This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Timolol maleate salt
catalog :
T6394
citations: 55
Reference
Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, et al. β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons. elife. 2019;8: pubmed publisher
Reyes Corral M, Sørensen N, Thrasivoulou C, Dasgupta P, Ashmore J, Ahmed A. Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines. J Pharmacol Exp Ther. 2019;369:152-162 pubmed publisher
Dixon P, Chauhan A. Effect of the surface layer on drug release from delefilcon-A (Dailies Total1®) contact lenses. Int J Pharm. 2017;529:89-101 pubmed publisher
Mehta P, Al Kinani A, Haj Ahmad R, Arshad M, Chang M, Alany R, et al. Electrically atomised formulations of timolol maleate for direct and on-demand ocular lens coatings. Eur J Pharm Biopharm. 2017;119:170-184 pubmed publisher
Cai F, Gao L, Gong H, Jiang F, Pei C, Zhang X, et al. Network Centrality of Resting-State fMRI in Primary Angle-Closure Glaucoma Before and After Surgery. PLoS ONE. 2015;10:e0141389 pubmed publisher
Stavinohova R, Newton J, Busse C. The effect of prophylactic topical carbonic anhydrase inhibitors in canine primary closed-angle glaucoma. J Small Anim Pract. 2015;56:662-6 pubmed publisher
Hsu K, Carbia B, Plummer C, Chauhan A. Dual drug delivery from vitamin E loaded contact lenses for glaucoma therapy. Eur J Pharm Biopharm. 2015;94:312-21 pubmed publisher
Boiero C, Allemandi D, Longhi M, Llabot J. RP-HPLC method development for the simultaneous determination of timolol maleate and human serum albumin in albumin nanoparticles. J Pharm Biomed Anal. 2015;111:186-9 pubmed publisher
Pakravan M, Yazdani S. Author reply: To PMID 24819857. Ophthalmology. 2014;121:e69 pubmed publisher
Goelz R, Poets C. Incidence and treatment of infantile haemangioma in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2015;100:F85-91 pubmed publisher
Fukuda M, Sasaki H. The transcorneal penetration of commercial ophthalmic formulations containing timolol maleate in rabbit eyes. J Ocul Pharmacol Ther. 2015;31:57-60 pubmed publisher
Lorenz K, Pfeiffer N. Efficacy and safety of tafluprost 0.0015% and timolol maleate 0.5% fixed combination in patients with ocular hypertension or open-angle glaucoma. Expert Opin Pharmacother. 2014;15:2255-62 pubmed publisher
Said D, Gatzioufas Z, Hafezi F. Author reply: To PMID 24576886. Ophthalmology. 2014;121:e68 pubmed publisher
Li J, Lin X, Yu M. Meta-analysis of randomized controlled trials comparing latanoprost with other glaucoma medications in chronic angle-closure glaucoma. Eur J Ophthalmol. 2015;25:18-26 pubmed publisher
. Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle. J Pharmacol Exp Ther. 2014;350:681-90 pubmed publisher
Smith T, Cornblath W. Alternating superior and inferior oblique myokymia. JAMA Ophthalmol. 2014;132:898-9 pubmed publisher
Beroukhim K, Rotunda A. Topical 0.5% timolol heals a recalcitrant irradiated surgical scalp wound. Dermatol Surg. 2014;40:924-6 pubmed publisher
Ho L, Conner I, Do C, Kim S, Wu E, Wollstein G, et al. In vivo assessment of aqueous humor dynamics upon chronic ocular hypertension and hypotensive drug treatment using gadolinium-enhanced MRI. Invest Ophthalmol Vis Sci. 2014;55:3747-57 pubmed publisher
Goldberg I, Gil Pina R, Lanzagorta Aresti A, Schiffman R, Liu C, Bejanian M. Bimatoprost 0.03%/timolol 0.5% preservative-free ophthalmic solution versus bimatoprost 0.03%/timolol 0.5% ophthalmic solution (Ganfort) for glaucoma or ocular hypertension: a 12-week randomised controlled trial. Br J Ophthalmol. 2014;98:926-31 pubmed publisher
Naderkhani E, Isaksson J, Ryzhakov A, Flaten G. Development of a biomimetic phospholipid vesicle-based permeation assay for the estimation of intestinal drug permeability. J Pharm Sci. 2014;103:1882-90 pubmed publisher
Furlanetto R, De Moraes C, Teng C, Liebmann J, Greenfield D, Gardiner S, et al. Risk factors for optic disc hemorrhage in the low-pressure glaucoma treatment study. Am J Ophthalmol. 2014;157:945-52 pubmed publisher
Ahmed I, Hassan M, Kondo T. Effect of lyophilized grapefruit juice on P-glycoprotein-mediated drug transport in-vitro and in-vivo. Drug Dev Ind Pharm. 2015;41:375-81 pubmed publisher
Seymenoğlu G, Baser E, Oztürk B, Gülhan C. Comparison of dorzolamide/timolol versus brimonidine/timolol fixed combination therapy in the management of steroid-induced ocular hypertension. J Glaucoma. 2015;24:111-6 pubmed publisher
Harrison C. Patent watch: one valid claim is all that is needed. Nat Rev Drug Discov. 2013;12:416-7 pubmed publisher
Konstas A, Hollo G, Mikropoulos D, Haidich A, Dimopoulos A, Empeslidis T, et al. 24-hour efficacy of the bimatoprost-timolol fixed combination versus latanoprost as first choice therapy in subjects with high-pressure exfoliation syndrome and glaucoma. Br J Ophthalmol. 2013;97:857-61 pubmed publisher
Chan H, McKay C, Adams S, Wargon O. RCT of timolol maleate gel for superficial infantile hemangiomas in 5- to 24-week-olds. Pediatrics. 2013;131:e1739-47 pubmed publisher
Hardarson S. Retinal oximetry. Acta Ophthalmol. 2013;91 Thesis 2:1-47 pubmed publisher
Prokosch V, Schallenberg M, Thanos S. Crystallins are regulated biomarkers for monitoring topical therapy of glaucomatous optic neuropathy. PLoS ONE. 2013;8:e49730 pubmed publisher
Craiglow B, Antaya R. Management of infantile hemangiomas : current and potential pharmacotherapeutic approaches. Paediatr Drugs. 2013;15:133-8 pubmed publisher
Sena D, Lindsley K. Neuroprotection for treatment of glaucoma in adults. Cochrane Database Syst Rev. 2013;:CD006539 pubmed publisher
Kim G, Han Y, Chung I, Seo S, Park J, Yoo J. Effect of Dorzolamide/Timolol or Brinzolamide/Timolol prophylaxis on intravitreal anti-VEGF injection-induced intraocular hypertension. Semin Ophthalmol. 2013;28:61-7 pubmed publisher
Schlote T. [Mode of action, clinical profile and significance of beta-blockers in antiglaucoma therapy]. Klin Monbl Augenheilkd. 2013;230:120-6 pubmed publisher
Khan A, Aldahmesh M, Mohamed J, Alkuraya F. Congenital glaucoma with acquired peripheral circumferential iris degeneration. J AAPOS. 2013;17:105-7 pubmed publisher
Berk D, Lehman P, Franz T, Blunt J, Bayliss S. On topical timolol gel-forming solution for infantile hemangiomas. Pediatr Dermatol. 2013;30:160-1 pubmed publisher
Arnold J, Hansen M, Gorman G, Inoue T, Rao V, Spellen S, et al. The effect of Rho-associated kinase inhibition on the ocular penetration of timolol maleate. Invest Ophthalmol Vis Sci. 2013;54:1118-26 pubmed publisher
Araie M, Yamazaki Y, Sugiyama K, Kuwayama Y, Tanihara H. [Phase III clinical trial of brimonidine in patients with primary open-angle glaucoma and ocular hypertension--comparison of the effects of brimonidine monotherapy versus timolol monotherapy, or combination brimonidine/prostaglandins therapy versus c. Nippon Ganka Gakkai Zasshi. 2012;116:955-66 pubmed
Mittag J, Lyons D, Sällström J, Vujovic M, Dudazy Gralla S, Warner A, et al. Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions. J Clin Invest. 2013;123:509-16 pubmed publisher
Chantasart D, Hao J, Li S. Evaluation of skin permeation of β-blockers for topical drug delivery. Pharm Res. 2013;30:866-77 pubmed publisher
Schmier J, Covert D, Lau E. Medical service encounters and payments associated with topical adjunctive therapy use of timolol for glaucoma. Clin Drug Investig. 2012;32:835-42 pubmed publisher
Khan N, Khaleque M, Islam M, Begum R, Uddin M, Hossain M, et al. Effect of topical Beta blocker (Timolol maleate 0.5%) in primary open angle glaucoma. Mymensingh Med J. 2012;21:648-53 pubmed
Jung H, Abou Jaoude M, Carbia B, Plummer C, Chauhan A. Glaucoma therapy by extended release of timolol from nanoparticle loaded silicone-hydrogel contact lenses. J Control Release. 2013;165:82-9 pubmed publisher
Shimanovskaia E, Beznos O, Kliachko N, Kost O, Nikol skaia I, Pavlenko T, et al. [Production of timolol containing calcium-phosphate nanoparticles and evaluation of their effect on intraocular pressure in experiment]. Vestn Oftalmol. 2012;128:15-8 pubmed
Gallarate M, Chirio D, Bussano R, Peira E, Battaglia L, Baratta F, et al. Development of O/W nanoemulsions for ophthalmic administration of timolol. Int J Pharm. 2013;440:126-34 pubmed publisher
Cheng J, Cheng S, Gao L, Lu G, Wei R. Intraocular pressure-lowering effects of commonly used fixed-combination drugs with timolol: a systematic review and meta-analysis. PLoS ONE. 2012;7:e45079 pubmed publisher
Ayaki M, Iwasawa A, Niwano Y. Cell viability score as an integrated indicator for cytotoxicity of benzalkonium chloride-containing antiglaucoma eyedrops. Biocontrol Sci. 2012;17:121-8 pubmed
Ayaki M, Iwasawa A, Niwano Y. Comparative study of in vitro ocular surface cytotoxicity of a fixed combination of 0.5% timolol/1% dorzolamide eyedrop and its components with 0.005% benzalkonium chloride. Biocontrol Sci. 2012;17:115-20 pubmed
Inoue K, Shiokawa M, Sugahara M, Wakakura M, Soeda S, Tomita G. Three-month evaluation of dorzolamide hydrochloride/timolol maleate fixed-combination eye drops versus the separate use of both drugs. Jpn J Ophthalmol. 2012;56:559-63 pubmed publisher
Shojaei A, Eslani M, Vali Y, MANSOURI M, Dadman N, Yaseri M. Effect of timolol on refractive outcomes in eyes with myopic regression after laser in situ keratomileusis: a prospective randomized clinical trial. Am J Ophthalmol. 2012;154:790-798.e1 pubmed publisher
Hardwick J, Southerland E, Girasole A, Ryan S, Negrotto S, Ardell J. Remodeling of intrinsic cardiac neurons: effects of ?-adrenergic receptor blockade in guinea pig models of chronic heart disease. Am J Physiol Regul Integr Comp Physiol. 2012;303:R950-8 pubmed publisher
Chakkittakandiyil A, Phillips R, Frieden I, Siegfried E, Lara Corrales I, Lam J, et al. Timolol maleate 0.5% or 0.1% gel-forming solution for infantile hemangiomas: a retrospective, multicenter, cohort study. Pediatr Dermatol. 2012;29:28-31 pubmed publisher
Tomidokoro A, Araie M, Tamaki Y, Muta K. Effects of topical carteolol and timolol on tissue circulation in the iris and choroid. Curr Eye Res. 1999;18:381-90 pubmed
Searles R, Shikher V, Balaban C, Severs W. Timolol effects on aqueous humor dynamics in eyes of anesthetized rats. J Pharmacol Exp Ther. 1999;288:838-42 pubmed
Viko H, Osnes J, Sjetnan A, Skomedal T. Improved isolation of cardiomyocytes by trypsination in addition to collagenase treatment. Pharmacol Toxicol. 1995;76:68-71 pubmed
Karhuvaara S, Kaila T, Huupponen R. Beta-adrenoceptor antagonist activities and binding affinities of timolol enantiomers in rat atria. J Pharm Pharmacol. 1989;41:649-50 pubmed
Chiou G, Chen Y. Effects of D- and L-isomers of timolol on retinal and choroidal blood flow in ocular hypertensive rabbit eyes. J Ocul Pharmacol. 1992;8:183-90 pubmed
product information
Catalog Number :
T6394
Product Name :
Timolol maleate salt
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (TLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA