resistance arteries. Eur J Pharmacol. 2019;853:201-209 pubmed publisher
Gao L, Chen H, Li C, Xiao Y, Yang D, Zhang M, et al. ER stress activation impairs the expression of circadian clock and clock-controlled genes in NIH3T3 cells via an ATF4-dependent mechanism. Cell Signal. 2019;57:89-101 pubmed publisher
Crivello P, Ahci M, Maaßen F, Wossidlo N, Arrieta Bolaños E, Heinold A, et al. Multiple Knockout of Classical HLA Class II β-Chains by CRISPR/Cas9 Genome Editing Driven by a Single Guide RNA. J Immunol. 2019;202:1895-1903 pubmed publisher
Dickerson M, Dadi P, Altman M, Verlage K, Thorson A, Jordan K, et al. Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion. Am J Physiol Endocrinol Metab. 2019;316:E646-E659 pubmed publisher
Magtanong L, Ko P, To M, Cao J, Forcina G, Tarangelo A, et al. Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State. Cell Chem Biol. 2019;26:420-432.e9 pubmed publisher
Witte M, Schumacher A, Mahler C, Bewersdorf J, Lehmitz J, Scheiter A, et al. Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Neuron. 2019;101:615-624.e5 pubmed publisher
Poirier Y, Grimm A, Schmitt K, Eckert A. Link between the unfolded protein response and dysregulation of mitochondrial bioenergetics in Alzheimer's disease. Cell Mol Life Sci. 2019;76:1419-1431 pubmed publisher
Gu S, Chen C, Lin P, Hsieh H. Role of protein phosphatase 2A in PTTH-stimulated prothoracic glands of the silkworm, Bombyx mori. Gen Comp Endocrinol. 2019;274:97-105 pubmed publisher
Duan T, Cil O, Thiagarajah J, Verkman A. Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI Insight. 2019;4: pubmed publisher
Duret G, Polali S, Anderson E, Bell A, Tzouanas C, Avants B, et al. Magnetic Entropy as a Proposed Gating Mechanism for Magnetogenetic Ion Channels. Biophys J. 2019;116:454-468 pubmed publisher
Rong B, Feng R, Liu C, Wu Q, Sun C. Reduced delivery of epididymal adipocyte-derived exosomal resistin is essential for melatonin ameliorating hepatic steatosis in mice. J Pineal Res. 2019;66:e12561 pubmed publisher
Reyes Corral M, Sørensen N, Thrasivoulou C, Dasgupta P, Ashmore J, Ahmed A. Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines. J Pharmacol Exp Ther. 2019;369:152-162 pubmed publisher
Wang Y, Osakue D, Yang E, Zhou Y, Gong H, Xia X, et al. Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway. Invest Ophthalmol Vis Sci. 2019;60:265-273 pubmed publisher
Stegen S, Laperre K, Eelen G, Rinaldi G, Fraisl P, Torrekens S, et al. HIF-1α metabolically controls collagen synthesis and modification in chondrocytes. Nature. 2019;565:511-515 pubmed publisher
Sawatani T, Kaneko Y, Doutsu I, Ogawa A, Ishikawa T. TRPV2 channels mediate insulin secretion induced by cell swelling in mouse pancreatic β-cells. Am J Physiol Cell Physiol. 2019;316:C434-C443 pubmed publisher
Srikanth S, Woo J, Wu B, El Sherbiny Y, Leung J, Chupradit K, et al. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019;20:152-162 pubmed publisher
Gutiérrez L, Hernández Morales M, Núñez L, Villalobos C. Inhibition of Polyamine Biosynthesis Reverses Ca2+ Channel Remodeling in Colon Cancer Cells. Cancers (Basel). 2019;11: pubmed publisher
Patel S, Alvarez Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka E, et al. GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. Cell Metab. 2019;: pubmed publisher
Zanatta A, Gonçalves R, Zanatta L, de Oliveria G, Ludwig Moraes A, Zamoner A, et al. New ionic targets of 3,3',5'-triiodothyronine at the plasma membrane of rat Sertoli cells. Biochim Biophys Acta Biomembr. 2019;1861:748-759 pubmed publisher
Wang Q, Liszt K, Deloose E, Canovai E, Thijs T, Farre R, et al. Obesity alters adrenergic and chemosensory signaling pathways that regulate ghrelin secretion in the human gut. FASEB J. 2019;33:4907-4920 pubmed publisher
Chen J, Yang T, Long J, Ding Y, Li J, Li X, et al. Palmitate enhanced the cytotoxicity of ZnO nanomaterials possibly by promoting endoplasmic reticulum stress. J Appl Toxicol. 2019;39:798-806 pubmed publisher
Seo M, Li H, An J, Jang J, Jung H, Kim T, et al. The vasodilatory effect of the antidiabetic drug linagliptin via inhibition of Rho-associated protein kinase in aortic smooth muscle. Life Sci. 2019;219:1-10 pubmed publisher
Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, et al. Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. EMBO Mol Med. 2019;11: pubmed publisher
Borkham Kamphorst E, Van De Leur E, Haas U, Weiskirchen R. Liver parenchymal cells lacking Lipocalin 2 (LCN2) are prone to endoplasmic reticulum stress and unfolded protein response. Cell Signal. 2019;55:90-99 pubmed publisher
Hu W, Zhang L, Li M, Shen J, Liu X, Xiao Z, et al. Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells. Autophagy. 2019;:1-19 pubmed publisher
Cao X, Song L, Zhang Y, Li Q, Shi T, Yang F, et al. Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease. Diabetes Metab Res Rev. 2019;35:e3123 pubmed publisher
Schinner C, Erber B, Yeruva S, Waschke J. Regulation of cardiac myocyte cohesion and gap junctions via desmosomal adhesion. Acta Physiol (Oxf). 2019;226:e13242 pubmed publisher
Zhao Z, Kesti T, Uğurlu H, Baur A, Fagerlund R, Saksela K. Tyrosine phosphorylation directs TACE into extracellular vesicles via unconventional secretion. Traffic. 2019;20:202-212 pubmed publisher
Liu W, Hashimoto T, Yamashita T, Hirano K. Coagulation factor XI induces Ca2+ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1. Am J Physiol Cell Physiol. 2019;316:C377-C392 pubmed publisher
Brigante G, Riccetti L, Lazzaretti C, Rofrano L, Sperduti S, Poti F, et al. Abacavir, nevirapine, and ritonavir modulate intracellular calcium levels without affecting GHRH-mediated growth hormone secretion in somatotropic cells in vitro. Mol Cell Endocrinol. 2019;482:37-44 pubmed publisher
Thoudam T, Ha C, Leem J, Chanda D, Park J, Kim H, et al. PDK4 Augments ER-Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity. Diabetes. 2019;68:571-586 pubmed publisher
Sprenkle N, Lahiri A, Simpkins J, Meares G. Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system. J Neurochem. 2019;148:516-530 pubmed publisher
Seo M, Li H, An J, Jung I, Jung W, Ha K, et al. Vildagliptin, an Anti-diabetic Drug of the DPP-4 Inhibitor, Induces Vasodilation via Kv Channel and SERCA Pump Activation in Aortic Smooth Muscle. Cardiovasc Toxicol. 2019;19:244-254 pubmed publisher
Ishikawa K, Hara T, Kato K, Shimomura T, Omori K. Involvement of natriuretic peptide system in C2C12 myocytes. Mol Cell Biochem. 2019;456:15-27 pubmed publisher
Shen J, Tu L, Chen D, Tan T, Wang Y, Wang S. TRPV4 channels stimulate Ca2+-induced Ca2+ release in mouse neurons and trigger endoplasmic reticulum stress after intracerebral hemorrhage. Brain Res Bull. 2019;146:143-152 pubmed publisher
Yu A, Jeong Y, Hwang C, Yoon K, Choe W, Ha J, et al. Alpha-naphthoflavone induces apoptosis through endoplasmic reticulum stress via c-Src-, ROS-, MAPKs-, and arylhydrocarbon receptor-dependent pathways in HT22 hippocampal neuronal cells. Neurotoxicology. 2019;71:39-51 pubmed publisher
Zhang M, Yang H, Wan X, Lu L, Zhang J, Zhang H, et al. Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR. J Bone Miner Res. 2019;34:726-738 pubmed publisher
Ji H, Huang C, Wu S, Kasim V. XBP1-s promotes colorectal cancer cell proliferation by inhibiting TAp73 transcriptional activity. Biochem Biophys Res Commun. 2019;508:203-209 pubmed publisher
Miyoshi A, Koyama S, Sasagawa Monden M, Kadoya M, Konishi K, Shoji T, et al. JNK and ATF4 as two important platforms for tumor necrosis factor-α-stimulated shedding of receptor for advanced glycation end products. FASEB J. 2019;33:3575-3589 pubmed publisher
Horibe T, Torisawa A, Masuda Y, Kawakami K. Functional analysis of protein disulfide isomerase P5 in glioblastoma cells as a novel anticancer target. Oncol Rep. 2019;41:961-972 pubmed publisher
Yang Y, Ma F, Liu Z, Su Q, Liu Y, Liu Z, et al. The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A/1B light chain 3. J Biol Chem. 2019;294:772-782 pubmed publisher
Sulis P, Dambrós B, Mascarello A, dos Santos A, Yunes R, Nunes R, et al. Sulfonyl(thio)urea derivative induction of insulin secretion is mediated by potassium, calcium, and sodium channel signal transduction. J Cell Physiol. 2019;234:10138-10147 pubmed publisher
Kim J, Lee M, Kim S, Kim S, Lee B, Kang E, et al. Sodium-glucose cotransporter 2 inhibitors regulate ketone body metabolism via inter-organ crosstalk. Diabetes Obes Metab. 2019;21:801-811 pubmed publisher
Virgolini M, Feliziani C, Cambiasso M, Lopez P, Bollo M. Neurite atrophy and apoptosis mediated by PERK signaling after accumulation of GM2-ganglioside. Biochim Biophys Acta Mol Cell Res. 2019;1866:225-239 pubmed publisher
Bulla M, Gyimesi G, Kim J, Bhardwaj R, Hediger M, Frieden M, et al. ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain. J Physiol. 2019;597:561-582 pubmed publisher
Liang Y, Fan C, Yan X, Lu X, Jiang H, Di S, et al. Berberine ameliorates lipopolysaccharide-induced acute lung injury via the PERK-mediated Nrf2/HO-1 signaling axis. Phytother Res. 2019;33:130-148 pubmed publisher
Wu X, Zhang L, Miao Y, Yang J, Wang X, Wang C, et al. Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis. Redox Biol. 2019;20:46-59 pubmed publisher
Prasad H, Dang D, Kondapalli K, Natarajan N, Cebotaru V, Rao R. NHA2 promotes cyst development in an in vitro model of polycystic kidney disease. J Physiol. 2019;597:499-519 pubmed publisher
Searfoss G, Paisley B, Goldstein K, Baker T, Willy J. The Integrated Stress Response Regulates Cell Health of Cardiac Progenitors. Toxicol Sci. 2019;167:202-210 pubmed publisher
Salvamoser R, Brinkmann K, O Reilly L, Whitehead L, Strasser A, Herold M. Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis. Cell Death Differ. 2019;26:1124-1137 pubmed publisher
Nguyen P, Calderon R, Rodriguez Ledezma Y, Araujo K, Bhandari D. GIV/Girdin promotes cell survival during endoplasmic reticulum stress. Mol Cell Biochem. 2019;453:79-88 pubmed publisher
Deurloo M, Turlova E, Chen W, Lin Y, Tam E, Tassew N, et al. Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models. Mol Neurobiol. 2019;56:3313-3325 pubmed publisher
Weissmann M, Bhattacharya U, Feld S, Hammond E, Ilan N, Vlodavsky I. The heparanase inhibitor PG545 is a potent anti-lymphoma drug: Mode of action. Matrix Biol. 2019;77:58-72 pubmed publisher
Liu Z, Wei Y, Zhang L, Yee P, Johnson M, Zhang X, et al. Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ. Oncogene. 2019;38:120-139 pubmed publisher
Kim D, Kim S, Lee J, Kim J, Che X, Ma H, et al. Lactobacillus acidophilus suppresses intestinal inflammation by inhibiting endoplasmic reticulum stress. J Gastroenterol Hepatol. 2019;34:178-185 pubmed publisher
Wang X, Yuan B, Cheng B, Liu Y, Zhang B, Wang X, et al. Crocin Alleviates Myocardial Ischemia/Reperfusion-Induced Endoplasmic Reticulum Stress via Regulation of miR-34a/Sirt1/Nrf2 Pathway. Shock. 2019;51:123-130 pubmed publisher
van der Krieken S, Popeijus H, Bendik I, Böhlendorf B, Konings M, Tayyeb J, et al. Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor α Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription i. Lipids. 2018;53:1021-1030 pubmed publisher
Dubouskaya T, Hrynevich S, Waseem T, Fedorovich S. Calcium release from intracellular stores is involved in mitochondria depolarization after lowering extracellular pH in rat brain synaptosomes. Acta Neurobiol Exp (Wars). 2018;78:343-351 pubmed
Chidawanyika T, Sergison E, Cole M, Mark K, Supattapone S. SEC24A identified as an essential mediator of thapsigargin-induced cell death in a genome-wide CRISPR/Cas9 screen. Cell Death Discov. 2018;4:115 pubmed publisher
Florean C, Kim K, Schnekenburger M, Kim H, Moriou C, Debitus C, et al. Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1'(R), 6'(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax. Mar Drugs. 2018;16: pubmed publisher
Wang G, Guo Z, Tong L, Xue F, Krafft P, Budbazar E, et al. TLR7 (Toll-Like Receptor 7) Facilitates Heme Scavenging Through the BTK (Bruton Tyrosine Kinase)-CRT (Calreticulin)-LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1)-Hx (Hemopexin) Pathway in Murine Intracerebral Hemorrhage. Stroke. 2018;49:3020-3029 pubmed publisher
Tailler M, Lindqvist L, Gibson L, Adams J. By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737. Cell Death Differ. 2018;: pubmed publisher
Xu N, Meng H, Liu T, Feng Y, Qi Y, Wang H. TRPC1 Deficiency Exacerbates Cerebral Ischemia/Reperfusion-Induced Neurological Injury by Potentiating Nox4-Derived Reactive Oxygen Species Generation. Cell Physiol Biochem. 2018;51:1723-1738 pubmed publisher
Jiang Y, Wang Z, Ma B, Fan L, Yi N, Lu B, et al. GLP-1 Improves Adipocyte Insulin Sensitivity Following Induction of Endoplasmic Reticulum Stress. Front Pharmacol. 2018;9:1168 pubmed publisher
Groenendyk J, Paskevicius T, Urra H, Viricel C, Wang K, Barakat K, et al. Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor. Sci Rep. 2018;8:16678 pubmed publisher
Wu J, Chen S, Liu H, Zhang Z, Ni Z, Chen J, et al. Tunicamycin specifically aggravates ER stress and overcomes chemoresistance in multidrug-resistant gastric cancer cells by inhibiting N-glycosylation. J Exp Clin Cancer Res. 2018;37:272 pubmed publisher
Balboa D, Saarimäki Vire J, Borshagovski D, Survila M, Lindholm P, Galli E, et al. Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes. elife. 2018;7: pubmed publisher
Wettmarshausen J, Goh V, Huang K, Arduino D, Tripathi U, Leimpek A, et al. MICU1 Confers Protection from MCU-Dependent Manganese Toxicity. Cell Rep. 2018;25:1425-1435.e7 pubmed publisher
Cheng C, Qi Y, Wang Y, Chi K, Chung Y, Ouyang C, et al. Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction. Commun Biol. 2018;1:178 pubmed publisher
van Galen P, Mbong N, Kreso A, Schoof E, Wagenblast E, Ng S, et al. Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia. Cell Rep. 2018;25:1109-1117.e5 pubmed publisher
Zhang Y, Willis Owen S, Spiegel S, Lloyd C, Moffatt M, Cookson W. The ORMDL3 Asthma Gene Regulates ICAM1 and has Multiple Effects on Cellular Inflammation. Am J Respir Crit Care Med. 2018;: pubmed publisher
Chauhan A, Liu X, Jing J, Lee H, Yadav R, Liu J, et al. STIM2 interacts with AMPK and regulates calcium-induced AMPK activation. FASEB J. 2018;:fj201801225R pubmed publisher
Cheruiyot A, Li S, Nickless A, Roth R, Fitzpatrick J, You Z. Compound C inhibits nonsense-mediated RNA decay independently of AMPK. PLoS ONE. 2018;13:e0204978 pubmed publisher
Hou X, Xiao H, Zhang Y, Zeng X, Huang M, Chen X, et al. Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation. Cell Death Dis. 2018;9:1015 pubmed publisher
Fink E, Moparthy S, Bagati A, Bianchi Smiraglia A, Lipchick B, Wolff D, et al. XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response. Cell Rep. 2018;25:212-223.e4 pubmed publisher
Lepannetier S, Gualdani R, Tempesta S, Schakman O, Seghers F, Kreis A, et al. Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory. Front Cell Neurosci. 2018;12:318 pubmed publisher
Woo Y, Kwak Y, Namkoong S, Kristjansdottir K, Lee S, Lee J, et al. TED-Seq Identifies the Dynamics of Poly(A) Length during ER Stress. Cell Rep. 2018;24:3630-3641.e7 pubmed publisher
Yu X, Ren L, Wang C, Zhu Y, Xing H, Zhao J, et al. Role of X-Box Binding Protein-1 in Fructose-Induced De Novo Lipogenesis in HepG2 Cells. Chin Med J (Engl). 2018;131:2310-2319 pubmed publisher
de la Fuente S, Lambert J, Nichtova Z, Fernandez Sanz C, Elrod J, Sheu S, et al. Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart. Cell Rep. 2018;24:3099-3107.e4 pubmed publisher
Ito N, Ruegg U, Takeda S. ATP-Induced Increase in Intracellular Calcium Levels and Subsequent Activation of mTOR as Regulators of Skeletal Muscle Hypertrophy. Int J Mol Sci. 2018;19: pubmed publisher
Kim J, Lee S, Jang Y, Park H, Kim J, Hong J, et al. Enhanced ANGPTL2 expression in adipose tissues and its association with insulin resistance in obese women. Sci Rep. 2018;8:13976 pubmed publisher
Jardin I, Diez Bello R, Lopez J, Redondo P, Salido G, Smani T, et al. TRPC6 Channels Are Required for Proliferation, Migration and Invasion of Breast Cancer Cell Lines by Modulation of Orai1 and Orai3 Surface Exposure. Cancers (Basel). 2018;10: pubmed publisher
Vashisht A, Tanwar J, Motiani R. Regulation of proto-oncogene Orai3 by miR18a/b and miR34a. Cell Calcium. 2018;75:101-111 pubmed publisher
Drullion C, Marot G, Martin N, Deslé J, Saas L, Salazar Cardozo C, et al. Pre-malignant transformation by senescence evasion is prevented by the PERK and ATF6alpha branches of the Unfolded Protein Response. Cancer Lett. 2018;438:187-196 pubmed publisher
Saint Fleur Lominy S, Maus M, Vaeth M, Lange I, Zee I, Suh D, et al. STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia. Cell Rep. 2018;24:3045-3060.e5 pubmed publisher
Luo P, Xu Z, Li G, Yan H, Zhu Y, Zhu H, et al. HMGB1 represses the anti-cancer activity of sunitinib by governing TP53 autophagic degradation via its nucleus-to-cytoplasm transport. Autophagy. 2018;14:2155-2170 pubmed publisher
Rinne M, Leino T, Turku A, Turunen P, Steynen Y, Xhaard H, et al. Pharmacological characterization of the orexin/hypocretin receptor agonist Nag 26. Eur J Pharmacol. 2018;837:137-144 pubmed publisher
Li J, Akil O, Rouse S, McLaughlin C, Matthews I, Lustig L, et al. Deletion of Tmtc4 activates the unfolded protein response causing postnatalhearing loss. J Clin Invest. 2018;: pubmed publisher
Ma Y, Wang C, Xue M, Fu F, Zhang X, Li L, et al. The Coronavirus Transmissible Gastroenteritis Virus Evades the Type I Interferon Response through IRE1α-Mediated Manipulation of the MicroRNA miR-30a-5p/SOCS1/3 Axis. J Virol. 2018;92: pubmed publisher
Augusto L, Martynowicz J, Staschke K, Wek R, Sullivan W. Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii. Antimicrob Agents Chemother. 2018;62: pubmed publisher
Asano T, Igarashi H, Ishizuka T, Yawo H. Organelle Optogenetics: Direct Manipulation of Intracellular Ca2+ Dynamics by Light. Front Neurosci. 2018;12:561 pubmed publisher
Tengah A, Syed N, Talip S, Bujang S, Kennedy C. Comparison of signalling mechanisms underlying UTP-evoked vasoconstriction of rat pulmonary and tail arteries. Eur J Pharmacol. 2018;837:45-52 pubmed publisher
Kim T, Lee S, Kim M, Cheon C, Ko S. Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells. Cell Death Dis. 2018;9:875 pubmed publisher
Brovkovych V, Izhar Y, Danes J, Dubrovskyi O, Sakallioglu I, Morrow L, et al. Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer. Oncogenesis. 2018;7:66 pubmed publisher
Wang G, Nie J, Bao Y, Yang X. Sulforaphane Rescues Ethanol-Suppressed Angiogenesis through Oxidative and Endoplasmic Reticulum Stress in Chick Embryos. J Agric Food Chem. 2018;66:9522-9533 pubmed publisher
Chang T, Lawrence D, Lu M, Tan J, Harnoss J, Marsters S, et al. Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate. Mol Cell. 2018;71:629-636.e5 pubmed publisher
Grasso E, Gori S, Soczewski E, Fernandez L, Gallino L, Vota D, et al. Impact of the Reticular Stress and Unfolded Protein Response on the inflammatory response in endometrial stromal cells. Sci Rep. 2018;8:12274 pubmed publisher
Logue S, McGrath E, Cleary P, Greene S, Mnich K, Almanza A, et al. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nat Commun. 2018;9:3267 pubmed publisher
Guo M, Kook Y, Shannon C, Buch S. Notch3/VEGF-A axis is involved in TAT-mediated proliferation of pulmonary artery smooth muscle cells: Implications for HIV-associated PAH. Cell Death Discov. 2018;4:22 pubmed publisher
Chen Y, Ou Y, Tao Y, Liu H, Yin H, Zhong S, et al. Effect and mechanisms of celastrol on the apoptosis of HOS osteosarcoma cells. Oncol Rep. 2018;40:2260-2268 pubmed publisher
Holowka D, Thanapuasuwan K, Baird B. Short chain ceramides disrupt immunoreceptor signaling by inhibiting segregation of Lo from Ld Plasma membrane components. Biol Open. 2018;7: pubmed publisher
Kang M, Lee E, Kim Y, Kim D, Oh H, Kim S, et al. Chrysin Ameliorates Malfunction of Retinoid Visual Cycle through Blocking Activation of AGE-RAGE-ER Stress in Glucose-Stimulated Retinal Pigment Epithelial Cells and Diabetic Eyes. Nutrients. 2018;10: pubmed publisher
Sun Y, Zhang D, Liu X, Li X, Liu F, Yu Y, et al. Endoplasmic Reticulum Stress Affects Lipid Metabolism in Atherosclerosis Via CHOP Activation and Over-Expression of miR-33. Cell Physiol Biochem. 2018;48:1995-2010 pubmed publisher
Lange J, Haslett L, Lloyd Evans E, Pocock J, Sands M, Williams B, et al. Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis. Acta Neuropathol Commun. 2018;6:74 pubmed publisher
Nougarède A, Tesnière C, Ylanko J, Rimokh R, Gillet G, Andrews D. Improved IRE1 and PERK Pathway Sensors for Multiplex Endoplasmic Reticulum Stress Assay Reveal Stress Response to Nuclear Dyes Used for Image Segmentation. Assay Drug Dev Technol. 2018;16:350-360 pubmed publisher
Pascual Caro C, Berrocal M, Lopez Guerrero A, Alvarez Barrientos A, Pozo Guisado E, Gutierrez Merino C, et al. STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry. J Mol Med (Berl). 2018;96:1061-1079 pubmed publisher
Maggio N, Vlachos A. Tumor necrosis factor (TNF) modulates synaptic plasticity in a concentration-dependent manner through intracellular calcium stores. J Mol Med (Berl). 2018;96:1039-1047 pubmed publisher
Levi N, Wilson C, Redweik G, Gray N, Grzybowski C, Lenkey J, et al. Obesity-related cellular stressors regulate gonadotropin releasing hormone gene expression via c-Fos/AP-1. Mol Cell Endocrinol. 2018;478:97-105 pubmed publisher
Chen C, Chang J, Chang E, Chen H, Yang Y. Crosstalk between transforming growth factor-?1 and endoplasmic reticulum stress regulates alpha-smooth muscle cell actin expression in podocytes. Life Sci. 2018;209:9-14 pubmed publisher
Nielsen K, Jacobsen K, Mirza A, Winther T, Størling J, Glebe D, et al. Hepatitis B virus upregulates host microRNAs that target apoptosis-regulatory genes in an in vitro cell model. Exp Cell Res. 2018;371:92-103 pubmed publisher
Zhang D, Lin J, Chao Y, Zhang L, Jin L, Li N, et al. Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression. J Exp Clin Cancer Res. 2018;37:176 pubmed publisher
Zhang H, Wu S, Yang Y, Su R, Wen J, Ke X, et al. Crocin Protects Human Umbilical Vein Endothelial Cells from High Glucose-Induced Injury Via Inhibiting the Endoplasmic Reticulum Stress Response. Curr Mol Med. 2018;18:166-177 pubmed publisher
Siddiquey M, Zhang H, Nguyen C, Domma A, Kamil J. The Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein Response. J Virol. 2018;92: pubmed publisher
Osaki Y, Saito A, Kanemoto S, Kaneko M, Matsuhisa K, Asada R, et al. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II. Cell Death Dis. 2018;9:808 pubmed publisher
Rubíková Z, Sulimenko V, Paulenda T, Draber P. Mast Cell Activation and Microtubule Organization Are Modulated by Miltefosine Through Protein Kinase C Inhibition. Front Immunol. 2018;9:1563 pubmed publisher
Zhang L, Wang Y. Tauroursodeoxycholic Acid Alleviates H2O2-Induced Oxidative Stress and Apoptosis via Suppressing Endoplasmic Reticulum Stress in Neonatal Rat Cardiomyocytes. Dose Response. 2018;16:1559325818782631 pubmed publisher
Rua C, Gueguinou M, Soubai I, Viel E, Potier Cartereau M, Chantome A, et al. SK3 Gene Polymorphism Is Associated with Taxane Neurotoxicity and Cell Calcium Homeostasis. Clin Cancer Res. 2018;24:5313-5320 pubmed publisher
Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, et al. DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling. Cell Res. 2018;28:833-854 pubmed publisher
Takahashi Y, He H, Tang Z, Hattori T, Liu Y, Young M, et al. An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure. Nat Commun. 2018;9:2855 pubmed publisher
Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, et al. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018;9:2812 pubmed publisher
Chen X, Kozhaya L, Tastan C, Placek L, Dogan M, Horne M, et al. Functional Interrogation of Primary Human T Cells via CRISPR Genetic Editing. J Immunol. 2018;201:1586-1598 pubmed publisher
Furmanik M, Shanahan C. ER stress regulates alkaline phosphatase gene expression in vascular smooth muscle cells via an ATF4-dependent mechanism. BMC Res Notes. 2018;11:483 pubmed publisher
Huang F, Wang P, Wang X. Thapsigargin induces apoptosis of prostate cancer through cofilin-1 and paxillin. Oncol Lett. 2018;16:1975-1980 pubmed publisher
Chava S, Chennakesavulu S, Gayatri B, Reddy A. A novel phosphorylation by AMP-activated kinase regulates RUNX2 from ubiquitination in osteogenesis over adipogenesis. Cell Death Dis. 2018;9:754 pubmed publisher
Johnson C, Dunlop E, Seifan S, McCann H, Hay T, Parfitt G, et al. Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir-bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death. Oncogene. 2018;37:5913-5925 pubmed publisher
Maltaneri R, Schiappacasse A, Chamorro M, Nesse A, Vittori D. Participation of membrane calcium channels in erythropoietin-induced endothelial cell migration. Eur J Cell Biol. 2018;97:411-421 pubmed publisher
Kato S, Inui N, Hakamata A, Suzuki Y, Enomoto N, Fujisawa T, et al. Changes in pulmonary endothelial cell properties during bleomycin-induced pulmonary fibrosis. Respir Res. 2018;19:127 pubmed publisher
Xu H, Zhao P, Zhang W, Qiu J, Tan L, Liu X, et al. Generation and Role of Oscillatory Contractions in Mouse Airway Smooth Muscle. Cell Physiol Biochem. 2018;47:1546-1555 pubmed publisher
Kim S, Joe Y, Park S, Jeong S, Kim J, Park S, et al. Induction of endoplasmic reticulum stress under endotoxin tolerance increases inflammatory responses and decreases Pseudomonas aeruginosa pneumonia. J Leukoc Biol. 2018;104:1003-1012 pubmed publisher
Xu D, Liang S, Yang H, Lüthi U, Riether C, Berezowska S, et al. Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma. Br J Cancer. 2018;119:65-75 pubmed publisher
Sun Y, Jiang F, Pan Y, Chen X, Chen J, Wang Y, et al. XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma. Oncol Rep. 2018;40:988-998 pubmed publisher
Chhipa R, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, et al. AMP kinase promotes glioblastoma bioenergetics and tumour growth. Nat Cell Biol. 2018;20:823-835 pubmed publisher
Musial T, Molina Campos E, Bean L, YBARRA N, Borenstein R, Russo M, et al. Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease. Neurobiol Learn Mem. 2018;154:141-157 pubmed publisher
Zheng H, Drumm B, Earley S, Sung T, Koh S, Sanders K. SOCE mediated by STIM and Orai is essential for pacemaker activity in the interstitial cells of Cajal in the gastrointestinal tract. Sci Signal. 2018;11: pubmed publisher
Krishnan V, Park S, Shin S, Alon L, Tressler C, Stokes W, et al. Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields. Sci Rep. 2018;8:8764 pubmed publisher
Glosse P, Feger M, Mutig K, Chen H, Hirche F, Hasan A, et al. AMP-activated kinase is a regulator of fibroblast growth factor 23 production. Kidney Int. 2018;94:491-501 pubmed publisher
Jiang S, He R, Zhu L, Liang T, Wang Z, Lu Y, et al. Endoplasmic reticulum stress-dependent ROS production mediates synovial myofibroblastic differentiation in the immobilization-induced rat knee joint contracture model. Exp Cell Res. 2018;369:325-334 pubmed publisher
Mallik A, Yammani R. Saturated fatty acid palmitate negatively regulates autophagy by promoting ATG5 protein degradation in meniscus cells. Biochem Biophys Res Commun. 2018;502:370-374 pubmed publisher
Kyrmizi I, Ferreira H, Carvalho A, Figueroa J, Zarmpas P, Cunha C, et al. Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis. Nat Microbiol. 2018;3:791-803 pubmed publisher
Tao L, Lin H, Wen J, Sun Q, Gao Y, Xu X, et al. The kinase receptor-interacting protein 1 is required for inflammasome activation induced by endoplasmic reticulum stress. Cell Death Dis. 2018;9:641 pubmed publisher
Gomes da Silva L, Zhao L, Bezu L, Zhou H, Sauvat A, Liu P, et al. Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus. EMBO J. 2018;37: pubmed publisher
Zhang J, Wang J, Wong Y, Sun X, Chen Y, Wang L, et al. Docetaxel enhances lysosomal function through TFEB activation. Cell Death Dis. 2018;9:614 pubmed publisher
Sonobe Y, Ghadge G, Masaki K, Sendoel A, Fuchs E, Roos R. Translation of dipeptide repeat proteins from the C9ORF72 expanded repeat is associated with cellular stress. Neurobiol Dis. 2018;116:155-165 pubmed publisher
Kotsiri M, Protopapa M, Roumelioti G, Economou Amilli A, Efthimiadou E, Dedos S. Probing the settlement signals of Amphibalanus amphitrite. Biofouling. 2018;34:492-506 pubmed publisher
Cao Y, Chen M, Tang D, Yan H, Ding X, Zhou F, et al. The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses. Cell Death Dis. 2018;9:604 pubmed publisher
Bhattacharjee S, Bose P, Patel K, Roy S, Gain C, Gowda H, et al. Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival. Cell Death Dis. 2018;9:605 pubmed publisher
Yuan X, Wang J, Li Y, He X, Niu B, Wu D, et al. Allergy immunotherapy restores airway epithelial barrier dysfunction through suppressing IL-25 -induced endoplasmic reticulum stress in asthma. Sci Rep. 2018;8:7950 pubmed publisher
Anon B, Largeau B, Girault A, Chantome A, Caulet M, Perray C, et al. Possible association of CAG repeat polymorphism in KCNN3 encoding the potassium channel SK3 with oxaliplatin-induced neurotoxicity. Cancer Chemother Pharmacol. 2018;82:149-157 pubmed publisher
Borkham Kamphorst E, Van De Leur E, Meurer S, Buhl E, Weiskirchen R. N-Glycosylation of Lipocalin 2 Is Not Required for Secretion or Exosome Targeting. Front Pharmacol. 2018;9:426 pubmed publisher
Perot B, Boussier J, Yatim N, Rossman J, Ingersoll M, Albert M. Autophagy diminishes the early interferon-? response to influenza A virus resulting in differential expression of interferon-stimulated genes. Cell Death Dis. 2018;9:539 pubmed publisher
Carmichael J, Yokota H, Craven R, SCHMITT A, Wills J. The HSV-1 mechanisms of cell-to-cell spread and fusion are critically dependent on host PTP1B. PLoS Pathog. 2018;14:e1007054 pubmed publisher
Gruenstein E, SCHLEMM D, Bethi M, Keller S. The early signaling pathway of live yeast cell derivative in THP-1 monocytes. Cell Calcium. 2018;73:112-120 pubmed publisher
Ando M, Matsumoto T, Taguchi K, Kobayashi T. Decreased contraction induced by endothelium-derived contracting factor in prolonged treatment of rat renal artery with endoplasmic reticulum stress inducer. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:793-802 pubmed publisher
Chvanov M, De Faveri F, MOORE D, Sherwood M, Awais M, Voronina S, et al. Intracellular rupture, exocytosis and actin interaction of endocytic vacuoles in pancreatic acinar cells: initiating events in acute pancreatitis. J Physiol. 2018;596:2547-2564 pubmed publisher
Kim K, Kim S, Han D, Jo Y, Lee Y, Lee M. Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice. Sci Rep. 2018;8:6789 pubmed publisher
Estornes Y, Dondelinger Y, Weber K, Bruggeman I, Peall A, MacFarlane M, et al. N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis. Cell Death Dis. 2018;9:494 pubmed publisher
Fan H, Huang H, Hu L, Zhu W, Yu Y, Lou J, et al. The activation of STIM1 mediates S-phase arrest and cell death in paraquat induced acute lung intoxication. Toxicol Lett. 2018;292:123-135 pubmed publisher
Hernández M, Aguilar A, Burillo J, Oca R, Manca M, Novials A, et al. Pancreatic ? cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics. Cell Death Dis. 2018;9:481 pubmed publisher
Wu J, Zhang W, Liu X, Wu L, He G, Li P, et al. Apocynin protects endothelial cells from endoplasmic reticulum stress-induced apoptosis via IRE1α engagement. Mol Cell Biochem. 2018;449:257-265 pubmed publisher
Sun Y, Bao Q, Xuan B, Xu W, Pan D, Li Q, et al. Human Cytomegalovirus Protein pUL38 Prevents Premature Cell Death by Binding to Ubiquitin-Specific Protease 24 and Regulating Iron Metabolism. J Virol. 2018;92: pubmed publisher
Kim K, Chung M, Park S, Cha J, Baek J, Lee S, et al. ER stress attenuation by Aloe-derived polysaccharides in the protection of pancreatic ?-cells from free fatty acid-induced lipotoxicity. Biochem Biophys Res Commun. 2018;500:797-803 pubmed publisher
Cheng X, Yao X, Xu S, Pan J, Yu H, Bao J, et al. Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells via NF-κB signaling pathway. Biomed Pharmacother. 2018;103:490-498 pubmed publisher
Kim D, Kim J, Nam J, Lee J, Kim S, Kim B. Modulation of Pacemaker Potentials in Murine Small Intestinal Interstitial Cells of Cajal by Gamisoyo-San, a Traditional Chinese Herbal Medicine. Digestion. 2018;98:56-68 pubmed publisher
Ramos Álvarez I, Jensen R. P21-activated kinase 4 in pancreatic acinar cells is activated by numerous gastrointestinal hormones/neurotransmitters and growth factors by novel signaling, and its activation stimulates secretory/growth cascades. Am J Physiol Gastrointest Liver Physiol. 2018;315:G302-G317 pubmed publisher
Li S, Xue J, Sun Z, Liu T, Zhang L, Wang L, et al. CaMKII Potentiates Store-Operated Ca2+ Entry Through Enhancing STIM1 Aggregation and Interaction with Orai1. Cell Physiol Biochem. 2018;46:1042-1054 pubmed publisher
Moure R, Domingo P, Villarroya J, Gasa L, Gallego Escuredo J, Quesada López T, et al. Reciprocal Effects of Antiretroviral Drugs Used To Treat HIV Infection on the Fibroblast Growth Factor 21/β-Klotho System. Antimicrob Agents Chemother. 2018;62: pubmed publisher
Aslamy A, Oh E, Olson E, Zhang J, Ahn M, Moin A, et al. Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function. Diabetes. 2018;67:1332-1344 pubmed publisher
Moon S, Parker R. EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response. RNA. 2018;24:841-852 pubmed publisher
Ronaldson Bouchard K, Ma S, Yeager K, Chen T, Song L, Sirabella D, et al. Advanced maturation of human cardiac tissue grown from pluripotent stem cells. Nature. 2018;556:239-243 pubmed publisher
Arya S, Kumar G, Kaur H, Kaur A, Tuli A. ARL11 regulates lipopolysaccharide-stimulated macrophage activation by promoting mitogen-activated protein kinase (MAPK) signaling. J Biol Chem. 2018;293:9892-9909 pubmed publisher
Betzer C, Lassen L, Olsen A, Kofoed R, Reimer L, Gregersen E, et al. Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation. EMBO Rep. 2018;19: pubmed publisher
Chen J, Zhang M, Zhu M, Gu J, Song J, Cui L, et al. Paeoniflorin prevents endoplasmic reticulum stress-associated inflammation in lipopolysaccharide-stimulated human umbilical vein endothelial cells via the IRE1α/NF-κB signaling pathway. Food Funct. 2018;9:2386-2397 pubmed publisher
Bohineust A, Garcia Z, Beuneu H, Lemaitre F, Bousso P. Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division. J Exp Med. 2018;215:1481-1492 pubmed publisher
Namkoong S, Ho A, Woo Y, Kwak H, Lee J. Systematic Characterization of Stress-Induced RNA Granulation. Mol Cell. 2018;70:175-187.e8 pubmed publisher
Yang D, Jiang T, Liu J, Hong J, Lin P, Chen H, et al. Interferon-Ï„ regulates prostaglandin release in goat endometrial stromal cells via JAB1 - unfolded protein response pathway. Theriogenology. 2018;113:237-246 pubmed publisher
Américo Da Silva L, Diaz J, Bustamante M, Mancilla G, Oyarzún I, Verdejo H, et al. A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization. FASEB J. 2018;32:4681-4695 pubmed publisher
Smaardijk S, Chen J, Kerselaers S, Voets T, Eggermont J, Vangheluwe P. Store-independent coupling between the Secretory Pathway Ca2+ transport ATPase SPCA1 and Orai1 in Golgi stress and Hailey-Hailey disease. Biochim Biophys Acta Mol Cell Res. 2018;1865:855-862 pubmed publisher
Johnson J, Lucas S, Amon L, Skelton S, Nazitto R, Carbonetti S, et al. Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection. Cell Host Microbe. 2018;23:366-381.e9 pubmed publisher
Dago C, Maux P, Roisnel T, Brigaudeau C, Bekro Y, Mignen O, et al. Preliminary Structure-Activity Relationship (SAR) of a Novel Series of Pyrazole SKF-96365 Analogues as Potential Store-Operated Calcium Entry (SOCE) Inhibitors. Int J Mol Sci. 2018;19: pubmed publisher
Sha Z, Schnell H, Ruoff K, Goldberg A. Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation. J Cell Biol. 2018;217:1757-1776 pubmed publisher
Streuli J, Harris A, Cottiny C, Allagnat F, Daly A, Grouzmann E, et al. Cellular effects of AP102, a somatostatin analog with balanced affinities for the hSSTR2 and hSSTR5 receptors. Neuropeptides. 2018;68:84-89 pubmed publisher
Bosco F, Valente P, Milanese M, Piccini A, Messa M, Bonanno G, et al. Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice. Mol Neurobiol. 2018;55:8084-8102 pubmed publisher
Mateus D, Marini E, Progida C, Bakke O. Rab7a modulates ER stress and ER morphology. Biochim Biophys Acta Mol Cell Res. 2018;1865:781-793 pubmed publisher
Kucharewicz K, Dudkowska M, Zawadzka A, Ogrodnik M, Szczepankiewicz A, Czarnocki Z, et al. Simultaneous induction and blockade of autophagy by a single agent. Cell Death Dis. 2018;9:353 pubmed publisher
Wan X, Serrill J, Humphreys I, Tan M, McPhail K, Ganley I, et al. ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A. Mar Drugs. 2018;16: pubmed publisher
Won J, Vang H, Kim J, Lee P, Kang Y, Oh S. TRPM7 Mediates Mechanosensitivity in Adult Rat Odontoblasts. J Dent Res. 2018;97:1039-1046 pubmed publisher
Gonçalves R, Zanatta A, Cavalari F, do Nascimento M, Delalande Lecapitaine C, Bouraïma Lelong H, et al. Acute effect of bisphenol A: Signaling pathways on calcium influx in immature rat testes. Reprod Toxicol. 2018;77:94-102 pubmed publisher
Ruggiero C, Doghman Bouguerra M, Ronco C, Benhida R, Rocchi S, Lalli E. The GRP78/BiP inhibitor HA15 synergizes with mitotane action against adrenocortical carcinoma cells through convergent activation of ER stress pathways. Mol Cell Endocrinol. 2018;474:57-64 pubmed publisher
Sun Z, Zhang H, Wang X, Wang Q, Zhang C, Wang J, et al. TMCO1 is essential for ovarian follicle development by regulating ER Ca2+ store of granulosa cells. Cell Death Differ. 2018;25:1686-1701 pubmed publisher
Aran G, Sanjurjo L, Bárcena C, Simon Coma M, Téllez É, Vázquez Vitali M, et al. CD5L is upregulated in hepatocellular carcinoma and promotes liver cancer cell proliferation and antiapoptotic responses by binding to HSPA5 (GRP78). FASEB J. 2018;32:3878-3891 pubmed publisher
Kaczara P, Proniewski B, Lovejoy C, Kus K, Motterlini R, Abramov A, et al. CORM-401 induces calcium signalling, NO increase and activation of pentose phosphate pathway in endothelial cells. FEBS J. 2018;285:1346-1358 pubmed publisher
Oh hashi K, Soga A, Naruse Y, Takahashi K, Kiuchi K, Hirata Y. Elucidating post-translational regulation of mouse CREB3 in Neuro2a cells. Mol Cell Biochem. 2018;448:287-297 pubmed publisher
Brijmohan A, Batchu S, Majumder S, Alghamdi T, Thieme K, McGaugh S, et al. HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease. Front Pharmacol. 2018;9:34 pubmed publisher
Du K, Liu M, Zhong X, Yao W, Xiao Q, Wen Q, et al. Epigallocatechin Gallate Reduces Amyloid β-Induced Neurotoxicity via Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis. Mol Nutr Food Res. 2018;62:e1700890 pubmed publisher
Heeley N, Kirwan P, Darwish T, Arnaud M, Evans M, Merkle F, et al. Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights. Mol Metab. 2018;10:14-27 pubmed publisher
Besio R, Iula G, Garibaldi N, Cipolla L, Sabbioneda S, Biggiogera M, et al. 4-PBA ameliorates cellular homeostasis in fibroblasts from osteogenesis imperfecta patients by enhancing autophagy and stimulating protein secretion. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1642-1652 pubmed publisher
Nishida K, Tamura A, Yui N. ER stress-mediated autophagic cell death induction through methylated β-cyclodextrins-threaded acid-labile polyrotaxanes. J Control Release. 2018;275:20-31 pubmed publisher
Shi C, Zeng J, Li Z, Chen Q, Hang W, Xia L, et al. Melatonin Mitigates Kainic Acid-Induced Neuronal Tau Hyperphosphorylation and Memory Deficits through Alleviating ER Stress. Front Mol Neurosci. 2018;11:5 pubmed publisher
Désir Vigné A, Haure Mirande V, de Coppet P, Darmaun D, Le Drean G, Segain J. Perinatal supplementation of 4-phenylbutyrate and glutamine attenuates endoplasmic reticulum stress and improves colonic epithelial barrier function in rats born with intrauterine growth restriction. J Nutr Biochem. 2018;55:104-112 pubmed publisher
Ruiz A, Alberdi E, Matute C. Mitochondrial Division Inhibitor 1 (mdivi-1) Protects Neurons against Excitotoxicity through the Modulation of Mitochondrial Function and Intracellular Ca2+ Signaling. Front Mol Neurosci. 2018;11:3 pubmed publisher
Nakahata Y, Yasukawa S, Khaidizar F, Shimba S, Matsui T, Bessho Y. Bmal1-deficient mouse fibroblast cells do not provide premature cellular senescence in vitro. Chronobiol Int. 2018;35:730-738 pubmed publisher
Jiang H, Zou S, Chaudhari S, Ma R. Short-term high-glucose treatment decreased abundance of Orai1 protein through posttranslational mechanisms in rat mesangial cells. Am J Physiol Renal Physiol. 2018;314:F855-F863 pubmed publisher
Kida R, Noguchi T, Murakami M, Hashimoto O, Kawada T, Matsui T, et al. Supra-pharmacological concentration of capsaicin stimulates brown adipogenesis through induction of endoplasmic reticulum stress. Sci Rep. 2018;8:845 pubmed publisher
Strong A, Indart M, Hill N, Daniels R. GL261 glioma tumor cells respond to ATP with an intracellular calcium rise and glutamate release. Mol Cell Biochem. 2018;446:53-62 pubmed publisher
Wu F, Wei X, Wu Y, Kong X, Hu A, Tong S, et al. Chloroquine promotes the recovery of acute spinal cord injury by inhibiting autophagy-associated inflammation and endoplasmic reticulum stress. J Neurotrauma. 2018;: pubmed publisher
Sohn E. MicroRNA 200c-3p regulates autophagy via upregulation of endoplasmic reticulum stress in PC-3 cells. Cancer Cell Int. 2018;18:2 pubmed publisher
Obata Y, Takeuchi K, Wei J, Hakamata A, Odagiri K, Nakajima Y, et al. Interactions between bradykinin and plasmin in the endothelial Ca2+ response. Mol Cell Biochem. 2018;445:179-186 pubmed publisher
Miyazaki Y, Ichimura A, Sato S, Fujii T, Oishi S, Sakai H, et al. The natural flavonoid myricetin inhibits gastric H+, K+-ATPase. Eur J Pharmacol. 2018;820:217-221 pubmed publisher
Ding C, Du Z, Li S, Wu L, Yu G. Ca2+-CaMKK? pathway is required for adiponectin-induced secretion in rat submandibular gland. J Mol Histol. 2018;49:99-110 pubmed publisher
Khaitin A, Rudkovskii M, Uzdensky A. Ca2+ mediates axotomy-induced necrosis and apoptosis of satellite glial cells remote from the transection site in the isolated crayfish mechanoreceptor. Mol Cell Neurosci. 2018;88:7-15 pubmed publisher
Sebag S, Koval O, Paschke J, Winters C, Comellas A, Grumbach I. Inhibition of the mitochondrial calcium uniporter prevents IL-13 and allergen-mediated airway epithelial apoptosis and loss of barrier function. Exp Cell Res. 2018;362:400-411 pubmed publisher
Xiao J, Rijal P, Schimanski L, Tharkeshwar A, Wright E, Annaert W, et al. Characterization of Influenza Virus Pseudotyped with Ebolavirus Glycoprotein. J Virol. 2018;92: pubmed publisher
Mnasri N, Mamarbachi M, Allen B, Mayer G. 5-Azacytidine engages an IRE1?-EGFR-ERK1/2 signaling pathway that stabilizes the LDL receptor mRNA. Biochim Biophys Acta Gene Regul Mech. 2018;1861:29-40 pubmed publisher
Ersoy B, Maner Smith K, Li Y, Alpertunga I, Cohen D. Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress. J Clin Invest. 2018;128:141-156 pubmed publisher
Tahtamouni L, Nawasreh M, Al Mazaydeh Z, Al Khateeb R, Abdellatif R, Bawadi R, et al. Cephalostatin 1 analogues activate apoptosis via the endoplasmic reticulum stress signaling pathway. Eur J Pharmacol. 2018;818:400-409 pubmed publisher
Chakrabarti R, Ji W, Stan R, de Juan Sanz J, Ryan T, Higgs H. INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division. J Cell Biol. 2018;217:251-268 pubmed publisher
Martucciello S, Paolella G, Muzashvili T, Skhirtladze A, Pizza C, Caputo I, et al. Steroids from Helleborus caucasicus reduce cancer cell viability inducing apoptosis and GRP78 down-regulation. Chem Biol Interact. 2018;279:43-50 pubmed publisher
Collier A, Spandau D, Wek R. Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes. Mol Biol Cell. 2018;29:29-41 pubmed publisher
Baumann J, Ignashkova T, Chirasani S, Ramírez Peinado S, Alborzinia H, Gendarme M, et al. Golgi stress-induced transcriptional changes mediated by MAPK signaling and three ETS transcription factors regulate MCL1 splicing. Mol Biol Cell. 2018;29:42-52 pubmed publisher
Goh C, Lee I, Sundaram J, George S, Yusoff P, Brush M, et al. Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration. J Biol Chem. 2018;293:163-176 pubmed publisher
Szpigel A, Hainault I, Carlier A, Venteclef N, Batto A, Hajduch E, et al. Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes. Diabetologia. 2018;61:399-412 pubmed publisher
Deftu A, Filippi A, Gheorghe R, Ristoiu V. CXCL1 activates TRPV1 via Gi/o protein and actin filaments. Life Sci. 2018;193:282-291 pubmed publisher
Sogkas G, Rau E, Atschekzei F, Syed S, Schmidt R. The Pyrazole Derivative BTP2 Attenuates IgG Immune Complex-induced Inflammation. Inflammation. 2018;41:42-49 pubmed publisher
Inoue Y, Hara H, Mitsugi Y, Yamaguchi E, Kamiya T, Itoh A, et al. 4-Hydroperoxy-2-decenoic acid ethyl ester protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways. Neurochem Int. 2018;112:288-296 pubmed publisher
Hadley G, Neuhaus A, Couch Y, Beard D, Adriaanse B, Vekrellis K, et al. The role of the endoplasmic reticulum stress response following cerebral ischemia. Int J Stroke. 2018;13:379-390 pubmed publisher
Ferreira Gomes M, Mangialavori I, Ontiveros M, Rinaldi D, Martiarena J, Verstraeten S, et al. Selectivity of plasma membrane calcium ATPase (PMCA)-mediated extrusion of toxic divalent cations in vitro and in cultured cells. Arch Toxicol. 2018;92:273-288 pubmed publisher
Ryazantseva M, Goncharova A, Skobeleva K, Erokhin M, Methner A, Georgiev P, et al. Presenilin-1 Delta E9 Mutant Induces STIM1-Driven Store-Operated Calcium Channel Hyperactivation in Hippocampal Neurons. Mol Neurobiol. 2018;55:4667-4680 pubmed publisher
Tomiyama R, Takakura K, Takatou S, Le T, Nishiuchi T, Nakamura Y, et al. 3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester induce preconditioning ER stress and autophagy in SH-SY5Y cells. J Cell Physiol. 2018;233:1671-1684 pubmed publisher
Rajani V, Zhang Y, Jalubula V, Rancic V, Sheikhbahaei S, Zwicker J, et al. Release of ATP by pre-Bötzinger complex astrocytes contributes to the hypoxic ventilatory response via a Ca2+ -dependent P2Y1 receptor mechanism. J Physiol. 2018;596:3245-3269 pubmed publisher
Xu X, Chen Y, Song J, Hou F, Ma X, Liu B, et al. Mangiferin suppresses endoplasmic reticulum stress in perivascular adipose tissue and prevents insulin resistance in the endothelium. Eur J Nutr. 2018;57:1563-1575 pubmed publisher
Zinecker H, Ouaret D, Ebner D, Gaidt M, Taylor S, Aulicino A, et al. ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect. Oncotarget. 2017;8:106764-106777 pubmed publisher
Gan L, Liu Z, Luo D, Ren Q, Wu H, Li C, et al. Reduced Endoplasmic Reticulum Stress-Mediated Autophagy Is Required for Leptin Alleviating Inflammation in Adipose Tissue. Front Immunol. 2017;8:1507 pubmed publisher
Eigner K, Filik Y, Mark F, Schütz B, Klambauer G, Moriggl R, et al. The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone. Sci Rep. 2017;7:17498 pubmed publisher
Li J, He J, Fu Y, Hu X, Sun L, Huang Y, et al. Hepatitis B virus X protein inhibits apoptosis by modulating endoplasmic reticulum stress response. Oncotarget. 2017;8:96027-96034 pubmed publisher
Guan B, van Hoef V, Jobava R, Elroy Stein O, Valasek L, Cargnello M, et al. A Unique ISR Program Determines Cellular Responses to Chronic Stress. Mol Cell. 2017;68:885-900.e6 pubmed publisher
Yang D, Jiang T, Liu J, Hong J, Lin P, Chen H, et al. Hormone regulates endometrial function via cooperation of endoplasmic reticulum stress and mTOR-autophagy. J Cell Physiol. 2017;: pubmed publisher
Austin S, Tavakoli M, Pfeiffer C, Seifert J, Mattarei A, De Stefani D, et al. LETM1-Mediated K+ and Na+ Homeostasis Regulates Mitochondrial Ca2+ Efflux. Front Physiol. 2017;8:839 pubmed publisher
Nguyen M, Ho Huynh T. Nam Dia long, a Vietnamese folk formula, induces apoptosis in MCF-7 cells through various mechanisms of action. BMC Complement Altern Med. 2017;17:522 pubmed publisher
Wang Y, Tu L, Li Y, Chen D, Liu Z, Hu X, et al. Notoginsenoside R1 Alleviates Oxygen-Glucose Deprivation/Reoxygenation Injury by Suppressing Endoplasmic Reticulum Calcium Release via PLC. Sci Rep. 2017;7:16226 pubmed publisher
Clarke D, Penrose M, Penstone T, Fuller Carter P, Hool L, Harvey A, et al. Frequency-specific effects of repetitive magnetic stimulation on primary astrocyte cultures. Restor Neurol Neurosci. 2017;35:557-569 pubmed publisher
Dabo S, Maillard P, Collados Rodriguez M, Hansen M, Mazouz S, Bigot D, et al. Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT. Sci Rep. 2017;7:16129 pubmed publisher
He W, Xu H, Gou H, Yuan J, Liao J, Chen Y, et al. CSFV Infection Up-Regulates the Unfolded Protein Response to Promote Its Replication. Front Microbiol. 2017;8:2129 pubmed publisher
Bajikar S, Wang C, Borten M, Pereira E, Atkins K, Janes K. Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer. Dev Cell. 2017;43:418-435.e13 pubmed publisher
Yang F, Fu Y, Li Y, He Y, Mu M, Liu Q, et al. Prostaglandin E1 protects hepatocytes against endoplasmic reticulum stress-induced apoptosis via protein kinase A-dependent induction of glucose-regulated protein 78 expression. World J Gastroenterol. 2017;23:7253-7264 pubmed publisher
Eberhardt M, Stueber T, de la Roche J, Herzog C, Leffler A, Reeh P, et al. TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons. PLoS ONE. 2017;12:e0188008 pubmed publisher
Khong A, Matheny T, Jain S, Mitchell S, Wheeler J, Parker R. The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules. Mol Cell. 2017;68:808-820.e5 pubmed publisher
Long J, Xiao Y, Liu L, Cao Y. The adverse vascular effects of multi-walled carbon nanotubes (MWCNTs) to human vein endothelial cells (HUVECs) in vitro: role of length of MWCNTs. J Nanobiotechnology. 2017;15:80 pubmed publisher
Matsuo Y, Hirota K. Transmembrane thioredoxin-related protein TMX1 is reversibly oxidized in response to protein accumulation in the endoplasmic reticulum. FEBS Open Bio. 2017;7:1768-1777 pubmed publisher
Liang R, Jia J, Li J, He N, Zhou Y, Jiang L, et al. Mitofusin-2 mediated mitochondrial Ca2+ uptake 1/2 induced liver injury in rat remote ischemic perconditioning liver transplantation and alpha mouse liver-12 hypoxia cell line models. World J Gastroenterol. 2017;23:6995-7008 pubmed publisher
Gendarme M, Baumann J, Ignashkova T, Lindemann R, Reiling J. Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1. Mol Biol Cell. 2017;28:3756-3772 pubmed publisher
Kim K, Lee I, Kim K, Park J, Kim Y, Choi J, et al. Activation of intestinal olfactory receptor stimulates glucagon-like peptide-1 secretion in enteroendocrine cells and attenuates hyperglycemia in type 2 diabetic mice. Sci Rep. 2017;7:13978 pubmed publisher
Li X, Wu G, Yang Y, Fu S, Liu X, Kang H, et al. Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers. Nat Commun. 2017;8:1042 pubmed publisher
Kim H, Han T, Kim Y, So I, Kim B. Magnolia Officinalis Bark Extract Induces Depolarization of Pacemaker Potentials Through M2 and M3 Muscarinic Receptors in Cultured Murine Small Intestine Interstitial Cells of Cajal. Cell Physiol Biochem. 2017;43:1790-1802 pubmed publisher
Fujii Y, Maekawa S, Morita M. Astrocyte calcium waves propagate proximally by gap junction and distally by extracellular diffusion of ATP released from volume-regulated anion channels. Sci Rep. 2017;7:13115 pubmed publisher
Hong Z, Pedersen N, Wang L, Torgersen M, Stenmark H, Raiborg C. PtdIns3P controls mTORC1 signaling through lysosomal positioning. J Cell Biol. 2017;216:4217-4233 pubmed publisher
Vanhove W, Nys K, Arijs I, Cleynen I, Noben M, De Schepper S, et al. Biopsy-derived intestinal epithelial cell cultures for pathway based stratification of patients with inflammatory bowel disease. J Crohns Colitis. 2017;: pubmed publisher
Masson S, Hedges C, Devaux J, James C, Hickey A. Mitochondrial glycerol 3-phosphate facilitates bumblebee pre-flight thermogenesis. Sci Rep. 2017;7:13107 pubmed publisher
Singh P, Roukounakis A, Frank D, Kirschnek S, Das K, Neumann S, et al. Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis. Genes Dev. 2017;31:1754-1769 pubmed publisher
van Raam B, Lacina T, Lindemann R, Reiling J. Secretory stressors induce intracellular death receptor accumulation to control apoptosis. Cell Death Dis. 2017;8:e3069 pubmed publisher
de Andrade Mello P, Bian S, Savio L, Zhang H, Zhang J, Junger W, et al. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. Oncotarget. 2017;8:67254-67268 pubmed publisher
Pinedo Carpio E, Davidson D, Marignac V, Panasci J, Aloyz R. Adaptive metabolic rewiring to chronic SFK inhibition. Oncotarget. 2017;8:66758-66768 pubmed publisher
Xia K, Ma Z, Shen J, Li M, Hou B, Gao M, et al. The 2-aminoethoxydiphenyl borate analog, DPB161 blocks store-operated Ca2+ entry in acutely dissociated rat submandibular cells. Oncotarget. 2017;8:61551-61560 pubmed publisher
Yu H, Qiu Y, Pang X, Li J, Wu S, Yin S, et al. Lycorine Promotes Autophagy and Apoptosis via TCRP1/Akt/mTOR Axis Inactivation in Human Hepatocellular Carcinoma. Mol Cancer Ther. 2017;16:2711-2723 pubmed publisher
Parikh S, Blackwell D, Gómez Hurtado N, Frisk M, Wang L, Kim K, et al. Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ Res. 2017;121:1323-1330 pubmed publisher
Inoh Y, Haneda A, Tadokoro S, Yokawa S, Furuno T. Cationic liposomes suppress intracellular calcium ion concentration increase via inhibition of PI3 kinase pathway in mast cells. Biochim Biophys Acta Biomembr. 2017;1859:2461-2466 pubmed publisher
Usuki F, Fujimura M, Yamashita A. Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters. Sci Rep. 2017;7:12390 pubmed publisher
Hsieh T, Chen Y, Chang C, Lee W, Liou J. Cortical actin contributes to spatial organization of ER-PM junctions. Mol Biol Cell. 2017;28:3171-3180 pubmed publisher
Teng Y, Zhao H, Gao L, Zhang W, Shull A, Shay C. FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4-GSK3β-Nrf2 Signaling. Cancer Res. 2017;77:6215-6225 pubmed publisher
Zhang M, Liu X, Wang Q, Ru Y, Xiong X, Wu K, et al. NDRG2 acts as a PERK co-factor to facilitate PERK branch and ERS-induced cell death. FEBS Lett. 2017;591:3670-3681 pubmed publisher
Nagai H, Satomi T, Abiru A, Miyamoto K, Nagasawa K, Maruyama M, et al. Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia. EBioMedicine. 2017;24:147-158 pubmed publisher
de Oliveira D, Batista Lima F, de Carvalho E, Havt A, da Silva M, dos Santos A, et al. Extracellular acidosis selectively inhibits pharmacomechanical coupling induced by carbachol in strips of rat gastric fundus. Exp Physiol. 2017;102:1607-1618 pubmed publisher
Briggs J, Ren L, Chakrabarti K, Tsai Y, Weissman A, Hansen R, et al. Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus. PLoS ONE. 2017;12:e0185089 pubmed publisher
Kabala P, Angiolilli C, Yeremenko N, Grabiec A, Giovannone B, Pots D, et al. Endoplasmic reticulum stress cooperates with Toll-like receptor ligation in driving activation of rheumatoid arthritis fibroblast-like synoviocytes. Arthritis Res Ther. 2017;19:207 pubmed publisher
Chen T, Zhu J, Yang L, Feng Y, Lin W, Wang Y. Glutamate-induced rapid induction of Arc/Arg3.1 requires NMDA receptor-mediated phosphorylation of ERK and CREB. Neurosci Lett. 2017;661:23-28 pubmed publisher
Steiner N, Borjan B, Hajek R, Johrer K, Göbel G, Willenbacher W, et al. Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma. Oncotarget. 2017;8:56243-56254 pubmed publisher
Chen Y, Chen Y, Chiu W, Chen H, Shen M. STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion. Sci Rep. 2017;7:11523 pubmed publisher
Spigoni V, Fantuzzi F, Fontana A, Cito M, Derlindati E, Zavaroni I, et al. Stearic acid at physiologic concentrations induces in vitro lipotoxicity in circulating angiogenic cells. Atherosclerosis. 2017;265:162-171 pubmed publisher
Takahashi N, Harada M, Hirota Y, Nose E, Azhary J, Koike H, et al. Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis. Sci Rep. 2017;7:10824 pubmed publisher
Chen M, Moily N, Bridgford J, Wood R, Radwan M, Smith T, et al. A thiol probe for measuring unfolded protein load and proteostasis in cells. Nat Commun. 2017;8:474 pubmed publisher
Le Moigne R, Aftab B, Djakovic S, Dhimolea E, Valle E, Murnane M, et al. The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma. Mol Cancer Ther. 2017;16:2375-2386 pubmed publisher
Taylor E, Pantazaka E, Shelley K, Taylor C. Prostaglandin E2 Inhibits Histamine-Evoked Ca2+ Release in Human Aortic Smooth Muscle Cells through Hyperactive cAMP Signaling Junctions and Protein Kinase A. Mol Pharmacol. 2017;92:533-545 pubmed publisher
Lee K, Kim Y, Cho Y, Chung S, Jo S, Choi S. Polychlorinated biphenyl 19 blocks the most common form of store-operated Ca2+ entry through Orai. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:1221-1228 pubmed publisher
Sahid M, Liu S, Kiyoi T, Maeyama K. Inhibition of the mevalonate pathway by simvastatin interferes with mast cell degranulation by disrupting the interaction between Rab27a and double C2 alpha proteins. Eur J Pharmacol. 2017;814:255-263 pubmed publisher
Li H, Kim H, Shin S, Seo M, An J, Ha K, et al. The vasorelaxant effect of mitiglinide via activation of voltage-dependent K+ channels and SERCA pump in aortic smooth muscle. Life Sci. 2017;188:1-9 pubmed publisher
Rahi S, Larsch J, Pecani K, Katsov A, Mansouri N, Tsaneva Atanasova K, et al. Oscillatory stimuli differentiate adapting circuit topologies. Nat Methods. 2017;14:1010-1016 pubmed publisher
Tanaka N, Takahashi S, Hu X, Lu Y, Fujimori N, Golla S, et al. Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet. Biochim Biophys Acta Mol Basis Dis. 2017;1863:3170-3182 pubmed publisher
Farias D, Lucena M, Garçon D, Mantelatto F, McNamara J, Leone F. A Kinetic Characterization of the Gill (Na+, K+)-ATPase from the Semi-terrestrial Mangrove Crab Cardisoma guanhumi Latreille, 1825 (Decapoda, Brachyura). J Membr Biol. 2017;250:517-534 pubmed publisher
Dayoub O, Le Lay S, Soleti R, Clere N, Hilairet G, Dubois S, et al. Estrogen receptor α/HDAC/NFAT axis for delphinidin effects on proliferation and differentiation of T lymphocytes from patients with cardiovascular risks. Sci Rep. 2017;7:9378 pubmed publisher
Mügge F, Silva A. Aspirin metabolite sodium salicylate selectively inhibits transcriptional activity of ATF6α and downstream target genes. Sci Rep. 2017;7:9190 pubmed publisher
Aydin Y, Chedid M, Chava S, Danielle Williams D, Liu S, Hagedorn C, et al. Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture. Sci Rep. 2017;7:9223 pubmed publisher
Roy G, Zhang S, Li L, Higham E, Wu H, Marelli M, et al. Development of a fluorescent reporter system for monitoring ER stress in Chinese hamster ovary cells and its application for therapeutic protein production. PLoS ONE. 2017;12:e0183694 pubmed publisher
Korthals M, Langnaese K, Smalla K, Kahne T, Herrera Molina R, Handschuh J, et al. A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation. Sci Rep. 2017;7:8358 pubmed publisher
Bower D, Lansdale N, Navarro S, Truong T, Bower D, Featherstone N, et al. SERCA directs cell migration and branching across species and germ layers. Biol Open. 2017;6:1458-1471 pubmed publisher
Tadros S, Shukla S, King R, Gunda V, Vernucci E, Abrego J, et al. De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer. Cancer Res. 2017;77:5503-5517 pubmed publisher
Vicario M, Cali T, Cieri D, Vallese F, Bortolotto R, Lopreiato R, et al. A novel PMCA3 mutation in an ataxic patient with hypomorphic phosphomannomutase 2 (PMM2) heterozygote mutations: Biochemical characterization of the pump defect. Biochim Biophys Acta Mol Basis Dis. 2017;1863:3303-3312 pubmed publisher
Pelzl L, Elsir B, Sahu I, Bissinger R, Singh Y, Sukkar B, et al. Lithium Sensitivity of Store Operated Ca2+ Entry and Survival of Fibroblasts Isolated from Chorea-Acanthocytosis Patients. Cell Physiol Biochem. 2017;42:2066-2077 pubmed publisher
Urban N, Neuser S, Hentschel A, Köhling S, Rademann J, Schaefer M. Pharmacological inhibition of focal segmental glomerulosclerosis-related, gain of function mutants of TRPC6 channels by semi-synthetic derivatives of larixol. Br J Pharmacol. 2017;174:4099-4122 pubmed publisher
Park J, Choi W, Lee P, Chung S, Kim B, Chung H, et al. The novel resveratrol derivative 3,5-diethoxy-3',4'-dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro. Acta Pharmacol Sin. 2017;38:1486-1500 pubmed publisher
Wu Y, Xu X, Ma L, Yi Q, Sun W, Tang L. Calreticulin regulates TGF-?1-induced epithelial mesenchymal transition through modulating Smad signaling and calcium signaling. Int J Biochem Cell Biol. 2017;90:103-113 pubmed publisher
McNeilly T, Frew D, Burgess S, Wright H, Bartley D, Bartley Y, et al. Niche-specific gene expression in a parasitic nematode; increased expression of immunomodulators in Teladorsagia circumcincta larvae derived from host mucosa. Sci Rep. 2017;7:7214 pubmed publisher
Hou Y, Kitaguchi T, Kriszt R, Tseng Y, Raghunath M, Suzuki M. Ca2+-associated triphasic pH changes in mitochondria during brown adipocyte activation. Mol Metab. 2017;6:797-808 pubmed publisher
Dang J, Bian X, Ma X, Li J, Long F, Shan S, et al. ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6?-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway. J Immunol. 2017;199:1647-1659 pubmed publisher
Pelzl L, Hauser S, Elsir B, Sukkar B, Sahu I, Singh Y, et al. Lithium Sensitive ORAI1 Expression, Store Operated Ca2+ Entry and Suicidal Death of Neurons in Chorea-Acanthocytosis. Sci Rep. 2017;7:6457 pubmed publisher
Horiuchi Y, Nakatsu D, Kano F, Murata M. Pyruvate kinase M1 interacts with A-Raf and inhibits endoplasmic reticulum stress-induced apoptosis by activating MEK1/ERK pathway in mouse insulinoma cells. Cell Signal. 2017;38:212-222 pubmed publisher
Ozdemir T, Srinivasan P, Zakheim D, Harrington D, Witt R, Farach Carson M, et al. Bottom-up assembly of salivary gland microtissues for assessing myoepithelial cell function. Biomaterials. 2017;142:124-135 pubmed publisher
Zhang Y, Zhang J, Zhu M, Zhang M, Xu Y, Cui L, et al. Effect of lysophosphatidylglycerol on intracellular free Ca2+ concentration in A10 vascular smooth muscle cells. Can J Physiol Pharmacol. 2017;95:1283-1288 pubmed publisher
Okumura N, Kitahara M, Okuda H, Hashimoto K, Ueda E, Nakahara M, et al. Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci. 2017;58:3697-3707 pubmed publisher
Korzeniowski M, Wisniewski E, Baird B, Holowka D, Balla T. Molecular anatomy of the early events in STIM1 activation - oligomerization or conformational change?. J Cell Sci. 2017;130:2821-2832 pubmed publisher
Clark A, Kanekura K, Lavagnino Z, Spears L, Abreu D, Mahadevan J, et al. Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death. Sci Rep. 2017;7:5611 pubmed publisher
Takahashi N, Kimura A, Naito S, Yoshida M, Kumano O, Suzuki T, et al. Sarcolipin expression is repressed by endoplasmic reticulum stress in C2C12 myotubes. J Physiol Biochem. 2017;73:531-538 pubmed publisher
Huang J, Zhao L, Yang P, Chen Z, Ruan X, Huang A, et al. Fatty acid translocase promoted hepatitis B virus replication by upregulating the levels of hepatic cytosolic calcium. Exp Cell Res. 2017;358:360-368 pubmed publisher
Hamel Côté G, Gendron D, Rola Pleszczynski M, Stankova J. Regulation of platelet-activating factor-mediated protein tyrosine phosphatase 1B activation by a Janus kinase 2/calpain pathway. PLoS ONE. 2017;12:e0180336 pubmed publisher
Pelzl L, Hosseinzadeh Z, Al Maghout T, Singh Y, Sahu I, Bissinger R, et al. Role of Na+/Ca2+ Exchangers in Therapy Resistance of Medulloblastoma Cells. Cell Physiol Biochem. 2017;42:1240-1251 pubmed publisher
Canfrán Duque A, Rotllan N, Zhang X, Fernández Fuertes M, Ramírez Hidalgo C, Araldi E, et al. Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis. EMBO Mol Med. 2017;9:1244-1262 pubmed publisher
Law B, Mok S, Chen J, Michelangeli F, Jiang Z, Han Y, et al. N-Desmethyldauricine Induces Autophagic Cell Death in Apoptosis-Defective Cells via Ca2+ Mobilization. Front Pharmacol. 2017;8:388 pubmed publisher
Metts J, Bradley H, Wang Z, Shah N, Kapur R, Arbiser J, et al. Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells. Sci Rep. 2017;7:4447 pubmed publisher
Huang H, Vandekeere S, Kalucka J, Bierhansl L, Zecchin A, Bruning U, et al. Role of glutamine and interlinked asparagine metabolism in vessel formation. EMBO J. 2017;36:2334-2352 pubmed publisher
Romecín P, Navarro E, Ortiz M, Iyu D, García Estañ J, Atucha N. Bile Acids Do Not Contribute to the Altered Calcium Homeostasis of Platelets from Rats with Biliary Cirrhosis. Front Physiol. 2017;8:384 pubmed publisher
Hatanaka M, Anderson Baucum E, Lakhter A, Kono T, Maier B, Tersey S, et al. Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation. Sci Rep. 2017;7:3758 pubmed publisher
Harris E, Burki U, Marini Bettolo C, Neri M, Scotton C, Hudson J, et al. Complex phenotypes associated with STIM1 mutations in both coiled coil and EF-hand domains. Neuromuscul Disord. 2017;27:861-872 pubmed publisher
Phillippe M, Adeli S. Cell-free DNA release by mouse placental explants. PLoS ONE. 2017;12:e0178845 pubmed publisher
Lopez I, Tournillon A, Prado Martins R, Karakostis K, Malbert Colas L, Nylander K, et al. p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress. Cell Death Differ. 2017;24:1717-1729 pubmed publisher
Dey N, Ali A, Podder S, Majumdar S, Nandi D, Bhattacharya S. Dual-Mode Optical Sensing of Histamine at Nanomolar Concentrations in Complex Biological Fluids and Living Cells. Chemistry. 2017;23:11891-11897 pubmed publisher
Tang H, Wang H, Lin Q, Fan F, Zhang F, Peng X, et al. Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function. J Immunol. 2017;199:570-580 pubmed publisher
Kung P, Hsieh P, Lin Y, Lee J, Chen I, Wu C. HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases. Redox Biol. 2017;13:266-277 pubmed publisher
Cho B, Cho H, Jo Y, Kim H, Song M, Moon C, et al. Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division. Nat Commun. 2017;8:15754 pubmed publisher
Song X, Liu G, Liu F, Yan Z, Wang Z, Liu Z, et al. Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells. Cell Death Dis. 2017;8:e2863 pubmed publisher
Dong Z, Zhao P, Xu M, Zhang C, Guo W, Chen H, et al. Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation. Sci Rep. 2017;7:2691 pubmed publisher
Dong Z, Zhang C, Chen Y, Chen Y, Yuan Z, Peng Y, et al. Astragaloside-IV Protects Against Heat-induced Apoptosis by Inhibiting Excessive Activation of Mitochondrial Ca2+ Uniporter. Cell Physiol Biochem. 2017;42:480-494 pubmed publisher
Di Filippo E, Mancinelli R, Marrone M, Doria C, Verratti V, Toniolo L, et al. Neuromuscular electrical stimulation improves skeletal muscle regeneration through satellite cell fusion with myofibers in healthy elderly subjects. J Appl Physiol (1985). 2017;123:501-512 pubmed publisher
Takata N, Ohshima Y, Suzuki Karasaki M, Yoshida Y, Tokuhashi Y, Suzuki Karasaki Y. Mitochondrial Ca2+ removal amplifies TRAIL cytotoxicity toward apoptosis-resistant tumor cells via promotion of multiple cell death modalities. Int J Oncol. 2017;51:193-203 pubmed publisher
Wu Y, Zhao P, Luo X, Xu J, Xue L, Zhou Q, et al. Chloroquine inhibits Ca2+ permeable ion channels-mediated Ca2+ signaling in primary B lymphocytes. Cell Biosci. 2017;7:28 pubmed publisher
Nazli S, Loeser R, Chubinskaya S, Willey J, Yammani R. High fat-diet and saturated fatty acid palmitate inhibits IGF-1 function in chondrocytes. Osteoarthritis Cartilage. 2017;25:1516-1521 pubmed publisher
Chen P, Zhang Y, Xu J, Yu M, Huang J, Zhao L, et al. Sodium tanshinone IIA sulfonate stimulated Cl- secretion in mouse trachea. PLoS ONE. 2017;12:e0178226 pubmed publisher
Chmielarz P, Konovalova J, Najam S, Alter H, Piepponen T, Erfle H, et al. Dicer and microRNAs protect adult dopamine neurons. Cell Death Dis. 2017;8:e2813 pubmed publisher
Ramírez Peinado S, Ignashkova T, van Raam B, Baumann J, Sennott E, Gendarme M, et al. TRAPPC13 modulates autophagy and the response to Golgi stress. J Cell Sci. 2017;130:2251-2265 pubmed publisher
Sharma M, Bhattacharyya S, Sharma K, Chauhan S, Asthana S, Abdin M, et al. Japanese encephalitis virus activates autophagy through XBP1 and ATF6 ER stress sensors in neuronal cells. J Gen Virol. 2017;98:1027-1039 pubmed publisher
Rasool R, Nayak D, Chakraborty S, Faheem M, Rah B, Mahajan P, et al. AKT is indispensable for coordinating Par-4/JNK cross talk in p21 downmodulation during ER stress. Oncogenesis. 2017;6:e341 pubmed publisher
Dalghi M, Ferreira Gomes M, Montalbetti N, Simonin A, Strehler E, Hediger M, et al. Cortical cytoskeleton dynamics regulates plasma membrane calcium ATPase isoform-2 (PMCA2) activity. Biochim Biophys Acta Mol Cell Res. 2017;1864:1413-1424 pubmed publisher
Arora P, Di Gregorio M, He P, McCulloch C. TRPV4 mediates the Ca2+ influx required for the interaction between flightless-1 and non-muscle myosin, and collagen remodeling. J Cell Sci. 2017;130:2196-2208 pubmed publisher
He X, Li S, Liu B, Susperreguy S, Formoso K, Yao J, et al. Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries. Proc Natl Acad Sci U S A. 2017;114:E4582-E4591 pubmed publisher
Bañuls C, Rovira Llopis S, Martinez de Marañon A, Veses S, Jover A, Gomez M, et al. Metabolic syndrome enhances endoplasmic reticulum, oxidative stress and leukocyte-endothelium interactions in PCOS. Metabolism. 2017;71:153-162 pubmed publisher
Duivenvoorden W, Hopmans S, Austin R, Pinthus J. Endoplasmic reticulum protein ERp46 in prostate adenocarcinoma. Oncol Lett. 2017;13:3624-3630 pubmed publisher
Wang L, Gundelach J, Bram R. Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme. Cell Death Dis. 2017;8:e2807 pubmed publisher
Makitani K, Nakagawa S, Izumi Y, Akaike A, Kume T. Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes. J Pharmacol Sci. 2017;134:37-44 pubmed publisher
Li P, Bian X, Chen Q, Yao X, Wang X, Zhang W, et al. Blocking of stromal interaction molecule 1 expression influence cell proliferation and promote cell apoptosis in vitro and inhibit tumor growth in vivo in head and neck squamous cell carcinoma. PLoS ONE. 2017;12:e0177484 pubmed publisher
Servas C, Kiehlmeier S, Hach J, Gross R, Götz C, Montenarh M. The mammalian STE20-like kinase 1 (MST1) is a substrate for the apoptosis inhibiting protein kinase CK2. Cell Signal. 2017;36:163-175 pubmed publisher
Li J, Wu W, Zhao M, Liu X. Involvement of TRPC1 in Nampt-induced cardiomyocyte hypertrophy through the activation of ER stress. Cell Mol Biol (Noisy-le-grand). 2017;63:33-37 pubmed publisher
Chan S, Zhao X, Elfowiris A, Ratnam C, Herbert T. The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells. Biochimie. 2017;138:156-167 pubmed publisher
Arruda Barbosa L, Teófilo T, Souza Neto F, Duarte G, Vale J, Borges R, et al. Trans-4-methoxy-?-nitrostyrene relaxes rat thoracic aorta through a sGC-dependent pathway. Eur J Pharmacol. 2017;807:182-189 pubmed publisher
Wright R, Newey S, Ilie A, Wefelmeyer W, Raimondo J, Ginham R, et al. Neuronal Chloride Regulation via KCC2 Is Modulated through a GABAB Receptor Protein Complex. J Neurosci. 2017;37:5447-5462 pubmed publisher
Yoshino H, Kumai Y, Kashiwakura I. Effects of endoplasmic reticulum stress on apoptosis induction in radioresistant macrophages. Mol Med Rep. 2017;15:2867-2872 pubmed publisher
Sahu I, Pelzl L, Sukkar B, Fakhri H, Al Maghout T, Cao H, et al. NFAT5-sensitive Orai1 expression and store-operated Ca2+ entry in megakaryocytes. FASEB J. 2017;31:3439-3448 pubmed publisher
Won J, Yu S, Hwang C, Cho S, Park S, Kim K, et al. Protein disulfide isomerase inhibition synergistically enhances the efficacy of sorafenib for hepatocellular carcinoma. Hepatology. 2017;66:855-868 pubmed publisher
Zheng X, Xu F, Liang H, Cao H, Cai M, Xu W, et al. SIRT1/HSF1/HSP pathway is essential for exenatide-alleviated, lipid-induced hepatic endoplasmic reticulum stress. Hepatology. 2017;66:809-824 pubmed publisher
Eshima H, Miura S, Senoo N, Hatakeyama K, Poole D, Kano Y. Improved skeletal muscle Ca2+ regulation in vivo following contractions in mice overexpressing PGC-1α. Am J Physiol Regul Integr Comp Physiol. 2017;312:R1017-R1028 pubmed publisher
Jegal K, Park S, Cho S, Byun S, Ku S, Kim S, et al. Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury. Biochim Biophys Acta Mol Cell Res. 2017;1864:1295-1307 pubmed publisher
Teófilo T, Arruda Barbosa L, Rodrigues Silva J, Vale J, Borges R, Duarte G, et al. Mechanism of the vasorelaxant effect induced by trans-4-methyl-β-nitrostyrene, a synthetic nitroderivative, in rat thoracic aorta. Clin Exp Pharmacol Physiol. 2017;44:787-794 pubmed publisher
Molteni L, Rizzi L, Bresciani E, Possenti R, Petrocchi Passeri P, Ghè C, et al. Pharmacological and Biochemical Characterization of TLQP-21 Activation of a Binding Site on CHO Cells. Front Pharmacol. 2017;8:167 pubmed publisher
Abdoul Azize S, Dubus I, Vannier J. Improvement of dexamethasone sensitivity by chelation of intracellular Ca2+ in pediatric acute lymphoblastic leukemia cells through the prosurvival kinase ERK1/2 deactivation. Oncotarget. 2017;8:27339-27352 pubmed publisher
Freis P, Bollard J, Lebeau J, Massoma P, Fauvre J, Vercherat C, et al. mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines. Oncotarget. 2017;8:20974-20987 pubmed publisher
Novakovic A, Marinko M, Jankovic G, Stojanovic I, Milojevic P, Nenezic D, et al. Endothelium-dependent vasorelaxant effect of procyanidin B2 on human internal mammary artery. Eur J Pharmacol. 2017;807:75-81 pubmed publisher
Attakpa E, Bertin G, Chabi N, Ategbo J, Seri B, Khan N. Moringa oleifera-rich diet and T cell calcium signaling in spontaneously hypertensive rats. Physiol Res. 2017;66:753-767 pubmed
Yin Y, Chen C, Chen J, Zhan R, Zhang Q, Xu X, et al. Cell surface GRP78 facilitates hepatoma cells proliferation and migration by activating IGF-IR. Cell Signal. 2017;35:154-162 pubmed publisher
Yiu A, Ibeh C, Roy S, Bandyopadhyay B. Melamine induces Ca2+-sensing receptor activation and elicits apoptosis in proximal tubular cells. Am J Physiol Cell Physiol. 2017;313:C27-C41 pubmed publisher
Jiang X, Wei Y, Zhang T, Zhang Z, Qiu S, Zhou X, et al. Effects of GSK2606414 on cell proliferation and endoplasmic reticulum stress‑associated gene expression in retinal pigment epithelial cells. Mol Med Rep. 2017;15:3105-3110 pubmed publisher
Chen Y, Chen L, Yeh Y, Wu P, Chen Y, Chang L, et al. Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy. Sci Rep. 2017;7:45366 pubmed publisher
Li H, Tan X, Yan L, Zeng B, Meng J, Xu H, et al. Multi-walled carbon nanotubes act as a chemokine and recruit macrophages by activating the PLC/IP3/CRAC channel signaling pathway. Sci Rep. 2017;7:226 pubmed publisher
Huang C, Lien C, Cheng C, Yen T, Chen C, Tsaur M. K+ Channel Kv3.4 Is Essential for Axon Growth by Limiting the Influx of Ca2+ into Growth Cones. J Neurosci. 2017;37:4433-4449 pubmed publisher
Marcassa E, Raimondi M, Anwar T, Eskelinen E, Myers M, Triolo G, et al. Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin. Biol Open. 2017;6:551-562 pubmed publisher
da Silva D, Andrade P, Valentão P, Pereira D. Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2? branch of the endoplasmic reticulum. J Steroid Biochem Mol Biol. 2017;171:178-186 pubmed publisher
Yasuda K, Clatterbuck Soper S, Jackrel M, Shorter J, Mili S. FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination. J Cell Biol. 2017;216:1015-1034 pubmed publisher
Conte E, Camerino G, Mele A, De Bellis M, Pierno S, Rana F, et al. Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia. J Cachexia Sarcopenia Muscle. 2017;8:386-404 pubmed publisher
Vaeth M, Yang J, Yamashita M, Zee I, Eckstein M, Knosp C, et al. ORAI2 modulates store-operated calcium entry and T cell-mediated immunity. Nat Commun. 2017;8:14714 pubmed publisher
Kuang S, Qian J, Yang H, Rao F, Chen X, Zhang M, et al. The enhancement of TXA2 receptors-mediated contractile response in intrarenal artery dysfunction in type 2 diabetic mice. Eur J Pharmacol. 2017;805:93-100 pubmed publisher
Yoon M, Kim D, Kim S, Park H. Hydrogen peroxide attenuates refilling of intracellular calcium store in mouse pancreatic acinar cells. Korean J Physiol Pharmacol. 2017;21:233-239 pubmed publisher
Stallaert W, Van der Westhuizen E, Schönegge A, Plouffe B, Hogue M, Lukashova V, et al. Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells. Mol Pharmacol. 2017;91:533-544 pubmed publisher
Weber L, Al Refae K, Ebbert J, Jagers P, Altmuller J, Becker C, et al. Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis. PLoS ONE. 2017;12:e0172491 pubmed publisher
Zhang C, Medzihradszky K, Sanchez E, Basbaum A, Julius D. Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release. Proc Natl Acad Sci U S A. 2017;114:E2524-E2532 pubmed publisher
Vera C, Oróstica L, Gabler F, Ferreira A, Selman A, Vega M, et al. The nerve growth factor alters calreticulin translocation from the endoplasmic reticulum to the cell surface and its signaling pathway in epithelial ovarian cancer cells. Int J Oncol. 2017;50:1261-1270 pubmed publisher
Turcotte C, Zarini S, Jean S, Martin C, Murphy R, Marsolais D, et al. The Endocannabinoid Metabolite Prostaglandin E2 (PGE2)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors. J Immunol. 2017;198:3255-3263 pubmed publisher
González A, Muñoz V, Cavieres V, Bustamante H, Cornejo V, Januário Y, et al. Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway. FASEB J. 2017;31:2446-2459 pubmed publisher
Luyten T, Welkenhuyzen K, Roest G, Kania E, Wang L, Bittremieux M, et al. Resveratrol-induced autophagy is dependent on IP3Rs and on cytosolic Ca2. Biochim Biophys Acta Mol Cell Res. 2017;1864:947-956 pubmed publisher
Ferdek P, Jakubowska M, Nicolaou P, Gerasimenko J, Gerasimenko O, Petersen O. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death Dis. 2017;8:e2640 pubmed publisher
Kang M, Kim J, An H, Ko J. Human leucine zipper protein promotes hepatic steatosis via induction of apolipoprotein A-IV. FASEB J. 2017;31:2548-2561 pubmed publisher
Falchi M, Varricchio L, Martelli F, Marra M, Picconi O, Tafuri A, et al. The Calreticulin control of human stress erythropoiesis is impaired by JAK2V617F in polycythemia vera. Exp Hematol. 2017;50:53-76 pubmed publisher
González Sánchez P, Pla Martín D, Martinez Valero P, Rueda C, Calpena E, del Arco A, et al. CMT-linked loss-of-function mutations in GDAP1 impair store-operated Ca2+ entry-stimulated respiration. Sci Rep. 2017;7:42993 pubmed publisher
Balaji R, Bielmeier C, Harz H, Bates J, Stadler C, Hildebrand A, et al. Calcium spikes, waves and oscillations in a large, patterned epithelial tissue. Sci Rep. 2017;7:42786 pubmed publisher
Yazbeck P, Tauseef M, Kruse K, Amin M, Sheikh R, Feske S, et al. STIM1 Phosphorylation at Y361 Recruits Orai1 to STIM1 Puncta and Induces Ca2+ Entry. Sci Rep. 2017;7:42758 pubmed publisher
Kim H, Kim H, Yang D, Jung M, Kim B. Depolarizing Effects of Daikenchuto on Interstitial Cells of Cajal from Mouse Small Intestine. Pharmacogn Mag. 2017;13:141-147 pubmed publisher
Gudipaty S, Lindblom J, Loftus P, Redd M, Edes K, Davey C, et al. Mechanical stretch triggers rapid epithelial cell division through Piezo1. Nature. 2017;543:118-121 pubmed publisher
Wolczyk M, Podszywalow Bartnicka P, Bugajski L, Piwocka K. Stress granules assembly affects detection of mRNA in living cells by the NanoFlares; an important aspect of the technology. Biochim Biophys Acta Gen Subj. 2017;1861:1024-1035 pubmed publisher
Richhariya S, Jayakumar S, Abruzzi K, Rosbash M, Hasan G. A pupal transcriptomic screen identifies Ral as a target of store-operated calcium entry in Drosophila neurons. Sci Rep. 2017;7:42586 pubmed publisher
Ocaña G, Perez L, Guindon L, Deffit S, Evans Molina C, Thurmond D, et al. Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90?. Immunology. 2017;151:198-210 pubmed publisher
Yuan Z, Cao A, Liu H, Guo H, Zang Y, Wang Y, et al. Calcium Uptake via Mitochondrial Uniporter Contributes to Palmitic Acid-Induced Apoptosis in Mouse Podocytes. J Cell Biochem. 2017;118:2809-2818 pubmed publisher
Boppana N, Kraveka J, Rahmaniyan M, Li L, Bielawska A, Bielawski J, et al. Fumonisin B1 Inhibits Endoplasmic Reticulum Stress Associated-apoptosis After FoscanPDT Combined with C6-Pyridinium Ceramide or Fenretinide. Anticancer Res. 2017;37:455-463 pubmed
Leon Aparicio D, Pacheco J, Chavez Reyes J, Galindo J, Valdés J, Vaca L, et al. Orai3 channel is the 2-APB-induced endoplasmic reticulum calcium leak. Cell Calcium. 2017;65:91-101 pubmed publisher
Kim E, Toyono T, Berlinicke C, Zack D, Jurkunas U, Usui T, et al. Screening and Characterization of Drugs That Protect Corneal Endothelial Cells Against Unfolded Protein Response and Oxidative Stress. Invest Ophthalmol Vis Sci. 2017;58:892-900 pubmed publisher
Romecín P, Atucha N, Navarro E, Ortiz M, Iyu D, Rosado J, et al. Role of homocysteine and folic acid on the altered calcium homeostasis of platelets from rats with biliary cirrhosis. Platelets. 2017;28:698-705 pubmed publisher
Sahu S, Visetsouk M, Garde R, Hennes L, Kwas C, Gutzman J. Calcium signals drive cell shape changes during zebrafish midbrain-hindbrain boundary formation. Mol Biol Cell. 2017;28:875-882 pubmed publisher
Dib I, Fauconnier M, Sindic M, Belmekki F, Assaidi A, Berrabah M, et al. Chemical composition, vasorelaxant, antioxidant and antiplatelet effects of essential oil of Artemisia campestris L. from Oriental Morocco. BMC Complement Altern Med. 2017;17:82 pubmed publisher
Tsuruwaka Y, Shimada E, Tsutsui K, Ogawa T. Ca2+ dynamics in zebrafish morphogenesis. Peerj. 2017;5:e2894 pubmed publisher
Li Z, Zhang C, Zhang Y, Chen L, Chen B, Li Q, et al. A novel HDAC6 inhibitor Tubastatin A: Controls HDAC6-p97/VCP-mediated ubiquitination-autophagy turnover and reverses Temozolomide-induced ER stress-tolerance in GBM cells. Cancer Lett. 2017;391:89-99 pubmed publisher
Hu Y, Li X, Xue W, Pang J, Meng Y, Shen Y, et al. TP53INP2-related basal autophagy is involved in the growth and malignant progression in human liposarcoma cells. Biomed Pharmacother. 2017;88:562-568 pubmed publisher
Chen T, Xu X, Zhao Z, Zhao F, Gao Y, Yan X, et al. Hydrogen peroxide is a critical regulator of the hypoxia-induced alterations of store-operated Ca2+ entry into rat pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2017;312:L477-L487 pubmed publisher
Lee S, Kim S, Kim H, Yang D, Kim H, Kim B. Effects of Prunus mume Siebold & Zucc. in the pacemaking activity of interstitial cells of Cajal in murine small intestine. Exp Ther Med. 2017;13:327-334 pubmed publisher
Cabukusta B, Kol M, Kneller L, Hilderink A, Bickert A, Mina J, et al. ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain. Sci Rep. 2017;7:41290 pubmed publisher
Fan H, Du X, Zhang J, Zheng H, Lu X, Wu Q, et al. Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium. Sci Rep. 2017;7:41226 pubmed publisher
Marino A, Arai S, Hou Y, Degl Innocenti A, Cappello V, Mazzolai B, et al. Gold Nanoshell-Mediated Remote Myotube Activation. ACS Nano. 2017;11:2494-2508 pubmed publisher
Fung Leung W, EDWARDS W, Liu Y, Ngo K, Angsana J, Castro G, et al. T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers. PLoS ONE. 2017;12:e0170102 pubmed publisher
Chen E, Tsai T, Li L, Saha P, Chan L, Chang B. PLIN2 is a Key Regulator of the Unfolded Protein Response and Endoplasmic Reticulum Stress Resolution in Pancreatic β Cells. Sci Rep. 2017;7:40855 pubmed publisher
Dalet A, Argüello R, Combes A, Spinelli L, Jaeger S, Fallet M, et al. Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA. EMBO J. 2017;36:761-782 pubmed publisher
Lee L, Ito T, Nakamura T, Jensen R, Igarashi H, Takayanagi R. Antifibrotic Effect of Saturated Fatty Acids via Endoplasmic Reticulum Stress Response in Rat Pancreatic Stellate Cells. Pancreas. 2017;46:385-394 pubmed publisher
Sato E, Williams M, Sanford J, Sen G, Nakama T, Imafuku S, et al. The parathyroid hormone family member TIP39 interacts with sarco/endoplasmic reticulum Ca2+ - ATPase activity by influencing calcium homoeostasis. Exp Dermatol. 2017;26:792-797 pubmed publisher
Gomart S, Gaudreau Ménard C, Jespers P, Dilek O, Hupkens E, Hanthazi A, et al. Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and Stores. PLoS ONE. 2017;12:e0169205 pubmed publisher
Sbano L, Bonora M, Marchi S, Baldassari F, Medina D, Ballabio A, et al. TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry. Sci Rep. 2017;7:40797 pubmed publisher
Qiang G, Whang Kong H, Gil V, Liew C. Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction. Sci Rep. 2017;7:40215 pubmed publisher
Ko J, Myeong J, Yang D, So I. Calcium permeability of transient receptor potential canonical (TRPC) 4 channels measured by TRPC4-GCaMP6s. Korean J Physiol Pharmacol. 2017;21:133-140 pubmed publisher
Zhu S, Liu H, Sha H, Qi L, Gao D, Zhang W. PERK and XBP1 differentially regulate CXCL10 and CCL2 production. Exp Eye Res. 2017;155:1-14 pubmed publisher
Maddox J, Gleason E. Nitric oxide promotes GABA release by activating a voltage-independent Ca2+ influx pathway in retinal amacrine cells. J Neurophysiol. 2017;117:1185-1199 pubmed publisher
Liu Z, Gu H, Gan L, Xu Y, Feng F, Saeed M, et al. Reducing Smad3/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue. Oncotarget. 2017;8:9267-9279 pubmed publisher
van der Krieken S, Popeijus H, Mensink R, Plat J. Link Between ER-Stress, PPAR-Alpha Activation, and BET Inhibition in Relation to Apolipoprotein A-I Transcription in HepG2 Cells. J Cell Biochem. 2017;118:2161-2167 pubmed publisher
Ni Y, Seballos S, Fletcher B, Romigh T, Yehia L, Mester J, et al. Germline compound heterozygous poly-glutamine deletion in USF3 may be involved in predisposition to heritable and sporadic epithelial thyroid carcinoma. Hum Mol Genet. 2017;26:243-257 pubmed publisher
Yoo Y, Lee D, Cha Molstad H, Kim H, Mun S, Ji C, et al. Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition. EMBO Rep. 2017;18:150-168 pubmed publisher
Adamson B, Norman T, Jost M, Cho M, Nuñez J, Chen Y, et al. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Cell. 2016;167:1867-1882.e21 pubmed publisher
Pabbidi M, Ji X, Maxwell J, Mignery G, Samarel A, Lipsius S. Inhibition of cAMP-Dependent PKA Activates ?2-Adrenergic Receptor Stimulation of Cytosolic Phospholipase A2 via Raf-1/MEK/ERK and IP3-Dependent Ca2+ Signaling in Atrial Myocytes. PLoS ONE. 2016;11:e0168505 pubmed publisher
Hirasawa K, Moriya S, Miyahara K, Kazama H, Hirota A, Takemura J, et al. Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines. PLoS ONE. 2016;11:e0164529 pubmed publisher
Dominguez G, Condamine T, Mony S, Hashimoto A, Wang F, Liu Q, et al. Selective Targeting of Myeloid-Derived Suppressor Cells in Cancer Patients Using DS-8273a, an Agonistic TRAIL-R2 Antibody. Clin Cancer Res. 2017;23:2942-2950 pubmed publisher
Yu W, Honisch S, Schmidt S, Yan J, Schmid E, Alkahtani S, et al. Chorein Sensitive Orai1 Expression and Store Operated Ca2+ Entry in Rhabdomyosarcoma Cells. Cell Physiol Biochem. 2016;40:1141-1152 pubmed
Xie Y, Ye S, Zhang J, He M, Dong C, Tu W, et al. Protective effect of mild endoplasmic reticulum stress on radiation-induced bystander effects in hepatocyte cells. Sci Rep. 2016;6:38832 pubmed publisher
Penny C, Rahman T, Sula A, Miles A, Wallace B, Patel S. Isolated pores dissected from human two-pore channel 2 are functional. Sci Rep. 2016;6:38426 pubmed publisher
Wu M, Zhang C, Li X, Liu Q, Wanggou S. Anti-Cancer Effect of Cap-Translation Inhibitor 4EGI-1 in Human Glioma U87 Cells: Involvement of Mitochondrial Dysfunction and ER Stress. Cell Physiol Biochem. 2016;40:1013-1028 pubmed
Ji Y, Guo X, Zhang Z, Huang Z, Zhu J, Chen Q, et al. CaMKIIδ meditates phenylephrine induced cardiomyocyte hypertrophy through store-operated Ca2+ entry. Cardiovasc Pathol. 2017;27:9-17 pubmed publisher
Hara H, Kimoto D, Kajita M, Takada C, Kamiya T, Adachi T. Apomorphine prevents LPS-induced IL-23 p19 mRNA expression via inhibition of JNK and ATF4 in HAPI cells. Eur J Pharmacol. 2017;795:108-114 pubmed publisher
Chantalat E, Boudou F, Laurell H, Palierne G, Houtman R, Melchers D, et al. The AF-1-deficient estrogen receptor ER?46 isoform is frequently expressed in human breast tumors. Breast Cancer Res. 2016;18:123 pubmed
Li J, Casteels T, Frogne T, Ingvorsen C, Honore C, Courtney M, et al. Artemisinins Target GABAA Receptor Signaling and Impair ? Cell Identity. Cell. 2017;168:86-100.e15 pubmed publisher
Diercks B, Fliegert R, Guse A. Mag-Fluo4 in T cells: Imaging of intra-organelle free Ca2+ concentrations. Biochim Biophys Acta Mol Cell Res. 2017;1864:977-986 pubmed publisher
Zhang T, Hu Q, Shi L, Qin L, Zhang Q, Mi M. Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells. PLoS ONE. 2016;11:e0167020 pubmed publisher
Torgersen M, Klokk T, Kavaliauskiene S, Klose C, Simons K, Skotland T, et al. The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Oncotarget. 2016;7:86871-86888 pubmed publisher
Takahashi N, Harada M, Hirota Y, Zhao L, Azhary J, Yoshino O, et al. A Potential Role for Endoplasmic Reticulum Stress in Progesterone Deficiency in Obese Women. Endocrinology. 2017;158:84-97 pubmed publisher
Baird M, Billington N, Wang A, Adelstein R, Sellers J, Fischer R, et al. Local pulsatile contractions are an intrinsic property of the myosin 2A motor in the cortical cytoskeleton of adherent cells. Mol Biol Cell. 2017;28:240-251 pubmed publisher
Schaaf T, Peterson K, Grant B, Thomas D, GILLISPIE G. Spectral Unmixing Plate Reader: High-Throughput, High-Precision FRET Assays in Living Cells. SLAS Discov. 2017;22:250-261 pubmed publisher
Beriault D, Dang V, Zhong L, Petlura C, McAlpine C, Shi Y, et al. Glucosamine induces ER stress by disrupting lipid-linked oligosaccharide biosynthesis and N-linked protein glycosylation. Am J Physiol Endocrinol Metab. 2017;312:E48-E57 pubmed publisher
Li S, Yan J, Zhang Y, Zhen C, Liu M, Jin J, et al. Niclosamide ethanolamine inhibits artery constriction. Pharmacol Res. 2017;115:78-86 pubmed publisher
Yan X, Liu J, Zhang Z, Li W, Sun S, Zhao J, et al. Low-level laser irradiation modulates brain-derived neurotrophic factor mRNA transcription through calcium-dependent activation of the ERK/CREB pathway. Lasers Med Sci. 2017;32:169-180 pubmed publisher
Cui X, Cui M, Asada R, Kanemoto S, Saito A, Matsuhisa K, et al. The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression. Sci Rep. 2016;6:37310 pubmed publisher
Hu D, Mai J, He L, Li P, Chen W, Yan J, et al. Glucocorticoids Prevent Enterovirus 71 Capsid Protein VP1 Induced Calreticulin Surface Exposure by Alleviating Neuronal ER Stress. Neurotox Res. 2017;31:204-217 pubmed publisher
Sokolova M, Vinge L, Alfsnes K, Olsen M, Eide L, Kaasbøll O, et al. Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:234-245 pubmed publisher
Jeong B, Kim J, Kim K, Kim I, Seong S, Kim N. ATF3 modulates calcium signaling in osteoclast differentiation and activity by associating with c-Fos and NFATc1 proteins. Bone. 2017;95:33-40 pubmed publisher
Prudent J, Popgeorgiev N, Gadet R, Deygas M, Rimokh R, Gillet G. Mitochondrial Ca2+ uptake controls actin cytoskeleton dynamics during cell migration. Sci Rep. 2016;6:36570 pubmed publisher
Iracheta Vellve A, Petrasek J, Gyöngyösi B, Satishchandran A, Lowe P, Kodys K, et al. Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes. J Biol Chem. 2016;291:26794-26805 pubmed publisher
Rueli R, Torres D, Dewing A, Kiyohara A, Barayuga S, Bellinger M, et al. Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology. J Alzheimers Dis. 2017;55:749-762 pubmed
Tang A, Saferali A, He G, Sandford A, Strug L, Turvey S. Endoplasmic Reticulum Stress and Chemokine Production in Cystic Fibrosis Airway Cells: Regulation by STAT3 Modulation. J Infect Dis. 2017;215:293-302 pubmed publisher
Matsunaga D, Sreekumar P, Ishikawa K, Terasaki H, Barron E, Cohen P, et al. Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione. PLoS ONE. 2016;11:e0165150 pubmed publisher
Ghosh A, Mau T, O Brien M, Garg S, Yung R. Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue. Aging (Albany NY). 2016;8:2525-2537 pubmed publisher
Certal M, Vinhas A, Barros Barbosa A, Ferreirinha F, Costa M, Correia de Sá P. ADP-Induced Ca2+ Signaling and Proliferation of Rat Ventricular Myofibroblasts Depend on Phospholipase C-Linked TRP Channels Activation Within Lipid Rafts. J Cell Physiol. 2017;232:1511-1526 pubmed publisher
Gu S, Hsieh Y, Lin P. Signaling involved in PTTH-stimulated 4E-BP phosphorylation in prothoracic gland cells of Bombyx mori. J Insect Physiol. 2017;96:1-8 pubmed publisher
Yang D, Wang L, Lin P, Jiang T, Wang N, Zhao F, et al. An immortalized steroidogenic goat granulosa cell line as a model system to study the effect of the endoplasmic reticulum (ER)-stress response on steroidogenesis. J Reprod Dev. 2017;63:27-36 pubmed publisher
Homma T, Fujii J. Heat stress promotes the down-regulation of IRE1? in cells: An atypical modulation of the UPR pathway. Exp Cell Res. 2016;349:128-138 pubmed publisher
Isaac R, Goldstein I, Furth N, Zilber N, Streim S, Boura Halfon S, et al. TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response. Cell Death Differ. 2017;24:132-143 pubmed publisher
Soultanova A, Mikulski Z, Pfeil U, Grau V, Kummer W. Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages. PLoS ONE. 2016;11:e0163483 pubmed publisher
Kanemoto S, Nitani R, Murakami T, Kaneko M, Asada R, Matsuhisa K, et al. Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress. Biochem Biophys Res Commun. 2016;480:166-172 pubmed publisher
Gan L, Liu Z, Wu T, Feng F, Sun C. αMSH promotes preadipocyte proliferation by alleviating ER stress-induced leptin resistance and by activating Notch1 signal in mice. Biochim Biophys Acta Mol Basis Dis. 2017;1863:231-238 pubmed publisher
Laasmaa M, Birkedal R, Vendelin M. Revealing calcium fluxes by analyzing inhibition dynamics in action potential clamp. J Mol Cell Cardiol. 2016;100:93-108 pubmed publisher
Ma J, Wang J, Li J, Pfeffer B, Zhong Y, Zhang S. The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions. Invest Ophthalmol Vis Sci. 2016;57:5244-5252 pubmed publisher
Gomez Bougie P, Halliez M, Moreau P, Pellat Deceunynck C, Amiot M. Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis. Cancer Lett. 2016;383:204-211 pubmed publisher
Korvers L, de Andrade Costa A, Mersch M, Matyash V, Kettenmann H, Semtner M. Spontaneous Ca2+ transients in mouse microglia. Cell Calcium. 2016;60:396-406 pubmed publisher
Larsen J, Bushnell P, Steffensen J, Pedersen M, Qvortrup K, Brill R. Characterization of the functional and anatomical differences in the atrial and ventricular myocardium from three species of elasmobranch fishes: smooth dogfish (Mustelus canis), sandbar shark (Carcharhinus plumbeus), and clearnose skate (Raja eglant. J Comp Physiol B. 2017;187:291-313 pubmed publisher
Yang J, Wu Q, Lv J, Nie H. 4-Phenyl butyric acid prevents glucocorticoid-induced osteoblast apoptosis by attenuating endoplasmic reticulum stress. J Bone Miner Metab. 2017;35:366-374 pubmed publisher
Liu F, Li Z, Wang Z, Wang L. Role of subcellular calcium redistribution in regulating apoptosis and autophagy in cadmium-exposed primary rat proximal tubular cells. J Inorg Biochem. 2016;164:99-109 pubmed publisher
Guo X, Cui R, Zhao J, Mo R, Peng L, Yan M. Corosolic acid protects hepatocytes against ethanol-induced damage by modulating mitogen-activated protein kinases and activating autophagy. Eur J Pharmacol. 2016;791:578-588 pubmed publisher
Rohde M, Sievers E, Janzer A, Willmann D, Egert A, Schorle H, et al. Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts. Exp Cell Res. 2016;348:123-131 pubmed publisher
Lepannetier S, Zanou N, Yerna X, Emeriau N, Dufour I, Masquelier J, et al. Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells. Cell Calcium. 2016;60:373-383 pubmed publisher
van der Krieken S, Popeijus H, Konings M, Dullens S, Mensink R, Plat J. C/EBP-β Is Differentially Affected by PPARα Agonists Fenofibric Acid and GW7647, But Does Not Change Apolipoprotein A-I Production During ER-Stress and Inflammation. J Cell Biochem. 2017;118:754-763 pubmed publisher
Girard Bock C, Benoit Biancamano M, Villeneuve L, Desjardins S, Guillemette C. A Rare UGT2B7 Variant Creates a Novel N-Glycosylation Site at Codon 121 with Impaired Enzyme Activity. Drug Metab Dispos. 2016;44:1867-1871 pubmed
Huml L, Jurášek M, Mikšátková P, Zimmermann T, Tomanová P, Budesinsky M, et al. Immunoassay for determination of trilobolide. Steroids. 2017;117:105-111 pubmed publisher
Izrailit J, Jaiswal A, Zheng W, Moran M, Reedijk M. Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer. Oncogene. 2017;36:1048-1057 pubmed publisher
Yamamoto A, Takahashi K, Saito S, Tominaga M, Ohta T. Two different avian cold-sensitive sensory neurons: Transient receptor potential melastatin 8 (TRPM8)-dependent and -independent activation mechanisms. Neuropharmacology. 2016;111:130-141 pubmed publisher
Kobylewski S, Henderson K, Yamada K, Eckhert C. Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake. Biol Trace Elem Res. 2017;176:278-293 pubmed publisher
Kilpatrick B, Yates E, Grimm C, Schapira A, Patel S. Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx. J Cell Sci. 2016;129:3859-3867 pubmed
Marino A, Martelli A, Citi V, Fu M, Wang R, Calderone V, et al. The novel H2 S donor 4-carboxy-phenyl isothiocyanate inhibits mast cell degranulation and renin release by decreasing intracellular calcium. Br J Pharmacol. 2016;173:3222-3234 pubmed publisher
Liu R, Fan W, Krüger K, Xiao Y, Pilat C, Seimetz M, et al. Exercise Affects T-Cell Function by Modifying Intracellular Calcium Homeostasis. Med Sci Sports Exerc. 2017;49:29-39 pubmed
Chen Y, Fang L, Su W, Hsu W, Yang K, Huang H. Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemia. Onco Targets Ther. 2016;9:4453-64 pubmed publisher
Ferrari L, Khomula E, Araldi D, Levine J. Marked Sexual Dimorphism in the Role of the Ryanodine Receptor in a Model of Pain Chronification in the Rat. Sci Rep. 2016;6:31221 pubmed publisher
Izumi K, Brett M, Nishi E, Drunat S, Tan E, Fujiki K, et al. ARCN1 Mutations Cause a Recognizable Craniofacial Syndrome Due to COPI-Mediated Transport Defects. Am J Hum Genet. 2016;99:451-9 pubmed publisher
Lao Peregrín C, Ballesteros J, Fernández M, Zamora Moratalla A, Saavedra A, Gomez Lazaro M, et al. Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling. Addict Biol. 2017;22:1706-1718 pubmed publisher
Lim Y, Budin S, Othman F, Latip J, Zainalabidin S. Roselle Polyphenols Exert Potent Negative Inotropic Effects via Modulation of Intracellular Calcium Regulatory Channels in Isolated Rat Heart. Cardiovasc Toxicol. 2017;17:251-259 pubmed publisher
Skalka N, Caspi M, Lahav Ariel L, Loh Y, Hirschberg K, Rosin Arbesfeld R. Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a. Oncogene. 2016;35:6416-6428 pubmed publisher
Cabrera E, Hernández Pérez S, Koundrioukoff S, Debatisse M, Kim D, Smolka M, et al. PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1. Oncogene. 2017;36:678-686 pubmed publisher
Araujo C, Hermidorff M, Amâncio G, Lemos D, Silva M, de Assis L, et al. Rapid effects of aldosterone in primary cultures of cardiomyocytes - do they suggest the existence of a membrane-bound receptor?. J Recept Signal Transduct Res. 2016;36:435-44 pubmed publisher
Schmid E, Stagno M, Yan J, Stournaras C, Lang F, Fuchs J, et al. Store-operated Ca(2+) entry in rhabdomyosarcoma cells. Biochem Biophys Res Commun. 2016;477:129-136 pubmed publisher
Ando T, Komatsu T, Naiki Y, Takahashi K, Yokochi T, Watanabe D, et al. GSK2656157, a PERK inhibitor, reduced LPS-induced IL-1? production through inhibiting Caspase 1 activation in macrophage-like J774.1 cells. Immunopharmacol Immunotoxicol. 2016;38:298-302 pubmed publisher
Yamamura H, Suzuki Y, Yamamura H, Asai K, Imaizumi Y. Hypoxic stress up-regulates Kir2.1 expression and facilitates cell proliferation in brain capillary endothelial cells. Biochem Biophys Res Commun. 2016;476:386-392 pubmed publisher
Abu Khamidakh A, Dos Santos F, Skottman H, Juuti Uusitalo K, Hyttinen J. Semi-automatic Method for Ca2+ Imaging Data Analysis of Maturing Human Embryonic Stem Cells-Derived Retinal Pigment Epithelium. Ann Biomed Eng. 2016;44:3408-3420 pubmed
Wang L, Zhang B, Huang F, Liu B, Xie Y. Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance. J Lipid Res. 2016;57:1243-55 pubmed publisher
Wang S, Wang Z, Fan Q, Guo J, Galli G, Du G, et al. Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway. Br J Pharmacol. 2016;173:2402-18 pubmed publisher
Sabourin J, Bartoli F, Antigny F, Gomez A, Benitah J. Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES. J Biol Chem. 2016;291:13394-409 pubmed publisher
Anania V, Yu K, Gnad F, Pferdehirt R, Li H, Ma T, et al. Uncovering a Dual Regulatory Role for Caspases During Endoplasmic Reticulum Stress-induced Cell Death. Mol Cell Proteomics. 2016;15:2293-307 pubmed publisher
Brown M, Strudwick N, Suwara M, Sutcliffe L, Mihai A, Ali A, et al. An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response. J Cell Sci. 2016;129:2317-2328 pubmed publisher
Zhang C, Thomas D. Stromal Interaction Molecule 1 rescues store-operated calcium entry and protects NG115-401L cells against cell death induced by endoplasmic reticulum and mitochondrial oxidative stress. Neurochem Int. 2016;97:137-45 pubmed publisher
Toral Ojeda I, Aldanondo G, Lasa Elgarresta J, Lasa Fernández H, Fernandez Torron R, Lopez de Munain A, et al. Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle. Expert Rev Mol Med. 2016;18:e7 pubmed publisher
Wang H, Sun R, Camera D, Zeng X, Jo E, Chan S, et al. Endoplasmic reticulum stress up-regulates Nedd4-2 to induce autophagy. FASEB J. 2016;30:2549-56 pubmed publisher
Pandey K, Ferreira P, Ishikawa T, Nagai T, Kaneko O, Yahata K. Ca(2+) monitoring in Plasmodium falciparum using the yellow cameleon-Nano biosensor. Sci Rep. 2016;6:23454 pubmed publisher
Justet C, Hernández J, Torriglia A, Chifflet S. Fast calcium wave inhibits excessive apoptosis during epithelial wound healing. Cell Tissue Res. 2016;365:343-56 pubmed publisher
Feng Y, Yang Y, Fan C, Di S, Hu W, Jiang S, et al. Pterostilbene Inhibits the Growth of Human Esophageal Cancer Cells by Regulating Endoplasmic Reticulum Stress. Cell Physiol Biochem. 2016;38:1226-44 pubmed publisher
Choi S, Lee K, Park Y, Lee S, Jo S, Chung S, et al. Non-Dioxin-Like Polychlorinated Biphenyls Inhibit G-Protein Coupled Receptor-Mediated Ca2+ Signaling by Blocking Store-Operated Ca2+ Entry. PLoS ONE. 2016;11:e0150921 pubmed publisher
Martínez Pizarro A, Desviat L, Ugarte M, Perez B, Richard E. Endoplasmic Reticulum Stress and Autophagy in Homocystinuria Patients with Remethylation Defects. PLoS ONE. 2016;11:e0150357 pubmed publisher
Yamaguchi M, Osuka S, Weitzmann M, El Rayes B, Shoji M, Murata T. Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human pancreatic cancer MIA PaCa-2 cells in vitro. Int J Oncol. 2016;48:1955-64 pubmed publisher
Fan C, Yang Y, Liu Y, Jiang S, Di S, Hu W, et al. Icariin displays anticancer activity against human esophageal cancer cells via regulating endoplasmic reticulum stress-mediated apoptotic signaling. Sci Rep. 2016;6:21145 pubmed publisher
Dedoni S, Olianas M, Ingianni A, Onali P. Interferon-? Inhibits Neurotrophin 3 Signalling and Pro-Survival Activity by Upregulating the Expression of Truncated TrkC-T1 Receptor. Mol Neurobiol. 2017;54:1825-1843 pubmed publisher
Shinde V, Kotla P, Strang C, Gorbatyuk M. Unfolded protein response-induced dysregulation of calcium homeostasis promotes retinal degeneration in rat models of autosomal dominant retinitis pigmentosa. Cell Death Dis. 2016;7:e2085 pubmed publisher
You W, Zhou T, Ma Z, Liang Q, Xiao C, Tang X, et al. Ophiopogonin D maintains Ca2+ homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/EETs and suppressing ER stress. Acta Pharmacol Sin. 2016;37:368-81 pubmed publisher
Cao L, Jing B, Yang D, Zeng X, Shen Y, Tu Y, et al. Distinct signaling of Drosophila chemoreceptors in olfactory sensory neurons. Proc Natl Acad Sci U S A. 2016;113:E902-11 pubmed publisher
Carrillo C, Giraldo M, Cavia M, Alonso Torre S. Effect of oleic acid on store-operated calcium entry in immune-competent cells. Eur J Nutr. 2017;56:1077-1084 pubmed publisher
Albarrán L, Lopez J, Woodard G, Salido G, Rosado J. Store-operated Ca2+ Entry-associated Regulatory factor (SARAF) Plays an Important Role in the Regulation of Arachidonate-regulated Ca2+ (ARC) Channels. J Biol Chem. 2016;291:6982-8 pubmed publisher
Young S, Palam L, Wu C, Sachs M, Wek R. Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response. J Biol Chem. 2016;291:6546-58 pubmed publisher
Martina J, Diab H, Brady O, Puertollano R. TFEB and TFE3 are novel components of the integrated stress response. EMBO J. 2016;35:479-95 pubmed publisher
Wolf K, Braun A, Haining E, Tseng Y, Kraft P, Schuhmann M, et al. Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice. PLoS ONE. 2016;11:e0147664 pubmed publisher
Sims Robinson C, Bakeman A, Glasser R, Boggs J, Pacut C, Feldman E. The role of endoplasmic reticulum stress in hippocampal insulin resistance. Exp Neurol. 2016;277:261-267 pubmed publisher
Lin J, Colon Gonzalez F, BLOMAIN E, Kim G, Aing A, Stoecker B, et al. Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis. Cancer Res. 2016;76:339-46 pubmed publisher
Schott M, Gonowolo F, Maliske B, Grove B. FRET biosensors reveal AKAP-mediated shaping of subcellular PKA activity and a novel mode of Ca(2+)/PKA crosstalk. Cell Signal. 2016;28:294-306 pubmed publisher
Kysenius K, Huttunen H. Stress-induced upregulation of VLDL receptor alters Wnt-signaling in neurons. Exp Cell Res. 2016;340:238-47 pubmed publisher
Jeon Y, Kim J, Shin J, Jeong M, Cho J, Lee K. Salubrinal-Mediated Upregulation of eIF2α Phosphorylation Increases Doxorubicin Sensitivity in MCF-7/ADR Cells. Mol Cells. 2016;39:129-35 pubmed publisher
Yuan Y, Atchison W. Multiple Sources of Ca2+ Contribute to Methylmercury-Induced Increased Frequency of Spontaneous Inhibitory Synaptic Responses in Cerebellar Slices of Rat. Toxicol Sci. 2016;150:117-30 pubmed publisher
Chen F, Lin P, Wang N, Yang D, Wen X, Zhou D, et al. Herp depletion inhibits zearalenone-induced cell death in RAW 264.7 macrophages. Toxicol In Vitro. 2016;32:115-22 pubmed publisher
Dadey D, Kapoor V, Khudanyan A, Urano F, Kim A, Thotala D, et al. The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma. Oncotarget. 2016;7:2080-92 pubmed publisher
Lu W, Hagiwara D, Morishita Y, Tochiya M, Azuma Y, Suga H, et al. Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice. Neurosci Lett. 2016;612:199-203 pubmed publisher
Wang C, Li T, Tang S, Zhao D, Zhang C, Zhang S, et al. Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway. Environ Toxicol Pharmacol. 2016;41:167-79 pubmed publisher
Shigemi Z, Baba Y, Hara N, Matsuhiro J, Kagawa H, Watanabe T, et al. Effects of ER stress on unfolded protein responses, cell survival, and viral replication in primary effusion lymphoma. Biochem Biophys Res Commun. 2016;469:565-72 pubmed publisher
Kilpatrick B, Magalhães J, Beavan M, McNeill A, Gegg M, Cleeter M, et al. Endoplasmic reticulum and lysosomal Ca²⁺ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts. Cell Calcium. 2016;59:12-20 pubmed publisher
Einbond L, Wu H, Sandu C, Ford M, Mighty J, Antonetti V, et al. Digitoxin enhances the growth inhibitory effects of thapsigargin and simvastatin on ER negative human breast cancer cells. Fitoterapia. 2016;109:146-54 pubmed publisher
Chen C, Gu S, Jiang X, Zhang Z. Arsenite-induced endoplasmic reticulum-dependent apoptosis through disturbance of calcium homeostasis in HBE cell line. Environ Toxicol. 2017;32:197-216 pubmed publisher
Yuniati L, van der Meer L, Tijchon E, van Ingen Schenau D, van Emst L, Levers M, et al. Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress. Oncotarget. 2016;7:3128-43 pubmed publisher
Bhattacharyya S, Vrati S. The Malat1 long non-coding RNA is upregulated by signalling through the PERK axis of unfolded protein response during flavivirus infection. Sci Rep. 2015;5:17794 pubmed publisher
Zhao N, Dong Q, Qian C, Li S, Wu Q, Ding D, et al. Lovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties. Sci Rep. 2015;5:17381 pubmed publisher
Kukkonen J. G-protein inhibition profile of the reported Gq/11 inhibitor UBO-QIC. Biochem Biophys Res Commun. 2016;469:101-107 pubmed publisher
Yang B, Zhang M, Gao J, Li J, Fan L, Xiang G, et al. Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer. Oncotarget. 2015;6:37613-25 pubmed publisher
Liu G, Liu G, Chen H, Alzoubi K, Umbach A, Gawaz M, et al. Rapid Upregulation of Orai1 Abundance in the Plasma Membrane of Platelets Following Activation with Thrombin and Collagen Related Peptide. Cell Physiol Biochem. 2015;37:1759-66 pubmed publisher
Shigeto M, Ramracheya R, Tarasov A, Cha C, Chibalina M, Hastoy B, et al. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. J Clin Invest. 2015;125:4714-28 pubmed publisher
Hsu W, Lu J, Noda M, Wu C, Liu J, Sakakibara M, et al. Derinat Protects Skin against Ultraviolet-B (UVB)-Induced Cellular Damage. Molecules. 2015;20:20297-311 pubmed publisher
Liao F, Zheng Y, Cai J, Fan J, Wang J, Yang J, et al. Catestatin attenuates endoplasmic reticulum induced cell apoptosis by activation type 2 muscarinic acetylcholine receptor in cardiac ischemia/reperfusion. Sci Rep. 2015;5:16590 pubmed publisher
Choy M, Zhang S, Costa V, Tan H, Horrevorts S, Ooi E. Proteasome Inhibition Suppresses Dengue Virus Egress in Antibody Dependent Infection. PLoS Negl Trop Dis. 2015;9:e0004058 pubmed publisher
Gowen B, Chim B, Marceau C, Greene T, Burr P, Gonzalez J, et al. A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells. elife. 2015;4: pubmed publisher
Guridi M, Tintignac L, Lin S, Kupr B, Castets P, Rüegg M. Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21. Sci Signal. 2015;8:ra113 pubmed publisher
Kim S, Kim H, Kim D, Lee K, Park H, Jeong J, et al. Blockade of Interplay between IL-17A and Endoplasmic Reticulum Stress Attenuates LPS-Induced Lung Injury. Theranostics. 2015;5:1343-62 pubmed publisher
Nurbaeva M, Eckstein M, Concepcion A, Smith C, Srikanth S, Paine M, et al. Dental enamel cells express functional SOCE channels. Sci Rep. 2015;5:15803 pubmed publisher
Han Z, Madara J, Herbert A, Prugar L, Ruthel G, Lu J, et al. Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention. PLoS Pathog. 2015;11:e1005220 pubmed publisher
Hari Y, Harashima N, Tajima Y, Harada M. Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL. Oncotarget. 2015;6:41902-15 pubmed publisher
Girola N, Figueiredo C, Farias C, Azevedo R, Ferreira A, Teixeira S, et al. Camphene isolated from essential oil of Piper cernuum (Piperaceae) induces intrinsic apoptosis in melanoma cells and displays antitumor activity in vivo. Biochem Biophys Res Commun. 2015;467:928-34 pubmed publisher
Cho H, Shin H, Haberstock Debic H, Xing Y, Owens T, Funk J, et al. A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression. J Immunol. 2015;195:4822-31 pubmed publisher
Pathak T, Agrawal T, Richhariya S, Sadaf S, Hasan G. Store-Operated Calcium Entry through Orai Is Required for Transcriptional Maturation of the Flight Circuit in Drosophila. J Neurosci. 2015;35:13784-99 pubmed publisher
Lever R, Hussain A, Sun B, Sage S, Harper A. Conventional protein kinase C isoforms differentially regulate ADP- and thrombin-evoked Ca²⁺ signalling in human platelets. Cell Calcium. 2015;58:577-88 pubmed publisher
Pushparaj C, Das A, Purroy R, Nàger M, Herreros J, Pamplona R, et al. Voltage-gated calcium channel blockers deregulate macroautophagy in cardiomyocytes. Int J Biochem Cell Biol. 2015;68:166-75 pubmed publisher
Zhang H, Wu L, Pchitskaya E, Zakharova O, Saito T, Saido T, et al. Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease. J Neurosci. 2015;35:13275-86 pubmed publisher
Collins T, Ylanko J, Geng F, Andrews D. A Versatile Cell Death Screening Assay Using Dye-Stained Cells and Multivariate Image Analysis. Assay Drug Dev Technol. 2015;13:547-57 pubmed publisher
Guo D, Li D, Ning M, Dang X, Zhang L, Zeng L, et al. Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models. Biochem Biophys Res Commun. 2015;466:740-7 pubmed publisher
Klokk T, Kavaliauskiene S, Sandvig K. Cross-linking of glycosphingolipids at the plasma membrane: consequences for intracellular signaling and traffic. Cell Mol Life Sci. 2016;73:1301-16 pubmed publisher
Borges Pereira L, Budu A, McKnight C, Moore C, Vella S, Hortua Triana M, et al. Calcium Signaling throughout the Toxoplasma gondii Lytic Cycle: A STUDY USING GENETICALLY ENCODED CALCIUM INDICATORS. J Biol Chem. 2015;290:26914-26 pubmed publisher
Okla M, Wang W, Kang I, Pashaj A, Carr T, Chung S. Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress. J Biol Chem. 2015;290:26476-90 pubmed publisher
Mo C, Cai G, Huang L, Deng Q, Lin D, Cui L, et al. Corticotropin-releasing hormone (CRH) stimulates cocaine- and amphetamine-regulated transcript gene (CART1) expression through CRH type 1 receptor (CRHR1) in chicken anterior pituitary. Mol Cell Endocrinol. 2015;417:166-77 pubmed publisher
Sobolewski C, Rhim J, Legrand N, Muller F, Cerella C, Mack F, et al. 2,5-Dimethyl-celecoxib inhibits cell cycle progression and induces apoptosis in human leukemia cells. J Pharmacol Exp Ther. 2015;355:308-28 pubmed publisher
Emde A, Eitan C, Liou L, Libby R, Rivkin N, Magen I, et al. Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS. EMBO J. 2015;34:2633-51 pubmed publisher
Karthikeyan B, Arun A, Harini L, Sundar K, Kathiresan T. Role of ZnS Nanoparticles on Endoplasmic Reticulum Stress-mediated Apoptosis in Retinal Pigment Epithelial Cells. Biol Trace Elem Res. 2016;170:390-400 pubmed publisher
Certal M, Vinhas A, Pinheiro A, Ferreirinha F, Barros Barbosa A, Silva I, et al. Calcium signaling and the novel anti-proliferative effect of the UTP-sensitive P2Y11 receptor in rat cardiac myofibroblasts. Cell Calcium. 2015;58:518-33 pubmed publisher
Li S, Wang G, Gao L, Lu W, Wang X, Chuai M, et al. Autophagy is involved in ethanol-induced cardia bifida during chick cardiogenesis. Cell Cycle. 2015;14:3306-17 pubmed publisher
Lin W, Suo Y, Deng Y, Fan Z, Zheng Y, Wei X, et al. Morphological change of CD4(+) T cell during contact with DC modulates T-cell activation by accumulation of F-actin in the immunology synapse. BMC Immunol. 2015;16:49 pubmed publisher
Sbiera S, Leich E, Liebisch G, Sbiera I, Schirbel A, Wiemer L, et al. Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells. Endocrinology. 2015;156:3895-908 pubmed publisher
Hunter M, Lee D, Harris T, Fernandez Gonzalez R. Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair. J Cell Biol. 2015;210:801-16 pubmed publisher
Kavaliauskis A, Arnemo M, Rishovd A, Gjøen T. Activation of unfolded protein response pathway during infectious salmon anemia virus (ISAV) infection in vitro an in vivo. Dev Comp Immunol. 2016;54:46-54 pubmed publisher
Murray J, Qian Y, Liu B, Elliott R, Aral J, Park C, et al. Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3. J Med Chem. 2015;58:6784-802 pubmed publisher
Fujii T, Takahashi Y, Takeshima H, Saitoh C, Shimizu T, Takeguchi N, et al. Inhibition of gastric H+,K+-ATPase by 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl)oxybutyric acid (DCPIB), an inhibitor of volume-regulated anion channel. Eur J Pharmacol. 2015;765:34-41 pubmed publisher
Mirando A, Fang P, Williams T, Baldor L, Howe A, Ebert A, et al. Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Sci Rep. 2015;5:13160 pubmed publisher
Sakabe I, Hu R, Jin L, Clarke R, Kasid U. TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling. Breast Cancer Res Treat. 2015;153:285-97 pubmed publisher
Rong J, Pass I, Diaz P, Ngo T, Sauer M, Magnuson G, et al. Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1. J Biomol Screen. 2015;20:1232-45 pubmed publisher
Lin P, Mobasher M, Hakakian Y, Kakarla V, Naseem A, Ziai H, et al. Differential requirements for H/ACA ribonucleoprotein components in cell proliferation and response to DNA damage. Histochem Cell Biol. 2015;144:543-58 pubmed publisher
Janyou A, Changtam C, Suksamrarn A, Tocharus C, Tocharus J. Suppression effects of O-demethyldemethoxycurcumin on thapsigargin triggered on endoplasmic reticulum stress in SK-N-SH cells. Neurotoxicology. 2015;50:92-100 pubmed publisher
Verras M, Papandreou I, Denko N. WNT16-expressing Acute Lymphoblastic Leukemia Cells are Sensitive to Autophagy Inhibitors after ER Stress Induction. Anticancer Res. 2015;35:4625-31 pubmed
Song W, Jin X. Brain-derived neurotrophic factor inhibits neuromuscular junction maturation mediated by inTracellular Ca(2+) and Ca(2+)/calmodulin-dependent kinase. Muscle Nerve. 2016;53:593-7 pubmed publisher
Chang C, Kuan C, Lin J, Lai J, Ho T. Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines. Chem Res Toxicol. 2015;28:1574-83 pubmed publisher
Idevall Hagren O, Lü A, Xie B, De Camilli P. Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering. EMBO J. 2015;34:2291-305 pubmed publisher
Rong G, Tang X, Guo T, Duan N, Wang Y, Yang L, et al. Advanced oxidation protein products induce apoptosis in podocytes through induction of endoplasmic reticulum stress. J Physiol Biochem. 2015;71:455-70 pubmed publisher
Mami I, Bouvier N, El Karoui K, Gallazzini M, Rabant M, Laurent Puig P, et al. Angiogenin Mediates Cell-Autonomous Translational Control under Endoplasmic Reticulum Stress and Attenuates Kidney Injury. J Am Soc Nephrol. 2016;27:863-76 pubmed publisher
Lu M, Huang W, Bao N, Zhou G, Zhao J. The flavonoid ampelopsin inhibited cell growth and induced apoptosis and G0/G1 arrest in human osteosarcoma MG-63 cells in vitro. Pharmazie. 2015;70:388-93 pubmed
Liu J, Han P, Li M, Yan W, Liu J, He J, et al. Histidine-rich calcium binding protein promotes growth of hepatocellular carcinoma in vitro and in vivo. Cancer Sci. 2015;106:1288-95 pubmed publisher
Marino A, Arai S, Hou Y, Sinibaldi E, Pellegrino M, Chang Y, et al. Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation. ACS Nano. 2015;9:7678-89 pubmed publisher
Chen D, Zhao J, Wang H, An N, Zhou Y, Fan J, et al. Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury. Sci Rep. 2015;5:11731 pubmed publisher
Miyata S, Inoue J, Shimizu M, Sato R. Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation. J Biol Chem. 2015;290:20565-79 pubmed publisher
Giroud C, Marin M, Hammonds J, Spearman P, Melikyan G. P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions. J Virol. 2015;89:9368-82 pubmed publisher
Tsalikis J, Tattoli I, Ling A, Sorbara M, Croitoru D, Philpott D, et al. Intracellular Bacterial Pathogens Trigger the Formation of U Small Nuclear RNA Bodies (U Bodies) through Metabolic Stress Induction. J Biol Chem. 2015;290:20904-18 pubmed publisher
Garcia Belinchón M, Sánchez Osuna M, Martínez Escardó L, Granados Colomina C, Pascual Guiral S, Iglesias Guimarais V, et al. An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death. J Biol Chem. 2015;290:20841-55 pubmed publisher
Lee A, Han Y, Kim J, Hong S, Park E, Cho M. Saururus chinensis Baill induces apoptosis through endoplasmic reticulum stress in HepG2 hepatocellular carcinoma cells. Food Chem Toxicol. 2015;83:183-92 pubmed publisher
Hodeify R, Selvaraj S, Wen J, Arredouani A, Hubrack S, Dib M, et al. A STIM1-dependent 'trafficking trap' mechanism regulates Orai1 plasma membrane residence and Ca²⁺ influx levels. J Cell Sci. 2015;128:3143-54 pubmed publisher
Aits S, Kricker J, Liu B, Ellegaard A, Hämälistö S, Tvingsholm S, et al. Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay. Autophagy. 2015;11:1408-24 pubmed publisher
Vaeth M, Zee I, Concepcion A, Maus M, Shaw P, Portal Celhay C, et al. Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells. J Immunol. 2015;195:1202-17 pubmed publisher
Gao F, Zhang L, Su T, Li L, Zhou R, Peng M, et al. Signaling Mechanism of Cannabinoid Receptor-2 Activation-Induced β-Endorphin Release. Mol Neurobiol. 2016;53:3616-3625 pubmed publisher
Kanekura K, Ma X, Murphy J, Zhu L, Diwan A, Urano F. IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions. Sci Signal. 2015;8:ra62 pubmed publisher
Ma S, Zhuang Q, Shen W, Peng Y, Qiu Y. Interleukin-6 reduces NMDAR-mediated cytosolic Ca²⁺ overload and neuronal death via JAK/CaN signaling. Cell Calcium. 2015;58:286-95 pubmed publisher
Gerasimenko J, Charlesworth R, Sherwood M, Ferdek P, Mikoshiba K, Parrington J, et al. Both RyRs and TPCs are required for NAADP-induced intracellular Ca²⁺ release. Cell Calcium. 2015;58:237-45 pubmed publisher
Pelissier Rota M, Pelosi L, Meresse P, Jacquier Sarlin M. Nicotine-induced cellular stresses and autophagy in human cancer colon cells: A supportive effect on cell homeostasis via up-regulation of Cox-2 and PGE(2) production. Int J Biochem Cell Biol. 2015;65:239-56 pubmed publisher
Wang L, Zhang L, Li S, Zheng Y, Yan X, Chen M, et al. Retrograde regulation of STIM1-Orai1 interaction and store-operated Ca2+ entry by calsequestrin. Sci Rep. 2015;5:11349 pubmed publisher
Kikuchi H, Kuribayashi F, Mimuro H, Imajoh Ohmi S, Nakayama M, Takami Y, et al. Lack of GCN5 remarkably enhances the resistance against prolonged endoplasmic reticulum stress-induced apoptosis through up-regulation of Bcl-2 gene expression. Biochem Biophys Res Commun. 2015;463:870-5 pubmed publisher
D Osualdo A, Anania V, Yu K, Lill J, Kaufman R, Matsuzawa S, et al. Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress. PLoS ONE. 2015;10:e0130635 pubmed publisher
Fu S, Yalcin A, Lee G, Li P, Fan J, Arruda A, et al. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci Transl Med. 2015;7:292ra98 pubmed publisher
van t Wout E, van Schadewijk A, van Boxtel R, Dalton L, Clarke H, Tommassen J, et al. Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells. PLoS Pathog. 2015;11:e1004946 pubmed publisher
Ji G, Yu N, Xue X, Li Z. PERK-mediated Autophagy in Osteosarcoma Cells Resists ER Stress-induced Cell Apoptosis. Int J Biol Sci. 2015;11:803-12 pubmed publisher
Lee I, Lee S, Kim H, Won Y, Kim B. Induction of endoplasmic reticulum-derived oxidative stress by an occult infection related S surface antigen variant. World J Gastroenterol. 2015;21:6872-83 pubmed publisher
Lajdova I, Spustova V, Oksa A, Kaderjakova Z, Chorvat D, Morvova M, et al. The Impact of Vitamin D3 Supplementation on Mechanisms of Cell Calcium Signaling in Chronic Kidney Disease. Biomed Res Int. 2015;2015:807673 pubmed publisher
Hikiji T, Norisada J, Hirata Y, Okuda K, Nagasawa H, Ishigaki S, et al. A highly sensitive assay of IRE1 activity using the small luciferase NanoLuc: Evaluation of ALS-related genetic and pathological factors. Biochem Biophys Res Commun. 2015;463:881-7 pubmed publisher
Castillero E, Akashi H, Pendrak K, Yerebakan H, Najjar M, Wang C, et al. Attenuation of the unfolded protein response and endoplasmic reticulum stress after mechanical unloading in dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2015;309:H459-70 pubmed publisher
Hooper R, Zhang X, Webster M, Go C, Kedra J, Marchbank K, et al. Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma. Mol Cell Biol. 2015;35:2790-8 pubmed
Tang X, Liang X, Li M, Guo T, Duan N, Wang Y, et al. ATF6 pathway of unfolded protein response mediates advanced oxidation protein product-induced hypertrophy and epithelial-to-mesenchymal transition in HK-2 cells. Mol Cell Biochem. 2015;407:197-207 pubmed publisher
Zhang H, Zhao C, Wang S, Huang Y, Wang H, Zhao J, et al. Anti-dsDNA antibodies induce inflammation via endoplasmic reticulum stress in human mesangial cells. J Transl Med. 2015;13:178 pubmed publisher
Heinick A, Husser X, Himmler K, Kirchhefer U, Nunes F, Schulte J, et al. Annexin A4 is a novel direct regulator of adenylyl cyclase type 5. FASEB J. 2015;29:3773-87 pubmed publisher
Luan Q, Jin L, Jiang C, Tay K, Lai F, Liu X, et al. RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy. Autophagy. 2015;11:975-94 pubmed publisher
Lindert U, Weis M, Rai J, Seeliger F, Hausser I, Leeb T, et al. Molecular Consequences of the SERPINH1/HSP47 Mutation in the Dachshund Natural Model of Osteogenesis Imperfecta. J Biol Chem. 2015;290:17679-89 pubmed publisher
Shambharkar P, Bittinger M, Latario B, Xiong Z, Bandyopadhyay S, Davis V, et al. TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis. PLoS ONE. 2015;10:e0127480 pubmed publisher
Godier Furnémont A, Tiburcy M, Wagner E, Dewenter M, Lämmle S, El Armouche A, et al. Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation. Biomaterials. 2015;60:82-91 pubmed publisher
Holczer M, Márton M, Kurucz A, Bánhegyi G, Kapuy O. A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress. Biomed Res Int. 2015;2015:319589 pubmed publisher
Nogalska A, D Agostino C, Engel W, Cacciottolo M, Asada S, Mori K, et al. Activation of the Unfolded Protein Response in Sporadic Inclusion-Body Myositis but Not in Hereditary GNE Inclusion-Body Myopathy. J Neuropathol Exp Neurol. 2015;74:538-46 pubmed publisher
Hamamura K, Nishimura A, Iino T, Takigawa S, Sudo A, Yokota H. Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis. Bone Joint Res. 2015;4:84-92 pubmed publisher
Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A. The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit. Biochem Biophys Res Commun. 2015;462:383-8 pubmed publisher
Goitea V, Hallak M. Calreticulin and Arginylated Calreticulin Have Different Susceptibilities to Proteasomal Degradation. J Biol Chem. 2015;290:16403-14 pubmed publisher
Mauvezin C, Nagy P, Juhász G, Neufeld T. Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification. Nat Commun. 2015;6:7007 pubmed publisher
Chernyavsky A, Galitovskiy V, Grando S. Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression. Int Immunopharmacol. 2015;29:15-20 pubmed publisher
Walter M, Rossius M, Zitzelsberger M, Vorgerd M, Müller Felber W, Ertl Wagner B, et al. 50 years to diagnosis: Autosomal dominant tubular aggregate myopathy caused by a novel STIM1 mutation. Neuromuscul Disord. 2015;25:577-84 pubmed publisher
Xiu F, Catapano M, Diao L, Stanojcic M, Jeschke M. Prolonged Endoplasmic Reticulum-Stressed Hepatocytes Drive an Alternative Macrophage Polarization. Shock. 2015;44:44-51 pubmed publisher
Liu R, Zhang L, Yang J, Zhang X, Mikkelsen R, Song S, et al. HIV Protease Inhibitors Sensitize Human Head and Neck Squamous Carcinoma Cells to Radiation by Activating Endoplasmic Reticulum Stress. PLoS ONE. 2015;10:e0125928 pubmed publisher
Oh hashi K, Sone A, Hikiji T, Hirata Y, Vitiello M, Fedele M, et al. Transcriptional and post-transcriptional regulation of transmembrane protein 132A. Mol Cell Biochem. 2015;405:291-9 pubmed publisher
Sun Y, Birnbaumer L, Singh B. TRPC1 regulates calcium-activated chloride channels in salivary gland cells. J Cell Physiol. 2015;230:2848-56 pubmed publisher
Sahoo S, Shaikh S, Sopariwala D, Bal N, Bruhn D, Kopeć W, et al. The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca2+-ATPase (SERCA) ATP Hydrolysis from Ca2+ Transport. J Biol Chem. 2015;290:14057-67 pubmed publisher
Chandrachud U, Walker M, Simas A, Heetveld S, Petcherski A, Klein M, et al. Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function. J Biol Chem. 2015;290:14361-80 pubmed publisher
Weems J, Slaughter B, Unruh J, Hall S, McLaird M, Gilmore J, et al. Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses. J Biol Chem. 2015;290:15030-41 pubmed publisher
Wilson P, Fitzgibbon W, Garrett S, Jaffa A, Luttrell L, Brands M, et al. Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. Mol Endocrinol. 2015;29:896-908 pubmed publisher
Thuringer D, Berthenet K, Cronier L, Jego G, Solary E, Garrido C. Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells. Oncotarget. 2015;6:10267-83 pubmed
Qureshi F, Dejene E, Corbin K, Nunemaker C. Stress-induced dissociations between intracellular calcium signaling and insulin secretion in pancreatic islets. Cell Calcium. 2015;57:366-375 pubmed publisher
Mani H, Tanaka H, Adachi T, Ikegawa M, Dai P, Fujita N, et al. How Does the Ca(2+)-paradox Injury Induce Contracture in the Heart?-A Combined Study of the Intracellular Ca(2+) Dynamics and Cell Structures in Perfused Rat Hearts. Acta Histochem Cytochem. 2015;48:1-8 pubmed publisher
Mota S, Costa R, Ferreira I, Santana I, Caldeira G, Padovano C, et al. Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease. Biochim Biophys Acta. 2015;1852:1428-41 pubmed publisher
Steinckwich N, Myers P, Janardhan K, Flagler N, King D, Petranka J, et al. Role of the store-operated calcium entry protein, STIM1, in neutrophil chemotaxis and infiltration into a murine model of psoriasis-inflamed skin. FASEB J. 2015;29:3003-13 pubmed publisher
Nussbaum C, Bannenberg S, Keul P, Gräler M, Gonçalves de Albuquerque C, Korhonen H, et al. Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nat Commun. 2015;6:6416 pubmed publisher
Teng Y, Ren X, Li H, Shull A, Kim J, Cowell J. Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein. Oncogene. 2016;35:333-43 pubmed publisher
Koc M, Mayerová V, Kračmerová J, Mairal A, Mališová L, Štich V, et al. Stress of endoplasmic reticulum modulates differentiation and lipogenesis of human adipocytes. Biochem Biophys Res Commun. 2015;460:684-90 pubmed publisher
Nakazato R, Takarada T, Ikeno S, Nakamura S, Kutsukake T, Hinoi E, et al. Upregulation of Runt-Related Transcription Factor-2 Through CCAAT Enhancer Binding Protein-β Signaling Pathway in Microglial BV-2 Cells Exposed to ATP. J Cell Physiol. 2015;230:2510-21 pubmed publisher
Carnesecchi S, Rougemont A, Doroshow J, Nagy M, Mouche S, Gumy Pause F, et al. The NADPH oxidase NOX5 protects against apoptosis in ALK-positive anaplastic large-cell lymphoma cell lines. Free Radic Biol Med. 2015;84:22-29 pubmed publisher
Li Y, Li J, Li S, Li Y, Wang X, Liu B, et al. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicol Appl Pharmacol. 2015;286:53-63 pubmed publisher
Kuboyama T, Lee Y, Nishiko H, Tohda C. Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage. Neurobiol Aging. 2015;36:1808-19 pubmed publisher
Dudek Perić A, Ferreira G, Muchowicz A, Wouters J, Prada N, Martin S, et al. Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulin. Cancer Res. 2015;75:1603-14 pubmed publisher
Kito H, Yamamura H, Suzuki Y, Yamamura H, Ohya S, Asai K, et al. Regulation of store-operated Ca2+ entry activity by cell cycle dependent up-regulation of Orai2 in brain capillary endothelial cells. Biochem Biophys Res Commun. 2015;459:457-62 pubmed publisher
Lazrak A, Creighton J, Yu Z, Komarova S, Doran S, Aggarwal S, et al. Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury. Am J Physiol Lung Cell Mol Physiol. 2015;308:L891-903 pubmed publisher
Jung E, Hong H, Kim C, Mook Jung I. Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation. Sci Rep. 2015;5:8805 pubmed publisher
Liu M, Chen H, Wei L, Hu D, Dong K, Jia W, et al. Endoplasmic reticulum (ER) localization is critical for DsbA-L protein to suppress ER stress and adiponectin down-regulation in adipocytes. J Biol Chem. 2015;290:10143-8 pubmed publisher
Iwasaki N, Sugiyama Y, Miyazaki S, Nakagawa H, Nishimura K, Matsuo S. An ATF4-Signal-Modulating Machine Other Than GADD34 Acts in ATF4-to-CHOP Signaling to Block CHOP Expression in ER-Stress-Related Autophagy. J Cell Biochem. 2015;116:1300-9 pubmed publisher
Qi C, Wang X, Ge F, Li Y, Shen F, Wang J, et al. mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling. Addict Biol. 2015;20:927-40 pubmed publisher
Tanaka N, Takahashi S, Zhang Y, Krausz K, Smith P, Patterson A, et al. Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet. Biochim Biophys Acta. 2015;1852:1242-52 pubmed publisher
Kaunisto A, Henry W, Montaser Kouhsari L, Jaminet S, Oh E, Zhao L, et al. NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer. Mol Oncol. 2015;9:1140-54 pubmed publisher
Yasuda H, Mukai H. Turning off of GluN2B subunits and turning on of CICR in hippocampal LTD induction after developmental GluN2 subunit switch. Hippocampus. 2015;25:1274-84 pubmed publisher
Vahabzadeh G, Rahbar Roshandel N, Ebrahimi S, Mahmoudian M. Neuroprotective effect of noscapine on cerebral oxygen-glucose deprivation injury. Pharmacol Rep. 2015;67:281-8 pubmed publisher
Silwal P, Shin K, Choi S, Kang S, Park J, Lee H, et al. Adenine suppresses IgE-mediated mast cell activation. Mol Immunol. 2015;65:242-9 pubmed publisher
Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, et al. Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis. Nat Commun. 2015;6:6239 pubmed publisher
Nakanishi K, Kakiguchi K, Yonemura S, Nakano A, Morishima N. Transient Ca2+ depletion from the endoplasmic reticulum is critical for skeletal myoblast differentiation. FASEB J. 2015;29:2137-49 pubmed publisher
Philippe R, Antigny F, Buscaglia P, Norez C, Becq F, Frieden M, et al. SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells. Biochim Biophys Acta. 2015;1853:892-903 pubmed publisher
Ishikawa K, Tsunekawa S, Ikeniwa M, Izumoto T, Iida A, Ogata H, et al. Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity. PLoS ONE. 2015;10:e0115350 pubmed publisher
AlSuleimani Y, Hiley C. The GPR55 agonist lysophosphatidylinositol relaxes rat mesenteric resistance artery and induces Ca(2+) release in rat mesenteric artery endothelial cells. Br J Pharmacol. 2015;172:3043-57 pubmed publisher
Du Z, Weinbaum S, Weinstein A, Wang T. Regulation of glomerulotubular balance. III. Implication of cytosolic calcium in flow-dependent proximal tubule transport. Am J Physiol Renal Physiol. 2015;308:F839-47 pubmed publisher
Huang Y, Chang S, Harn H, Huang H, Lin H, Shen M, et al. Mechanosensitive store-operated calcium entry regulates the formation of cell polarity. J Cell Physiol. 2015;230:2086-97 pubmed publisher
Ho D, Chan J. Induction of Herpud1 expression by ER stress is regulated by Nrf1. FEBS Lett. 2015;589:615-20 pubmed publisher
Zhu M, Sung T, O Driscoll K, Koh S, Sanders K. Intracellular Ca(2+) release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal. Am J Physiol Cell Physiol. 2015;308:C608-20 pubmed publisher
von Stechow L, Typas D, Carreras Puigvert J, Oort L, Siddappa R, Pines A, et al. The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest. Mol Cell Biol. 2015;35:1254-68 pubmed publisher
Lorin C, Vögeli I, Niggli E. Dystrophic cardiomyopathy: role of TRPV2 channels in stretch-induced cell damage. Cardiovasc Res. 2015;106:153-62 pubmed publisher
Yeh Y, Chen R, Hessler J, Mahoney E, Lehman A, Heerema N, et al. Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia. Oncotarget. 2015;6:2667-79 pubmed
Tang M, Huang J, Weng X, Yang L, Liu M, Zhou M, et al. Evaluation of a dansyl-based amino acid DNSBA as an imaging probe for apoptosis detection. Apoptosis. 2015;20:410-20 pubmed publisher
Song W, Jin X. Cyclic AMP inhibits neuromuscular junction maturation mediated by intracellular Ca2+. Neurosci Lett. 2015;589:104-9 pubmed publisher
Read C, Kuijper J, Hjorth S, Heipel M, Tang X, Fleetwood A, et al. Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1. J Immunol. 2015;194:1417-21 pubmed publisher
Toro C, Eger S, Veliz L, Sotelo Hitschfeld P, Cabezas D, Castro M, et al. Agonist-dependent modulation of cell surface expression of the cold receptor TRPM8. J Neurosci. 2015;35:571-82 pubmed publisher
Sunkaria A, Bhardwaj S, Halder A, Yadav A, Sandhir R. Migration and Phagocytic Ability of Activated Microglia During Post-natal Development is Mediated by Calcium-Dependent Purinergic Signalling. Mol Neurobiol. 2016;53:944-54 pubmed publisher
Saveljeva S, Mc Laughlin S, Vandenabeele P, Samali A, Bertrand M. Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells. Cell Death Dis. 2015;6:e1587 pubmed publisher
Milhem R, Al Gazali L, Ali B. Improved plasma membrane expression of the trafficking defective P344R mutant of muscle, skeletal, receptor tyrosine kinase (MuSK) causing congenital myasthenic syndrome. Int J Biochem Cell Biol. 2015;60:119-29 pubmed publisher
Shintani S, Oyama K, Fukuda N, Ishiwata S. High-frequency sarcomeric auto-oscillations induced by heating in living neonatal cardiomyocytes of the rat. Biochem Biophys Res Commun. 2015;457:165-70 pubmed publisher
Zou H, Limpert A, Zou J, Dembo A, Lee P, Grant D, et al. Benzodiazepinone derivatives protect against endoplasmic reticulum stress-mediated cell death in human neuronal cell lines. ACS Chem Neurosci. 2015;6:464-75 pubmed publisher
Kim D, Kim H, Kim K, Park J, Lee B. NELL2 function in the protection of cells against endoplasmic reticulum stress. Mol Cells. 2015;38:145-50 pubmed publisher
Wada N, Kawano Y, Fujiwara S, Kikukawa Y, Okuno Y, Tasaki M, et al. Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells. Int J Oncol. 2015;46:963-72 pubmed publisher
Shan J, Donelan W, Hayner J, Zhang F, Dudenhausen E, Kilberg M. MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells. Biochim Biophys Acta. 2015;1853:539-48 pubmed publisher
Chakraborty S, Li L, Puliyappadamba V, Guo G, Hatanpaa K, Mickey B, et al. Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks. Nat Commun. 2014;5:5811 pubmed publisher
Wang J, Liu S, Yin Y, Li M, Wang B, Yang L, et al. FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis. Apoptosis. 2015;20:399-409 pubmed publisher
Song J, Li J, Hou F, Wang X, Liu B. Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells. Metabolism. 2015;64:428-37 pubmed publisher
Bina S, Capacchione J, Munkhuu B, Muldoon S, Bunger R. Is lymphocyte adenosine a diagnostic marker of clinical malignant hyperthermia? A pilot study. Crit Care Med. 2015;43:584-93 pubmed publisher
Zhang L, Dai F, Cui L, Jing H, Fan P, Tan X, et al. Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells. Biochim Biophys Acta. 2015;1853:377-87 pubmed publisher
Wilson L, McKeown L, Tumova S, Li J, Beech D. Expression of a long variant of CRACR2A that belongs to the Rab GTPase protein family in endothelial cells. Biochem Biophys Res Commun. 2015;456:398-402 pubmed publisher
Wang G, Liu K, Li Y, Yi W, Yang Y, Zhao D, et al. Endoplasmic reticulum stress mediates the anti-inflammatory effect of ethyl pyruvate in endothelial cells. PLoS ONE. 2014;9:e113983 pubmed publisher
Wu Q, Sun M, Wu C, Li Y, Du J, Zeng J, et al. Activation of calcium-sensing receptor increases TRPC3/6 expression in T lymphocyte in sepsis. Mol Immunol. 2015;64:18-25 pubmed publisher
Tang Y, Yin Y, Miao L, Wei B, Zhai K, Ji G. Nitric oxide enhances extracellular ATP induced Ca²⁺ oscillation in HeLa cells. Arch Biochem Biophys. 2015;565:68-75 pubmed publisher
Hendron E, Wang X, Zhou Y, Cai X, Goto J, Mikoshiba K, et al. Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs. Cell Calcium. 2014;56:482-92 pubmed publisher
Lee M, Bingham K, Mitchell T, Meredith J, Rawlings J. Calcium mobilization is both required and sufficient for initiating chromatin decondensation during activation of peripheral T-cells. Mol Immunol. 2015;63:540-9 pubmed publisher
Casas Rua V, Tomas Martin P, Lopez Guerrero A, Alvarez I, Pozo Guisado E, Martín Romero F. STIM1 phosphorylation triggered by epidermal growth factor mediates cell migration. Biochim Biophys Acta. 2015;1853:233-43 pubmed publisher
Clark O, Park I, Di Florio A, Cichon A, Rustin S, Jugov R, et al. Oxovanadium-based inhibitors can drive redox-sensitive cytotoxicity in neuroblastoma cells and synergise strongly with buthionine sulfoximine. Cancer Lett. 2015;357:316-27 pubmed publisher
Xu N, Cioffi D, Alexeyev M, Rich T, Stevens T. Sodium entry through endothelial store-operated calcium entry channels: regulation by Orai1. Am J Physiol Cell Physiol. 2015;308:C277-88 pubmed publisher
Rodrigues B, Pauli L, de Souza C, da Silva A, Cintra D, Marinho R, et al. Acute Exercise Decreases Tribbles Homolog 3 Protein Levels in the Hypothalamus of Obese Rats. Med Sci Sports Exerc. 2015;47:1613-23 pubmed publisher
Polo M, Alegre F, Funes H, Blas Garcia A, Victor V, Esplugues J, et al. Mitochondrial (dys)function - a factor underlying the variability of efavirenz-induced hepatotoxicity?. Br J Pharmacol. 2015;172:1713-27 pubmed publisher
Lukas J, Pockrandt A, Seemann S, Sharif M, Runge F, Pohlers S, et al. Enzyme enhancers for the treatment of Fabry and Pompe disease. Mol Ther. 2015;23:456-64 pubmed publisher
Jiang X, Kanda T, Wu S, Nakamoto S, Wakita T, Shirasawa H, et al. Hepatitis C virus nonstructural protein 5A inhibits thapsigargin-induced apoptosis. PLoS ONE. 2014;9:e113499 pubmed publisher
Wali J, Gurzov E, Fynch S, Elkerbout L, Kay T, Masters S, et al. Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets. PLoS ONE. 2014;9:e113128 pubmed publisher
Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A. TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress. PLoS ONE. 2014;9:e112761 pubmed publisher
Cho J, Zhang X, Miller G, Lencer W, Nery F. 4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models. PLoS ONE. 2014;9:e110086 pubmed publisher
Smrz D, Cruse G, Beaven M, Kirshenbaum A, Metcalfe D, Gilfillan A. Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation. J Immunol. 2014;193:5924-32 pubmed publisher
Samak G, Chaudhry K, Gangwar R, Narayanan D, Jaggar J, Rao R. Calcium/Ask1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium. Biochem J. 2015;465:503-15 pubmed publisher
Zieminska E, Stafiej A, Toczylowska B, Lazarewicz J. Bastadin 12 and ryanodine reveal similarities between thapsigargin- and tetrabromobisphenol A-induced intracellular Ca(2+) release in cultured cerebellar granule cells. J Physiol Pharmacol. 2014;65:679-86 pubmed
Steward A, Kelly D, Wagner D. The role of calcium signalling in the chondrogenic response of mesenchymal stem cells to hydrostatic pressure. Eur Cell Mater. 2014;28:358-71 pubmed
Zhang B, Wang X, Chen H, Liu B. Involvement of the Nrf2 pathway in the regulation of pterostilbene-induced apoptosis in HeLa cells via ER stress. J Pharmacol Sci. 2014;126:216-29 pubmed
Jiang X, Kanda T, Nakamoto S, Haga Y, Sasaki R, Nakamura M, et al. Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress. Oncol Rep. 2014;32:2343-8 pubmed publisher
Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, et al. Involvement of endoplasmic reticulum stress in all-trans-retinal-induced retinal pigment epithelium degeneration. Toxicol Sci. 2015;143:196-208 pubmed publisher
Böhm J, Chevessier F, Koch C, Peche G, Mora M, Morandi L, et al. Clinical, histological and genetic characterisation of patients with tubular aggregate myopathy caused by mutations in STIM1. J Med Genet. 2014;51:824-33 pubmed publisher
Ghosh A, Garg S, Mau T, O Brien M, Liu J, Yung R. Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging. J Gerontol A Biol Sci Med Sci. 2015;70:1320-9 pubmed publisher
Wu Y, Wang J, Zhou H, Yu X, Hu L, Meng F, et al. Effects of calcium signaling on coagulation factor VIIa-induced proliferation and migration of the SW620 colon cancer cell line. Mol Med Rep. 2014;10:3021-6 pubmed publisher
Kim Y, Park K, Kim J, Seo H, Shin K, Lee Y, et al. An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. Mol Cell Biol. 2014;34:4368-78 pubmed publisher
Zhao N, Dong Q, Fu X, Du L, Cheng X, Du Y, et al. Acacetin blocks kv1.3 channels and inhibits human T cell activation. Cell Physiol Biochem. 2014;34:1359-72 pubmed publisher
Lombardi A, Inabnet W, Owen R, Farenholtz K, Tomer Y. Endoplasmic reticulum stress as a novel mechanism in amiodarone-induced destructive thyroiditis. J Clin Endocrinol Metab. 2015;100:E1-10 pubmed publisher
Yu N, Jiang J, Yu Y, Li H, Huang X, Ma Y, et al. SLC41A1 knockdown inhibits angiotensin II-induced cardiac fibrosis by preventing Mg(2+) efflux and Ca(2+) signaling in cardiac fibroblasts. Arch Biochem Biophys. 2014;564:74-82 pubmed publisher
Velásquez Martínez M, Vázquez Torres R, Rojas L, SANABRIA P, Jiménez Rivera C. Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons. Neuropharmacology. 2015;88:110-21 pubmed publisher
Hu F, Pan L, Zhang K, Xing F, Wang X, Lee I, et al. Elevation of extracellular Ca2+ induces store-operated calcium entry via calcium-sensing receptors: a pathway contributes to the proliferation of osteoblasts. PLoS ONE. 2014;9:e107217 pubmed publisher
Shanware N, Bray K, Eng C, Wang F, Follettie M, Myers J, et al. Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion. Nat Commun. 2014;5:4900 pubmed publisher
Chen S, Zhao Y, Zhang Y, Zhang D. Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades. PLoS ONE. 2014;9:e108157 pubmed publisher
Nishiyama K, Azuma Y, Shintaku K, Yoshida N, Nakajima H, Takeuchi T. Evidence that nitric oxide is a non-adrenergic non-cholinergic inhibitory neurotransmitter in the circular muscle of the mouse distal colon: a study on the mechanism of nitric oxide-induced relaxation. Pharmacology. 2014;94:99-108 pubmed publisher
Gao Z, Ma Y, Zhao D, Zhang X, Zhou H, Liu H, et al. Neochromine S5 improves contact hypersensitivity through a selective effect on activated T lymphocytes. Biochem Pharmacol. 2014;92:358-68 pubmed publisher
Kim S, Ha G, Bae J, Kim G, Son C, Park Y, et al. COX-2- and endoplasmic reticulum stress-independent induction of ULBP-1 and enhancement of sensitivity to NK cell-mediated cytotoxicity by celecoxib in colon cancer cells. Exp Cell Res. 2015;330:451-9 pubmed publisher
Traister A, Li M, Aafaqi S, Lu M, Arab S, Radisic M, et al. Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function. Nat Commun. 2014;5:4533 pubmed publisher
Del Vecchio C, Feng Y, Sokol E, Tillman E, Sanduja S, Reinhardt F, et al. De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling. PLoS Biol. 2014;12:e1001945 pubmed publisher
Deng C, Yang H, Kuang S, Rao F, Xue Y, Zhou Z, et al. Upregulation of 5-hydroxytryptamine receptor signaling in coronary arteries after organ culture. PLoS ONE. 2014;9:e107128 pubmed publisher
Edwards S, Baron J, Moore C, Liu Y, Perlman D, Hart R, et al. Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes. J Hematol Oncol. 2014;7:56 pubmed publisher
Akita M, Suzuki Karasaki M, Fujiwara K, Nakagawa C, Soma M, Yoshida Y, et al. Mitochondrial division inhibitor-1 induces mitochondrial hyperfusion and sensitizes human cancer cells to TRAIL-induced apoptosis. Int J Oncol. 2014;45:1901-12 pubmed publisher
Noronha Matos J, Coimbra J, Sá e Sousa A, Rocha R, Marinhas J, Freitas R, et al. P2X7-induced zeiosis promotes osteogenic differentiation and mineralization of postmenopausal bone marrow-derived mesenchymal stem cells. FASEB J. 2014;28:5208-22 pubmed publisher
Granato M, Santarelli R, Farina A, Gonnella R, Lotti L, Faggioni A, et al. Epstein-barr virus blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication. J Virol. 2014;88:12715-26 pubmed publisher
Arruda Barbosa L, Rodrigues K, Souza Neto F, Duarte G, Borges R, Magalhães P, et al. Vasorelaxant effects of 1-nitro-2-phenylethene in rat isolated aortic rings. Vascul Pharmacol. 2014;63:55-62 pubmed publisher
Boztug K, Järvinen P, Salzer E, Racek T, Mönch S, Garncarz W, et al. JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia. Nat Genet. 2014;46:1021-7 pubmed publisher
Zhang X, Yuan Y, Jiang L, Zhang J, Gao J, Shen Z, et al. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Autophagy. 2014;10:1801-13 pubmed publisher
Chamberland S, Evstratova A, Tóth K. Interplay between synchronization of multivesicular release and recruitment of additional release sites support short-term facilitation at hippocampal mossy fiber to CA3 pyramidal cells synapses. J Neurosci. 2014;34:11032-47 pubmed publisher
Mathur A, Abd Elmageed Z, Liu X, Kostochka M, Zhang H, Abdel Mageed A, et al. Subverting ER-stress towards apoptosis by nelfinavir and curcumin coexposure augments docetaxel efficacy in castration resistant prostate cancer cells. PLoS ONE. 2014;9:e103109 pubmed publisher
Meares G, Liu Y, Rajbhandari R, Qin H, Nozell S, Mobley J, et al. PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation. Mol Cell Biol. 2014;34:3911-25 pubmed publisher
Liang C, Du T, Zhou J, Verkhratsky A, Peng L. Ammonium increases Ca(2+) signalling and up-regulates expression of TRPC1 gene in astrocytes in primary cultures and in the in vivo brain. Neurochem Res. 2014;39:2127-35 pubmed publisher
Chaudhri R, Hadadi A, Lobachev K, Schwartz Z, Boyan B. Estrogen receptor-alpha 36 mediates the anti-apoptotic effect of estradiol in triple negative breast cancer cells via a membrane-associated mechanism. Biochim Biophys Acta. 2014;1843:2796-806 pubmed publisher
Zhou Y, Liang X, Chang H, Shu F, Wu Y, Zhang T, et al. Ampelopsin-induced autophagy protects breast cancer cells from apoptosis through Akt-mTOR pathway via endoplasmic reticulum stress. Cancer Sci. 2014;105:1279-87 pubmed publisher
Albarrán L, Dionisio N, Lopez E, Salido G, Redondo P, Rosado J. STIM1 regulates TRPC6 heteromultimerization and subcellular location. Biochem J. 2014;463:373-81 pubmed publisher
Deegan S, Saveljeva S, Gupta S, Macdonald D, Samali A. ER stress responses in the absence of apoptosome: a comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts. Biochem Biophys Res Commun. 2014;451:367-73 pubmed publisher
Santofimia Castaño P, Ruy D, Fernandez Bermejo M, Salido G, Gonzalez A. Pharmacological dose of melatonin reduces cytosolic calcium load in response to cholecystokinin in mouse pancreatic acinar cells. Mol Cell Biochem. 2014;397:75-86 pubmed publisher
Liantonio A, Camerino G, Scaramuzzi A, Cannone M, Pierno S, De Bellis M, et al. Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats: cytofluorimetric and gene expression analysis. Am J Pathol. 2014;184:2803-15 pubmed publisher
Olivares S, Green R, Henkel A. Endoplasmic reticulum stress activates the hepatic activator protein 1 complex via mitogen activated protein kinase-dependent signaling pathways. PLoS ONE. 2014;9:e103828 pubmed publisher
Huang G, He C, Meng F, Li J, Zhang J, Wang Y. Glucagon-like peptide (GCGL) is a novel potential TSH-releasing factor (TRF) in Chickens: I) Evidence for its potent and specific action on stimulating TSH mRNA expression and secretion in the pituitary. Endocrinology. 2014;155:4568-80 pubmed publisher
Santofimia Castaño P, García Sanchez L, Ruy D, Fernandez Bermejo M, Salido G, Gonzalez A. The seleno-organic compound ebselen impairs mitochondrial physiology and induces cell death in AR42J cells. Toxicol Lett. 2014;229:465-73 pubmed publisher
Dennis M, Coleman C, Berg A, Jefferson L, Kimball S. REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling. Sci Signal. 2014;7:ra68 pubmed publisher
Wang C, Rong M, Wang L, Ren Z, Chen L, Jia J, et al. CD147 up-regulates calcium-induced chemotaxis, adhesion ability and invasiveness of human neutrophils via a TRPM-7-mediated mechanism. Rheumatology (Oxford). 2014;53:2288-96 pubmed publisher
Hamouda M, Belhacene N, Puissant A, Colosetti P, Robert G, Jacquel A, et al. The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells. Oncotarget. 2014;5:6252-66 pubmed
Paudel R, Kiviluoto S, Parys J, Bultynck G. Resveratrol is not compatible with a Fura-2-based assay for measuring intracellular Ca²⁺ signaling. Biochem Biophys Res Commun. 2014;450:1626-30 pubmed publisher
Hirai S, Endo S, Saito R, Hirose M, Ueno T, Suzuki H, et al. Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation. PLoS ONE. 2014;9:e102831 pubmed publisher
Treinys R, Kaselis A, Jover E, Bagnard D, Satkauskas S. R-type calcium channels are crucial for semaphorin 3A-induced DRG axon growth cone collapse. PLoS ONE. 2014;9:e102357 pubmed publisher
Henderson M, Wires E, Trychta K, Richie C, Harvey B. SERCaMP: a carboxy-terminal protein modification that enables monitoring of ER calcium homeostasis. Mol Biol Cell. 2014;25:2828-39 pubmed publisher
Schmidt S, Liu G, Liu G, Yang W, Honisch S, Pantelakos S, et al. Enhanced Orai1 and STIM1 expression as well as store operated Ca2+ entry in therapy resistant ovary carcinoma cells. Oncotarget. 2014;5:4799-810 pubmed
Pallagi Kunstár É, Farkas K, Maléth J, Rakonczay Z, Nagy F, Molnar T, et al. Bile acids inhibit Na⁺/H⁺ exchanger and Cl⁻/HCO₃⁻ exchanger activities via cellular energy breakdown and Ca²⁺ overload in human colonic crypts. Pflugers Arch. 2015;467:1277-90 pubmed
Cadavez L, Montane J, Alcarraz Vizán G, Visa M, Vidal Fàbrega L, Servitja J, et al. Chaperones ameliorate beta cell dysfunction associated with human islet amyloid polypeptide overexpression. PLoS ONE. 2014;9:e101797 pubmed publisher
Gibbons E, Murri M, Grabner A, Moss E, Campbell L, Nelson J, et al. Ionomycin causes susceptibility to phospholipase A2 while temperature-induced increases in membrane fluidity fail: possible involvement of actin fragmentation. Biochim Biophys Acta. 2014;1838:2607-14 pubmed publisher
Balasuriya D, Srivats S, Murrell Lagnado R, Edwardson J. Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry. FEBS Lett. 2014;588:2874-80 pubmed publisher
Park E, Kim S, Hong Y, Hwang J, Cho G, Cha H, et al. Inhibition of CYP4A reduces hepatic endoplasmic reticulum stress and features of diabetes in mice. Gastroenterology. 2014;147:860-9 pubmed publisher
Lee E, Lee H, Lee Y, Jeong J, Kang S, Lim Y. Chemical chaperones reduce ionizing radiation-induced endoplasmic reticulum stress and cell death in IEC-6 cells. Biochem Biophys Res Commun. 2014;450:1005-9 pubmed publisher
Kaur G, Ly Huynh J, Jans D. Intracellular calcium levels can regulate Importin-dependent nuclear import. Biochem Biophys Res Commun. 2014;450:812-7 pubmed publisher
Kim B, Kim H, Lee G, So I, Kim S. Effects of San-Huang-Xie-Xin-tang, a traditional Chinese prescription for clearing away heat and toxin, on the pacemaker activities of interstitial cells of Cajal from the murine small intestine. J Ethnopharmacol. 2014;155:744-52 pubmed publisher
Kim E, Meng H, Jun A. N-Acetylcysteine increases corneal endothelial cell survival in a mouse model of Fuchs endothelial corneal dystrophy. Exp Eye Res. 2014;127:20-5 pubmed publisher
Nunemaker C, Chung H, Verrilli G, Corbin K, Upadhye A, Sharma P. Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function. J Endocrinol. 2014;222:267-76 pubmed publisher
Vollrath J, Sechi A, Dreser A, Katona I, Wiemuth D, Vervoorts J, et al. Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances. Cell Death Dis. 2014;5:e1290 pubmed publisher
Zhao C, Pavicic P, Datta S, Sun D, Novotny M, Hamilton T. Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1. J Immunol. 2014;193:879-88 pubmed publisher
Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty M, Dufey E, et al. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal. 2014;7:ra54 pubmed publisher
Fritze D, Zhang W, Li J, Chai B, Mulholland M. Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease. J Gastrointest Surg. 2014;18:1495-506 pubmed publisher
Pierre N, Barbé C, Gilson H, Deldicque L, Raymackers J, Francaux M. Activation of ER stress by hydrogen peroxide in C2C12 myotubes. Biochem Biophys Res Commun. 2014;450:459-63 pubmed publisher
Trebinska A, Högstrand K, Grandien A, Grzybowska E, Fadeel B. Exploring the anti-apoptotic role of HAX-1 versus BCL-XL in cytokine-dependent bone marrow-derived cells from mice. FEBS Lett. 2014;588:2921-7 pubmed publisher
Araujo L, Fert I, Jouhault Q, Labroquère K, Andrieu M, Chiocchia G, et al. Increased production of interleukin-17 over interleukin-10 by treg cells implicates inducible costimulator molecule in experimental spondyloarthritis. Arthritis Rheumatol. 2014;66:2412-22 pubmed publisher
Lim K, Kwon J, Kim K, Noh J, Kang S, Park J, et al. Emodin inhibits tonic tension through suppressing PKC?-mediated inhibition of myosin phosphatase in rat isolated thoracic aorta. Br J Pharmacol. 2014;171:4300-10 pubmed publisher
Meng K, Xu J, Zhang C, Zhang R, Yang H, Liao C, et al. Calcium sensing receptor modulates extracellular calcium entry and proliferation via TRPC3/6 channels in cultured human mesangial cells. PLoS ONE. 2014;9:e98777 pubmed publisher
Rao J, Yue S, Fu Y, Zhu J, Wang X, Busuttil R, et al. ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury. Am J Transplant. 2014;14:1552-61 pubmed publisher
Dersh D, Jones S, Eletto D, Christianson J, Argon Y. OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation. Mol Biol Cell. 2014;25:2220-34 pubmed publisher
Montague K, Malik B, Gray A, La Spada A, Hanna M, Szabadkai G, et al. Endoplasmic reticulum stress in spinal and bulbar muscular atrophy: a potential target for therapy. Brain. 2014;137:1894-906 pubmed publisher
Simon Szabó L, Kokas M, Mandl J, Keri G, Csala M. Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. PLoS ONE. 2014;9:e97868 pubmed publisher
Neuber C, Uebeler J, Schulze T, Sotoud H, El Armouche A, Eschenhagen T. Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes. PLoS ONE. 2014;9:e98893 pubmed publisher
Sasaki M, Kondo M, Sato K, Umeda M, Kawabata K, Takahashi Y, et al. Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism. Pigment Cell Melanoma Res. 2014;27:754-63 pubmed publisher
Hu J, Oda S, Shotts K, Donovan E, Strauch P, Pujanauski L, et al. Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response. J Immunol. 2014;193:85-95 pubmed publisher
Chen S, Xuan J, Couch L, Iyer A, Wu Y, Li Q, et al. Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014;322:78-88 pubmed publisher
Jakob R, Beutner G, Sharma V, Duan Y, Gross R, Hurst S, et al. Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett. 2014;575:7-12 pubmed publisher
Desmet A, Cirillo C, Vanden Berghe P. Distinct subcellular localization of the neuronal marker HuC/D reveals hypoxia-induced damage in enteric neurons. Neurogastroenterol Motil. 2014;26:1131-43 pubmed publisher
Xia J, Pan R, Gao X, Meucci O, Hu H. Native store-operated calcium channels are functionally expressed in mouse spinal cord dorsal horn neurons and regulate resting calcium homeostasis. J Physiol. 2014;592:3443-61 pubmed publisher
Kosakowska Cholody T, Lin J, Srideshikan S, Scheffer L, Tarasova N, Acharya J. HKH40A downregulates GRP78/BiP expression in cancer cells. Cell Death Dis. 2014;5:e1240 pubmed publisher
Lu J, He L, Behrends C, Araki M, Araki K, Jun Wang Q, et al. NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nat Commun. 2014;5:3920 pubmed publisher
Maas N, Singh N, Diehl J. Generation and characterization of an analog-sensitive PERK allele. Cancer Biol Ther. 2014;15:1106-11 pubmed publisher
Norisada J, Hirata Y, Amaya F, Kiuchi K, Oh hashi K. A sensitive assay for the biosynthesis and secretion of MANF using NanoLuc activity. Biochem Biophys Res Commun. 2014;449:483-9 pubmed publisher
Hou N, Gutschmidt A, Choi D, Pather K, Shi X, Watts J, et al. Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo. Proc Natl Acad Sci U S A. 2014;111:E2271-80 pubmed publisher
Rosekrans S, Heijmans J, Büller N, Westerlund J, Lee A, Muncan V, et al. ER stress induces epithelial differentiation in the mouse oesophagus. Gut. 2015;64:195-202 pubmed publisher
Grace M, Lieu T, Darby B, Abogadie F, Veldhuis N, Bunnett N, et al. The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo. Br J Pharmacol. 2014;171:3881-94 pubmed publisher
Ziomek G, Cheraghi Zanjani P, Arman D, van Breemen C, Esfandiarei M. Calcium regulation in aortic smooth muscle cells during the initial phase of tunicamycin-induced endo/sarcoplasmic reticulum stress. Eur J Pharmacol. 2014;735:86-96 pubmed publisher
Holowka D, Korzeniowski M, Bryant K, Baird B. Polyunsaturated fatty acids inhibit stimulated coupling between the ER Ca(2+) sensor STIM1 and the Ca(2+) channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization. Biochim Biophys Acta. 2014;1841:1210-6 pubmed publisher
Hosoi T, Inoue Y, Nakatsu K, Matsushima N, Kiyose N, Shimamoto A, et al. TERT attenuated ER stress-induced cell death. Biochem Biophys Res Commun. 2014;447:378-82 pubmed publisher
Milhem R, Ben Salem S, Al Gazali L, Ali B. Identification of the cellular mechanisms that modulate trafficking of frizzled family receptor 4 (FZD4) missense mutants associated with familial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2014;55:3423-31 pubmed publisher
Schöbel N, Radtke D, Kyereme J, Wollmann N, Cichy A, Obst K, et al. Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds. Chem Senses. 2014;39:471-87 pubmed publisher
Hu X, Pang Q, Shen Q, Liu H, He J, Wang J, et al. Ubiquitin-fold modifier 1 inhibits apoptosis by suppressing the endoplasmic reticulum stress response in Raw264.7 cells. Int J Mol Med. 2014;33:1539-46 pubmed publisher
Partridge J, Lewin A, Yasko J, Vicini S. Contrasting actions of group I metabotropic glutamate receptors in distinct mouse striatal neurones. J Physiol. 2014;592:2721-33 pubmed publisher
Weisthal S, Keinan N, Ben Hail D, Arif T, Shoshan Barmatz V. Ca(2+)-mediated regulation of VDAC1 expression levels is associated with cell death induction. Biochim Biophys Acta. 2014;1843:2270-81 pubmed publisher
Li M, Liu Y, Xia F, Wu Z, Deng L, Jiang R, et al. Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2. Cell Signal. 2014;26:1539-48 pubmed publisher
Ha J, Shil P, Zhu P, Gu L, Li Q, Chung S. Ocular inflammation and endoplasmic reticulum stress are attenuated by supplementation with grape polyphenols in human retinal pigmented epithelium cells and in C57BL/6 mice. J Nutr. 2014;144:799-806 pubmed publisher
Zhang N, Fissore R. Role of caspase-3 cleaved IP3 R1 on Ca(2+) homeostasis and developmental competence of mouse oocytes and eggs. J Cell Physiol. 2014;229:1842-54 pubmed publisher
Giurisato E, Gamberucci A, Ulivieri C, Marruganti S, Rossi E, Giacomello E, et al. The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE). Mol Biol Cell. 2014;25:1769-81 pubmed publisher
Djillani A, Nüße O, Dellis O. Characterization of novel store-operated calcium entry effectors. Biochim Biophys Acta. 2014;1843:2341-7 pubmed publisher
Taylor K, Wright J, Vial C, Evans R, Mahaut Smith M. Amplification of human platelet activation by surface pannexin-1 channels. J Thromb Haemost. 2014;12:987-98 pubmed publisher
Song M, Chen D, Yu S. The TRPC channel blocker SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na(+) /Ca(2+) exchanger and increasing intracellular Ca(2+). Br J Pharmacol. 2014;171:3432-47 pubmed publisher
Schwarzer C, Ravishankar B, Patanwala M, Shuai S, Fu Z, Illek B, et al. Thapsigargin blocks Pseudomonas aeruginosa homoserine lactone-induced apoptosis in airway epithelia. Am J Physiol Cell Physiol. 2014;306:C844-55 pubmed publisher
Nunes V, Portioli Sanches E, Rosim M, Araujo M, Praxedes Garcia P, Valle M, et al. Progesterone induces apoptosis of insulin-secreting cells: insights into the molecular mechanism. J Endocrinol. 2014;221:273-84 pubmed publisher
Todd D, Gowers I, Dowler S, Wall M, McAllister G, Fischer D, et al. A monoclonal antibody TrkB receptor agonist as a potential therapeutic for Huntington's disease. PLoS ONE. 2014;9:e87923 pubmed publisher
Yammani R, Loeser R. Brief report: stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes. Arthritis Rheumatol. 2014;66:1266-71 pubmed publisher
Savignac M, Simon M, Edir A, Guibbal L, Hovnanian A. SERCA2 dysfunction in Darier disease causes endoplasmic reticulum stress and impaired cell-to-cell adhesion strength: rescue by Miglustat. J Invest Dermatol. 2014;134:1961-1970 pubmed publisher
Fritz J, Dong M, Apsley K, Martin E, Na C, Sitaraman S, et al. Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects. Mol Biol Cell. 2014;25:431-40 pubmed publisher
Morel J, Dabertrand F, Porte Y, Prevot A, Macrez N. Up-regulation of ryanodine receptor expression increases the calcium-induced calcium release and spontaneous calcium signals in cerebral arteries from hindlimb unloaded rats. Pflugers Arch. 2014;466:1517-28 pubmed
Jemal I, Soriano S, Conte A, Morenilla C, Gomis A. G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels. Pflugers Arch. 2014;466:1635-46 pubmed publisher
Martinsen A, Schakman O, Yerna X, Dessy C, Morel N. Myosin light chain kinase controls voltage-dependent calcium channels in vascular smooth muscle. Pflugers Arch. 2014;466:1377-89 pubmed publisher
Xu X, Prough R, Samuelson D. Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway. Mol Carcinog. 2015;54:134-47 pubmed publisher
Fang C, Illingworth C, Qian L, Wormstone I. Serum deprivation can suppress receptor-mediated calcium signaling in pterygial-derived fibroblasts. Invest Ophthalmol Vis Sci. 2013;54:4563-70 pubmed publisher
Paulsen E, Villadsen J, Tenori E, Liu H, Bonde D, Lie M, et al. Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase. J Med Chem. 2013;56:3609-19 pubmed publisher
Marada S, Stewart D, Bodeen W, Han Y, Ogden S. The unfolded protein response selectively targets active smoothened mutants. Mol Cell Biol. 2013;33:2375-87 pubmed publisher
Nakamura S, Takizawa H, Shimazawa M, Hashimoto Y, Sugitani S, Tsuruma K, et al. Mild endoplasmic reticulum stress promotes retinal neovascularization via induction of BiP/GRP78. PLoS ONE. 2013;8:e60517 pubmed publisher
Keinan N, Pahima H, Ben Hail D, Shoshan Barmatz V. The role of calcium in VDAC1 oligomerization and mitochondria-mediated apoptosis. Biochim Biophys Acta. 2013;1833:1745-54 pubmed publisher
Lukyanets I, Lukyanetz E. Modulation of calcium signalling by the endoplasmic reticulum in Carassius neurons. Biochem Biophys Res Commun. 2013;433:591-4 pubmed publisher
Castelo Branco R, Leite Delova D, De Mello Aires M. Dose-dependent effects of angiotensin-(1-7) on the NHE3 exchanger and [Ca(2+)](i) in in vivo proximal tubules. Am J Physiol Renal Physiol. 2013;304:F1258-65 pubmed publisher
Gallerne C, Prola A, Lemaire C. Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2. Biochim Biophys Acta. 2013;1833:1356-66 pubmed publisher
Monteith A, Marszalec W, Chan P, Logan J, Yu W, Schwarz N, et al. Imaging of mitochondrial and non-mitochondrial responses in cultured rat hippocampal neurons exposed to micromolar concentrations of TMRM. PLoS ONE. 2013;8:e58059 pubmed publisher
Roti G, Carlton A, Ross K, Markstein M, Pajcini K, Su A, et al. Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell. 2013;23:390-405 pubmed publisher
Esfandiarei M, Fameli N, Choi Y, Tehrani A, Hoskins J, van Breemen C. Waves of calcium depletion in the sarcoplasmic reticulum of vascular smooth muscle cells: an inside view of spatiotemporal Ca2+ regulation. PLoS ONE. 2013;8:e55333 pubmed publisher
Zheng M, Zhang Q, Joe Y, Kim S, Uddin M, Rhew H, et al. Carbon monoxide-releasing molecules reverse leptin resistance induced by endoplasmic reticulum stress. Am J Physiol Endocrinol Metab. 2013;304:E780-8 pubmed publisher
Lenna S, Farina A, Martyanov V, Christmann R, Wood T, Farber H, et al. Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension. Arthritis Rheum. 2013;65:1357-66 pubmed publisher
Hooper J, Hadley S, Mathews A, Taylor Clark T. Store-operated calcium entry in vagal sensory nerves is independent of Orai channels. Brain Res. 2013;1503:7-15 pubmed publisher
Gandia J, Fernández Dueñas V, Morató X, Caltabiano G, González Muñiz R, Pardo L, et al. The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain. J Neurochem. 2013;125:362-72 pubmed publisher
Grant J, Parker K, Moore C, Keddy P, Mayne M, Robertson G. Over-expression of X-linked inhibitor of apoptosis protein modulates multiple aspects of neuronal Ca2+ signaling. Neurochem Res. 2013;38:847-56 pubmed publisher
Kim K, Ji H, Yang H. Taurine may not alleviate hyperglycemia-mediated endoplasmic reticulum stress in human adipocytes. Adv Exp Med Biol. 2013;775:395-403 pubmed publisher
Zhou J, Perelman J, Kolosov V, Zhou X. Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2. Mol Cell Biochem. 2013;377:75-85 pubmed publisher
Madaro L, Marrocco V, Carnio S, Sandri M, Bouché M. Intracellular signaling in ER stress-induced autophagy in skeletal muscle cells. FASEB J. 2013;27:1990-2000 pubmed publisher
Grebinyk S, Palyvoda K, Prylutska S, Grynyuk I, Samoylenko A, Drobot L, et al. Photoactivated fullerene C60 induces store-operated Ca2 entry and cytochrome c release in Jurkat cells. Ukr Biokhim Zh (1999). 2012;84:58-63 pubmed
Shabman R, Hoenen T, Groseth A, Jabado O, Binning J, Amarasinghe G, et al. An upstream open reading frame modulates ebola virus polymerase translation and virus replication. PLoS Pathog. 2013;9:e1003147 pubmed publisher
Abiodun O, Brun R, Wittlin S. In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains. Malar J. 2013;12:43 pubmed publisher
Abu Khamidakh A, Juuti Uusitalo K, Larsson K, Skottman H, Hyttinen J. Intercellular Ca(2+) wave propagation in human retinal pigment epithelium cells induced by mechanical stimulation. Exp Eye Res. 2013;108:129-39 pubmed publisher
Chen C, Wang J, Li J, Yu Q, Zhang S. Quinotrierixin inhibits proliferation of human retinal pigment epithelial cells. Mol Vis. 2013;19:39-46 pubmed
Younce C, Burmeister M, Ayala J. Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a. Am J Physiol Cell Physiol. 2013;304:C508-18 pubmed publisher
O Dell B, Browning J. Zinc deficiency induced in Swiss 3T3 cells by a low-zinc medium impairs calcium entry and two mechanisms of entry are involved. Biol Trace Elem Res. 2013;152:98-104 pubmed publisher
Takahashi N, Yoshizaki T, Hiranaka N, Suzuki T, Yui T, Akanuma M, et al. Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2013;431:25-30 pubmed publisher
Yang Y, Lin P, Chen F, Wang A, Lan X, Song Y, et al. Luman recruiting factor regulates endoplasmic reticulum stress in mouse ovarian granulosa cell apoptosis. Theriogenology. 2013;79:633-9.e1-3 pubmed publisher
Redondo N, Sanz M, Welnowska E, Carrasco L. Translation without eIF2 promoted by poliovirus 2A protease. PLoS ONE. 2011;6:e25699 pubmed publisher
McCarthy J, Gong X, Nahirney D, Duszyk M, Radomski M. Polystyrene nanoparticles activate ion transport in human airway epithelial cells. Int J Nanomedicine. 2011;6:1343-56 pubmed publisher
Ganley I, Wong P, Gammoh N, Jiang X. Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell. 2011;42:731-43 pubmed publisher
Fontana M, Banga S, Barry K, Shen X, Tan Y, Luo Z, et al. Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog. 2011;7:e1001289 pubmed publisher
Hobbs R, Amargo E, Somasundaram A, Simpson C, Prakriya M, Denning M, et al. The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling. FASEB J. 2011;25:990-1001 pubmed publisher
Sun L, Shah F, Helal M, Wu Y, Pedduri Y, Chittiboyina A, et al. Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents. J Med Chem. 2010;53:7864-8 pubmed publisher
Brisac C, Téoulé F, Autret A, Pelletier I, Colbere Garapin F, Brenner C, et al. Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis. J Virol. 2010;84:12226-35 pubmed publisher
Lew Q, Chu K, Lee J, Koh P, Rajasegaran V, Teo J, et al. PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription. Nucleic Acids Res. 2011;39:429-39 pubmed publisher
Rottmann M, McNamara C, Yeung B, Lee M, Zou B, Russell B, et al. Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010;329:1175-80 pubmed publisher
Bosco D, Lemay N, Ko H, Zhou H, Burke C, Kwiatkowski T, et al. Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules. Hum Mol Genet. 2010;19:4160-75 pubmed publisher
Skytte D, Møller J, Liu H, Nielsen H, Svenningsen L, Jensen C, et al. Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase. Bioorg Med Chem. 2010;18:5634-46 pubmed publisher
Kerbiriou M, Teng L, Benz N, Trouvé P, Ferec C. The calpain, caspase 12, caspase 3 cascade leading to apoptosis is altered in F508del-CFTR expressing cells. PLoS ONE. 2009;4:e8436 pubmed publisher
Shimizu Y, Meunier L, Hendershot L. pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin. Proc Natl Acad Sci U S A. 2009;106:17013-8 pubmed publisher
Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher
Sekiguchi Tonosaki M, Obata M, Haruki A, Himi T, Kosaka J. Acetylcholine induces Ca2+ signaling in chicken retinal pigmented epithelial cells during dedifferentiation. Am J Physiol Cell Physiol. 2009;296:C1195-206 pubmed publisher
Overgaard C, Sanzone K, Spiczka K, Sheff D, Sandra A, Yeaman C. Deciliation is associated with dramatic remodeling of epithelial cell junctions and surface domains. Mol Biol Cell. 2009;20:102-13 pubmed publisher
Navarro Borelly L, Somasundaram A, Yamashita M, Ren D, Miller R, Prakriya M. STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy. J Physiol. 2008;586:5383-401 pubmed publisher
Gonzales J, Gentile C, Pfaffenbach K, Wei Y, Wang D, Pagliassotti M. Chemical induction of the unfolded protein response in the liver increases glucose production and is activated during insulin-induced hypoglycaemia in rats. Diabetologia. 2008;51:1920-9 pubmed publisher
Williams A, Sarkar S, Cuddon P, Ttofi E, Saiki S, Siddiqi F, et al. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol. 2008;4:295-305 pubmed publisher
Chen C, Chen C, Kung C, Kuo S, Kuo S. [6]-gingerol induces Ca2+ mobilization in Madin-Darby canine kidney cells. J Nat Prod. 2008;71:137-40 pubmed publisher
Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, et al. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A. 2007;104:19023-8 pubmed
Nagamune K, Moreno S, Sibley L. Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis. Antimicrob Agents Chemother. 2007;51:3816-23 pubmed
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
Mishina Y, Krishna S, Haynes R, Meade J. Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth. Antimicrob Agents Chemother. 2007;51:1852-4 pubmed
Uhlemann A, Wittlin S, Matile H, Bustamante L, Krishna S. Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277). Antimicrob Agents Chemother. 2007;51:667-72 pubmed
Søhoel H, Liljefors T, Ley S, Oliver S, Antonello A, Smith M, et al. Total synthesis of two novel subpicomolar sarco/endoplasmatic reticulum Ca2+-ATPase inhibitors designed by an analysis of the binding site of thapsigargin. J Med Chem. 2005;48:7005-11 pubmed
Appendino G, Prosperini S, Valdivia C, Ballero M, Colombano G, Billington R, et al. SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis. J Nat Prod. 2005;68:1213-7 pubmed
Singh P, Mhaka A, Christensen S, Gray J, Denmeade S, Isaacs J. Applying linear interaction energy method for rational design of noncompetitive allosteric inhibitors of the sarco- and endoplasmic reticulum calcium-ATPase. J Med Chem. 2005;48:3005-14 pubmed
Deng J, Lu P, Zhang Y, Scheuner D, Kaufman R, Sonenberg N, et al. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol. 2004;24:10161-8 pubmed
Grønning L, Wang J, Ree A, Haugen T, Tasken K, Taskén K. Regulation of tissue inhibitor of metalloproteinases-1 in rat Sertoli cells: induction by germ cell residual bodies, interleukin-1alpha, and second messengers. Biol Reprod. 2000;62:1040-6 pubmed
Inesi G, Wade R, Rogers T. The sarcoplasmic reticulum Ca2+ pump: inhibition by thapsigargin and enhancement by adenovirus-mediated gene transfer. Ann N Y Acad Sci. 1998;853:195-206 pubmed
Korge P, Weiss J. Thapsigargin directly induces the mitochondrial permeability transition. Eur J Biochem. 1999;265:273-80 pubmed
Thomas G, Sanderson J, Duncan G. Thapsigargin inhibits a potassium conductance and stimulates calcium influx in the intact rat lens. J Physiol. 1999;516 ( Pt 1):191-9 pubmed
Treiman M, Caspersen C, Christensen S. A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases. Trends Pharmacol Sci. 1998;19:131-5 pubmed
Rogers T, Inesi G, Wade R, Lederer W. Use of thapsigargin to study Ca2+ homeostasis in cardiac cells. Biosci Rep. 1995;15:341-9 pubmed
Sabała P, Czarny M, Woronczak J, Baranska J. Thapsigargin: potent inhibitor of Ca2+ transport ATP-ases of endoplasmic and sarcoplasmic reticulum. Acta Biochim Pol. 1993;40:309-19 pubmed
Thastrup O. Role of Ca2(+)-ATPases in regulation of cellular Ca2+ signalling, as studied with the selective microsomal Ca2(+)-ATPase inhibitor, thapsigargin. Agents Actions. 1990;29:8-15 pubmed
Inesi G, Sagara Y. Thapsigargin, a high affinity and global inhibitor of intracellular Ca2+ transport ATPases. Arch Biochem Biophys. 1992;298:313-7 pubmed
product information
Catalog Number :
T9033
Product Name :
Thapsigargin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC), solid film
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA