This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Trifluoperazine dihydrochloride
catalog :
T8516
citations: 19
Reference
Lin C, Tan X, Chen M, Kusi M, Hung C, Chou C, et al. ERα-related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer. BMC Med Genomics. 2020;13:69 pubmed publisher
Yen C, Chen L, Li C, Chen S, Chua W, Lin Y, et al. Identification of phenothiazine as an ETV1‑targeting agent in gastrointestinal stromal tumors using the Connectivity Map. Int J Oncol. 2019;55:536-546 pubmed publisher
Janssens G, Lin X, Millán Ariño L, Kavšek A, Sen I, Seinstra R, et al. Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell Rep. 2019;27:467-480.e6 pubmed publisher
Denis K, Le Bris M, Le Guennec L, Barnier J, Faure C, Gouge A, et al. Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease. Nat Microbiol. 2019;4:972-984 pubmed publisher
Kim J, Choi S, Lee S, Park K. Voltage-dependent Ca2+ channels promote branching morphogenesis of salivary glands by patterning differential growth. Sci Rep. 2018;8:7566 pubmed publisher
Graham C, Kaza N, Klocke B, Gillespie G, Shevde L, Carroll S, et al. Tamoxifen Induces Cytotoxic Autophagy in Glioblastoma. J Neuropathol Exp Neurol. 2016;75:946-954 pubmed
Olianas M, Dedoni S, Onali P. Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts. Biochem Pharmacol. 2015;95:311-23 pubmed publisher
Pulkoski Gross A, Li J, Zheng C, Li Y, Ouyang N, Rigas B, et al. Repurposing the antipsychotic trifluoperazine as an antimetastasis agent. Mol Pharmacol. 2015;87:501-12 pubmed publisher
Lee S, Park J, Kim D, Bae S, Chin Y, Oh E, et al. In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug-drug interactions. Toxicol Lett. 2015;232:458-65 pubmed publisher
Brosius S, Turk A, Byer S, Longo J, Kappes J, Roth K, et al. Combinatorial therapy with tamoxifen and trifluoperazine effectively inhibits malignant peripheral nerve sheath tumor growth by targeting complementary signaling cascades. J Neuropathol Exp Neurol. 2014;73:1078-90 pubmed publisher
Choi E, Park J, Yoon K, Bae S. Evaluation of the in vitro/in vivo potential of five berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) commonly used as herbal supplements to inhibit uridine diphospho-glucuronosyltransferase. Food Chem Toxicol. 2014;72:13-9 pubmed publisher
Bae S, Kwon M, Park J, Kim D, Kim D, Kang J, et al. Metabolic drug-drug interaction potential of macrolactin A and 7-O-succinyl macrolactin A assessed by evaluating cytochrome P450 inhibition and induction and UDP-glucuronosyltransferase inhibition in vitro. Antimicrob Agents Chemother. 2014;58:5036-46 pubmed publisher
Zheng Y, Bae S, Choi E, Park J, Kim S, Jang M, et al. Evaluation of the in vitro/in vivo drug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition. Food Chem Toxicol. 2014;68:117-27 pubmed publisher
Khuituan P, Wongdee K, Jantarajit W, Suntornsaratoon P, Krishnamra N, Charoenphandhu N. Fibroblast growth factor-23 negates 1,25(OH)2D3-induced intestinal calcium transport by reducing the transcellular and paracellular calcium fluxes. Arch Biochem Biophys. 2013;536:46-52 pubmed publisher
Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher
Hung A, Magoski N. Activity-dependent initiation of a prolonged depolarization in aplysia bag cell neurons: role for a cation channel. J Neurophysiol. 2007;97:2465-79 pubmed
Carballo M, Marquez G, Conde M, Martin Nieto J, Monteseirin J, Conde J, et al. Characterization of calcineurin in human neutrophils. Inhibitory effect of hydrogen peroxide on its enzyme activity and on NF-kappaB DNA binding. J Biol Chem. 1999;274:93-100 pubmed
Mach R, Zeilinger S, Kristufek D, Kubicek C. Ca2+-calmodulin antagonists interfere with xylanase formation and secretion in Trichoderma reesei. Biochim Biophys Acta. 1998;1403:281-9 pubmed
Samouilidou E, Karli J, Levis G, Darsinos J. The sarcolemmal Ca2+-ATPase of the ischemic-reperfused myocardium: protective effect of hypocalcemia on calmodulin-stimulated activity. Life Sci. 1998;62:29-36 pubmed
product information
Catalog Number :
T8516
Product Name :
Trifluoperazine dihydrochloride
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥99%, powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA